WordNet
- make fit for, or change to suit a new purpose; "Adapt our native cuisine to the available food resources of the new country" (同)accommodate
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
PrepTutorEJDIC
- (…に)…'を'『適応させる』,適合させる《+『名』+『to』+『名』(do『ing』)》 / (…向きに)〈小説・戯曲など〉'を'『脚色する』,翻案する,書きかえる《+『名』+『for』+『名』》 / (環境などに)適応する,順応する《+『to』+『名』》
- 蛋白(たんばく)質
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/30 11:44:14」(JST)
wiki en
| Growth factor receptor-bound protein 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PDB rendering based on 1gri. |
|||||||||||||
|
|||||||||||||
| Identifiers | |||||||||||||
| Symbols | GRB2 ; ASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084; NCKAP2 | ||||||||||||
| External IDs | OMIM: 108355 MGI: 95805 HomoloGene: 1576 ChEMBL: 3663 GeneCards: GRB2 Gene | ||||||||||||
|
|||||||||||||
| RNA expression pattern | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2885 | 14784 | |||||||||||
| Ensembl | ENSG00000177885 | ENSMUSG00000059923 | |||||||||||
| UniProt | P62993 | Q60631 | |||||||||||
| RefSeq (mRNA) | NM_002086 | NM_008163 | |||||||||||
| RefSeq (protein) | NP_002077 | NP_032189 | |||||||||||
| Location (UCSC) | Chr 17: 73.31 – 73.4 Mb |
Chr 11: 115.64 – 115.71 Mb |
|||||||||||
| PubMed search | [1] | [2] | |||||||||||
|
This box:
|
|||||||||||||
Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.[1][2]
The protein encoded by this gene binds receptors such as the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the sem-5 gene of Caenorhabditis elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[3]
Contents
- 1 Function and expression
- 2 Domains
- 3 Interactions
- 4 See also
- 5 References
- 6 Further reading
- 7 External links
Function and expression
Grb2 is widely expressed and is essential for multiple cellular functions. Inhibition of Grb2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types, and so it is not surprising that a targeted gene disruption of Grb2 in mouse is lethal at an early embryonic stage. Grb2 is best known for its ability to link the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases, ERK1,2. Grb2 is composed of an SH2 domain flanked on each side by an SH3 domain. Grb2 has two closely related proteins with similar domain organizations, Gads and Grap. Gads and Grap are expressed specifically in hematopoietic cells and function in the coordination of tyrosine kinase mediated signal transduction.
Domains
The SH2 domain of Grb2 binds to phosphorylated tyrosine-containing peptides on receptors or scaffold proteins with a preference for pY-X-N-X, where X is generally a hydrophobic residue such as valine (see [3]).
The N-terminal SH3 domain binds to proline-rich peptides and can bind to the Ras-guanine exchange factor SOS.
The C-terminal SH3 domain binds to peptides conforming to a P-X-I/L/V/-D/N-R-X-X-K-P motif that allows it to specifically bind to proteins such as Gab-1.[4]
Interactions
Grb2 has been shown to interact with Arachidonate 5-lipoxygenase,[5][6] Lymphocyte cytosolic protein 2,[7][8][9][10][11] GAB2,[12][13][14] B-cell linker,[15][16][17][18] Abl gene,[19][20] CD28,[21][22] FRS2,[23][24][25][26] Mitogen-activated protein kinase 9,[27][28] CD22,[29][30] NEU3,[31] ETV6,[12] MAP2,[32][33] Dock180,[34][35] PIK3R1,[36][37] SH2B1,[38][39] CRK,[40][41][42] GAB1,[7][43][44] MST1R,[45][46] DNM1,[47][48] Huntingtin,[49] Src,[50][51] Beta-2 adrenergic receptor,[52] VAV2,[53][54] ADAM15,[55] RAPGEF1,[56][57] VAV1,[58][59][60][61] HER2/neu,[54][62][63] Epidermal growth factor receptor,[2][43][53][62][64][65][66][67][68][69] PDGFRB,[69][70][71] PTK2,[72][73][74][75][76] Erythropoietin receptor,[77][78] Linker of activated T cells,[79][80][81] Dystroglycan,[82] SH3KBP1,[83][84] Granulocyte colony-stimulating factor receptor,[85] DCTN1,[86] CDKN1B,[87] Colony stimulating factor 1 receptor,[88] EPH receptor A2,[89] KHDRBS1,[43][90][91] RET proto-oncogene,[92][93] PLCG1,[94][95][96] TrkA,[97][98] PRKAR1A,[66] Janus kinase 2,[99][100] MUC1,[101] CD117,[78][102][103] Fas ligand,[104][105] Janus kinase 1,[100][106] VAV3,[53][107] BCAR1,[73][108] PTPN1,[109][110] INPP5D,[111] ITK,[112][113] SHC1,[51][53][114][115][116][117][118][119][120][121][122][123][124][125][126][127][128][129][130][131][132] PTPN12,[133] C-Met,[134][135] PTPN11,[71][85][127][136][137][138][139][140][141] Glycoprotein 130,[61] PTPN6,[51][136][142] Syk,[51][136] MAP4K1,[143][144][145][146] Wiskott-Aldrich syndrome protein,[147][148] NCKIPSD,[149][150] PTPRA,[151][152][153] BCR gene,[12][115][154][155][156][157] CBLB,[158][159][160] Cbl gene,[9][24][51][90][124][158][161][162][163][164][165][166][167] SOS1,[8][24][42][43][48][51][53][60][68][90][95][101][115][122][124][131][168][169][170][171][172] IRS1,[100][114][173] TNK2,[116][174] MED28,[175] MAP3K1[176] and HNRNPC.[177]
See also
- MAPK/ERK pathway
References
- ^ Matuoka K, Shibata M, Yamakawa A, Takenawa T (October 1992). "Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries". Proc. Natl. Acad. Sci. U.S.A. 89 (19): 9015–9. doi:10.1073/pnas.89.19.9015. PMC 50055. PMID 1384039.
- ^ a b Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J (August 1992). "The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling". Cell 70 (3): 431–42. doi:10.1016/0092-8674(92)90167-B. PMID 1322798.
- ^ "Entrez Gene: GRB2 growth factor receptor-bound protein 2".
- ^ Berry DM, Nash P, Liu SK, Pawson T, McGlade CJ (2002). "A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling". Curr. Biol. 12 (15): 1336–41. doi:10.1016/S0960-9822(02)01038-2. PMID 12176364.
- ^ VanderNoot, V A; Fitzpatrick F A (Sep 1995). "Competitive binding assay of src homology domain 3 interactions between 5-lipoxygenase and growth factor receptor binding protein 2". Anal. Biochem. (UNITED STATES) 230 (1): 108–14. doi:10.1006/abio.1995.1444. ISSN 0003-2697. PMID 8585605.
- ^ Lepley, R A; Fitzpatrick F A (Sep 1994). "5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins". J. Biol. Chem. (UNITED STATES) 269 (39): 24163–8. ISSN 0021-9258. PMID 7929073.
- ^ a b Lewitzky, M; Kardinal C; Gehring N H; Schmidt E K; Konkol B; Eulitz M; Birchmeier W; Schaeper U; Feller S M (Mar 2001). "The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif". Oncogene (England) 20 (9): 1052–62. doi:10.1038/sj.onc.1204202. ISSN 0950-9232. PMID 11314042.
- ^ a b Robinson, A; Gibbins J; Rodríguez-Liñares B; Finan P M; Wilson L; Kellie S; Findell P; Watson S P (Jul 1996). "Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking". Blood (UNITED STATES) 88 (2): 522–30. ISSN 0006-4971. PMID 8695800.
- ^ a b Erdreich-Epstein, A; Liu M; Kant A M; Izadi K D; Nolta J A; Durden D L (Apr 1999). "Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages". J. Leukoc. Biol. (UNITED STATES) 65 (4): 523–34. ISSN 0741-5400. PMID 10204582.
- ^ Hendricks-Taylor, L R; Motto D G; Zhang J; Siraganian R P; Koretzky G A (Jan 1997). "SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells". J. Biol. Chem. (UNITED STATES) 272 (2): 1363–7. doi:10.1074/jbc.272.2.1363. ISSN 0021-9258. PMID 8995445.
- ^ Asada, H; Ishii N; Sasaki Y; Endo K; Kasai H; Tanaka N; Takeshita T; Tsuchiya S; Konno T; Sugamura K (May 1999). "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT". J. Exp. Med. (UNITED STATES) 189 (9): 1383–90. doi:10.1084/jem.189.9.1383. ISSN 0022-1007. PMC 2193052. PMID 10224278.
