Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/26 11:44:02」(JST)

wiki en

Leukotriene B4 is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the endothelium, allowing them to bind to and cross it into the tissue.^[1] In neutrophils, it is also a potent chemoattractant, and is able to induce the formation of reactive oxygen species and the release of lysosome enzymes by these cells.^[1] It is synthesized by leukotriene-A4 hydrolase from leukotriene A4.^[2]

Eicosanoid synthesis. (Leukotrienes at right.)

References[edit]

^ ^a ^b Cotran; Kumar, Collins. Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X. Cite uses deprecated parameters (help)
^ http://www.uniprot.org/uniprot/P09960. Retrieved 9 April 2013. Missing or empty |title= (help)

This biochemistry article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 喘息の治療において5-リポキシゲナーゼ経路に影響する薬剤 agents affecting the 5 lipoxygenase pathway in the treatment of asthma
2. 肥満細胞由来のメディエーター mast cell derived mediators
3. 12歳未満の小児における慢性喘息：持続性喘息の治療およびコントロール薬 asthma in children younger than 12 years treatment of persistent asthma with controller medications
4. 好酸球の生物学および好酸球増多症の原因 eosinophil biology and causes of eosinophilia
5. アスピリンによる呼吸器疾患の増悪 aspirin exacerbated respiratory disease

English Journal

Opuntia dillenii cladode: Opuntiol and opuntioside attenuated cytokines and eicosanoids mediated inflammation.

Siddiqui F1, Naqvi S2, Abidi L3, Faizi S4, Lubna5, Avesi L6, Mirza T7, Farooq AD8.
Journal of ethnopharmacology.J Ethnopharmacol.2016 Apr 22;182:221-34. doi: 10.1016/j.jep.2016.02.016. Epub 2016 Feb 18.
ETHANOPHARMACOLOGICAL RELEVANCE: Opuntia dillenii Haw (Nagphana) traditionally used against inflammation. The present study addressed the anti-inflammatory activity of O. dillenii derived methanol extract, fractions and pure compounds and their underlying mechanism of action.MATERIALS AND METHODS: O
PMID 26900126

Plasma eicosanoid profiles determined by high-performance liquid chromatography coupled with tandem mass spectrometry in stimulated peripheral blood from healthy individuals and sickle cell anemia patients in treatment.

Galvão AF1, Petta T1, Flamand N2, Bollela VR3, Silva CL4, Jarduli LR1, Malmegrim KC1,5, Simões BP3, de Moraes LA6, Faccioli LH7.
Analytical and bioanalytical chemistry.Anal Bioanal Chem.2016 Mar 11. [Epub ahead of print]
Eicosanoids play an important role in homeostasis and in the pathogenesis of various human diseases. Pharmacological agents such as Ca2+ ionophores and Ca2+-ATPase inhibitors, as well as natural agonists such as formylmethionine-leucyl-phenylalanine (fMLP), can stimulate eicosanoid biosynthesis. The
PMID 26968567

Inhalation of two putative Gulf War toxins by mice.

Repine JE1, Wilson P1, Elkins N1, Klawitter J1, Christians U1, Peters B2, Smith DM2.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.J Environ Sci Health B.2016 Mar 7:1-8. [Epub ahead of print]
We employed our inhalation methodology to examine whether biomarkers of inflammation and oxidative stress would be produced in mice following inhalation of aerosols containing carbonaceous particles or the vapor of pesticides prevalent during the first Gulf War. Exposure to two putative Gulf War Ill
PMID 26950528

Japanese Journal

LTB4受容体発現が規定する抗原提示細胞サブセット

上原記念生命科学財団研究報告集 29, 1-6, 2015
NAID 40020702921

The role of leukotrienes in allergic diseases

Allergology International 64(1), 17-26, 2015
NAID 130004873117

Anethole and eugenol reduce in vitro and in vivo leukocyte migration induced by fMLP, LTB₄, and carrageenan

Journal of natural medicines 68(3), 567-575, 2014
NAID 40020091196

Related Pictures

LTB4 – LAPTOP BRIEFCASE CUM TROLLEY BAG | SwissMilitary Diabetes | The Big Diabetes Lie Molecular Link between Obesity and Type 2 Diabetes Reveals Potential Therapy

★リンクテーブル★

リンク元	「ロイコトリエン」「leukotriene B」「ロイコトリエンB4」
拡張検索	「LTB4 receptor」「LTB4受容体」「LTB4レセプター」
関連記事	「LT」

「ロイコトリエン」

Leukotriene B4
	IUPAC name 5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
Identifiers
CAS number	71160-24-2
PubChem	169
MeSH	Leukotriene+B4
ChEMBL	CHEMBL65061
Jmol-3D images	Image 1
	SMILES CCCCCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O ;
	InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12- 17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24); Key: VNYSSYRCGWBHLG-UHFFFAOYSA-N ;
Properties
Molecular formula	C20H32O4
Molar mass	336.466 g/mol
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
	Infobox references

　　[★]

英: leukotriene, LT
関: アラキドン酸、5-リポキシゲナーゼ

合成

ホスホリパーゼA₂の作用によりホスファチジルコリンから遊離したアラキドン酸から合成される。

アラキドン酸→LTA4→LTB4

白血球遊走

アラキドン酸→LTA4→LTC4→LTD4→LTE4

気管支平滑筋収縮、細動脈収縮、血管透過性亢進

構造

二重結合を複数持つ不飽和脂肪酸。トリエン構造

種類

ロイコトリエンA₄	ロイコトリエンB₄とロイコトリエンC₄の前駆物質
ロイコトリエンB₄	chemotaxis
ロイコトリエンC₄	気管支収縮、血管拡張、血管透過性亢進、ロイコトリエンD₄の前駆物質
ロイコトリエンD₄	気管支収縮、血管拡張、血管透過性亢進、ロイコトリエンE₄の前駆物質
ロイコトリエンE₄	気管支収縮、血管拡張、血管透過性亢進