fibroblast growth factor 8

線維芽細胞増殖因子8

WordNet

1. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
2. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
3. become attached by or as if by the process of growth; "The tree trunks had grown together"
4. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
5. cause to grow or develop; "He grows vegetables in his backyard"
6. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
7. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
8. (pathology) an abnormal proliferation of tissue (as in a tumor)
9. a progression from simpler to more complex forms; "the growth of culture"
10. something grown or growing; "a growth of hair"
11. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
12. be a contributing factor; "make things factor into a companys profitability"
13. any of the numbers (or symbols) that form a product when multiplied together
14. an independent variable in statistics
15. anything that contributes causally to a result; "a number of factors determined the outcome"
16. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
17. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
18. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
19. a concept whose truth can be proved; "scientific hypotheses are not facts"
20. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
21. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
22. a cell from which connective tissue develops

PrepTutorEJDIC

1. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
2. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
3. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
4. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/05/13 10:41:57」(JST)

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FGF8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FDB
Identifiers
Aliases	FGF8, AIGF, FGF-8, HBGF-8, HH6, KAL6, fibroblast growth factor 8
External IDs	MGI: 99604 HomoloGene: 7715 GeneCards: FGF8
Gene ontology Molecular function • type 1 fibroblast growth factor receptor binding • type 2 fibroblast growth factor receptor binding • growth factor activity • fibroblast growth factor receptor binding • chemoattractant activity • protein tyrosine kinase activity • 1-phosphatidylinositol-3-kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • Ras guanyl-nucleotide exchange factor activity Cellular component • extracellular region • intracellular • external side of plasma membrane • extracellular space Biological process • negative regulation of neuron apoptotic process • cell migration involved in mesendoderm migration • male genitalia development • epithelial to mesenchymal transition involved in endocardial cushion formation • outflow tract morphogenesis • embryonic heart tube development • mesonephros development • heart looping • forebrain neuron development • blood vessel remodeling • central nervous system neuron development • positive regulation of ERK1 and ERK2 cascade • metanephros development • cell proliferation in forebrain • positive regulation of mitotic nuclear division • gonad development • pharyngeal system development • branching involved in salivary gland morphogenesis • apoptotic process • dopaminergic neuron differentiation • cell fate commitment • limb morphogenesis • kidney development • lung development • anatomical structure morphogenesis • signal transduction involved in regulation of gene expression • regulation of odontogenesis of dentin-containing tooth • response to oxidative stress • embryo development ending in birth or egg hatching • forebrain morphogenesis • heart development • telencephalon development • branching involved in ureteric bud morphogenesis • midbrain-hindbrain boundary development • branching involved in blood vessel morphogenesis • thyroid-stimulating hormone-secreting cell differentiation • positive chemotaxis • mesodermal cell migration • cell differentiation • dorsal/ventral axon guidance • corticotropin hormone secreting cell differentiation • organ induction • neural plate morphogenesis • positive regulation of organ growth • negative regulation of apoptotic process • BMP signaling pathway • outflow tract septum morphogenesis • odontogenesis • thyroid gland development • pallium development • gastrulation • canonical Wnt signaling pathway • phosphatidylinositol-mediated signaling • subpallium development • lung morphogenesis • response to organic cyclic compound • otic vesicle formation • forebrain dorsal/ventral pattern formation • heart morphogenesis • aorta morphogenesis • generation of neurons • MAPK cascade • neuroepithelial cell differentiation • multicellular organism development • fibroblast growth factor receptor signaling pathway • positive regulation of gene expression • negative regulation of cardiac muscle tissue development • determination of left/right symmetry • inner ear morphogenesis • positive regulation of cell proliferation • bone development • motor neuron axon guidance • positive regulation of cell division • response to drug • embryonic hindlimb morphogenesis • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • phosphatidylinositol-3-phosphate biosynthetic process • peptidyl-tyrosine phosphorylation • regulation of phosphatidylinositol 3-kinase signaling • positive regulation of cell differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2253	14179
Ensembl	ENSG00000107831	ENSMUSG00000025219
UniProt	P55075	P37237
RefSeq (mRNA)	NM_001206389 NM_006119 NM_033163 NM_033164 NM_033165	NM_001166361 NM_001166362 NM_001166363 NM_010205
RefSeq (protein)	NP_001193318 NP_006110 NP_149353 NP_149354 NP_149355	NP_001159834.1 NP_001159835.1 NP_034335.1 NP_001159833 NP_001159834 NP_001159835 NP_034335
Location (UCSC)	Chr 10: 101.77 – 101.78 Mb	Chr 19: 45.74 – 45.74 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Fibroblast growth factor 8 is a protein that in humans is encoded by the FGF8 gene.