- ^ a b c Million, Ryan P; Harakawa Nari; Roumiantsev Sergei; Varticovski Lyuba; Van Etten Richard A (Jun 2004). "A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase". Mol. Cell. Biol. (United States) 24 (11): 4685–95. doi:10.1128/MCB.24.11.4685-4695.2004. ISSN 0270-7306. PMC 416425. PMID 15143164.
- ^ Lynch, Danielle K; Daly Roger J (Jan 2002). "PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2". EMBO J. (England) 21 (1–2): 72–82. doi:10.1093/emboj/21.1.72. ISSN 0261-4189. PMC 125816. PMID 11782427.
- ^ Zhao, C; Yu D H; Shen R; Feng G S (Jul 1999). "Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1". J. Biol. Chem. (UNITED STATES) 274 (28): 19649–54. doi:10.1074/jbc.274.28.19649. ISSN 0021-9258. PMID 10391903.
- ^ Fu, C; Turck C W; Kurosaki T; Chan A C (Jul 1998). "BLNK: a central linker protein in B cell activation". Immunity (UNITED STATES) 9 (1): 93–103. doi:10.1016/S1074-7613(00)80591-9. ISSN 1074-7613. PMID 9697839.
- ^ Engels, N; Wollscheid B; Wienands J (Jul 2001). "Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha". Eur. J. Immunol. (Germany) 31 (7): 2126–34. doi:10.1002/1521-4141(200107)31:7<2126::AID-IMMU2126>3.0.CO;2-O. ISSN 0014-2980. PMID 11449366.
- ^ Fusaki, N; Tomita S; Wu Y; Okamoto N; Goitsuka R; Kitamura D; Hozumi N (May 2000). "BLNK is associated with the CD72/SHP-1/Grb2 complex in the WEHI231 cell line after membrane IgM cross-linking". Eur. J. Immunol. (GERMANY) 30 (5): 1326–30. doi:10.1002/(SICI)1521-4141(200005)30:5<1326::AID-IMMU1326>3.0.CO;2-Q. ISSN 0014-2980. PMID 10820378.
- ^ Wienands, J; Schweikert J; Wollscheid B; Jumaa H; Nielsen P J; Reth M (Aug 1998). "SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation". J. Exp. Med. (UNITED STATES) 188 (4): 791–5. doi:10.1084/jem.188.4.791. ISSN 0022-1007. PMC 2213353. PMID 9705962.
- ^ Warmuth, M; Bergmann M; Priess A; Häuslmann K; Emmerich B; Hallek M (Dec 1997). "The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr". J. Biol. Chem. (UNITED STATES) 272 (52): 33260–70. doi:10.1074/jbc.272.52.33260. ISSN 0021-9258. PMID 9407116.
- ^ Ren, R; Ye Z S; Baltimore D (Apr 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites". Genes Dev. (UNITED STATES) 8 (7): 783–95. doi:10.1101/gad.8.7.783. ISSN 0890-9369. PMID 7926767.
- ^ Okkenhaug, K; Rottapel R (Aug 1998). "Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction". J. Biol. Chem. (UNITED STATES) 273 (33): 21194–202. doi:10.1074/jbc.273.33.21194. ISSN 0021-9258. PMID 9694876.
- ^ Nunès, J A; Truneh A; Olive D; Cantrell D A (Jan 1996). "Signal transduction by CD28 costimulatory receptor on T cells. B7-1 and B7-2 regulation of tyrosine kinase adaptor molecules". J. Biol. Chem. (UNITED STATES) 271 (3): 1591–8. doi:10.1074/jbc.271.3.1591. ISSN 0021-9258. PMID 8576157.
- ^ Ong, S H; Goh K C; Lim Y P; Low B C; Klint P; Claesson-Welsh L; Cao X; Tan Y H; Guy G R (Aug 1996). "Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2". Biochem. Biophys. Res. Commun. (UNITED STATES) 225 (3): 1021–6. doi:10.1006/bbrc.1996.1288. ISSN 0006-291X. PMID 8780727.
- ^ a b c Wong, Andy; Lamothe Betty; Lee Arnold; Schlessinger Joseph; Lax Irit; Li Arnold (May 2002). "FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (10): 6684–9. doi:10.1073/pnas.052138899. ISSN 0027-8424. PMC 124463. PMID 11997436.
- ^ Meakin, S O; MacDonald J I; Gryz E A; Kubu C J; Verdi J M (Apr 1999). "The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation". J. Biol. Chem. (UNITED STATES) 274 (14): 9861–70. doi:10.1074/jbc.274.14.9861. ISSN 0021-9258. PMID 10092678.
- ^ Kouhara, H; Hadari Y R; Spivak-Kroizman T; Schilling J; Bar-Sagi D; Lax I; Schlessinger J (May 1997). "A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway". Cell (UNITED STATES) 89 (5): 693–702. doi:10.1016/S0092-8674(00)80252-4. ISSN 0092-8674. PMID 9182757.
- ^ Saleem, A; Datta R; Yuan Z M; Kharbanda S; Kufe D (Dec 1995). "Involvement of stress-activated protein kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents". Cell Growth Differ. (UNITED STATES) 6 (12): 1651–8. ISSN 1044-9523. PMID 9019171.
- ^ Kharbanda, S; Saleem A; Shafman T; Emoto Y; Taneja N; Rubin E; Weichselbaum R; Woodgett J; Avruch J; Kyriakis J (Aug 1995). "Ionizing radiation stimulates a Grb2-mediated association of the stress-activated protein kinase with phosphatidylinositol 3-kinase". J. Biol. Chem. (UNITED STATES) 270 (32): 18871–4. doi:10.1074/jbc.270.32.18871. ISSN 0021-9258. PMID 7642542.
- ^ Poe, J C; Fujimoto M; Jansen P J; Miller A S; Tedder T F (Jun 2000). "CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux". J. Biol. Chem. (UNITED STATES) 275 (23): 17420–7. doi:10.1074/jbc.M001892200. ISSN 0021-9258. PMID 10748054.
- ^ Otipoby, K L; Draves K E; Clark E A (Nov 2001). "CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1". J. Biol. Chem. (United States) 276 (47): 44315–22. doi:10.1074/jbc.M105446200. ISSN 0021-9258. PMID 11551923.
- ^ Sasaki, Akinori; Hata Keiko; Suzuki Susumu; Sawada Masashi; Wada Tadashi; Yamaguchi Kazunori; Obinata Masuo; Tateno Hiroo; Suzuki Hiroshi; Miyagi Taeko (Jul 2003). "Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice". J. Biol. Chem. (United States) 278 (30): 27896–902. doi:10.1074/jbc.M212200200. ISSN 0021-9258. PMID 12730204.
- ^ Lim, R W; Halpain S (Jul 2000). "Regulated association of microtubule-associated protein 2 (MAP2) with Src and Grb2: evidence for MAP2 as a scaffolding protein". J. Biol. Chem. (UNITED STATES) 275 (27): 20578–87. doi:10.1074/jbc.M001887200. ISSN 0021-9258. PMID 10781592.
- ^ Zamora-Leon, S P; Lee G; Davies P; Shafit-Zagardo B (Oct 2001). "Binding of Fyn to MAP-2c through an SH3 binding domain. Regulation of the interaction by ERK2". J. Biol. Chem. (United States) 276 (43): 39950–8. doi:10.1074/jbc.M107807200. ISSN 0021-9258. PMID 11546790.
- ^ Hsia, Datsun A; Mitra Satyajit K, Hauck Christof R, Streblow Daniel N, Nelson Jay A, Ilic Dusko, Huang Shuang, Li Erguang, Nemerow Glen R, Leng Jay, Spencer Kathryn S R, Cheresh David A, Schlaepfer David D (Mar 2003). "Differential regulation of cell motility and invasion by FAK". J. Cell Biol. (United States) 160 (5): 753–67. doi:10.1083/jcb.200212114. ISSN 0021-9525. PMC 2173366. PMID 12615911. Cite uses deprecated parameters (help)
- ^ Hasegawa, H; Kiyokawa E; Tanaka S; Nagashima K; Gotoh N; Shibuya M; Kurata T; Matsuda M (Apr 1996). "DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane". Mol. Cell. Biol. (UNITED STATES) 16 (4): 1770–6. ISSN 0270-7306. PMC 231163. PMID 8657152.
- ^ Saleem, A; Kharbanda S; Yuan Z M; Kufe D (May 1995). "Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytes". J. Biol. Chem. (UNITED STATES) 270 (18): 10380–3. doi:10.1074/jbc.270.18.10380. ISSN 0021-9258. PMID 7737969.
