真核生物・訳開始因子4E

関: eIF-4E、eIF4E、eukaryotic initiation factor-4E

WordNet

be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
(genetics) the process whereby genetic information coded in messenger RNA directs the formation of a specific protein at a ribosome in the cytoplasm
(mathematics) a transformation in which the origin of the coordinate system is moved to another position but the direction of each axis remains the same
the act of uniform movement (同)displacement
a written communication in a second language having the same meaning as the written communication in a first language (同)interlingual rendition, rendering, version
a uniform movement without rotation
rewording something in less technical terminology
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
the act of starting something for the first time; introducing something new; "she looked forward to her initiation as an adult"; "the foundation of a new scientific society" (同)founding, foundation, institution, origination, creation, innovation, introduction, instauration
a formal entry into an organization or position or office; "his initiation into the club"; "he was ordered to report for induction into the army"; "he gave a speech as part of his installation into the hall of fame" (同)induction, installation
having cells with `good or membrane-bound nuclei (同)eucaryotic

PrepTutorEJDIC

(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈U〉『訳すこと,翻訳』 / 〈C〉翻訳されたもの
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
〈U〉開始;創業 / 〈U〉入会,入門;〈C〉入会(入門)式 / 〈U〉手ほどき,伝授

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/23 12:56:40」(JST)

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[Wiki en表示]

Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein that in humans is encoded by the EIF4E gene.^[1]^[2]

Function[edit]

All eukaryotic cellular mRNAs are blocked at their 5-prime ends with the 7-methyl-guanosine cap structure, m7GpppX (where X is any nucleotide). This structure is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export. EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is a 24-kD polypeptide that exists as both a free form and as part of a multiprotein complex termed EIF4F. The EIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis. The other subunits of EIF4F are a 50-kD polypeptide, termed EIF4A, that possesses ATPase and RNA helicase activities, and a 220-kD polypeptide, EIF4G.^[3]^[4]

eIF4E's function is to bind an mRNA cap and ultimately bring it to the ribosome. eIF4E is part of the eIF4F pre-initiation complex, which is made up of eIF4E, and eIF4G (eIF4F is sometimes considered to have additional protein components). Almost all cellular proteins require eIF4E in order to be translated into protein. eIF4E binds the first nucleotide on the 5' end of an mRNA molecule (known as the cap): a 7 methyl guanosine (m7G). It sandwiches m7G between 2 tryptophan residues, and other amino acids are involved in the binding.

Some viruses cut eIF4G in such a way that the eIF4E binding site is removed and the virus is able to translate its proteins without eIF4E. Also some cellular proteins, the most notable being heat shock proteins, do not require eIF4E in order to be translated. Both viruses and cellular proteins achieve this through an IRES structure in the RNA.

FMRP represses translation through EIF4E binding[edit]

Fragile X mental retardation protein (FMR1) acts to regulate translation of specific mRNAs through its binding of eIF4E. FMRP acts by binding CYFIP1, which directly binds eIF4e at a domain that is structurally similar to those found in 4E-BPs including EIF4EBP3, EIF4EBP1, and EIF4EBP2. The FMRP/CYFIP1 complex binds in such a way as to prevent the eIF4E-eIF4G interaction, which is necessary for translation to occur. The FMRP/CYFIP1/eIF4E interaction is strengthened by the presence of mRNA(s). In particular, BC1 RNA allows for an optimal interaction between FMRP and CYFIP1.^[5] RNA-BC1 is a non-translatable, dendritic mRNA, which binds FMRP to allow for its association with a specific target mRNA. BC1 may function to regulate FMRP and mRNA interactions at synapse(s) through its recruitment of FMRP to the appropriate mRNA.^[6] In addition, FMRP may recruit CYFIP1 to specific mRNAs in order to repress translation. The FMRP-CYFIP1 translational inhibitor is regulated by stimulation of neuron(s). Increased synaptic stimulation resulted in the dissociation of eIF4E and CYFIP1, allowing for the initiation of translation.^[5]

Interactions[edit]

EIF4E has been shown to interact with EIF4A1,^[7]^[8] EIF4EBP3,^[9]^[10] EIF4EBP1,^[7]^[8]^[11]^[12]^[13]^[14]^[15]^[16]^[17]^[18]^[19]^[20]^[21] EIF4EBP2,^[12]^[22] Eukaryotic translation initiation factor 4 gamma,^[8]^[12]^[17]^[23]^[24] EIF4G2^[25] and EIF4ENIF1.^[26]

