fatty acid synthesis inhibitor

• 脂肪酸合成阻害薬、脂肪酸合成阻害剤

WordNet

1. having an (over)abundance of flesh; "he hadnt remembered how fat she was"
2. a soft greasy substance occurring in organic tissue and consisting of a mixture of lipids (mostly triglycerides); "pizza has too much fat"
3. marked by great fruitfulness; "fertile farmland"; "a fat land"; "a productive vineyard"; "rich soil" (同)fertile, productive, rich
4. lucrative; "a juicy contract"; "a nice fat job" (同)juicy
5. having a relatively large diameter; "a fat rope"
6. limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
7. control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
8. limit the range or extent of; "Contact between the young was inhibited by strict social customs"
9. street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
10. any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
11. having the characteristics of an acid; "an acid reaction"
12. the process of producing a chemical compound (usually by the union of simpler chemical compounds)
13. the combination of ideas into a complex whole (同)synthetic thinking
14. a substance that retards or stops an activity

PrepTutorEJDIC

1. 『脂肪』,脂肪分 / (動物の)あぶら身 / (料理用の)油,ヘット / 肥満,太り過ぎ / 『太った』,肥満した / 『脂肪の多い』 / たっぷりとはいった,分厚い / もうかる / (土地が)肥えた / …‘を'太らせる / ふとる,肥える
2. 〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》
3. 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
4. 〈U〉総合,統合[すること] / 〈C〉総合体,統合されたもの / 〈U〉合成
5. 抑制する人(物) / 化学反応抑制剤

UpToDate Contents

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• 1. シクロスポリンおよびタクロリムスの腎毒性 cyclosporine and tacrolimus nephrotoxicity
• 2. 食事中の脂肪 dietary fat
• 3. 早期産児および正期産児におけるn-3長鎖多価不飽和脂肪酸（LCPUFA） n 3 long chain polyunsaturated fatty acids lcpufa for preterm and term infants
• 4. 魚油と海洋由来オメガ3脂肪酸 fish oil and marine omega 3 fatty acids
• 5. 食事または栄養補助食品による脂質低下 lipid lowering with diet or dietary supplements

English Journal

• Short-term comparative study of the influence of fried edible oils intake on the metabolism of essential fatty acids in obese individuals.

• Ferreiro-Vera C, Priego-Capote F, Mata-Granados JM, Luque de Castro MD.SourceDepartment of Analytical Chemistry, Annex C-3, Campus of Rabanales, University of Córdoba, E-14071 Córdoba, Spain; Institute of Biomedical Research Maimónides (IMIBIC), Reina Sofía Hospital, University of Córdoba, E-14071 Córdoba, Spain.
• Food chemistry.Food Chem.2013 Jan 15;136(2):576-84. doi: 10.1016/j.foodchem.2012.08.081. Epub 2012 Sep 8.
• The effect of breakfast intake of fried oils containing natural antioxidants or a synthetic autooxidation inhibitor on the metabolism of essential fatty acids focused on obese individuals. Serum levels of eicosanoids were compared in individuals before and after intake of different breakfasts. Univa
• PMID 23122100

• Cortisol-mediated adhesion of synovial fibroblasts is dependent on the degradation of anandamide and activation of the endocannabinoid system.

• Lowin T, Zhu W, Dettmer-Wilde K, Straub RH.SourceUniversity Hospital Regensburg, Regensburg, Germany. torsten.lowin@ukr.de.
• Arthritis and rheumatism.Arthritis Rheum.2012 Dec;64(12):3867-76. doi: 10.1002/art.37684.
• OBJECTIVE: In rheumatoid arthritis (RA) synovial fluid, levels of the endocannabinoids anandamide (AEA) and 2-arachidonylglycerol are elevated. Since synovial fibroblasts (SFs) possess all of the enzymes necessary for endocannabinoid synthesis, it is likely that these cells contribute significantly
• PMID 22933357

Japanese Journal

• An R132H Mutation in Isocitrate Dehydrogenase 1 Enhances p21 Expression and Inhibits Phosphorylation of Retinoblastoma Protein in Glioma Cells