- ^ Wang, J; Auger K R; Jarvis L; Shi Y; Roberts T M (May 1995). "Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase". J. Biol. Chem. (UNITED STATES) 270 (21): 12774–80. doi:10.1074/jbc.270.21.12774. ISSN 0021-9258. PMID 7759531.
- ^ Qian, X; Riccio A; Zhang Y; Ginty D D (Nov 1998). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron (UNITED STATES) 21 (5): 1017–29. doi:10.1016/S0896-6273(00)80620-0. ISSN 0896-6273. PMID 9856458.
- ^ Kotani, K; Wilden P; Pillay T S (Oct 1998). "SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase". Biochem. J. (ENGLAND) 335 (1): 103–9. ISSN 0264-6021. PMC 1219757. PMID 9742218.
- ^ Riordan, S M; Lidder S; Williams R; Skouteris G G (Sep 2000). "The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis". Biochem. J. (ENGLAND) 350 (3): 925–32. doi:10.1042/0264-6021:3500925. ISSN 0264-6021. PMC 1221328. PMID 10970810.
- ^ Matsuda, M; Ota S; Tanimura R; Nakamura H; Matuoka K; Takenawa T; Nagashima K; Kurata T (Jun 1996). "Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins". J. Biol. Chem. (UNITED STATES) 271 (24): 14468–72. doi:10.1074/jbc.271.24.14468. ISSN 0021-9258. PMID 8662907.
- ^ a b Okada, S; Pessin J E (Oct 1996). "Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor". J. Biol. Chem. (UNITED STATES) 271 (41): 25533–8. doi:10.1074/jbc.271.41.25533. ISSN 0021-9258. PMID 8810325.
- ^ a b c d Oneyama, Chitose; Nakano Hirofumi; Sharma Sreenath V (Mar 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein–protein interaction blocking drug". Oncogene (England) 21 (13): 2037–50. doi:10.1038/sj.onc.1205271. ISSN 0950-9232. PMID 11960376.
- ^ Holgado-Madruga, M; Emlet D R; Moscatello D K; Godwin A K; Wong A J (Feb 1996). "A Grb2-associated docking protein in EGF- and insulin-receptor signalling". Nature (ENGLAND) 379 (6565): 560–4. doi:10.1038/379560a0. ISSN 0028-0836. PMID 8596638.
- ^ Li, B Q; Wang M H; Kung H F; Ronsin C; Breathnach R; Leonard E J; Kamata T (Nov 1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor". Biochem. Biophys. Res. Commun. (UNITED STATES) 216 (1): 110–8. doi:10.1006/bbrc.1995.2598. ISSN 0006-291X. PMID 7488076.
- ^ Iwama, A; Yamaguchi N; Suda T (Nov 1996). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family". EMBO J. (ENGLAND) 15 (21): 5866–75. ISSN 0261-4189. PMC 452340. PMID 8918464.
- ^ Miki, H; Miura K; Matuoka K; Nakata T; Hirokawa N; Orita S; Kaibuchi K; Takai Y; Takenawa T (Feb 1994). "Association of Ash/Grb-2 with dynamin through the Src homology 3 domain". J. Biol. Chem. (UNITED STATES) 269 (8): 5489–92. ISSN 0021-9258. PMID 8119878.
- ^ a b Sastry, L; Cao T; King C R (Jan 1997). "Multiple Grb2-protein complexes in human cancer cells". Int. J. Cancer (UNITED STATES) 70 (2): 208–13. doi:10.1002/(SICI)1097-0215(19970117)70:2<208::AID-IJC12>3.0.CO;2-E. ISSN 0020-7136. PMID 9009162.
- ^ Liu, Y F; Deth R C; Devys D (Mar 1997). "SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signaling complexes". J. Biol. Chem. (UNITED STATES) 272 (13): 8121–4. doi:10.1074/jbc.272.13.8121. ISSN 0021-9258. PMID 9079622.
- ^ Wan, Kah Fei; Sambi Balwinder S; Tate Rothwelle; Waters Catherine; Pyne Nigel J (May 2003). "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor". J. Biol. Chem. (United States) 278 (20): 18658–63. doi:10.1074/jbc.M212103200. ISSN 0021-9258. PMID 12624098.
- ^ a b c d e f Saci, Abdelhafid; Liu Wang-Qing, Vidal Michel, Garbay Christiane, Rendu Francine, Bachelot-Loza Christilla (May 2002). "Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement". Biochem. J. (England) 363 (Pt 3): 717–25. doi:10.1042/0264-6021:3630717. ISSN 0264-6021. PMC 1222524. PMID 11964172. Cite uses deprecated parameters (help)
- ^ Karoor, V; Wang L; Wang H Y; Malbon C C (Dec 1998). "Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 via tyrosine 350". J. Biol. Chem. (UNITED STATES) 273 (49): 33035–41. doi:10.1074/jbc.273.49.33035. ISSN 0021-9258. PMID 9830057.
- ^ a b c d e Blagoev, Blagoy; Kratchmarova Irina; Ong Shao-En; Nielsen Mogens; Foster Leonard J; Mann Matthias (Mar 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. (United States) 21 (3): 315–8. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067.
- ^ a b Bourguignon, L Y; Zhu H; Zhou B; Diedrich F; Singleton P A; Hung M C (Dec 2001). "Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth". J. Biol. Chem. (United States) 276 (52): 48679–92. doi:10.1074/jbc.M106759200. ISSN 0021-9258. PMID 11606575.
- ^ Poghosyan, Zaruhi; Robbins Stephen M; Houslay Miles D; Webster Ailsa; Murphy Gillian; Edwards Dylan R (Feb 2002). "Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases". J. Biol. Chem. (United States) 277 (7): 4999–5007. doi:10.1074/jbc.M107430200. ISSN 0021-9258. PMID 11741929.
- ^ Smit, L; van der Horst G; Borst J (Apr 1996). "Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors". J. Biol. Chem. (UNITED STATES) 271 (15): 8564–9. doi:10.1074/jbc.271.15.8564. ISSN 0021-9258. PMID 8621483.
- ^ Tanaka, S; Morishita T; Hashimoto Y; Hattori S; Nakamura S; Shibuya M; Matuoka K; Takenawa T; Kurata T; Nagashima K (Apr 1994). "C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (8): 3443–7. doi:10.1073/pnas.91.8.3443. ISSN 0027-8424. PMC 43593. PMID 7512734.
- ^ Song, J S; Gomez J; Stancato L F; Rivera J (Oct 1996). "Association of a p95 Vav-containing signaling complex with the FcepsilonRI gamma chain in the RBL-2H3 mast cell line. Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex". J. Biol. Chem. (UNITED STATES) 271 (43): 26962–70. doi:10.1074/jbc.271.43.26962. ISSN 0021-9258. PMID 8900182.
- ^ Ye, Z S; Baltimore D (Dec 1994). "Binding of Vav to Grb2 through dimerization of Src homology 3 domains". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (26): 12629–33. doi:10.1073/pnas.91.26.12629. ISSN 0027-8424. PMC 45492. PMID 7809090.
- ^ a b Germani, A; Romero F; Houlard M; Camonis J; Gisselbrecht S; Fischer S; Varin-Blank N (May 1999). "hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways". Mol. Cell. Biol. (UNITED STATES) 19 (5): 3798–807. ISSN 0270-7306. PMC 84217. PMID 10207103.
- ^ a b Lee, I S; Liu Y; Narazaki M; Hibi M; Kishimoto T; Taga T (Jan 1997). "Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6". FEBS Lett. (NETHERLANDS) 401 (2–3): 133–7. doi:10.1016/S0014-5793(96)01456-1. ISSN 0014-5793. PMID 9013873.
- ^ a b Schulze, Waltraud X; Deng Lei; Mann Matthias (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. (England) 1 (1): 2005.0008. doi:10.1038/msb4100012. PMC 1681463. PMID 16729043.
- ^ Olayioye, M A; Graus-Porta D; Beerli R R; Rohrer J; Gay B; Hynes N E (Sep 1998). "ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner". Mol. Cell. Biol. (UNITED STATES) 18 (9): 5042–51. ISSN 0270-7306. PMC 109089. PMID 9710588.
- ^ Wong, L; Deb T B; Thompson S A; Wells A; Johnson G R (Mar 1999). "A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling". J. Biol. Chem. (UNITED STATES) 274 (13): 8900–9. doi:10.1074/jbc.274.13.8900. ISSN 0021-9258. PMID 10085134.
