WordNet
- a drug that neutralizes or counteracts the effects of another drug
- a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- 対立する人,敵対者,競争相手(opponent)
- =sense organ / 受信装置
UpToDate Contents
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- 1. 肥満細胞由来のメディエーターmast cell derived mediators [show details]
… stimuli will result in eicosanoid generation. Anaphylatoxins and neuropeptides activate mast cells in such a manner that minimal eicosanoids are produced .… CysLT2R is resistant to montelukast and other CysLT1R antagonists and binds LTC4 and LTD4 equally.…
- 2. 血小板生物学platelet biology [show details]
… Vorapaxar and atopaxar are orally active selective PAR-1 antagonists that block thrombin-mediated platelet activation without… are the phosphoinositide hydrolysis pathway and the eicosanoid synthesis pathway.…
- 3. 魚油：生理的効果および投与fish oil physiologic effects and administration [show details]
…have potential antiinflammatory effects due to the role of EPA and DHA as precursors to specific eicosanoids and other inflammatory mediators . However, production and breakdown of these inflammatory metabolites …
- 4. 免疫系に対するステロイドの影響glucocorticoid effects on the immune system [show details]
…central to the generation of some forms of angioedema . Suppressing production of inflammatory eicosanoids in phagocytic cells by inducing the synthesis of lipocortin-1 (annexin 1), macrocortin, and/or …
- 5. 肥満細胞：表面受容体とシグナル伝達mast cells surface receptors and signal transduction [show details]
…of calcium mobilization . Isolated human lung mast cells display inhibition of degranulation and eicosanoid generation after treatment with beta-agonists . The immunoglobulin G (IgG) receptor Fc-gamma-RIIb…
English Journal
- Estradiol-17β increases 12- and 15-lipoxygenase (type2) expression and activity and reactive oxygen species in human umbilical vascular smooth muscle cells.
- Somjen D1, Kohen F2, Limor R2, Sharon O2, Knoll E2, Many A2, Stern N2.
- The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2016 Mar 28. pii: S0960-0760(16)30079-6. doi: 10.1016/j.jsbmb.2016.03.032. [Epub ahead of print]
- The net vascular effect of estrogens on the vasculature is still under debate. Here we tested the effects of estradiol- 17β (E2) as well as estrogen-receptor subtype specific and non-specific agonists and antagonists on the expression and eicosanoid production of lipoxygenase (LO) enzymes expressed
- PMID 27033413
- Thrombin-induced lysosomal exocytosis in human platelets is dependent on secondary activation by ADP and regulated by endothelial-derived substances.
- Södergren AL1, Svensson Holm AC1, Ramström S1, Lindström EG2, Grenegård M2,3, Öllinger K1.
- Platelets.Platelets.2016 Jan;27(1):86-92. doi: 10.3109/09537104.2015.1042446. Epub 2015 May 13.
- Exocytosis of lysosomal contents from platelets has been speculated to participate in clearance of thrombi and vessel wall remodelling. The mechanisms that regulate lysosomal exocytosis in platelets are, however, still unclear. The aim of this study was to identify the pathways underlying platelet l
- PMID 25970449
Japanese Journal
- モルモットの過換気誘発気道収縮モデルにおけるタキキニンの関与
- 津田 香織,馬島 徹,伊藤 玲子 [他],服部 知洋,赤柴 恒人
- 日大醫學雜誌 67(6), 339-345, 2008-12-01
- NAID 10024923223
- モルモットの過換気誘発気道収縮モデルにおけるタキキニンの関与
- 津田 香織,馬島 徹,伊藤 玲子,服部 知洋,赤柴 恒人
- 日大医学雑誌 67(6), 339-345, 2008
- タキキニン受容体拮抗薬は喘息患者の気道収縮を減弱する．本研究では，モルモットの過換気誘発気道収縮 (HIB) モデルを人工換気下に過換気負荷をして，タキキニン受容体拮抗薬の選択的 NK1 受容体拮抗薬 (FK 888) と NK1 + NK2 受容体拮抗薬 (FK224) を投与し，肺抵抗，気管支肺胞洗浄液中のメディエーター・細胞分画を測定した．その結果，過換気負荷群は負荷 5 分後に肺抵抗が上昇 …
- NAID 130004548757
Related Links
- Receptor Agonist Antagonist DP 1 PGD 2, PGE 2, PGF 2 α, BW245C, BW192C86, AH6809, BWA868C, ONO-AE3-237 Empty Cell LY 644,698, SQ 27986, ZK 118182 ...
- Eicosanoids comprise a group of oxidation products of arachidonic and 5,8,11,14,17-eicosapentaenoic acids formed by oxygenases and downstream enzymes. The two major pathways for eicosanoid formation are initiated by the actions of 5-lipoxygenase (5-LO), leading to leukotrienes (LTs) and 5-oxo-6,8,11 …
- The effective antitumorigenic potential of nonsteroidal anti-inflammatory drugs (NSAIDs) and eicosonoid (EP; EP1-4) receptor antagonists prompted us to test their efficacy in Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) related lymphomas. Our study demonstrated that (1 …
★リンクテーブル★
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- 関
- エイコサノイド、eicosanoid receptor agonist、eicosanoid receptor antagonist
| 受容体
|
リガンド
|
Gタンパク
|
セカンドメッセンジャー
|
作用
|
| DP1
|
PGD2
|
Gs
|
cAMP↑
|
アレルギー性喘息↓
|
| DP2
|
Gi
|
Ca2+↑
|
？
|
| DP1
|
PGE2
|
Gq
|
|
大腸の発癌物質に対する反応性↓
|
| DP2
|
-
|
cAMP↑
|
排卵と受精を障害。塩感受性高血圧
|
| EP3A-D
|
Gi
Gs
Gq
|
cAMP↓
cAMP↑
PLC↑
|
発熱物質に抵抗
|
| EP4
|
Gs
|
cAMP↑
|
動脈管開存症
|
| FPA,B
|
PGF2α
|
Gq
|
|
分娩不全
|
| IP
|
PGI2
|
Gs
|
cAMP↑
|
血栓形成反応↑、血管障害反応↓
|
| TPα,β
|
TXA2
|
Gq,Gi,G12/13,G16
|
PLC↑
|
出血時間↑、血管障害反応↑
|
| BLT1
|
LTB4
|
Gi,G16
|
|
炎症反応を抑制
|
| BLT2
|
Gq-like
Gi-like
Gz-like
|
|
？
|
| CysLT1
|
LTD4
|
Gq
|
PLC↑
|
自然免疫・獲得免疫の血管透過性↓、
肺炎症・線維化反応↑
|
| CysLT2
|
LTC4|LTD4
|
Gq
|
PLC↑
|
肺炎症・線維化反応↓
|
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エイコサノイド受容体、エイコサノイドレセプター