WordNet
- (biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction
- a muscle that contracts while another relaxes; "when bending the elbow the biceps are the agonist"
- someone involved in a contest or battle (as in an agon)
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- =sense organ / 受信装置
UpToDate Contents
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English Journal
- Protection by vascular prostaglandin E2 signaling in hypoxic-ischemic encephalopathy.
- Taniguchi H1, Anacker C1, Wang Q1, Andreasson K2.
- Experimental neurology.Exp Neurol.2014 May;255:30-7. doi: 10.1016/j.expneurol.2014.02.012. Epub 2014 Feb 20.
- Hypoxic-ischemic encephalopathy (HIE) in neonates is a leading cause of neurological impairment. Significant progress has been achieved investigating the pathologic contributions of excitotoxicity, oxidative stress, and neuroinflammation to cerebral injury in HIE. Less extensively investigated has b
- PMID 24560715
- Prostaglandin E2 (EP) receptors mediate PGE2-specific events in ovulation and luteinization within primate ovarian follicles.
- Kim SO1, Harris SM, Duffy DM.
- Endocrinology.Endocrinology.2014 Apr;155(4):1466-75. doi: 10.1210/en.2013-2096. Epub 2014 Feb 7.
- Prostaglandin E2 (PGE2) is a key mediator of ovulation. All 4 PGE2 receptors (EP receptors) are expressed in the primate follicle, but the specific role of each EP receptor in ovulatory events is poorly understood. To examine the ovulatory events mediated via these EP receptors, preovulatory monkey
- PMID 24506073
Related Links
- Introduction Liver X receptor-α (LXRα) and LXRβ (Nr1h3 and Nr1h2, respectively) are oxysterol-activated nuclear receptors that regulate the expression of genes involved in different pathways, such as cholesterol and ...
- vasodilation, prostaglandins, brain, sleep, platelets, aggregation., H-PGDS, synthases, mast, cells, hematopoietic, allergic, allergy, asthmatic ... PGD2 is the major eicosanoid product of mast cells and is released in large quantities ...
★リンクテーブル★
[★]
- 関
- エイコサノイド、eicosanoid receptor agonist、eicosanoid receptor antagonist
| 受容体
|
リガンド
|
Gタンパク
|
セカンドメッセンジャー
|
作用
|
| DP1
|
PGD2
|
Gs
|
cAMP↑
|
アレルギー性喘息↓
|
| DP2
|
Gi
|
Ca2+↑
|
？
|
| DP1
|
PGE2
|
Gq
|
|
大腸の発癌物質に対する反応性↓
|
| DP2
|
-
|
cAMP↑
|
排卵と受精を障害。塩感受性高血圧
|
| EP3A-D
|
Gi
Gs
Gq
|
cAMP↓
cAMP↑
PLC↑
|
発熱物質に抵抗
|
| EP4
|
Gs
|
cAMP↑
|
動脈管開存症
|
| FPA,B
|
PGF2α
|
Gq
|
|
分娩不全
|
| IP
|
PGI2
|
Gs
|
cAMP↑
|
血栓形成反応↑、血管障害反応↓
|
| TPα,β
|
TXA2
|
Gq,Gi,G12/13,G16
|
PLC↑
|
出血時間↑、血管障害反応↑
|
| BLT1
|
LTB4
|
Gi,G16
|
|
炎症反応を抑制
|
| BLT2
|
Gq-like
Gi-like
Gz-like
|
|
？
|
| CysLT1
|
LTD4
|
Gq
|
PLC↑
|
自然免疫・獲得免疫の血管透過性↓、
肺炎症・線維化反応↑
|
| CysLT2
|
LTC4|LTD4
|
Gq
|
PLC↑
|
肺炎症・線維化反応↓
|
[★]
- 関
- agonist、agonistic
[★]
エイコサノイド受容体、エイコサノイドレセプター