- ^ Okutani, T; Okabayashi Y; Kido Y; Sugimoto Y; Sakaguchi K; Matuoka K; Takenawa T; Kasuga M (Dec 1994). "Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells". J. Biol. Chem. (UNITED STATES) 269 (49): 31310–4. ISSN 0021-9258. PMID 7527043.
- ^ a b Tortora, G; Damiano V; Bianco C; Baldassarre G; Bianco A R; Lanfrancone L; Pelicci P G; Ciardiello F (Feb 1997). "The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor". Oncogene (ENGLAND) 14 (8): 923–8. doi:10.1038/sj.onc.1200906. ISSN 0950-9232. PMID 9050991.
- ^ Daly, R J; Sanderson G M; Janes P W; Sutherland R L (May 1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family". J. Biol. Chem. (UNITED STATES) 271 (21): 12502–10. doi:10.1074/jbc.271.21.12502. ISSN 0021-9258. PMID 8647858.
- ^ a b Buday, L; Egan S E; Rodriguez Viciana P; Cantrell D A; Downward J (Mar 1994). "A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells". J. Biol. Chem. (UNITED STATES) 269 (12): 9019–23. ISSN 0021-9258. PMID 7510700.
- ^ a b Braverman, L E; Quilliam L A (Feb 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck". J. Biol. Chem. (UNITED STATES) 274 (9): 5542–9. doi:10.1074/jbc.274.9.5542. ISSN 0021-9258. PMID 10026169.
- ^ Arvidsson, A K; Rupp E; Nånberg E; Downward J; Rönnstrand L; Wennström S; Schlessinger J; Heldin C H; Claesson-Welsh L (Oct 1994). "Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation". Mol. Cell. Biol. (UNITED STATES) 14 (10): 6715–26. ISSN 0270-7306. PMC 359202. PMID 7935391.
- ^ a b Tang, J; Feng G S; Li W (Oct 1997). "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor". Oncogene (ENGLAND) 15 (15): 1823–32. doi:10.1038/sj.onc.1201351. ISSN 0950-9232. PMID 9362449.
- ^ Sieg, D J; Hauck C R; Ilic D; Klingbeil C K; Schaefer E; Damsky C H; Schlaepfer D D (May 2000). "FAK integrates growth-factor and integrin signals to promote cell migration". Nat. Cell Biol. (ENGLAND) 2 (5): 249–56. doi:10.1038/35010517. ISSN 1465-7392. PMID 10806474.
- ^ a b Angers-Loustau, A; Côté J F; Charest A; Dowbenko D; Spencer S; Lasky L A; Tremblay M L (Mar 1999). "Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts". J. Cell Biol. (UNITED STATES) 144 (5): 1019–31. doi:10.1083/jcb.144.5.1019. ISSN 0021-9525. PMC 2148201. PMID 10085298.
- ^ Hildebrand, J D; Taylor J M; Parsons J T (Jun 1996). "An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase". Mol. Cell. Biol. (UNITED STATES) 16 (6): 3169–78. ISSN 0270-7306. PMC 231310. PMID 8649427.
- ^ Messina, Samantha; Onofri Franco, Bongiorno-Borbone Lucilla, Giovedì Silvia, Valtorta Flavia, Girault Jean-Antoine, Benfenati Fabio (Jan 2003). "Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin". J. Neurochem. (England) 84 (2): 253–65. doi:10.1046/j.1471-4159.2003.01519.x. ISSN 0022-3042. PMID 12558988. Cite uses deprecated parameters (help)
- ^ Arold, Stefan T; Hoellerer Maria K; Noble Martin E M (Mar 2002). "The structural basis of localization and signaling by the focal adhesion targeting domain". Structure (United States) 10 (3): 319–27. doi:10.1016/S0969-2126(02)00717-7. ISSN 0969-2126. PMID 12005431.
- ^ Tauchi, T; Feng G S; Shen R; Hoatlin M; Bagby G C; Kabat D; Lu L; Broxmeyer H E (Mar 1995). "Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways". J. Biol. Chem. (UNITED STATES) 270 (10): 5631–5. doi:10.1074/jbc.270.10.5631. ISSN 0021-9258. PMID 7534299.
- ^ a b Feng, G S; Ouyang Y B; Hu D P; Shi Z Q; Gentz R; Ni J (May 1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway". J. Biol. Chem. (UNITED STATES) 271 (21): 12129–32. doi:10.1074/jbc.271.21.12129. ISSN 0021-9258. PMID 8647802.
- ^ Paz, P E; Wang S; Clarke H; Lu X; Stokoe D; Abo A (Jun 2001). "Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells". Biochem. J. (England) 356 (Pt 2): 461–71. doi:10.1042/0264-6021:3560461. ISSN 0264-6021. PMC 1221857. PMID 11368773.
- ^ Zhang, W; Sloan-Lancaster J; Kitchen J; Trible R P; Samelson L E (Jan 1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation". Cell (UNITED STATES) 92 (1): 83–92. doi:10.1016/S0092-8674(00)80901-0. ISSN 0092-8674. PMID 9489702.
- ^ Perez-Villar, Juan J; Whitney Gena S, Sitnick Mitchell T, Dunn Robert J, Venkatesan Srividhya, O'Day Kathleen, Schieven Gary L, Lin Tai-An, Kanner Steven B (Aug 2002). "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry (United States) 41 (34): 10732–40. doi:10.1021/bi025554o. ISSN 0006-2960. PMID 12186560. Cite uses deprecated parameters (help)
- ^ Yang, B; Jung D; Motto D; Meyer J; Koretzky G; Campbell K P (May 1995). "SH3 domain-mediated interaction of dystroglycan and Grb2". J. Biol. Chem. (UNITED STATES) 270 (20): 11711–4. doi:10.1074/jbc.270.20.11711. ISSN 0021-9258. PMID 7744812.
- ^ Gout, I; Middleton G; Adu J; Ninkina N N; Drobot L B; Filonenko V; Matsuka G; Davies A M; Waterfield M; Buchman V L (Aug 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". EMBO J. (ENGLAND) 19 (15): 4015–25. doi:10.1093/emboj/19.15.4015. ISSN 0261-4189. PMC 306608. PMID 10921882.
- ^ Borinstein, S C; Hyatt M A; Sykes V W; Straub R E; Lipkowitz S; Boulter J; Bogler O (Dec 2000). "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cell. Signal. (ENGLAND) 12 (11–12): 769–79. doi:10.1016/S0898-6568(00)00129-7. ISSN 0898-6568. PMID 11152963.
- ^ a b Ward, A C; Monkhouse J L; Hamilton J A; Csar X F (Nov 1998). "Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor". Biochim. Biophys. Acta (NETHERLANDS) 1448 (1): 70–6. doi:10.1016/S0167-4889(98)00120-7. ISSN 0006-3002. PMID 9824671.
- ^ Sahni, M; Zhou X M; Bakiri L; Schlessinger J; Baron R; Levy J B (Dec 1996). "Identification of a novel 135-kDa Grb2-binding protein in osteoclasts". J. Biol. Chem. (UNITED STATES) 271 (51): 33141–7. doi:10.1074/jbc.271.51.33141. ISSN 0021-9258. PMID 8955163.
- ^ Sugiyama, Y; Tomoda K; Tanaka T; Arata Y; Yoneda-Kato N; Kato J (Apr 2001). "Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1". J. Biol. Chem. (United States) 276 (15): 12084–90. doi:10.1074/jbc.M010811200. ISSN 0021-9258. PMID 11278754.
- ^ Mancini, A; Niedenthal R; Joos H; Koch A; Trouliaris S; Niemann H; Tamura T (Sep 1997). "Identification of a second Grb2 binding site in the v-Fms tyrosine kinase". Oncogene (ENGLAND) 15 (13): 1565–72. doi:10.1038/sj.onc.1201518. ISSN 0950-9232. PMID 9380408.
- ^ Pratt, Rebecca L; Kinch Michael S (Oct 2002). "Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade". Oncogene (England) 21 (50): 7690–9. doi:10.1038/sj.onc.1205758. ISSN 0950-9232. PMID 12400011.
- ^ a b c Liu, S K; McGlade C J (Dec 1998). "Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc". Oncogene (ENGLAND) 17 (24): 3073–82. doi:10.1038/sj.onc.1202337. ISSN 0950-9232. PMID 9872323.
- ^ Shen, Z; Batzer A; Koehler J A; Polakis P; Schlessinger J; Lydon N B; Moran M F (Aug 1999). "Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src". Oncogene (ENGLAND) 18 (33): 4647–53. doi:10.1038/sj.onc.1203079. ISSN 0950-9232. PMID 10467411.
