受動拡散型ヌクレオシド輸送体、受動拡散型ヌクレオシドトランス・ーター
- 関
- equilibrative nucleoside transport protein
WordNet
- move something or somebody around; usually over long distances
- an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
- move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
- transport commercially (同)send, ship
- a long truck for carrying motor vehicles (同)car transporter
- a crane for moving material with dispatch as in loading and unloading ships
- a glycoside formed by partial hydrolysis of a nucleic acid
PrepTutorEJDIC
- (ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
- 自動車運搬用大型トラック
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/14 00:35:02」(JST)
[Wiki en表示]
The equilibrative nucleoside transporter (ENT) family, also known as SLC29, is a group of plasmalemmal transport proteins which transport nucleoside substrates like adenosine into cells.[1] There are four known ENTs, designated ENT1, ENT2, ENT3, and ENT4.[1][2] ENTs are blocked by adenosine reuptake inhibitors like dipyridamole and dilazep, drugs used clinically for their vasodilatory properties.[2][3]
See also[edit]
- Nucleoside transporter
- Concentrative nucleoside transporter
References[edit]
- ^ a b Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD (February 2004). "The equilibrative nucleoside transporter family, SLC29". Pflügers Archiv : European Journal of Physiology 447 (5): 735–43. doi:10.1007/s00424-003-1103-2. PMID 12838422.
- ^ a b Molina-Arcas M, Casado FJ, Pastor-Anglada M (October 2009). "Nucleoside transporter proteins". Current Vascular Pharmacology 7 (4): 426–34. PMID 19485885.
- ^ Noji T, Karasawa A, Kusaka H (July 2004). "Adenosine uptake inhibitors". European Journal of Pharmacology 495 (1): 1–16. doi:10.1016/j.ejphar.2004.05.003. PMID 15219815.
Further reading[edit]
- Molina-Arcas M, Casado FJ, Pastor-Anglada M (October 2009). "Nucleoside Transporter Proteins". Current Vascular Pharmacology 7 (4): 426–34. PMID 19485885.
- Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD (February 2004). "The equilibrative nucleoside transporter family, SLC29". Pflügers Archiv : European Journal of Physiology 447 (5): 735–43. doi:10.1007/s00424-003-1103-2. PMID 12838422.
- Molina-Arcas M, Trigueros-Motos L, Casado FJ, Pastor-Anglada M (June 2008). "Physiological and pharmacological roles of nucleoside transporter proteins". Nucleosides, Nucleotides & Nucleic Acids 27 (6): 769–78. doi:10.1080/15257770802145819. PMID 18600539.
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Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
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Ion pumps
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| Symporter, Cotransporter |
- Na+/K+,l-
- Na/Pi3
- Na+/Cl-
- Na/glucose
- Na+/I-
- Cl-/K+
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| Antiporter (exchanger) |
- Na+/H+
- Na+/Ca2+
- Na+/(Ca2+-K+) - Cl-/HCO3- (Band 3)
- Cl-formate exchanger
- Cl-oxalate exchanger
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see also solute carrier disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), other
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Membrane transport protein: neurotransmitter transporters (TC 2.A.1.2)
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| Vesicular |
- Vesicular monoamine
- VMAT1
- VMAT2- Vesicular acetylcholine
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| Other |
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anat (h/r/t/c/b/l/s/a)/phys (r)/devp/prot/nttr/nttm/ntrp
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noco/auto/cong/tumr, sysi/epon, injr
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Adenosinergics
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Receptor
ligands |
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Agonists
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- 2-(1-Hexynyl)-N-methyladenosine
- 2-Cl-IB-MECA
- 2'-MeCCPA
- 5'-N-ethylcarboxamidoadenosine
- ATL-146e
- BAY 60–6583
- CCPA
- CGS-21680
- CP-532,903
- GR 79236
- LUF-5835
- LUF-5845
- N6-Cyclopentyladenosine
- Regadenoson
- SDZ WAG 994
- UK-432,097
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Antagonists
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- 8-Phenyl-1,3-dipropylxanthine
- Acefylline
- Aminophylline
- Bamifylline
- Caffeine
- CGS-15943
- 8-Chlorotheophylline
- CPX
- CVT-6883
- Dimethazan
- DPCPX
- Fenethylline
- Istradefylline
- KF-26777
- MRE3008F20
- MRS-1220
- MRS-1334
- MRS-1706
- MRS-1754
- MRS-3777
- Paraxanthine
- Pentoxifylline
- Preladenant
- Propentofylline
- PSB-10
- PSB-11
- PSB 36
- PSB-603
- PSB-788
- PSB-1115
- Rolofylline
- SCH-442,416
- SCH-58261
- Theobromine
- Theophylline
- VUF-5574
- ZM-241,385
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Reuptake
inhibitors |
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Plasmalemmal
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ENT inhibitors
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- Dilazep
- Dipyridamole
- Hexobendine
- Pentoxifylline
- Propentofylline
- Barbiturates
- Ethanol
- Benzodiazepines
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Vesicular
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UpToDate Contents
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English Journal
- Concurrent analysis of human equilibrative nucleoside transporter 1 and ribonucleotide reductase subunit 1 expression increases predictive value for prognosis in cholangiocarcinoma patients treated with adjuvant gemcitabine-based chemotherapy.