References[edit]

^ Pelletier J, Brook JD, Housman DE (August 1991). "Assignment of two of the translation initiation factor-4E (EIF4EL1 and EIF4EL2) genes to human chromosomes 4 and 20". Genomics 10 (4): 1079–82. doi:10.1016/0888-7543(91)90203-Q. PMID 1916814.
^ Jones RM, MacDonald ME, Branda J, Altherr MR, Louis DN, Schmidt EV (May 1997). "Assignment of the human gene encoding eukaryotic initiation factor 4E (EIF4E) to the region q21-25 on chromosome 4". Somat. Cell Mol. Genet. 23 (3): 221–3. doi:10.1007/BF02721373. PMID 9330633.
^ Rychlik W, Domier LL, Gardner PR, Hellmann GM, Rhoads RE (February 1987). "Amino acid sequence of the mRNA cap-binding protein from human tissues". Proc. Natl. Acad. Sci. U.S.A. 84 (4): 945–9. doi:10.1073/pnas.84.4.945. PMC 304336. PMID 3469651.
^ "Entrez Gene: eIF4E Eukaryotic translation initiation factor 4E".
^ ^a ^b Napoli, I.; Mercaldo, V.; Boyl, P. P.; Eleuteri, B.; Zalfa, F.; De Rubeis, S.; Di Marino, D.; Mohr, E.; Massimi, M.; Falconi, M.; Witke, W.; Costa-Mattioli, M.; Sonenberg, N.; Achsel, T.; Bagni, C. (2008). "The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP". Cell 134 (6): 1042–1054. doi:10.1016/j.cell.2008.07.031. PMID 18805096. edit
^ Zalfa, F.; Giorgi, M.; Primerano, B.; Moro, A.; Di Penta, A.; Reis, S.; Oostra, B.; Bagni, C. (2003). "The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses". Cell 112 (3): 317–327. doi:10.1016/S0092-8674(03)00079-5. PMID 12581522. edit
^ ^a ^b Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. Cite uses deprecated parameters (help)
^ ^a ^b ^c Connolly, Eileen; Braunstein Steve, Formenti Silvia, Schneider Robert J (May 2006). "Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells". Mol. Cell. Biol. (United States) 26 (10): 3955–65. doi:10.1128/MCB.26.10.3955-3965.2006. ISSN 0270-7306. PMC 1489005. PMID 16648488. Cite uses deprecated parameters (help)
^ Kleijn, Miranda; Scheper Gert C, Wilson Mary L, Tee Andrew R, Proud Christopher G (December 2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. (Netherlands) 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. ISSN 0014-5793. PMID 12482586. Cite uses deprecated parameters (help)
^ Poulin, F; Gingras A C, Olsen H, Chevalier S, Sonenberg N (May 1998). "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family". J. Biol. Chem. (UNITED STATES) 273 (22): 14002–7. doi:10.1074/jbc.273.22.14002. ISSN 0021-9258. PMID 9593750. Cite uses deprecated parameters (help)
^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. Cite uses deprecated parameters (help)
^ ^a ^b ^c Mader, S; Lee H, Pause A, Sonenberg N (September 1995). "The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins". Mol. Cell. Biol. (UNITED STATES) 15 (9): 4990–7. ISSN 0270-7306. PMC 230746. PMID 7651417. Cite uses deprecated parameters (help)
^ Rao, Ravi D; Mladek Ann C, Lamont Jeffrey D, Goble Jennie M, Erlichman Charles, James C David, Sarkaria Jann N (October 2005). "Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells". Neoplasia (United States) 7 (10): 921–9. doi:10.1593/neo.05361. ISSN 1522-8002. PMC 1502028. PMID 16242075. Cite uses deprecated parameters (help)
^ Eguchi, Satoshi; Tokunaga Chiharu, Hidayat Sujuti, Oshiro Noriko, Yoshino Ken-ichi, Kikkawa Ushio, Yonezawa Kazuyoshi (July 2006). "Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size". Genes Cells (England) 11 (7): 757–66. doi:10.1111/j.1365-2443.2006.00977.x. ISSN 1356-9597. PMID 16824195. Cite uses deprecated parameters (help)
^ Yang, D; Brunn G J, Lawrence J C (June 1999). "Mutational analysis of sites in the translational regulator, PHAS-I, that are selectively phosphorylated by mTOR". FEBS Lett. (NETHERLANDS) 453 (3): 387–90. doi:10.1016/S0014-5793(99)00762-0. ISSN 0014-5793. PMID 10405182. Cite uses deprecated parameters (help)