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

Fgf8 is important and necessary for setting up and maintaining the midbrain/hindbrain border (or mesencephalon/met-encephalon border) which plays the vital role of “organizer” in development, like the Spemann “organizer” of the gastrulating embryo. Fgf8 is expressed in the region where Otx2 and Gbx2 cross inhibit each other and is maintained expression by this interaction. Once expressed, the Fgf8 induces other transcription factors to form cross-regulatory loops between cells, thus the border is established. Through development, the Fgf8 goes to regulate the growth and differentiation of progenitor cells in this region to produce ultimate structure of midbrain and hindbrain. Crossely’s experiment proves that the Fgf8 is sufficient to induce the repatterning of midbrain and hindbrain structure.

In the development of forebrain, cortical patterning centers are the boundaries or poles of cortical primordium, where multiple BMP and WNT genes are expressed. Besides, at the anterior pole several FGF family including Fgf3, 8,17 and 18 overlap in expression. The similarity in cortical gene expression in Emx2 mutants and mice in which the anterior FGF8 source is augmented suggests that FGF8 controls the graded expression(low anterior, high posterior) of Emx2 in the cortical primordium. Emx2 is one of the protomap molecular determinants that prove to be closely interacted with Pax6. Emx2 and Pax6 are expressed in opposing gradients along the A/P axis of the cortical primordium and cooperate to set up area pattern. Fgf8 and Emx2 antagonize each other to create the development map. Fgf8 promotes the development of anterior part and suppresses posterior fate, while the Emx2 does the reverse. What's more, FGF8 manipulations suggest FGF8 controls the cortical graded expression of COUP-TF1. Moreover, the sharpness of both COUPTF1 and COUP-TF2 expression borders would be expected of genes involved in boundary specification.Thus, the interaction between them regulates the A/P axis of cortical primordium and directs the development map of cortical area.

Clinical significance

This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogenesis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs reveal roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.

References

Further reading

• Powers CJ, McLeskey SW, Wellstein A (2000). "Fibroblast growth factors, their receptors and signaling.". Endocr. Relat. Cancer. 7 (3): 165–97. doi:10.1677/erc.0.0070165. PMID 11021964. 
• Mattila MM, Härkönen PL (2007). "Role of fibroblast growth factor 8 in growth and progression of hormonal cancer.". Cytokine Growth Factor Rev. 18 (3–4): 257–66. doi:10.1016/j.cytogfr.2007.04.010. PMID 17512240. 
• Duester G (2007). "Retinoic acid regulation of the somitogenesis clock". Birth Defects Res. C Embryo Today. 81 (2): 84–92. doi:10.1002/bdrc.20092. PMC 2235195 . PMID 17600781. 
• Tanaka A, Miyamoto K, Matsuo H, et al. (1995). "Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties". FEBS Lett. 363 (3): 226–30. doi:10.1016/0014-5793(95)00324-3. PMID 7737407. 
• Gemel J, Gorry M, Ehrlich GD, MacArthur CA (1996). "Structure and sequence of human FGF8". Genomics. 35 (1): 253–7. doi:10.1006/geno.1996.0349. PMID 8661131. 
• Ornitz DM, Xu J, Colvin JS, et al. (1996). "Receptor specificity of the fibroblast growth factor family". J. Biol. Chem. 271 (25): 15292–7. doi:10.1074/jbc.271.25.15292. PMID 8663044. 
• Payson RA, Wu J, Liu Y, Chiu IM (1996). "The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells". Oncogene. 13 (1): 47–53. PMID 8700553. 
• Ghosh AK, Shankar DB, Shackleford GM, et al. (1997). "Molecular cloning and characterization of human FGF8 alternative messenger RNA forms". Cell Growth Differ. 7 (10): 1425–34. PMID 8891346. 
• Yoshiura K, Leysens NJ, Chang J, et al. (1997). "Genomic structure, sequence, and mapping of human FGF8 with no evidence for its role in craniosynostosis/limb defect syndromes". Am. J. Med. Genet. 72 (3): 354–62. doi:10.1002/(SICI)1096-8628(19971031)72:3<354::AID-AJMG21>3.0.CO;2-R. PMID 9332670. 
• Chellaiah A, Yuan W, Chellaiah M, Ornitz DM (2000). "Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity". J. Biol. Chem. 274 (49): 34785–94. doi:10.1074/jbc.274.49.34785. PMID 10574949. 
• Loo BB, Darwish KK, Vainikka SS, et al. (2001). "Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4". Int. J. Biochem. Cell Biol. 32 (5): 489–97. doi:10.1016/S1357-2725(99)00145-4. PMID 10736564. 
• Xu J, Liu Z, Ornitz DM (2000). "Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures". Development. 127 (9): 1833–43. PMID 10751172. 
• Tanaka S, Ueo H, Mafune K, et al. (2001). "A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma". Dig. Dis. Sci. 46 (5): 1016–21. doi:10.1023/A:1010753826788. PMID 11341643. 
• Ruohola JK, Viitanen TP, Valve EM, et al. (2001). "Enhanced invasion and tumor growth of fibroblast growth factor 8b-overexpressing MCF-7 human breast cancer cells". Cancer Res. 61 (10): 4229–37. PMID 11358849. 
• Mattila MM, Ruohola JK, Valve EM, et al. (2001). "FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells". Oncogene. 20 (22): 2791–804. doi:10.1038/sj.onc.1204430. PMID 11420691. 
• Zammit C, Coope R, Gomm JJ, et al. (2002). "Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer". Br. J. Cancer. 86 (7): 1097–103. doi:10.1038/sj.bjc.6600213. PMC 2364190 . PMID 11953856. 
• Brondani V, Klimkait T, Egly JM, Hamy F (2002). "Promoter of FGF8 reveals a unique regulation by unliganded RARalpha". J. Mol. Biol. 319 (3): 715–28. doi:10.1016/S0022-2836(02)00376-5. PMID 12054865. 
• Gnanapragasam VJ, Robson CN, Neal DE, Leung HY (2002). "Regulation of FGF8 expression by the androgen receptor in human prostate cancer". Oncogene. 21 (33): 5069–80. doi:10.1038/sj.onc.1205663. PMID 12140757. 

