equilibrative nucleoside transporter 2

受動拡散型ヌクレオシド輸送体2、受動拡散型ヌクレオシドトランス・ーター2

関

ENT2

WordNet

1. move something or somebody around; usually over long distances
2. an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
3. move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
4. transport commercially (同)send, ship
5. a long truck for carrying motor vehicles (同)car transporter
6. a crane for moving material with dispatch as in loading and unloading ships
7. a glycoside formed by partial hydrolysis of a nucleic acid

PrepTutorEJDIC

1. (ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
2. 自動車運搬用大型トラック

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/08/17 11:13:45」(JST)

wiki en

[Wiki en表示]

Solute carrier family 29 (nucleoside transporters), member 2
Identifiers
Symbols	SLC29A2; DER12; ENT2; HNP36
External IDs	OMIM: 602110 MGI: 1345278 HomoloGene: 37493 GeneCards: SLC29A2 Gene
Gene Ontology Molecular function • nucleoside transmembrane transporter activity Cellular component • nucleolus • plasma membrane • integral to plasma membrane • basolateral plasma membrane • nuclear membrane Biological process • nucleobase-containing compound metabolic process • cell proliferation • nucleoside transport • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3177	13340
Ensembl	ENSG00000174669	ENSMUSG00000024891
UniProt	Q14542	Q61672
RefSeq (mRNA)	NM_001532	NM_007854
RefSeq (protein)	NP_001523	NP_031880
Location (UCSC)	Chr 11: 66.13 – 66.14 Mb	Chr 19: 5.02 – 5.03 Mb
PubMed search	[1]	[2]

Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene.

See also

• Solute carrier family
• Equilibrative nucleoside transporters
• Nucleoside transporters

References

Further reading

• Baldwin SA, Beal PR, Yao SY, et al. (2004). "The equilibrative nucleoside transporter family, SLC29.". Pflugers Arch. 447 (5): 735–43. doi:10.1007/s00424-003-1103-2. PMID 12838422. 
• Mangravite LM, Badagnani I, Giacomini KM (2004). "Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney.". Eur. J. Pharmacol. 479 (1-3): 269–81. doi:10.1016/j.ejphar.2003.08.076. PMID 14612157. 
• Williams JB, Lanahan AA (1995). "A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein.". Biochem. Biophys. Res. Commun. 213 (1): 325–33. doi:10.1006/bbrc.1995.2133. PMID 7639753. 
• Griffiths M, Yao SY, Abidi F, et al. (1998). "Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta.". Biochem. J. 328 (3): 739–43. PMC 1218980. PMID 9396714. 
• Yao SY, Ng AM, Vickers MF, et al. (2002). "Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation.". J. Biol. Chem. 277 (28): 24938–48. doi:10.1074/jbc.M200966200. PMID 12006583. 
• Molina-Arcas M, Bellosillo B, Casado FJ, et al. (2003). "Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia.". Blood 101 (6): 2328–34. doi:10.1182/blood-2002-07-2236. PMID 12411296. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Mangravite LM, Xiao G, Giacomini KM (2003). "Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells.". Am. J. Physiol. Renal Physiol. 284 (5): F902–10. doi:10.1152/ajprenal.00215.2002. PMID 12527552. 
• Ward JL, Leung GP, Toan SV, Tse CM (2003). "Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2.". Arch. Biochem. Biophys. 411 (1): 19–26. doi:10.1016/S0003-9861(02)00718-X. PMID 12590919. 
• Szkotak AJ, Ng AM, Man SF, et al. (2003). "Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells.". J. Membr. Biol. 192 (3): 169–79. doi:10.1007/s00232-002-1073-x. PMID 12820662. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Farré X, Guillén-Gómez E, Sánchez L, et al. (2004). "Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors.". Int. J. Cancer 112 (6): 959–66. doi:10.1002/ijc.20524. PMID 15386342. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Visser F, Zhang J, Raborn RT, et al. (2005). "Residue 33 of human equilibrative nucleoside transporter 2 is a functionally important component of both the dipyridamole and nucleoside binding sites.". Mol. Pharmacol. 67 (4): 1291–8. doi:10.1124/mol.104.005884. PMID 15644498. 
• Visser F, Baldwin SA, Isaac RE, et al. (2005). "Identification and mutational analysis of amino acid residues involved in dipyridamole interactions with human and Caenorhabditis elegans equilibrative nucleoside transporters.". J. Biol. Chem. 280 (12): 11025–34. doi:10.1074/jbc.M410348200. PMID 15649894. 
• Owen RP, Lagpacan LL, Taylor TR, et al. (2006). "Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2.". Drug Metab. Dispos. 34 (1): 12–5. doi:10.1124/dmd.105.006270. PMID 16214850. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

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• 5. プリンヌクレオシドホスホリラーゼ欠損症 purine nucleoside phosphorylase deficiency

English Journal

• The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells.