^ Patel, Jashmin; McLeod Laura E, Vries Robert G J, Flynn Andrea, Wang Xuemin, Proud Christopher G (June 2002). "Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors". Eur. J. Biochem. (Germany) 269 (12): 3076–85. doi:10.1046/j.1432-1033.2002.02992.x. ISSN 0014-2956. PMID 12071973. Cite uses deprecated parameters (help)
^ ^a ^b Kumar, V; Sabatini D, Pandey P, Gingras A C, Majumder P K, Kumar M, Yuan Z M, Carmichael G, Weichselbaum R, Sonenberg N, Kufe D, Kharbanda S (April 2000). "Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase". J. Biol. Chem. (UNITED STATES) 275 (15): 10779–87. doi:10.1074/jbc.275.15.10779. ISSN 0021-9258. PMID 10753870. Cite uses deprecated parameters (help)
^ Kumar, V; Pandey P, Sabatini D, Kumar M, Majumder P K, Bharti A, Carmichael G, Kufe D, Kharbanda S (March 2000). "Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation". EMBO J. (ENGLAND) 19 (5): 1087–97. doi:10.1093/emboj/19.5.1087. ISSN 0261-4189. PMC 305647. PMID 10698949. Cite uses deprecated parameters (help)
^ Gingras, A C; Gygi S P, Raught B, Polakiewicz R D, Abraham R T, Hoekstra M F, Aebersold R, Sonenberg N (June 1999). "Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism". Genes Dev. (UNITED STATES) 13 (11): 1422–37. doi:10.1101/gad.13.11.1422. ISSN 0890-9369. PMC 316780. PMID 10364159. Cite uses deprecated parameters (help)
^ Shen, X; Tomoo K, Uchiyama S, Kobayashi Y, Ishida T (October 2001). "Structural and thermodynamic behavior of eukaryotic initiation factor 4E in supramolecular formation with 4E-binding protein 1 and mRNA cap analogue, studied by spectroscopic methods". Chem. Pharm. Bull. (Japan) 49 (10): 1299–303. doi:10.1248/cpb.49.1299. ISSN 0009-2363. PMID 11605658. Cite uses deprecated parameters (help)
^ Adegoke, Olasunkanmi A J; Chevalier Stéphanie, Morais José A, Gougeon Réjeanne, Kimball Scot R, Jefferson Leonard S, Wing Simon S, Marliss Errol B (January 2009). "Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men". Am. J. Physiol. Endocrinol. Metab. (United States) 296 (1): E105–13. doi:10.1152/ajpendo.90752.2008. ISSN 0193-1849. PMC 2636991. PMID 18957614. Cite uses deprecated parameters (help)
^ Pause, A; Belsham G J, Gingras A C, Donzé O, Lin T A, Lawrence J C, Sonenberg N (October 1994). "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function". Nature (ENGLAND) 371 (6500): 762–7. doi:10.1038/371762a0. ISSN 0028-0836. PMID 7935831. Cite uses deprecated parameters (help)
^ Vary, T C; Jefferson L S, Kimball S R (December 1999). "Amino acid-induced stimulation of translation initiation in rat skeletal muscle". Am. J. Physiol. (UNITED STATES) 277 (6 Pt 1): E1077–86. ISSN 0002-9513. PMID 10600798. Cite uses deprecated parameters (help)
^ Harris, Thurl E; Chi An, Shabanowitz Jeffrey, Hunt Donald F, Rhoads Robert E, Lawrence John C (April 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO J. (England) 25 (8): 1659–68. doi:10.1038/sj.emboj.7601047. ISSN 0261-4189. PMC 1440840. PMID 16541103. Cite uses deprecated parameters (help)
^ Gradi, A; Imataka H, Svitkin Y V, Rom E, Raught B, Morino S, Sonenberg N (January 1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. (UNITED STATES) 18 (1): 334–42. ISSN 0270-7306. PMC 121501. PMID 9418880. Cite uses deprecated parameters (help)
^ Dostie, J; Ferraiuolo M, Pause A, Adam S A, Sonenberg N (June 2000). "A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E". EMBO J. (ENGLAND) 19 (12): 3142–56. doi:10.1093/emboj/19.12.3142. ISSN 0261-4189. PMC 203362. PMID 10856257. Cite uses deprecated parameters (help)

External links[edit]

Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors.

