English Journal

Expression and purification of human and Saccharomyces cerevisiae equilibrative nucleoside transporters.

Boswell-Casteel RC1, Johnson JM1, Roe-Žurž Z2, Duggan KD1, Schmitz H1, Hays FA3.
Protein expression and purification.Protein Expr Purif.2018 Feb;142:68-74. doi: 10.1016/j.pep.2017.09.002. Epub 2017 Sep 14.
PMID 28918196

Demonstration of Nucleoside Transporter Activity in the Nose-to-Brain Distribution of [18F]Fluorothymidine Using PET Imaging.

Ponto LLB1,2, Huang J3,4, Walsh SA5, Acevedo MR5, Mundt C5,6, Sunderland J5,6, Donovan M3.
The AAPS journal.AAPS J.2017 Dec 7;20(1):16. doi: 10.1208/s12248-017-0158-5.
PMID 29218445

Monophosphorylation by deoxycytidine kinase affects apparent cellular uptake of decitabine in HCT116 colon cancer cells.

Ueda K1, Masuda A2, Fukuda M3, Tanaka S4, Hosokawa M5, Iwakawa S6.
Drug metabolism and pharmacokinetics.Drug Metab Pharmacokinet.2017 Dec;32(6):301-310. doi: 10.1016/j.dmpk.2017.10.001. Epub 2017 Oct 10.
PMID 29174536

Japanese Journal

Cellular Uptake of Decitabine by Equilibrative Nucleoside Transporters in HCT116 Cells

Ueda Kumiko,Hosokawa Mika,Iwakawa Seigo
Biological and Pharmaceutical Bulletin 38(8), 1113-1119, 2015
… Real-time polymerase chain reaction analysis revealed that ENT1 mRNA was the most abundant among the nucleoside transporters examined in HCT116 cells. … The ENT1 protein was detected in the membrane fraction, as determined by Western blotting. … The uptake of these agents was inhibited by S-(4-nitrobenzyl)-6-thioinosine (NBMPR), an inhibitor of equilibrative nucleoside transporters (ENTs), and was also decreased in cells treated with ENT1 small interfering RNA. …
NAID 130005090657

The Anti-overactive Bladder Activity of KW-7158 Is Mediated by Blocking Equilibrative Nucleoside Transporter-1

Nishiya Yoichi,Yamagata Tsuyoshi,Fukuda Ayumu [他],Yokokawa Sachiko,Seishi Takashi,Sakuma Takashi,Sasho Setsuya,Shimizu Yukiko,Sato Hidetaka,Sekine Susumu,Kamigaki Masayo,Yoshida Tetsuo,Shibata Kenji
Biological and Pharmaceutical Bulletin 37(1), 130-136, 2014
… We herein report the identification of the KW-7158 target to be equilibrative nucleoside transporter-1 (ENT1). … The screening revealed that only cells transfected with an ENT1 expression vector exhibited significant binding. … We next performed [3H]KW-7158 binding experiments and an adenosine influx assay and found that KW-7158 binds to and inhibits ENT1. …
NAID 130003382115

ヒト平衡化ヌクレオシドトランスポーター1の抗原賦活法に関する研究

米田操,金山和樹,白石泰三 [他],AZUMA Masami
大阪教育大学紀要. 第3部門, 自然科学・応用科学 61(1), 41-45, 2012-09
… The heat treatments and proteolytic enzyme treatments were studied for antigen retrieval in the immunohistochemical staining of human equilibrative nucleoside transporter 1 (h-ENT 1), one of prognostic factors in pancreas cancer. … Among 90℃ treatments for 8 min, 30 min and 60 min, the treatment for 30 min was the best in stain property of h-ENT 1. …
NAID 120004875350

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