- ^ Borrello, M G; Pelicci G; Arighi E; De Filippis L; Greco A; Bongarzone I; Rizzetti M; Pelicci P G; Pierotti M A (Jun 1994). "The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins". Oncogene (ENGLAND) 9 (6): 1661–8. ISSN 0950-9232. PMID 8183561.
- ^ Pandey, A; Duan H; Di Fiore P P; Dixit V M (Sep 1995). "The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10". J. Biol. Chem. (UNITED STATES) 270 (37): 21461–3. doi:10.1074/jbc.270.37.21461. ISSN 0021-9258. PMID 7665556.
- ^ Pei, Z; Maloney J A; Yang L; Williamson J R (Sep 1997). "A new function for phospholipase C-gamma1: coupling to the adaptor protein GRB2". Arch. Biochem. Biophys. (UNITED STATES) 345 (1): 103–10. doi:10.1006/abbi.1997.0245. ISSN 0003-9861. PMID 9281317.
- ^ a b Nel, A E; Gupta S; Lee L; Ledbetter J A; Kanner S B (Aug 1995). "Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR". J. Biol. Chem. (UNITED STATES) 270 (31): 18428–36. doi:10.1074/jbc.270.31.18428. ISSN 0021-9258. PMID 7629168.
- ^ Scholler, J K; Perez-Villar J J; O'Day K; Kanner S B (Aug 2000). "Engagement of the T lymphocyte antigen receptor regulates association of son-of-sevenless homologues with the SH3 domain of phospholipase Cgamma1". Eur. J. Immunol. (GERMANY) 30 (8): 2378–87. doi:10.1002/1521-4141(2000)30:8<2378::AID-IMMU2378>3.0.CO;2-E. ISSN 0014-2980. PMID 10940929.
- ^ Song, Cheng; Perides George; Liu Ya Fang (Feb 2002). "Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells". J. Biol. Chem. (United States) 277 (8): 6703–7. doi:10.1074/jbc.M110338200. ISSN 0021-9258. PMID 11733534.
- ^ MacDonald, J I; Gryz E A; Kubu C J; Verdi J M; Meakin S O (Jun 2000). "Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA". J. Biol. Chem. (UNITED STATES) 275 (24): 18225–33. doi:10.1074/jbc.M001862200. ISSN 0021-9258. PMID 10748052.
- ^ Chauhan, D; Kharbanda S M; Ogata A; Urashima M; Frank D; Malik N; Kufe D W; Anderson K C (Dec 1995). "Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells". J. Exp. Med. (UNITED STATES) 182 (6): 1801–6. doi:10.1084/jem.182.6.1801. ISSN 0022-1007. PMC 2192257. PMID 7500025.
- ^ a b c Giorgetti-Peraldi, S; Peyrade F; Baron V; Van Obberghen E (Dec 1995). "Involvement of Janus kinases in the insulin signaling pathway". Eur. J. Biochem. (GERMANY) 234 (2): 656–60. doi:10.1111/j.1432-1033.1995.656_b.x. ISSN 0014-2956. PMID 8536716.
- ^ a b Pandey, P; Kharbanda S; Kufe D (Sep 1995). "Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein". Cancer Res. (UNITED STATES) 55 (18): 4000–3. ISSN 0008-5472. PMID 7664271.
- ^ De Sepulveda, P; Okkenhaug K; Rose J L; Hawley R G; Dubreuil P; Rottapel R (Feb 1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation". EMBO J. (ENGLAND) 18 (4): 904–15. doi:10.1093/emboj/18.4.904. ISSN 0261-4189. PMC 1171183. PMID 10022833.
- ^ Thömmes, K; Lennartsson J; Carlberg M; Rönnstrand L (Jul 1999). "Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor". Biochem. J. (ENGLAND) 341 (1): 211–6. doi:10.1042/0264-6021:3410211. ISSN 0264-6021. PMC 1220349. PMID 10377264.
- ^ Ghadimi, Markus Philipp; Sanzenbacher Ralf; Thiede Bernd; Wenzel Jennifer; Jing Qian; Plomann Markus; Borkhardt Arndt; Kabelitz Dieter; Janssen Ottmar (May 2002). "Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178)". FEBS Lett. (Netherlands) 519 (1–3): 50–8. doi:10.1016/S0014-5793(02)02709-6. ISSN 0014-5793. PMID 12023017.
- ^ Wenzel, J; Sanzenbacher R; Ghadimi M; Lewitzky M; Zhou Q; Kaplan D R; Kabelitz D; Feller S M; Janssen O (Dec 2001). "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor". FEBS Lett. (Netherlands) 509 (2): 255–62. doi:10.1016/S0014-5793(01)03174-X. ISSN 0014-5793. PMID 11741599.
- ^ Kim, H; Lee Y H; Won J; Yun Y (Sep 2001). "Through induction of juxtaposition and tyrosine kinase activity of Jak1, X-gene product of hepatitis B virus stimulates Ras and the transcriptional activation through AP-1, NF-kappaB, and SRE enhancers". Biochem. Biophys. Res. Commun. (United States) 286 (5): 886–94. doi:10.1006/bbrc.2001.5496. ISSN 0006-291X. PMID 11527382.
- ^ Zeng, L; Sachdev P; Yan L; Chan J L; Trenkle T; McClelland M; Welsh J; Wang L H (Dec 2000). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. (UNITED STATES) 20 (24): 9212–24. doi:10.1128/MCB.20.24.9212-9224.2000. ISSN 0270-7306. PMC 102179. PMID 11094073.
- ^ Wang, X; Weng L P; Yu Q (May 2000). "Specific inhibition of FGF-induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR". Oncogene (ENGLAND) 19 (19): 2346–53. doi:10.1038/sj.onc.1203558. ISSN 0950-9232. PMID 10822386.
- ^ Goldstein, B J; Bittner-Kowalczyk A; White M F; Harbeck M (Feb 2000). "Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein". J. Biol. Chem. (UNITED STATES) 275 (6): 4283–9. doi:10.1074/jbc.275.6.4283. ISSN 0021-9258. PMID 10660596.
- ^ Liu, F; Hill D E; Chernoff J (Dec 1996). "Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)". J. Biol. Chem. (UNITED STATES) 271 (49): 31290–5. doi:10.1074/jbc.271.49.31290. ISSN 0021-9258. PMID 8940134.
- ^ Kavanaugh, W M; Pot D A; Chin S M; Deuter-Reinhard M; Jefferson A B; Norris F A; Masiarz F R; Cousens L S; Majerus P W; Williams L T (Apr 1996). "Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2". Curr. Biol. (ENGLAND) 6 (4): 438–45. doi:10.1016/S0960-9822(02)00511-0. ISSN 0960-9822. PMID 8723348.
- ^ Bunnell, S C; Diehn M; Yaffe M B; Findell P R; Cantley L C; Berg L J (Jan 2000). "Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade". J. Biol. Chem. (UNITED STATES) 275 (3): 2219–30. doi:10.1074/jbc.275.3.2219. ISSN 0021-9258. PMID 10636929.
- ^ Andreotti, A H; Bunnell S C; Feng S; Berg L J; Schreiber S L (Jan 1997). "Regulatory intramolecular association in a tyrosine kinase of the Tec family". Nature (ENGLAND) 385 (6611): 93–7. doi:10.1038/385093a0. ISSN 0028-0836. PMID 8985255.
- ^ a b Skolnik, E Y; Lee C H; Batzer A; Vicentini L M; Zhou M; Daly R; Myers M J; Backer J M; Ullrich A; White M F (May 1993). "The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling". EMBO J. (ENGLAND) 12 (5): 1929–36. ISSN 0261-4189. PMC 413414. PMID 8491186.
- ^ a b c Puil, L; Liu J; Gish G; Mbamalu G; Bowtell D; Pelicci P G; Arlinghaus R; Pawson T (Feb 1994). "Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway". EMBO J. (ENGLAND) 13 (4): 764–73. ISSN 0261-4189. PMC 394874. PMID 8112292.
- ^ a b Satoh, T; Kato J; Nishida K; Kaziro Y (May 1996). "Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation". FEBS Lett. (NETHERLANDS) 386 (2–3): 230–4. doi:10.1016/0014-5793(96)00449-8. ISSN 0014-5793. PMID 8647288.
- ^ Fixman, E D; Fournier T M; Kamikura D M; Naujokas M A; Park M (May 1996). "Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein". J. Biol. Chem. (UNITED STATES) 271 (22): 13116–22. doi:10.1074/jbc.271.22.13116. ISSN 0021-9258. PMID 8662733.
