受動拡散型ヌクレオシド輸送体1、受動拡散型ヌクレオシドトランス・ーター1

関: ENT1

WordNet

move something or somebody around; usually over long distances
an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
transport commercially (同)send, ship
a long truck for carrying motor vehicles (同)car transporter
a crane for moving material with dispatch as in loading and unloading ships
a glycoside formed by partial hydrolysis of a nucleic acid

PrepTutorEJDIC

(ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
自動車運搬用大型トラック

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/11/30 07:04:13」(JST)

wiki en

[Wiki en表示]

Equilibrative nucleoside transporter 1 (ENT1) is a protein that in humans is encoded by the SLC29A1 gene.^[1]^[2] Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.^[3]

Function

This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylmercaptopurine ribonucleoside (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies.^[3]

Genomics

The gene encoding this protein is located on the short arm of chromosome 6 at 6p21.2-p21.1 on the Watson (plus) strand. It is 14,647 bases in length. The encoded protein has 456 amino acid residues with 11 predicted transmembrane domains. The predicted molecular weight is 50.219 kiloDaltons. The protein is post translationally glycosylated and expressed in all tissue with the apparent exception of skeletal muscle. The highest levels are found in the liver, heart, testis, spleen, lung, kidney and brain.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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Fluorouracil (5-FU) Activity edit

^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

Clinical

Mutations in this gene have been associated with H syndrome, pigmented hypertrichosis with insulin dependent diabetes and Faisalabad histiocytosis.^[4]

References

^ Griffiths M, Beaumont N, Yao SY, Sundaram M, Boumah CE, Davies A, Kwong FY, Coe I, Cass CE, Young JD, Baldwin SA (Jan 1997). "Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs". Nat Med 3 (1): 89–93. doi:10.1038/nm0197-89. PMID 8986748.
^ Coe IR, Griffiths M, Young JD, Baldwin SA, Cass CE (Feb 1998). "Assignment of the human equilibrative nucleoside transporter (hENT1) to 6p21.1-p21.2". Genomics 45 (2): 459–60. doi:10.1006/geno.1997.4928. PMID 9344680.
^ ^a ^b "Entrez Gene: SLC29A1 solute carrier family 29 (nucleoside transporters), member 1".
^ Bolze A, Abhyankar A, Grant AV, Patel B, Yadav R, Byun M, Caillez D, Emile JF, Pastor-Anglada M, Abel L, Puel A, Govindarajan R, de Pontual L, Casanova JL (2012). "A Mild Form of SLC29A3 Disorder: A Frameshift Deletion Leads to the Paradoxical Translation of an Otherwise Noncoding mRNA Splice Variant". PLoS ONE 7 (1): e29708. doi:10.1371/journal.pone.0029708. PMC 3251605. PMID 22238637.

UpToDate Contents

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4. HIV感染患者における心血管疾患の疫学および危険因子 epidemiology of cardiovascular disease and risk factors in hiv infected patients
5. プリンヌクレオシドホスホリラーゼ欠損症 purine nucleoside phosphorylase deficiency

English Journal

Expression, purification and functional characterization of human equilibrative nucleoside transporter subtype-1 (hENT1) protein from Sf9 insect cells.

Rehan S1, Jaakola VP2.
Protein expression and purification.Protein Expr Purif.2015 Oct;114:99-107. doi: 10.1016/j.pep.2015.07.003. Epub 2015 Jul 7.
Human equilibrative nucleoside transporter-1 (hENT1) is the major plasma membrane transporter involved in transportation of natural nucleosides as well as nucleoside analog drugs, used in anti-cancer and anti-viral therapies. Despite extensive biochemical and pharmacological studies, little is known
PMID 26162242

Thermodynamics and kinetics of inhibitor binding to human equilibrative nucleoside transporter subtype-1.

Rehan S1, Ashok Y1, Nanekar R1, Jaakola VP2.
Biochemical pharmacology.Biochem Pharmacol.2015 Sep 30. pii: S0006-2952(15)00629-2. doi: 10.1016/j.bcp.2015.09.019. [Epub ahead of print]
Many nucleoside transport inhibitors are in clinical use as anti-cancer, vasodilator and cardioprotective drugs. However, little is known about the binding energetics of these inhibitors to nucleoside transporters (NTs) due to their low endogenous expression levels and difficulties in the biophysica
PMID 26428002

Cytidine Deaminase as a Molecular Predictor of Gemcitabine Response in Patients with Biliary Tract Cancer.