UpToDate Contents

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English Journal

Mammalian target of rapamycin/eukaryotic initiation factor 4F pathway regulates follicle growth and development of theca cells in mice.

Zhang C, Liu XR, Cao YC, Tian JL, Zhen D, Luo XF, Wang XM, Tian JH, Gao JM.
Reproduction, fertility, and development.Reprod Fertil Dev.2016 Jan 11. doi: 10.1071/RD15230. [Epub ahead of print]
The aim of the present study was to clarify the roles of the mammalian target of rapamycin (mTOR) signalling pathway in follicular growth and development of thecal cells. Using in vivo-grown and in vitro-cultured ovaries, histological changes were evaluated using haematoxylin and eosin (HE) staining
PMID 26748416

Ubiquilin Mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling.

Coffey RT1, Shi Y1, Long MJ1, Marr MT 2nd1, Hedstrom L2.
The Journal of biological chemistry.J Biol Chem.2016 Jan 6. pii: jbc.M115.691584. [Epub ahead of print]
Mammalian target of rapamycin complex1 (mTORC1) is a master regulator of cellular metabolism, growth and proliferation. mTORC1 has been implicated in many diseases such as cancer, diabetes, and neurodegeneration, and is a target to prolong lifespan. Here we report a small molecule inhibitor (Cbz-B3A
PMID 26740621

Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells.

García-Recio EM1, Pinto-Díez C1, Pérez-Morgado MI1, García-Hernández M2, Fernández G2, Martín ME1, González VM1.
Molecular therapy. Nucleic acids.Mol Ther Nucleic Acids.2016 Jan 5;5:e275. doi: 10.1038/mtna.2015.50.
Elevated expression levels of eukaryotic initiation factor 4E (eIF4E) promote cancer development and progression. MAP kinase interacting kinases (MNKs) modulate the function of eIF4E through the phosphorylation that is necessary for oncogenic transformation. Therefore, pharmacologic MNK inhibitors m
PMID 26730812

Japanese Journal

4′,6-Dihydroxy-4-methoxyisoaurone Inhibits the HIF-1α Pathway Through Inhibition of Akt/mTOR/p70S6K/4E-BP1 Phosphorylation

Journal of Pharmacological Sciences 125(2), 193-201, 2014
NAID 130004438624

Control of muscle protein synthesis in response to exercise and amino acids

The journal of physical fitness and sports medicine : JPFSM 1(2), 297-305, 2012-07-25
NAID 10031158957

Anticancer Properties of Pomolic Acid-Induced AMP-Activated Protein Kinase Activation in MCF7 Human Breast Cancer Cells

Biological and Pharmaceutical Bulletin 35(1), 105-110, 2012
NAID 130001872332

「真核生物翻訳開始因子4E」

Eukaryotic translation initiation factor 4E
	; PDB rendering based on 1ej1.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1IPB, 1IPC, 1WKW, 2GPQ, 2V8W, 2V8X, 2V8Y, 2W97, 3AM7, 3TF2, 3U7X, 4AZA, 4DT6, 4DUM
Identifiers
Symbols	EIF4E (; AUTS19; CBP; EIF4E1; EIF4EL1; EIF4F)
External IDs	OMIM: 133440 MGI: 95305 HomoloGene: 123817 ChEMBL: 4848 GeneCards: EIF4E Gene
Gene Ontology
Molecular function	• RNA cap binding; • translation initiation factor activity; • protein binding; • eukaryotic initiation factor 4G binding;
Cellular component	• cytoplasmic mRNA processing body; • cytosol; • mRNA cap binding complex; • cytoplasmic stress granule; • eukaryotic translation initiation factor 4F complex; • RNA-induced silencing complex;
Biological process	• G1/S transition of mitotic cell cycle; • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; • nuclear-transcribed mRNA poly(A) tail shortening; • mRNA export from nucleus; • translation; • translational initiation; • regulation of translation; • insulin receptor signaling pathway; • gene expression; • RNA metabolic process; • mRNA metabolic process; • virus-host interaction; • cytokine-mediated signaling pathway; • lung development; • cellular protein metabolic process; • positive regulation of mitotic cell cycle;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

英: eukaryotic initiation factor-4E、eukaryotic translation initiation factor 4E、eIF4E、eIF-4E
関: ・訳開始因子4E

「eukaryotic initiation factor-4E」

　　[★]

真核生物翻訳開始因子4E、翻訳開始因子4E

関: eIF-4E、eIF4E、eukaryotic translation initiation factor 4E

「eIF4E」

　　[★]

真核生物・訳開始因子4E

関: eIF-4E、eukaryotic initiation factor-4E、eukaryotic translation initiation factor 4E

「initiation」

　　[★]

n.