- ^ Ishihara, H; Sasaoka T; Ishiki M; Takata Y; Imamura T; Usui I; Langlois W J; Sawa T; Kobayashi M (Apr 1997). "Functional importance of Shc tyrosine 317 on insulin signaling in Rat1 fibroblasts expressing insulin receptors". J. Biol. Chem. (UNITED STATES) 272 (14): 9581–6. doi:10.1074/jbc.272.14.9581. ISSN 0021-9258. PMID 9083103.
- ^ Fournier, E; Blaikie P; Rosnet O; Margolis B; Birnbaum D; Borg J P (Jan 1999). "Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling". Oncogene (ENGLAND) 18 (2): 507–14. doi:10.1038/sj.onc.1202315. ISSN 0950-9232. PMID 9927207.
- ^ Ravichandran, K S; Burakoff S J (Jan 1994). "The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation". J. Biol. Chem. (UNITED STATES) 269 (3): 1599–602. ISSN 0021-9258. PMID 8294403.
- ^ Lamprecht, Raphael; Farb Claudia R; LeDoux Joseph E (Nov 2002). "Fear memory formation involves p190 RhoGAP and ROCK proteins through a GRB2-mediated complex". Neuron (United States) 36 (4): 727–38. doi:10.1016/S0896-6273(02)01047-4. ISSN 0896-6273. PMID 12441060.
- ^ a b Park, R K; Izadi K D; Deo Y M; Durden D L (Sep 1999). "Role of Src in the modulation of multiple adaptor proteins in FcalphaRI oxidant signaling". Blood (UNITED STATES) 94 (6): 2112–20. ISSN 0006-4971. PMID 10477741.
- ^ Sakaguchi, K; Okabayashi Y; Kasuga M (Apr 2001). "Shc mediates ligand-induced internalization of epidermal growth factor receptors". Biochem. Biophys. Res. Commun. (United States) 282 (5): 1154–60. doi:10.1006/bbrc.2001.4680. ISSN 0006-291X. PMID 11302736.
- ^ a b c Park, R K; Erdreich-Epstein A; Liu M; Izadi K D; Durden D L (Dec 1999). "High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase". J. Immunol. (UNITED STATES) 163 (11): 6023–34. ISSN 0022-1767. PMID 10570290.
- ^ Hallak, H; Seiler A E; Green J S; Henderson A; Ross B N; Rubin R (Jul 2001). "Inhibition of insulin-like growth factor-I signaling by ethanol in neuronal cells". Alcohol. Clin. Exp. Res. (United States) 25 (7): 1058–64. doi:10.1111/j.1530-0277.2001.tb02317.x. ISSN 0145-6008. PMID 11505033.
- ^ Yokote, K; Mori S; Hansen K; McGlade J; Pawson T; Heldin C H; Claesson-Welsh L (May 1994). "Direct interaction between Shc and the platelet-derived growth factor beta-receptor". J. Biol. Chem. (UNITED STATES) 269 (21): 15337–43. ISSN 0021-9258. PMID 8195171.
- ^ a b Zhang, S; Mantel C; Broxmeyer H E (Mar 1999). "Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells". J. Leukoc. Biol. (UNITED STATES) 65 (3): 372–80. ISSN 0741-5400. PMID 10080542.
- ^ Lazar, D F; Knez J J; Medof M E; Cuatrecasas P; Saltiel A R (Oct 1994). "Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositol". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (21): 9665–9. doi:10.1073/pnas.91.21.9665. ISSN 0027-8424. PMC 44877. PMID 7524086.
- ^ VanderKuur, J; Allevato G; Billestrup N; Norstedt G; Carter-Su C (Mar 1995). "Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2". J. Biol. Chem. (UNITED STATES) 270 (13): 7587–93. doi:10.1074/jbc.270.13.7587. ISSN 0021-9258. PMID 7535773.
- ^ Kanai, M; Göke M; Tsunekawa S; Podolsky D K (Mar 1997). "Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein". J. Biol. Chem. (UNITED STATES) 272 (10): 6621–8. doi:10.1074/jbc.272.10.6621. ISSN 0021-9258. PMID 9045692.
- ^ a b Spivak-Kroizman, T; Mohammadi M; Hu P; Jaye M; Schlessinger J; Lax I (May 1994). "Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells". J. Biol. Chem. (UNITED STATES) 269 (20): 14419–23. ISSN 0021-9258. PMID 7514169.
- ^ Giordano, V; De Falco G; Chiari R; Quinto I; Pelicci P G; Bartholomew L; Delmastro P; Gadina M; Scala G (May 1997). "Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase". J. Immunol. (UNITED STATES) 158 (9): 4097–103. ISSN 0022-1767. PMID 9126968.
- ^ Charest, A; Wagner J; Kwan M; Tremblay M L (Apr 1997). "Coupling of the murine protein tyrosine phosphatase PEST to the epidermal growth factor (EGF) receptor through a Src homology 3 (SH3) domain-mediated association with Grb2". Oncogene (ENGLAND) 14 (14): 1643–51. doi:10.1038/sj.onc.1201008. ISSN 0950-9232. PMID 9135065.
- ^ Ponzetto, C; Zhen Z; Audero E; Maina F; Bardelli A; Basile M L; Giordano S; Narsimhan R; Comoglio P (Jun 1996). "Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility". J. Biol. Chem. (UNITED STATES) 271 (24): 14119–23. doi:10.1074/jbc.271.24.14119. ISSN 0021-9258. PMID 8662889.
- ^ Liang, Q; Mohan R R; Chen L; Wilson S E (Jul 1998). "Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways". Invest. Ophthalmol. Vis. Sci. (UNITED STATES) 39 (8): 1329–38. ISSN 0146-0404. PMID 9660480.
- ^ a b c Ganju, R K; Brubaker S A; Chernock R D; Avraham S; Groopman J E (Jun 2000). "Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk". J. Biol. Chem. (UNITED STATES) 275 (23): 17263–8. doi:10.1074/jbc.M000689200. ISSN 0021-9258. PMID 10747947.
- ^ Bennett, A M; Tang T L; Sugimoto S; Walsh C T; Neel B G (Jul 1994). "Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (15): 7335–9. doi:10.1073/pnas.91.15.7335. ISSN 0027-8424. PMC 44394. PMID 8041791.
- ^ Yin, T; Shen R; Feng G S; Yang Y C (Jan 1997). "Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases". J. Biol. Chem. (UNITED STATES) 272 (2): 1032–7. doi:10.1074/jbc.272.2.1032. ISSN 0021-9258. PMID 8995399.
- ^ Tang, H; Zhao Z J; Huang X Y; Landon E J; Inagami T (Apr 1999). "Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells". J. Biol. Chem. (UNITED STATES) 274 (18): 12401–7. doi:10.1074/jbc.274.18.12401. ISSN 0021-9258. PMID 10212213.
- ^ Hadari, Y R; Kouhara H; Lax I; Schlessinger J (Jul 1998). "Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation". Mol. Cell. Biol. (UNITED STATES) 18 (7): 3966–73. ISSN 0270-7306. PMC 108981. PMID 9632781.
- ^ Wong, L; Johnson G R (Aug 1996). "Epidermal growth factor induces coupling of protein-tyrosine phosphatase 1D to GRB2 via the COOH-terminal SH3 domain of GRB2". J. Biol. Chem. (UNITED STATES) 271 (35): 20981–4. doi:10.1074/jbc.271.35.20981. ISSN 0021-9258. PMID 8702859.
- ^ Kon-Kozlowski, M; Pani G; Pawson T; Siminovitch K A (Feb 1996). "The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells". J. Biol. Chem. (UNITED STATES) 271 (7): 3856–62. doi:10.1074/jbc.271.7.3856. ISSN 0021-9258. PMID 8632004.
- ^ Oehrl, W; Kardinal C; Ruf S; Adermann K; Groffen J; Feng G S; Blenis J; Tan T H; Feller S M (Oct 1998). "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". Oncogene (ENGLAND) 17 (15): 1893–901. doi:10.1038/sj.onc.1202108. ISSN 0950-9232. PMID 9788432.
- ^ Anafi, M; Kiefer F; Gish G D; Mbamalu G; Iscove N N; Pawson T (Oct 1997). "SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1". J. Biol. Chem. (UNITED STATES) 272 (44): 27804–11. doi:10.1074/jbc.272.44.27804. ISSN 0021-9258. PMID 9346925.