External links

• GeneReviews/NCBI/NIH/UW entry on Kallmann syndrome
• FGF8 human gene location in the UCSC Genome Browser.
• FGF8 human gene details in the UCSC Genome Browser.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

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English Journal

• Regulation of fibroblast growth factor 8 (FGF8) in chicken embryonic stem cells differentiation into spermatogonial stem cells.

• Wang M1, Zhang C1, Huang C2, Cheng S1, He N1, Wang Y1, Ahmed MF3, Zhao R1, Jin J1, Zuo Q1, Zhang Y1, Li B1.
• Journal of cellular biochemistry.J Cell Biochem.2018 Feb;119(2):2396-2407. doi: 10.1002/jcb.26402. Epub 2017 Oct 18.
• PMID 28898437

• Identification of Isthmin 1 as a Novel Clefting and Craniofacial Patterning Gene in Humans.

• Lansdon LA1,2,3, Darbro BW1,3, Petrin AL1,4, Hulstrand AM5, Standley JM1, Brouillette RB2, Long A2, Mansilla MA1, Cornell RA3,6, Murray JC1,2,6,3,4, Houston DW2,3, Manak JR7,2,3.
• Genetics.Genetics.2018 Jan;208(1):283-296. doi: 10.1534/genetics.117.300535. Epub 2017 Nov 21.
• PMID 29162626

• The fibroblast growth factor 8 family in the female reproductive tract.

• Estienne A1, Price CA2.
• Reproduction (Cambridge, England).Reproduction.2018 Jan;155(1):R53-R62. doi: 10.1530/REP-17-0542.
• PMID 29269444

Japanese Journal

• 専門医試験をめざす症例問題トレーニング 小児整形外科疾患

• 整形外科 = Orthopedic surgery 68(3), 271-274, 2017-03
• NAID 40021110598

• Tfap2 and Sox1/2/3 cooperatively specify ectodermal fates in ascidian embryos

• Development 144(1), 33-37, 2017-01-01
• NAID 120005941282

• DDS技術を活用した獣医再生治療 (特集 医療と生物医学研究のためのDDS技術)

• Drug delivery system : DDS : official journal of the Japan Society of Drug Delivery System 32(1), 29-38, 2017-01
• NAID 40021076977

Related Links

• FIBROBLAST GROWTH FACTOR 8; FGF8 - OMIM - Online ...

TEXT Cloning and Expression Fibroblast growth factors are secreted proteins that interact with FGF tyrosine kinase receptors to mediate growth and ...

• FGF8 fibroblast growth factor 8 [ (human)]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes ...

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★リンクテーブル★

リンク元	「線維芽細胞増殖因子8」
関連記事	「grow」「fact」「factor」「fibroblast」「growth」

「線維芽細胞増殖因子8」

　　[★]

英

fibroblast growth factor 8, FGF-8

関

AIGF

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「fibroblast」

　　[★] 線維芽細胞

同

fibroblasts, scleroderma phenotype

　

「growth」

　　[★]

• n.

• 成長