興奮性アミノ酸トランスポーター4、4型興奮性アミノ酸輸送体
- 関
- EAAT4
WordNet
- move something or somebody around; usually over long distances
- an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
- move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
- transport commercially (同)send, ship
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
- a long truck for carrying motor vehicles (同)car transporter
- a crane for moving material with dispatch as in loading and unloading ships
- pertaining to or containing any of a group of organic compounds of nitrogen derived from ammonia (同)aminic
- the radical -NH2 (同)amino_group
PrepTutorEJDIC
- (ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
- 自動車運搬用大型トラック
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/30 14:44:29」(JST)
[Wiki en表示]
SLC1A6 |
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Identifiers |
Aliases |
SLC1A6, EAAT4 |
External IDs |
OMIM: 600637 MGI: 1096331 HomoloGene: 21055 GeneCards: 6511 |
Gene ontology |
Molecular function |
• L-aspartate transmembrane transporter activity
• symporter activity
• L-glutamate transmembrane transporter activity
• sodium:dicarboxylate symporter activity
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Cellular component |
• integral component of membrane
• Golgi apparatus
• membrane
• plasma membrane
• integral component of plasma membrane
• presynapse
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Biological process |
• synaptic transmission
• dicarboxylic acid transport
• regulation of membrane potential
• ion transport
• glutamate secretion
• transmembrane transport
• L-glutamate transmembrane transport
• transport
• aspartate transport
• neurotransmitter secretion
• L-glutamate transport
• L-aspartate transmembrane transport
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Sources:Amigo / QuickGO |
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Orthologs |
Species |
Human |
Mouse |
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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NM_001272087
NM_001272088
NM_005071
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RefSeq (protein) |
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NP_001259016.1
NP_001259017.1
NP_005062.1
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Location (UCSC) |
Chr 19: 14.95 – 15.02 Mb |
Chr 10: 78.78 – 78.81 Mb |
PubMed search |
[1] |
[2] |
Wikidata |
View/Edit Human |
View/Edit Mouse |
Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.[1][2]
EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.[2]
References
- ^ "Entrez Gene: solute carrier family 1 (high affinity aspartate/glutamate transporter)".
- ^ a b Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG (June 1995). "An excitatory amino-acid transporter with properties of a ligand-gated chloride channel". Nature 375 (6532): 599–603. doi:10.1038/375599a0. PMID 7791878.
Further reading
- Deng X, Shibata H, Takeuchi N, et al. (2007). "Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (3): 271–8. doi:10.1002/ajmg.b.30351. PMID 17221839.
- Need AC, Keefe RS, Ge D, et al. (2009). "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.". Eur. J. Hum. Genet. 17 (7): 946–57. doi:10.1038/ejhg.2008.264. PMC 2986499. PMID 19156168.
- Poulsen MV, Vandenberg RJ (2001). "Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4.". J. Physiol. (Lond.) 534 (Pt 1): 159–67. doi:10.1111/j.1469-7793.2001.00159.x. PMC 2278676. PMID 11432999.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Koch HP, Brown RL, Larsson HP (2007). "The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits.". J. Neurosci. 27 (11): 2943–7. doi:10.1523/JNEUROSCI.0118-07.2007. PMC 2435202. PMID 17360917.
- Jackson M, Song W, Liu MY, et al. (2001). "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins.". Nature 410 (6824): 89–93. doi:10.1038/35065091. PMID 11242047.
- Rajamanickam J, Palmada M, Lang F, Boehmer C (2007). "EAAT4 phosphorylation at the SGK1 consensus site is required for transport modulation by the kinase.". J. Neurochem. 102 (3): 858–66. doi:10.1111/j.1471-4159.2007.04585.x. PMID 17442044.
- Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
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Ion pumps
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Symporter, Cotransporter |
- Na+/K+,Cl−
- Na+/Pi3
- Na+/Cl−
- Na+/glucose
- Na+/I−
- Cl−/K+
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Antiporter (exchanger) |
- Na+/H+
- Na+/Ca2+
- Na+/(Ca2+-K+) - Cl−/HCO−
3 (Band 3)
- Cl−-formate
- Cl−-oxalate
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see also solute carrier disorders
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UpToDate Contents
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English Journal
- Molecular identification and cellular localization of a potential transport system involved in cystine/cysteine uptake in human lenses.
- Lim JC1, Lam L, Li B, Donaldson PJ.
- Experimental eye research.Exp Eye Res.2013 Nov;116:219-26. doi: 10.1016/j.exer.2013.09.002. Epub 2013 Sep 19.
- In this study we have sought to identify whether cystine uptake mechanisms previously identified in the rat lens are also found in the human lens. Using a combination of reverse transcriptase PCR, Western blotting and immunohistochemistry, we show that the light chain subunit of the cystine/glutamat
- PMID 24056007
- Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment.
- Wilmsdorff MV1, Blaich C, Zink M, Treutlein J, Bauer M, Schulze T, Schneider-Axmann T, Gruber O, Rietschel M, Schmitt A, Falkai P.
- The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.World J Biol Psychiatry.2013 Sep;14(7):490-9. doi: 10.3109/15622975.2011.645877. Epub 2012 Mar 16.
- OBJECTIVES: The glutamatergic hypothesis of schizophrenia proposes alterations of excitatory amino acid transporters (solute carrier family, SLCs) expression and cerebellar dysfunctions. The influence of the neuregulin-1 (NRG1) risk genotype or effects of antipsychotics on expression of EAATs are un
- PMID 22424243
- Klotho sensitivity of the neuronal excitatory amino acid transporters EAAT3 and EAAT4.
- Almilaji A1, Munoz C, Pakladok T, Alesutan I, Feger M, Föller M, Lang UE, Shumilina E, Lang F.
- PloS one.PLoS One.2013 Jul 29;8(7):e70988. doi: 10.1371/journal.pone.0070988. Print 2013.
- Klotho, a transmembrane protein, which can be cleaved off as β-glucuronidase and hormone, is released in both, kidney and choroid plexus and encountered in blood and cerebrospinal fluid. Klotho deficiency leads to early appearance of age-related disorders and premature death. Klotho may modify tran
- PMID 23923038
Japanese Journal
- Functional Expression of Organic Ion Transporters in Astrocytes and Their Potential as a Drug Target in the Treatment of Central Nervous System Diseases
- Excitatory Amino Acid Transporter 1-Mediated L-Glutamate Transport at the Inner Blood–Retinal Barrier: Possible Role in L-Glutamate Elimination from the Retina
- <i>In Vitro</i> Study of L-Glutamate and L-Glutamine Transport in Retinal Pericytes: Involvement of Excitatory Amino Acid Transporter 1 and Alanine–Serine–Cysteine Transporter 2
Related Links
- SLC1A6 SLC1A6 A gene on chromosome 19p13.12 that encodes an amino acid (L-glutamate and L- and D-aspartate) transporter and sodium co-transporter.
- Excitatory Amino Acid Transporter 4 information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Excitatory Amino Acid Transporter 4 Description of Excitatory ...
★リンクテーブル★
[★]
- 関
- excitatory amino acid transporter 4
[★]
- 英
- excitatory amino acid transporter 4、EAAT4
- 関
- 興奮性アミノ酸トランスポーター4
[★]
- 英
- excitatory amino acid transporter 4、EAAT4
- 関
- 4型興奮性アミノ酸輸送体
[★]
[★]
- 関
- bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation
[★]
- 関
- excitability、excitable、excitation、excite、excitement、exciting、excito、fire
[★]
トランスポーター
- 関
- translocator、transport protein、transporter protein