- ^ Ling, P; Yao Z; Meyer C F; Wang X S; Oehrl W; Feller S M; Tan T H (Feb 1999). "Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase". Mol. Cell. Biol. (UNITED STATES) 19 (2): 1359–68. ISSN 0270-7306. PMC 116064. PMID 9891069.
- ^ Ling, P; Meyer C F; Redmond L P; Shui J W; Davis B; Rich R R; Hu M C; Wange R L; Tan T H (Jun 2001). "Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling". J. Biol. Chem. (United States) 276 (22): 18908–14. doi:10.1074/jbc.M101485200. ISSN 0021-9258. PMID 11279207.
- ^ Banin, S; Truong O; Katz D R; Waterfield M D; Brickell P M; Gout I (Aug 1996). "Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases". Curr. Biol. (ENGLAND) 6 (8): 981–8. doi:10.1016/S0960-9822(02)00642-5. ISSN 0960-9822. PMID 8805332.
- ^ She, H Y; Rockow S; Tang J; Nishimura R; Skolnik E Y; Chen M; Margolis B; Li W (Sep 1997). "Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells". Mol. Biol. Cell (UNITED STATES) 8 (9): 1709–21. doi:10.1091/mbc.8.9.1709. ISSN 1059-1524. PMC 305731. PMID 9307968.
- ^ Satoh, S; Tominaga T (Oct 2001). "mDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber formation". J. Biol. Chem. (United States) 276 (42): 39290–4. doi:10.1074/jbc.M107026200. ISSN 0021-9258. PMID 11509578.
- ^ Fukuoka, M; Suetsugu S; Miki H; Fukami K; Endo T; Takenawa T (Feb 2001). "A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42". J. Cell Biol. (United States) 152 (3): 471–82. doi:10.1083/jcb.152.3.471. ISSN 0021-9525. PMC 2196001. PMID 11157975.
- ^ den Hertog, J; Hunter T (Jun 1996). "Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains". EMBO J. (ENGLAND) 15 (12): 3016–27. ISSN 0261-4189. PMC 450243. PMID 8670803.
- ^ den Hertog, J; Tracy S; Hunter T (Jul 1994). "Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo". EMBO J. (ENGLAND) 13 (13): 3020–32. ISSN 0261-4189. PMC 395191. PMID 7518772.
- ^ Zheng, Xin-Min; Resnick Ross J; Shalloway David (Jun 2002). "Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation". J. Biol. Chem. (United States) 277 (24): 21922–9. doi:10.1074/jbc.M201394200. ISSN 0021-9258. PMID 11923305.
- ^ Million, R P; Van Etten R A (Jul 2000). "The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase". Blood (UNITED STATES) 96 (2): 664–70. ISSN 0006-4971. PMID 10887132.
- ^ Bai, R Y; Jahn T; Schrem S; Munzert G; Weidner K M; Wang J Y; Duyster J (Aug 1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL". Oncogene (ENGLAND) 17 (8): 941–8. doi:10.1038/sj.onc.1202024. ISSN 0950-9232. PMID 9747873.
- ^ Ma, G; Lu D; Wu Y; Liu J; Arlinghaus R B (May 1997). "Bcr phosphorylated on tyrosine 177 binds Grb2". Oncogene (ENGLAND) 14 (19): 2367–72. doi:10.1038/sj.onc.1201053. ISSN 0950-9232. PMID 9178913.
- ^ Maru, Y; Peters K L; Afar D E; Shibuya M; Witte O N; Smithgall T E (Feb 1995). "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Mol. Cell. Biol. (UNITED STATES) 15 (2): 835–42. ISSN 0270-7306. PMC 231961. PMID 7529874.
- ^ a b Ettenberg, S A; Keane M M; Nau M M; Frankel M; Wang L M; Pierce J H; Lipkowitz S (Mar 1999). "cbl-b inhibits epidermal growth factor receptor signaling". Oncogene (ENGLAND) 18 (10): 1855–66. doi:10.1038/sj.onc.1202499. ISSN 0950-9232. PMID 10086340.
- ^ Lavagna-Sévenier, C; Marchetto S; Birnbaum D; Rosnet O (Jun 1998). "The CBL-related protein CBLB participates in FLT3 and interleukin-7 receptor signal transduction in pro-B cells". J. Biol. Chem. (UNITED STATES) 273 (24): 14962–7. doi:10.1074/jbc.273.24.14962. ISSN 0021-9258. PMID 9614102.
- ^ Elly, C; Witte S; Zhang Z; Rosnet O; Lipkowitz S; Altman A; Liu Y C (Feb 1999). "Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation". Oncogene (ENGLAND) 18 (5): 1147–56. doi:10.1038/sj.onc.1202411. ISSN 0950-9232. PMID 10022120.
- ^ Jain, S K; Langdon W Y; Varticovski L (May 1997). "Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase". Oncogene (ENGLAND) 14 (18): 2217–28. doi:10.1038/sj.onc.1201049. ISSN 0950-9232. PMID 9174058.
- ^ Robertson, H; Langdon W Y; Thien C B; Bowtell D D (Nov 1997). "A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components". Biochem. Biophys. Res. Commun. (UNITED STATES) 240 (1): 46–50. doi:10.1006/bbrc.1997.7608. ISSN 0006-291X. PMID 9367879.
- ^ Donovan, J A; Wange R L; Langdon W Y; Samelson L E (Sep 1994). "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor". J. Biol. Chem. (UNITED STATES) 269 (37): 22921–4. ISSN 0021-9258. PMID 8083187.
- ^ Gesbert, F; Garbay C; Bertoglio J (Feb 1998). "Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells". J. Biol. Chem. (UNITED STATES) 273 (7): 3986–93. doi:10.1074/jbc.273.7.3986. ISSN 0021-9258. PMID 9461587.
- ^ Husson, H; Mograbi B; Schmid-Antomarchi H; Fischer S; Rossi B (May 1997). "CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2". Oncogene (ENGLAND) 14 (19): 2331–8. doi:10.1038/sj.onc.1201074. ISSN 0950-9232. PMID 9178909.
- ^ Odai, H; Sasaki K; Iwamatsu A; Nakamoto T; Ueno H; Yamagata T; Mitani K; Yazaki Y; Hirai H (Apr 1997). "Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl". Blood (UNITED STATES) 89 (8): 2745–56. ISSN 0006-4971. PMID 9108392.
- ^ Ng, Cherlyn; Jackson Rebecca A; Buschdorf Jan P; Sun Qingxiang; Guy Graeme R; Sivaraman J (Mar 2008). "Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates". EMBO J. (England) 27 (5): 804–16. doi:10.1038/emboj.2008.18. PMC 2265755. PMID 18273061.
- ^ Li, N; Batzer A; Daly R; Yajnik V; Skolnik E; Chardin P; Bar-Sagi D; Margolis B; Schlessinger J (May 1993). "Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling". Nature (ENGLAND) 363 (6424): 85–8. doi:10.1038/363085a0. ISSN 0028-0836. PMID 8479541.
- ^ Reif, K; Buday L; Downward J; Cantrell D A (May 1994). "SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases". J. Biol. Chem. (UNITED STATES) 269 (19): 14081–7. ISSN 0021-9258. PMID 8188688.
- ^ D'Angelo, G; Martini J F; Iiri T; Fantl W J; Martial J; Weiner R I (May 1999). "16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells". Mol. Endocrinol. (UNITED STATES) 13 (5): 692–704. doi:10.1210/me.13.5.692. ISSN 0888-8809. PMID 10319320.
- ^ Tong, X K; Hussain N K, de Heuvel E, Kurakin A, Abi-Jaoude E, Quinn C C, Olson M F, Marais R, Baranes D, Kay B K, McPherson P S (Mar 2000). "The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain". EMBO J. (ENGLAND) 19 (6): 1263–71. doi:10.1093/emboj/19.6.1263. ISSN 0261-4189. PMC 305667. PMID 10716926. Cite uses deprecated parameters (help)
- ^ Chin, H; Saito T; Arai A; Yamamoto K; Kamiyama R; Miyasaka N; Miura O (Oct 1997). "Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells". Biochem. Biophys. Res. Commun. (UNITED STATES) 239 (2): 412–7. doi:10.1006/bbrc.1997.7480. ISSN 0006-291X. PMID 9344843.
- ^ Morrison, Kevin B; Tognon Cristina E; Garnett Mathew J; Deal Cheri; Sorensen Poul H B (Aug 2002). "ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation". Oncogene (England) 21 (37): 5684–95. doi:10.1038/sj.onc.1205669. ISSN 0950-9232. PMID 12173038.