開始、惹起、イニシエーション

関: commence、commencement、evoke、initiate、institute、mount、onset、start

「fact」

　　[★]

n.

事実、現状、実際、実態

関: actual、actually、in fact、in practice、indeed、practically

「factor」

　　[★]

n.

因子、要因、要素、ファクター

関: element、elementary、factorial、parameter

「eukaryotic」

　　[★]

真核生物の

関: eucaryote、eukaryote、eukaryotic organism

「translation」

　　[★]

n.

翻訳

[pmid1916814-1] Pelletier J, Brook JD, Housman DE (August 1991). "Assignment of two of the translation initiation factor-4E (EIF4EL1 and EIF4EL2) genes to human chromosomes 4 and 20". Genomics 10 (4): 1079–82. doi:10.1016/0888-7543(91)90203-Q. PMID 1916814.

[pmid9330633-2] Jones RM, MacDonald ME, Branda J, Altherr MR, Louis DN, Schmidt EV (May 1997). "Assignment of the human gene encoding eukaryotic initiation factor 4E (EIF4E) to the region q21-25 on chromosome 4". Somat. Cell Mol. Genet. 23 (3): 221–3. doi:10.1007/BF02721373. PMID 9330633.

[pmid3469651-3] Rychlik W, Domier LL, Gardner PR, Hellmann GM, Rhoads RE (February 1987). "Amino acid sequence of the mRNA cap-binding protein from human tissues". Proc. Natl. Acad. Sci. U.S.A. 84 (4): 945–9. doi:10.1073/pnas.84.4.945. PMC 304336. PMID 3469651.

[entrez-4] "Entrez Gene: eIF4E Eukaryotic translation initiation factor 4E".

[Napoli2008-5] Napoli, I.; Mercaldo, V.; Boyl, P. P.; Eleuteri, B.; Zalfa, F.; De Rubeis, S.; Di Marino, D.; Mohr, E.; Massimi, M.; Falconi, M.; Witke, W.; Costa-Mattioli, M.; Sonenberg, N.; Achsel, T.; Bagni, C. (2008). "The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP". Cell 134 (6): 1042–1054. doi:10.1016/j.cell.2008.07.031. PMID 18805096. edit

[6] Zalfa, F.; Giorgi, M.; Primerano, B.; Moro, A.; Di Penta, A.; Reis, S.; Oostra, B.; Bagni, C. (2003). "The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses". Cell 112 (3): 317–327. doi:10.1016/S0092-8674(03)00079-5. PMID 12581522. edit

[pmid17353931-7] Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. Cite uses deprecated parameters (help)

[pmid16648488-8] Connolly, Eileen; Braunstein Steve, Formenti Silvia, Schneider Robert J (May 2006). "Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells". Mol. Cell. Biol. (United States) 26 (10): 3955–65. doi:10.1128/MCB.26.10.3955-3965.2006. ISSN 0270-7306. PMC 1489005. PMID 16648488. Cite uses deprecated parameters (help)

[pmid12482586-9] Kleijn, Miranda; Scheper Gert C, Wilson Mary L, Tee Andrew R, Proud Christopher G (December 2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. (Netherlands) 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. ISSN 0014-5793. PMID 12482586. Cite uses deprecated parameters (help)

[pmid9593750-10] Poulin, F; Gingras A C, Olsen H, Chevalier S, Sonenberg N (May 1998). "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family". J. Biol. Chem. (UNITED STATES) 273 (22): 14002–7. doi:10.1074/jbc.273.22.14002. ISSN 0021-9258. PMID 9593750. Cite uses deprecated parameters (help)

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リンク元	「真核生物翻訳開始因子4E」「eukaryotic initiation factor-4E」「eIF4E」
関連記事	「initiation」「fact」「factor」「eukaryotic」「translation」

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案内

eukaryotic translation initiation factor 4E