Yoon KA1, Woo SM, Hong EK, Jung MK, Park WS, Bae K, Han SS, Kim TH, Koh YH, Park SJ, Lee WJ.
Oncology.Oncology.2015 Sep 30. [Epub ahead of print]
OBJECTIVE: Gemcitabine-based chemotherapy is regarded as the standard treatment for biliary tract cancer (BTC). Potential biomarkers for gemcitabine response include the activities of cytidine deaminase (CDA), human equilibrative nucleoside transporter 1 (hENT1), deoxycytidine kinase (DCK), and ribo
PMID 26418006

Japanese Journal

Long-term Complete Response in a Patient with Disseminated Pulmonary Pleomorphic Carcinoma Induced by Cisplatin and Gemcitabine

Tamiya Akihiro,Asami Kazuhiro,Shimizu Shigeki,Matsumura Akihide,Isa Shun-Ichi,Okishio Kyoichi,Kitaichi Masanori,Atagi Shinji,Takada Minoru,Kawaguchi Tomoya,Kubo Akihito
Internal Medicine 53(22), 2625-2628, 2014
… An immunohistochemical analysis revealed that the tumor was highly expressive of gemcitabine transporter human equilibrative nucleoside transporter 1, thus suggesting a high sensitivity to gemcitabine. …
NAID 130004713245

Identification of Primary Equilibrative Nucleoside Transporter 1 mRNA Isoforms Resulting from Alternative Promoter Usage in Human Hepatocytes

FURIHATA Tomomi,MIZUGUCHI Misa,SUZUKI Yuki,MATSUMOTO Shogo,KOBAYASHI Kaoru,CHIBA Kan
Drug Metabolism and Pharmacokinetics 29(4), 325-332, 2014
… Human equilibrative nucleoside transporter 1 (hENT1) transports various nucleoside analogues into cells. …
NAID 130004463392

Improvements of Doxorubicin-Induced Antitumor Activity and Adverse Reaction by Combined Citrulline

Miyashita Michiko,Sadzuka Yasuyuki
Biological and Pharmaceutical Bulletin 37(3), 447-453, 2014
… This effect of citrulline on DOX influx is identical to that of S-(4-nitrobenzyl)-6-thioinosine, promoting DOX influx through the equilibrative nucleoside transporter 1. …
NAID 130003390950

「受動拡散型ヌクレオシド輸送体1」

Solute carrier family 29 (equilibrative nucleoside transporter), member 1
Identifiers
Symbols	SLC29A1 ; ENT1
External IDs	OMIM: 602193 MGI: 1927073 HomoloGene: 37985 ChEMBL: 1997 GeneCards: SLC29A1 Gene
Gene ontology
Molecular function	• nucleoside transmembrane transporter activity;
Cellular component	• plasma membrane; • integral component of plasma membrane; • membrane; • basolateral plasma membrane; • apical plasma membrane;
Biological process	• nucleobase-containing compound metabolic process; • lactation; • nucleoside transport; • uridine transport; • sleep; • transmembrane transport; • regulation of excitatory postsynaptic membrane potential; • cellular response to glucose stimulus; • cellular response to hypoxia; • nucleoside transmembrane transport;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

英: equilibrative nucleoside transporter 1、ENT1
関: 受動拡散型ヌクレオシドトランス・ーター1

「受動拡散型ヌクレオシドトランスポーター1」

　　[★]

英: equilibrative nucleoside transporter 1
関: 受動拡散型ヌクレオシド輸送体1

「ENT1」

　　[★]

受動拡散型ヌクレオシド輸送体1

関: equilibrative nucleoside transporter 1

「SLC29A1」

　　[★]

equilibrative nucleoside transporter 1

「transport」

　　[★]

n.

輸送、運搬

v.

輸送する、運搬する、運ぶ

関: bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation

「transporter」

　　[★] トランスポーター

関: translocator、transport protein、transporter protein

「nucleoside」

　　[★]

ヌクレオシド

関: N、nucleosidic

[WikiPathways-4] The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

[pmid8986748-1] Griffiths M, Beaumont N, Yao SY, Sundaram M, Boumah CE, Davies A, Kwong FY, Coe I, Cass CE, Young JD, Baldwin SA (Jan 1997). "Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs". Nat Med 3 (1): 89–93. doi:10.1038/nm0197-89. PMID 8986748.

[pmid9344680-2] Coe IR, Griffiths M, Young JD, Baldwin SA, Cass CE (Feb 1998). "Assignment of the human equilibrative nucleoside transporter (hENT1) to 6p21.1-p21.2". Genomics 45 (2): 459–60. doi:10.1006/geno.1997.4928. PMID 9344680.

[entrez-3] "Entrez Gene: SLC29A1 solute carrier family 29 (nucleoside transporters), member 1".

[pmid22238637-5] Bolze A, Abhyankar A, Grant AV, Patel B, Yadav R, Byun M, Caillez D, Emile JF, Pastor-Anglada M, Abel L, Puel A, Govindarajan R, de Pontual L, Casanova JL (2012). "A Mild Form of SLC29A3 Disorder: A Frameshift Deletion Leads to the Paradoxical Translation of an Otherwise Noncoding mRNA Splice Variant". PLoS ONE 7 (1): e29708. doi:10.1371/journal.pone.0029708. PMC 3251605. PMID 22238637.

リンク元	「受動拡散型ヌクレオシド輸送体1」「受動拡散型ヌクレオシドトランスポーター1」「ENT1」「SLC29A1」
関連記事	「transport」「transporter」「nucleoside」

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案内

案内

equilibrative nucleoside transporter 1