WordNet

unconstrained or not chemically bound in a molecule or not fixed and capable of relatively unrestricted motion; "free expansion"; "free oxygen"; "a free electron"
people who are free; "the home of the free and the brave" (同)free people
free from obligations or duties (同)discharge
free or remove obstruction from; "free a path across the cluttered floor" (同)disengage
grant freedom to; free from confinement (同)liberate, release, unloose, unloosen, loose
not literal; "a loose interpretation of what she had been told"; "a free translation of the poem" (同)loose, liberal
make (information) available for publication; "release the list with the names of the prisoners" (同)release
able to act at will; not hampered; not under compulsion or restraint; "free enterprise"; "a free port"; "a free country"; "I have an hour free"; "free will"; "free of racism"; "feel free to stay as long as you wish"; "a free choice"
not held in servitude; "after the Civil War he was a free man"
not occupied or in use; "a free locker"; "a free lane"
be very cold, below the freezing point; "It is freezing in Kalamazoo"
prohibit the conversion or use of (assets); "Blocked funds"; "Freeze the assets of this hostile government" (同)block, immobilize, immobilise
the withdrawal of heat to change something from a liquid to a solid (同)freezing
weather cold enough to cause freezing (同)frost
stop a process or a habit by imposing a freeze on it; "Suspend the aid to the war-torn country" (同)suspend
anesthetize by cold
be cold; "I could freeze to death in this office when the air conditioning is turned on"
cause to freeze; "Freeze the leftover food"
change to ice; "The water in the bowl froze"
suddenly behave coldly and formally; "She froze when she saw her ex-husband"
an interruption or temporary suspension of progress or movement; "a halt in the arms race"; "a nuclear freeze" (同)halt
fixing (of prices or wages etc) at a particular level; "a freeze on hiring"
change from a liquid to a solid when cold; "Water freezes at 32 degrees Fahrenheit" (同)freeze out, freeze down
stop moving or become immobilized; "When he saw the police car he froze" (同)stop dead
the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B
not still wet; "the ink has dried"; "a face marked with dried tears"
preserved by removing natural moisture; "dried beef"; "dried fruit"; "dehydrated eggs"; "shredded and desiccated coconut meat" (同)dehydrated, desiccated

PrepTutorEJDIC

(束縛された状態になく)『自由な』,自由の身の / (国家・国民などが)『独立している』 / (思想・行為などが)強制されない,自発的な / (動作が)拘束されない,無理のない / 《補語にのみ用いて》(苦痛・制約などを)『免れている』,(誤り・偏見などの)ない《+『from』(『of』)+『名』》 / 《補語にのみ用いて》《『be free to』do》『自由に』…『できる』 / (仕事から)解放された,暇になった;(部屋などが)使用されていない,空いた / 『無料の』;無税の / 出し惜しみしない / 遠慮のない,慎みがない / (道路などが)障害のない,自由に通れる / 固定していない,離れた / 無料で / 自由に,妨げられずに(freely) / (…から)〈人・国など〉‘を'『自由にする』,解放する《+『名』+『from』+『名』》 / (困難などから)〈人〉‘を'救う《+『名』+『form』+『名』》 / (障害などを)〈人・物〉‘から'取り除く《+『名』+『of』(『from』)+『名』》 / (物を)…‘から'片付ける,外す《+『名』+『of』+『名』》
『凍る』;冷凍される / 《『it』を主語にして》凍るほど寒い;《it・場所を主語にして》氷が張る / 〈体が〉凍える,《話》冷えきる / (恐怖・シヨックなどで)〈体などが〉こわばる,〈態度などが〉ぎごちなくなる;ぞっと(ぎょっと)する;〈気持ちなどが〉冷たくなる,ひんやりする / (霜などで)〈植物が〉枯れる / 〈物〉‘を'『凍らせる』,冷凍する / 〈人〉‘を'『凍えさせる』,凍死させる / …‘を'『ぞっとさせる』;〈体・態度など〉‘を'こわばらせる《+『名』+『up』,+『up』+『名』》 / 〈気持ちなど〉‘を'冷たくする / 〈物価など〉‘を'凍結する / 氷結,凍結状態 / (物価・賃金などの)凍結
dryの過去・過去分詞 / 乾燥した
凍るように寒い,(雨などが)氷混じりの / 冷凍する / 冷淡な,よそよそしい / 《副詞的に》凍るように