- ^ Kato-Stankiewicz, J; Ueda S; Kataoka T; Kaziro Y; Satoh T (Jun 2001). "Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner". Biochem. Biophys. Res. Commun. (United States) 284 (2): 470–7. doi:10.1006/bbrc.2001.5004. ISSN 0006-291X. PMID 11394904.
- ^ Wiederhold, Thorsten; Lee Ming-Fen; James Marianne; Neujahr Ralph; Smith Nicole; Murthy Anita; Hartwig John; Gusella James F; Ramesh Vijaya (Nov 2004). "Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2". Oncogene (England) 23 (54): 8815–25. doi:10.1038/sj.onc.1208110. ISSN 0950-9232. PMID 15467741.
- ^ Pomérance, M; Multon M C; Parker F; Venot C; Blondeau J P; Tocqué B; Schweighoffer F (Sep 1998). "Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor". J. Biol. Chem. (UNITED STATES) 273 (38): 24301–4. doi:10.1074/jbc.273.38.24301. ISSN 0021-9258. PMID 9733714.
- ^ Romero, F; Ramos-Morales F; Domínguez A; Rios R M; Schweighoffer F; Tocqué B; Pintor-Toro J A; Fischer S; Tortolero M (Mar 1998). "Grb2 and its apoptotic isoform Grb3-3 associate with heterogeneous nuclear ribonucleoprotein C, and these interactions are modulated by poly(U) RNA". J. Biol. Chem. (UNITED STATES) 273 (13): 7776–81. doi:10.1074/jbc.273.13.7776. ISSN 0021-9258. PMID 9516488.
Further reading
- Colledge M, Froehner SC (1998). "Interaction between the nicotinic acetylcholine receptor and Grb2. Implications for signaling at the neuromuscular junction.". Ann. N. Y. Acad. Sci. 841: 17–27. doi:10.1111/j.1749-6632.1998.tb10907.x. PMID 9668219.
- Ramesh N, Antón IM, Martínez-Quiles N, Geha RS (1999). "Waltzing with WASP.". Trends Cell Biol. 9 (1): 15–9. doi:10.1016/S0962-8924(98)01411-1. PMID 10087612.
- O'Sullivan E, Kinnon C, Brickell P (1999). "Wiskott-Aldrich syndrome protein, WASP.". Int. J. Biochem. Cell Biol. 31 (3–4): 383–7. doi:10.1016/S1357-2725(98)00118-6. PMID 10224664.
- Schlaepfer DD, Hauck CR, Sieg DJ (1999). "Signaling through focal adhesion kinase.". Prog. Biophys. Mol. Biol. 71 (3–4): 435–78. doi:10.1016/S0079-6107(98)00052-2. PMID 10354709.
- Vidal M, Liu WQ, Gril B, et al. (2004). "[Design of new anti-tumor agents interrupting deregulated signaling pathways induced by tyrosine kinase proteins. Inhibition of protein-protein interaction involving Grb2]". J. Soc. Biol. 198 (2): 133–7. PMID 15368963.
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
External links
- GRB2 Adaptor Protein at the US National Library of Medicine Medical Subject Headings (MeSH)
- The Grb2 protein page on The SH2 Website
- GeneCards entry for Grb2
- Human Protein Resource Database entry for Grb2
- Grb2 information on iHOP (Information Hyperlinked over Proteins)
- GRB2 Info with links in the Cell Migration Gateway
|
||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. T細胞受容体シグナル伝達 t cell receptor signaling
- 2. プロテインS欠乏症：臨床症状および診断 protein s deficiency clinical manifestations and diagnosis
- 3. プロテインC欠乏症：臨床症状および診断 protein c deficiency clinical manifestations and diagnosis
- 4. 幼児の食物蛋白誘発性直腸炎/大腸炎および腸疾患 food protein induced proctitis colitis and enteropathy of infancy
- 5. 第V因子ライデンおよび活性化プロテインC抵抗性：臨床症状および診断 factor v leiden and activated protein c resistance clinical manifestations and diagnosis
English Journal
- Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptor.
- Landry M1, Pomerleau V1, Saucier C2.
- The Biochemical journal.Biochem J.2016 Jun 1;473(11):1617-27. doi: 10.1042/BCJ20160249. Epub 2016 Apr 5.
- Met receptor tyrosine kinase (RTK) is known to bind to the three distinct protein isoforms encoded by the ShcA (Shc) gene. Structure-function studies have unveiled critical roles for p52Shc-dependent signalling pathways in Met-regulated biological functions. The molecular basis of the interaction be
- PMID 27048591
- Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.
- Zvezdova E1, Mikolajczak J2, Garreau A2, Marcellin M3, Rigal L2, Lee J1, Choi S1, Blaize G2, Argenty J2, Familiades J2, Li L1, Gonzalez de Peredo A3, Burlet-Schiltz O3, Love PE1, Lesourne R4.
- Science signaling.Sci Signal.2016 May 17;9(428):ra51. doi: 10.1126/scisignal.aad1576.
- The T cell signaling protein Themis1 is essential for the positive and negative selection of thymocytes in the thymus. Although the developmental defect that results from the loss of Themis1 suggests that it enhances T cell receptor (TCR) signaling, Themis1 also recruits Src homology 2 domain-contai
- PMID 27188442
- Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer.
- Timsah Z1,2, Ahmed Z1,3, Ivan C4,5, Berrout J2,6, Gagea M7, Zhou Y8, Pena GN4, Hu X9, Vallien C7, Kingsley CV10, Lu Y11, Hancock JF8, Liu J12, Gladden AB13, Mills GB11, Lopez-Berestein G4,5,14, Hung MC15, Sood AK4,5,16, Bogdanov M17, Ladbury JE1,2,3.
- Oncogene.Oncogene.2016 Apr 28;35(17):2186-96. doi: 10.1038/onc.2015.279. Epub 2015 Jul 27.
- In the absence of extracellular stimulation the adaptor protein growth factor receptor-bound protein (Grb2) and the phospholipase Plcγ1 compete for the same binding site on fibroblast growth factor receptor 2 (FGFR2). Reducing cellular Grb2 results in upregulation of Plcγ1 and depletion of the pho
- PMID 26212011
Japanese Journal
- 1P195 In vitro再構成系における上皮成長因子受容体とアダプター分子間相互作用の1分子可視化解析(接着・運動・骨格・伝達・膜)))
- 森松 美紀,太田 康友,柳田 敏雄,佐甲 靖志
- 生物物理 45(SUPPLEMENT_1), S80, 2005-10-19
- NAID 110004571176
- Optical Bioimaging : From Living Tissue to a Single Molecule : Single-Molecule Visualization of Cell Signaling Processes of Epidermal Growth Factor Receptor
- SAKO Yasushi,ICHINOSE Junya,MORIMATSU Miki,OHTA Kosuke,UYEMURA Takeshi
- Journal of pharmacological sciences 93(3), 253-258, 2003-11-01
- … Using this technique, we have studied the process of early signal transduction of epidermal growth factor (EGF) in single molecules: binding of EGF to its receptor (EGFR) on the cell surface, dimerization of EGFR induced by binding of EGF, fluctuation of the structure of EGFR clusters, activation of EGFR through tyrosine phosphorylations on its cytoplasmic domain, and recognition of activated EGFR by a cytoplasmic adaptor protein, Grb2. …
- NAID 10012544852
Related Links
- HT027, SH2/SH3 adapter GRB2, abundant SRC homology, epidermal growth factor receptor-binding protein GRB2, growth factor receptor-bound protein 3, protein Ash GeneRIFs: Gene References Into Functions suppression of ...
- 英語をクリック → GRB2 Adaptor Protein との組み合わせでEntrez を検索 チロシン (Tyrosine); Src相同領域 (src Homology Domain); リン酸化 (Phosphorylation); セブンレスの息子 (Son of Sevenless Protein); タンパク質チロシンキナーゼ ...
Related Pictures
★リンクテーブル★
| リンク元 | 「増殖因子受容体結合タンパク質2」「growth factor receptor-bound protein 2」「Grb2タンパク質」 |
| 関連記事 | 「adapt」「adaptor protein」「adaptor」 |
「増殖因子受容体結合タンパク質2」
「growth factor receptor-bound protein 2」
増殖因子受容体結合タンパク質2、成長因子受容体結合タンパク質2
「Grb2タンパク質」
「adapt」
- 順応する、適応する
「adaptor protein」
アダプタータンパク質、アダプター蛋白質、アダプタータンパク、アダプター蛋白
「adaptor」
- 関
- adapter