• MIYATA Satsuki,URABE Masashi,GOMI Akira,NAGAI Mutsumi,YAMAGUCHI Takashi,TSUKAHARA Tomonori,MIZUKAMI Hiroaki,KUME Akihiro,OZAWA Keiya,WATANABE Eiju
• Neurologia medico-chirurgica 53(10), 645-654, 2013
• … The IDH1 mutation induces down-regulation of tricarboxylic acid cycle intermediates and up-regulation of lipid metabolism. … Sterol regulatory element-binding proteins (SREBPs) regulate not only the synthesis of cholesterol and fatty acids but also acyclin-dependent kinase inhibitor p21 that halts the cell cycle at G1. …
• NAID 130003383193

• Okadaic Acid Suppresses Melanogenesis via Proteasomal Degradation of Tyrosinase

• Jeong Hyo-Soon,Yun Hye-Young,Baek Kwang Jin [他],Kwon Nyoun Soo,Park Kyoung-Chan,Kim Dong-Seok
• Biological and Pharmaceutical Bulletin 36(9), 1503-1508, 2013
• … Okadaic acid is a C38 fatty acid derivative that is known to specifically inhibit the activity of protein phosphatase 2A (PP2A). … Previously, we reported that inhibition of PP2A by okadaic acid elicited extracellular signal-regulated kinase (ERK) activation, and that PP2A may be involved in melanogenesis. … However, the effects of okadaic acid on melanogenesis have not been completely evaluated. …
• NAID 130003361516

• Anticancer Activity of Pristimerin in Epidermal Growth Factor Receptor 2-Positive SKBR3 Human Breast Cancer Cells

• Lee Jin Sun,Yoon In Sang,Lee Myung Sun [他],Cha Eun Young,Thuong Phuong Thien,Diep Trinh Thi,Kim Je Ryong
• Biological and Pharmaceutical Bulletin 36(2), 316-325, 2013
• … Fatty acid synthase (FASN) expression and FASN activity were downregulated by pristimerin. … Adding of exogenous palmitate, the end product of de novo fatty acid synthesis, reduced the proliferation activity of pristimerin. … Pristimerin inhibited migration and invasion of cells, and co-treatment with the mTOR inhibitor rapamycin additionally suppressed these activities. …
• NAID 130003361370

Related Links

• Proteasome inhibitor treatment reduced fatty acid ...

1. Exp Mol Pathol. 2012 Aug;93(1):26-34. doi: 10.1016/j.yexmp.2012.03.006. Epub 2012 Mar 16. Proteasome inhibitor treatment reduced fatty acid, triacylglycerol and cholesterol synthesis. Oliva J, French SW, Li J, Bardag-Gorce F.

• Synthesis and antitumor activity of an inhibitor of fatty acid ...

Abstract Compared to normal human tissues, many common human cancers, including carcinoma of the colon, prostate, ovary, breast, and endometrium, express high levels of fatty acid synthase (FAS, EC 2.3.1 ...

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★リンクテーブル★

リンク元	「脂肪酸合成阻害剤」「脂肪酸合成阻害薬」
関連記事	「inhibit」「synthesis」「inhibitor」「fatty」「fat」

「脂肪酸合成阻害剤」

　　[★]

英

fatty acid synthesis inhibitor

関

脂肪酸合成阻害薬

「脂肪酸合成阻害薬」

　　[★]

英

fatty acid synthesis inhibitor

関

脂肪酸合成阻害剤

「inhibit」

　　[★]

• v.

• 抑制する、阻害する、阻止する

関

abrogate、block、depress、depression、deter、inhibition、interdict、prevent、prevention、repress、repression、restrain、restraint、suppress、suppression

　 　 　 　

「synthesis」

　　[★]

• n.

• 総合、統合、組み立て(opp.analysis。総合体、統合体。(化)合成、人造。(外科)接骨、復位。

関

construction、elaboration、syntheses、synthesize、synthetic

　 　 　

「inhibitor」

　　[★]

• n.

• 阻害剤、阻害薬、抑制薬、抑制剤、(内在性物質について)インヒビター、抑制物質

関

blocker、depressant、suppressant

　 　

「fatty」

　　[★]

• adj.

• 脂肪性の、脂肪質の

関

adipose、aliphatic、lipogenous

　 　

「fat」

　　[★] 脂肪