UpToDate Contents

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1. 膀胱内BCG免疫療法の合併症 complications of intravesical bcg immunotherapy
2. BCG接種 bcg vaccination
3. 尿路上皮（移行上皮）膀胱癌に対する根治的膀胱全摘除術および膀胱温存治療 radical cystectomy and bladder sparing treatments for urothelial transitional cell bladder cancer
4. ウシ型結核菌 mycobacterium bovis
5. HIV感染患者における予防接種 immunizations in hiv infected patients

English Journal

Improved formulation and lyophilization cycle for rBCG vaccine.

Jin TH, Nguyen L, Qu T, Tsao E.SourceAeras, 1405 Research Blvd, Suite 300, Rockville, MD 20850, USA.
Vaccine.Vaccine.2011 Jun 24;29(29-30):4848-52. Epub 2011 May 5.
To improve the conventional BCG vaccine in cake appearance and integrity, a new formulation with corresponding freeze drying cycle was developed for a recombinant BCG vaccine. The new formulation contains mannitol as a bulking agent, and trehalose, sucrose and sodium glutamate as stabilizers. The fo
PMID 21549782

Mycobacterium bovis Bacillus Calmette-Guerin Killed by Extended Freeze-Drying Reduces Colitis in Mice.

Lagranderie M, Kluge C, Kiefer-Biasizzo H, Abolhassani M, Nahori MA, Fitting C, Huerre M, Bandeira A, Bercovier H, Marchal G.SourceLaboratoire d'Immunotherapie, Institut Pasteur, Paris, France; Immunotherapix, BioTop Institut Pasteur, Paris, France.
Gastroenterology.Gastroenterology.2011 May 14. [Epub ahead of print]
BACKGROUND & AIMS: Mycobacterium bovis Bacillus Calmette-Guerin (BCG), killed by extended freeze-drying (EFD), induces secretion of interleukin-10 and reduces lung inflammation in a mouse model of asthma. We investigated the effects of EFD BCG in mouse models of inflammatory bowel disease.METHO
PMID 21683076

Japanese Journal

日本におけるBCG接種による重大な有害事象

戸井田一郎,中田志津子
結核 82(11), 809-824, 2007-11-15
… 1951年の結核予防法大改正によって凍結乾燥BCGワクチンの接種が法制化されてから2004年までに結核予防法によるBCG接種者総数は2億1380万人に達している。 … ほかに,BCGとの関連に疑問があるがBCG接種にひきつづいて起こった重大な有害事象症例として4症例の報告があった。 …
NAID 10025687819

結核温故知新

島尾忠男
結核 80(6), 481-489, 2005-06-15
… of the pathogenesis of TB when TB was highly prevalent in Japan by high incidence of TB from primarily infected youth, the development of mass screening for TB using radiophotography technique developed in Japan, completion of the interpretation method of chest X-ray findings, first success in the mass production of freeze-dried BCG vaccine in the world, the first implementation of the TB prevalence survey using random sampling method in 1953, and the development of a new drug for TB, …
NAID 10016782636

BCG Tokyo 172株の抗結核効果:結核菌噴霧感染によるモルモット肺結核実験モデルを用いた防御効果の検討

山本十糸子,PHALEN Susan,内田和幸,梅森清子,野島康弘,堀内善信,後藤義孝,MCMURRAY David N.,山本三郎
結核 75(5), 379-388, 2000-05-15
… BCG Tokyo 172 strain was examined for its protective efficacy against pulmonary tuberculosis in a guinea pig model. … CFU of BCG Tokyo 172 strain. … BCG Copenhagen 1331 was employed as a control strain. …
NAID 10005617763