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the 6th letter of the Roman alphabet (同)f

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/19 22:33:57」(JST)

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Fibroblast growth factor 8 is a protein that in humans is encoded by the FGF8 gene.^[1]^[2]

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.^[2]

Fgf8 is important and necessary for setting up and maintaining the midbrain/hindbrain border (or mesencephalon/met-encephalon border) which plays the vital role of “organizer” in development, like the Spemann “organizer” of the gastrulating embryo. Fgf8 is expressed in the region where Otx2 and Gbx2 cross inhibit each other and is maintained expression by this interaction. Once expressed, the Fgf8 induces other transcription factors to form cross-regulatory loops between cells, thus the border is established. Through development, the Fgf8 goes to regulate the growth and differentiation of progenitor cells in this region to produce ultimate structure of midbrain and hindbrain.^[3] Crossely’s experiment proves that the Fgf8 is sufficient to induce the repatterning of midbrain and hindbrain structure.^[4]

In the development of forebrain, cortical patterning centers are the boundaries or poles of cortical primordium, where multiple BMP and WNT genes are expressed. Besides, at the anterior pole several FGF family including Fgf3, 8,17 and 18 overlap in expression.^[5] The similarity in cortical gene expression in Emx2 mutants and mice in which the anterior FGF8 source is augmented suggests that FGF8 controls the graded expression(low anterior, high posterior) of Emx2 in the cortical primordium. Emx2 is one of the protomap molecular determinants that prove to be closely interacted with Pax6. Emx2 and Pax6 are expressed in opposing gradients along the A/P axis of the cortical primordium and cooperate to set up area pattern. Fgf8 and Emx2 antagonize each other to create the development map. Fgf8 promotes the development of anterior part and suppresses posterior fate, while the Emx2 does the reverse. What's more, FGF8 manipulations suggest FGF8 controls the cortical graded expression of COUP-TF1.^[6] Moreover, the sharpness of both COUPTF1 and COUP-TF2 expression borders would be expected of genes involved in boundary specification.Thus, the interaction between them regulates the A/P axis of cortical primordium and directs the development map of cortical area.

Clinical signficance

This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogenesis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs reveal roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.^[2]

References

^ White RA, Dowler LL, Angeloni SV, Pasztor LM, MacArthur CA (Apr 1996). "Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region". Genomics 30 (1): 109–11. doi:10.1006/geno.1995.0020. PMID 8595889.
^ ^a ^b ^c "Entrez Gene: FGF8 fibroblast growth factor 8 (androgen-induced)".
^ Harris WA, Sanes DH, Reh TA (2011). Development of the Nervous System, Third Edition. Boston: Academic Press. pp. 33–34. ISBN 0-12-374539-X.
^ Crossley PH, Martin GR (February 1995). "The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo". Development 121 (2): 439–51. PMID 7768185.
^ Grove EA, Fukuchi-Shimogori T (2003). "Generating the cerebral cortical area map". Annu. Rev. Neurosci. 26: 355–80. doi:10.1146/annurev.neuro.26.041002.131137. PMID 14527269.
^ Rebsam A, Seif I, Gaspar P (October 2002). "Refinement of thalamocortical arbors and emergence of barrel domains in primary somatosensory cortex: a study of normal and monoamine oxidase A knock-out mice". J.Neurosci 22 (19): 8541–8552. PMID 12351728.

External links

GeneReviews/NCBI/NIH/UW entry on Kallmann syndrome
FGF8 human gene location in the UCSC Genome Browser.
FGF8 human gene details in the UCSC Genome Browser.

UpToDate Contents

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English Journal

Fibroblast growth factor-8 inhibits oxidative stress-induced apoptosis in H9c2 cells.

Singla RD1, Wang J1, Singla DK2,3.
Molecular and cellular biochemistry.Mol Cell Biochem.2017 Jan;425(1-2):77-84. doi: 10.1007/s11010-016-2863-2. Epub 2016 Nov 1.
PMID 27804049

Disruption of the Suprachiasmatic Nucleus in Fibroblast Growth Factor Signaling-Deficient Mice.