• Karim H, Hashemi J, Larsson C, Moshfegh A, Fotoohi AK, Albertioni F.SourceDepartment of Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
• Biochemical and biophysical research communications.Biochem Biophys Res Commun.2011 Jul 22;411(1):156-61. Epub 2011 Jun 23.
• Exposure of MOLT4 human T-cell leukemia cells to 6-Mercaptopurine (6-MP) and 6-Thioguanine (6-TG) resulted in acquired resistance associated with attenuated expression of the genes encoding concentrative nucleoside transporter 3 (CNT3) and equilibrative nucleoside transporter 2 (ENT2). To identify o
• PMID 21723252

• Role of nucleoside transporters SLC28A2/3 and SLC29A1/2 genetics in ribavirin therapy: protection against anemia in patients with chronic hepatitis C.

• Doehring A, Hofmann WP, Schlecker C, Zeuzem S, Sarrazin C, Berg T, Muller T, Herrmann E, Geisslinger G, Lotsch J.Sourcepharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University Hospital, Frankfurt am Main, Germany.
• Pharmacogenetics and genomics.Pharmacogenet Genomics.2011 May;21(5):289-96.
• BACKGROUND AND AIM: The standard of hepatitis C antiviral therapy combines pegylated interferon-α with ribavirin. This polar guanosine analog improves the sustained virological response (SVR) rates, but may induce hemolytic anemia. As its pharmacokinetics depend on facilitated transmembrane transpo
• PMID 21346688

Japanese Journal

• ゲムシタビンとシスプラチンを含む併用化学療法を施行した転移性膀胱癌患者の生存に関するHuman equilibrative nucleoside transporter 1(hENT1)発現の意義 (第59回日本泌尿器科学会中部総会)

• 松村 永秀,原 勲
• 泌尿器科紀要 57(3), 157-161, 2011-03
• Systemic combination chemotherapy, such as the methotrexate, vinblastine, doxorubicin and cisplatin (MVAC) regimen, has shown certain activity in advanced bladder cancer, but is associated with a sign …
• NAID 120003001360

• OP-249-2 浸潤性膵管癌におけるhuman equilibrative nucleoside transporter 1発現とgemcitabine術後補助化学療法の成績(膵化療-1,一般口演,第110回日本外科学会定期学術集会)

• 森永 聡一郎,田村 周三,金澤 周,稲垣 大輔,山本 直人,塩澤 学,赤池 信
• 日本外科学会雑誌 111(臨時増刊号_2), 669, 2010-03-05
• NAID 110007718173

Related Links

• Equilibrative nucleoside transporter 2 - Wikipedia, the free ...

Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene. See also. Solute carrier family · Equilibrative nucleoside transporters · Nucleoside transporters. References. ^ Williams JB, Rexer B, ...

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★リンクテーブル★

リンク元	「受動拡散型ヌクレオシド輸送体2」「受動拡散型ヌクレオシドトランスポーター2」「ENT2」「SLC29A2」
関連記事	「transport」「transporter」「nucleoside」

「受動拡散型ヌクレオシド輸送体2」

　　[★]

英

equilibrative nucleoside transporter 2、ENT2

関

受動拡散型ヌクレオシドトランス・ーター2

「受動拡散型ヌクレオシドトランスポーター2」

　　[★]

英

equilibrative nucleoside transporter 2

関

受動拡散型ヌクレオシド輸送体2

「ENT2」

　　[★]

• 受動拡散型ヌクレオシド輸送体2

関

equilibrative nucleoside transporter 2

「SLC29A2」

　　[★]

• equilibrative nucleoside transporter 2

「transport」

　　[★]

• n.

• 輸送、運搬

• v.

• 輸送する、運搬する、運ぶ

関

bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation

　 　 　 　 　

「transporter」

　　[★] トランスポーター

関

translocator、transport protein、transporter protein

　 　 　

「nucleoside」

　　[★]

ヌクレオシド

関

N、nucleosidic