- Sasaki H, Murakami Y, Uemura K, Sudo T, Hashimoto Y, Kondo N, Sueda T.
- British journal of cancer.Br J Cancer.2014 Jul 17. doi: 10.1038/bjc.2014.399. [Epub ahead of print]
- Background:The aim of this study was to investigate the predictive and prognostic values of intratumoural human equilibrative nucleoside transporter 1 (hENT1) and ribonucleotide reductase subunit 1 (RRM1) expression in advanced cholangiocarcinoma patients treated with adjuvant gemcitabine-based chem
- PMID 25032731
- Function Unknown Now 26 (FUN26) Protein from Saccharomyces cerevisiae is a Broad Selectivity, High-Affinity, Nucleoside and Nucleobase Transporter.
- Boswell-Casteel RC1, Johnson JM1, Duggan KD1, Roe-Žurž Z2, Schmitz H1, Burleson C1, Hays FA3.
- The Journal of biological chemistry.J Biol Chem.2014 Jul 17. pii: jbc.M114.553503. [Epub ahead of print]
- Equilibrative nucleoside transporters (ENTs) are polytopic integral membrane proteins (IMPs) that transport nucleosides, and to a lesser extent nucleobases, across cell membranes. ENTs modulate efficacy for a range of human therapeutics and function in a diffusion-controlled bidirectional manner. A
- PMID 25035431
- hENT1 expression is predictive of gemcitabine outcome in pancreatic cancer: A systematic review.
- Nordh S, Ansari D, Andersson R.
- World journal of gastroenterology : WJG.World J Gastroenterol.2014 Jul 14;20(26):8482-8490.
- High human equilibrative nucleoside transporter 1 (hENT1)-expression has shown a survival benefit in pancreatic cancer patients treated with gemcitabine in several studies. The aim of this systematic review was to summarize the results and try to assess the predictive value of hENT1 for determining
- PMID 25024604
Japanese Journal
- Different mechanisms of extracellular adenosine accumulation by reduction of the external Ca2+ concentration and inhibition of adenosine metabolism in spinal astrocytes
- Cellular Uptake of Decitabine by Equilibrative Nucleoside Transporters in HCT116 Cells
- Long-term Complete Response in a Patient with Disseminated Pulmonary Pleomorphic Carcinoma Induced by Cisplatin and Gemcitabine
Related Links
- Wikipedia(ウィキペディア)記事検索 > [ Equilibrative nucleoside transporter ] の検索結果
- 1. Xenobiotica. 2008 Jul;38(7-8):995-1021. doi: 10.1080/00498250801927427 . Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins. Young JD(1), Yao SY, Sun L, Cass ...
★リンクテーブル★
[★]
- 英
- equilibrative nucleoside transporter
- 関
- 受動拡散型ヌクレオシドトランス・ーター
[★]
- 英
- equilibrative nucleoside transporter
- 関
- 受動拡散型ヌクレオシド輸送体
[★]
受動拡散型ヌクレオシド輸送体1、受動拡散型ヌクレオシドトランス・ーター1
- 関
- ENT1
[★]
受動拡散型ヌクレオシド輸送体2、受動拡散型ヌクレオシドトランス・ーター2
- 関
- ENT2
[★]
- 関
- bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation
[★]
トランスポーター
- 関
- translocator、transport protein、transporter protein
[★]
ヌクレオシド
- 関
- N、nucleosidic