Miller AV1, Kavanaugh SI1, Tsai PS1.
Frontiers in endocrinology.Front Endocrinol (Lausanne).2016 Feb 8;7:11. doi: 10.3389/fendo.2016.00011. eCollection 2016.
PMID 26903947

Comparative Study on the Differentiation of Mesenchymal Stem Cells Between Fetal and Postnatal Rat Spinal Cord Niche.

Cao S1, Wei X, Li H, Miao J, Zhao G, Wu D, Liu B, Zhang Y, Gu H, Wang L, Fan Y, An D, Yuan Z.
Cell transplantation.Cell Transplant.2016;25(6):1115-30. doi: 10.3727/096368915X689910. Epub 2015 Nov 19.
PMID 26651539

Japanese Journal

Retinoic acid regulates Lhx8 expression via FGF-8b to the upper jaw development of chick embryo(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)

Journal of bioscience and bioengineering 119(3), 260-266, 2015-03
NAID 110009923564

研究フロンティア卵母細胞因子FGF-8とBMPによる新たな卵胞ステロイド分泌調節の検討

日本生殖内分泌学会雑誌 15, 47-51, 2010
NAID 40017350220

顎顔面形態形成に関わるFGF-8の解析

川崎医学会誌 31(3), 151-159, 2005
NAID 110004675926

Related Pictures

FGF 8 TOYOTA 02-8 FGF 25 forklift for sale FGF 8 ANOS PDB rendering based on 2fdb. TOYOTA 02 8 FGF 30 forklift for sale from накаливания NAGARES FGF/8-12 immagini-fgf-8 FGF‑8 in Human Prostate.

★リンクテーブル★

リンク元	「線維芽細胞増殖因子8」
関連記事	「FGF」「F」「FGFs」

「線維芽細胞増殖因子8」

FGF8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FDB
Identifiers
Aliases	FGF8, AIGF, FGF-8, HBGF-8, HH6, KAL6, fibroblast growth factor 8
External IDs	MGI: 99604 HomoloGene: 7715 GeneCards: 2253
Gene ontology
Molecular function	• type 1 fibroblast growth factor receptor binding; • receptor binding; • type 2 fibroblast growth factor receptor binding; • growth factor activity; • fibroblast growth factor receptor binding; • chemoattractant activity;
Cellular component	• extracellular region; • extracellular space; • intracellular; • external side of plasma membrane;
Biological process	• negative regulation of neuron apoptotic process; • cell migration involved in mesendoderm migration; • insulin receptor signaling pathway; • male genitalia development; • epithelial to mesenchymal transition involved in endocardial cushion formation; • outflow tract morphogenesis; • embryonic heart tube development; • mesonephros development; • heart looping; • Fc-epsilon receptor signaling pathway; • forebrain neuron development; • blood vessel remodeling; • vascular endothelial growth factor receptor signaling pathway; • central nervous system neuron development; • positive regulation of ERK1 and ERK2 cascade; • Ras protein signal transduction; • metanephros development; • cell proliferation in forebrain; • positive regulation of mitotic nuclear division; • gonad development; • pharyngeal system development; • branching involved in salivary gland morphogenesis; • apoptotic process; • dopaminergic neuron differentiation; • cell fate commitment; • limb morphogenesis; • epidermal growth factor receptor signaling pathway; • activation of MAPKK activity; • kidney development; • lung development; • anatomical structure morphogenesis; • signal transduction involved in regulation of gene expression; • regulation of odontogenesis of dentin-containing tooth; • response to oxidative stress; • embryo development ending in birth or egg hatching; • forebrain morphogenesis; • heart development; • telencephalon development; • branching involved in ureteric bud morphogenesis; • midbrain-hindbrain boundary development; • patterning of blood vessels; • thyroid-stimulating hormone-secreting cell differentiation; • positive chemotaxis; • innate immune response; • mesodermal cell migration; • cell differentiation; • dorsal/ventral axon guidance; • neurotrophin TRK receptor signaling pathway; • corticotropin hormone secreting cell differentiation; • organ induction; • neural plate morphogenesis; • small GTPase mediated signal transduction; • positive regulation of organ growth; • negative regulation of apoptotic process; • BMP signaling pathway; • outflow tract septum morphogenesis; • odontogenesis; • thyroid gland development; • pallium development; • gastrulation; • canonical Wnt signaling pathway; • phosphatidylinositol-mediated signaling; • subpallium development; • lung morphogenesis; • response to organic cyclic compound; • otic vesicle formation; • forebrain dorsal/ventral pattern formation; • heart morphogenesis; • aorta morphogenesis; • generation of neurons; • MAPK cascade; • neuroepithelial cell differentiation; • axon guidance; • multicellular organism development; • fibroblast growth factor receptor signaling pathway; • positive regulation of gene expression; • negative regulation of cardiac muscle tissue development; • determination of left/right symmetry; • inner ear morphogenesis; • positive regulation of cell proliferation; • bone development; • motor neuron axon guidance; • positive regulation of cell division; • response to drug; • embryonic hindlimb morphogenesis;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	2253
	14179
	ENSG00000107831
	ENSMUSG00000025219
	P55075
	P37237
	NM_001206389; NM_006119; NM_033163; NM_033164; NM_033165
	NM_001166361; NM_001166362; NM_001166363; NM_010205
	NP_006110.1; NP_149353.1; NP_149354.1; NP_149355.1
	NP_001159834.1; NP_001159835.1; NP_034335.1
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

英: fibroblast growth factor 8, FGF-8
関: AIGF

「FGF」

　　[★] 線維芽細胞増殖因子 fibroblast growth factor

「F」

　　[★] フェニルアラニン phenylalanine 　

「FGFs」

　　[★]

関: See Fibroblast growth factors

[pmid8595889-1] White RA, Dowler LL, Angeloni SV, Pasztor LM, MacArthur CA (Apr 1996). "Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region". Genomics 30 (1): 109–11. doi:10.1006/geno.1995.0020. PMID 8595889.

[entrez-2] "Entrez Gene: FGF8 fibroblast growth factor 8 (androgen-induced)".

[isbn0-12-374539-X-3] Harris WA, Sanes DH, Reh TA (2011). Development of the Nervous System, Third Edition. Boston: Academic Press. pp. 33–34. ISBN 0-12-374539-X.

[pmid7768185-4] Crossley PH, Martin GR (February 1995). "The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo". Development 121 (2): 439–51. PMID 7768185.

[pmid14527269-5] Grove EA, Fukuchi-Shimogori T (2003). "Generating the cerebral cortical area map". Annu. Rev. Neurosci. 26: 355–80. doi:10.1146/annurev.neuro.26.041002.131137. PMID 14527269.

[pmid12351728-6] Rebsam A, Seif I, Gaspar P (October 2002). "Refinement of thalamocortical arbors and emergence of barrel domains in primary somatosensory cortex: a study of normal and monoamine oxidase A knock-out mice". J.Neurosci 22 (19): 8541–8552. PMID 12351728.

v t e Intercellular signaling peptides and proteins / ligands

Growth factors	Epidermal growth factor Fibroblast growth factor Nerve growth factor Platelet-derived growth factor Transforming growth factor beta superfamily Vascular endothelial growth factor

Ephrin	EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3

Other	Adipokine Agouti signaling protein Agouti-related protein Angiogenic protein CCN intercellular signaling protein Cysteine-rich protein 61 Connective tissue growth factor Nephroblastoma overexpressed protein Cytokine Endothelin EDN1 EDN2 EDN3 Hedgehog protein Interferon Kinin Parathyroid hormone-related protein Semaphorin Somatomedin Tolloid-like metalloproteinase Tumor necrosis factor Wnt protein

see also extracellular ligand disorders

匿名

検索

案内

案内

FGF-8