エイコサノイド受容体、エイコサノイドレセプター
WordNet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/22 04:12:54」(JST)
[Wiki en表示]
An eicosanoid receptor is an integral membrane protein which detects the presence of eicosanoid signaling molecules. Most, though not all, are G protein-coupled receptors (GPCRs). An example of a non-GPCR receptor that binds eicosanoids is PPAR-γ.[1]
The following is a list of the known human eicosanoid GPCRs grouped according to the type of eicosanoid ligand that each binds:[2][3]
Contents
- 1 Leukotriene
- 2 Lipoxin
- 3 Oxoeicosanoid
- 4 Prostanoid
- 5 References
- 6 External links
Leukotriene[edit]
Leukotrienes:
- CysLT1 (Cysteinyl leukotriene receptor 1) - CYSLTR1
- CysLT2 (Cysteinyl leukotriene receptor 2) - CYSLTR2
- BLT1 (Leukotriene B4 receptor) - LTB4R
- BLT2 (Leukotriene B4 receptor 2) - LTB4R2
Lipoxin[edit]
Lipoxins:
- LXA4R (Formyl peptide receptor-like 1) - FPRL1
Oxoeicosanoid[edit]
Oxoeicosanoid:[4]
- Oxoeicosanoid (OXE) receptor 1 - OXER1
Prostanoid[edit]
Prostanoids:
- PGD2: DP-(PGD2)
- DP1 (Prostaglandin D2 receptor) - PTGDR
- DP2 (GPR44) - GPR44
- PGE2:
- EP1-(PGE2) (PTGER1) - PTGER1
- EP2-(PGE2) (PTGER2) - PTGER2
- EP3-(PGE2) (PTGER3) - PTGER3
- EP4-(PGE2) (PTGER4) - PTGER4
- PGF2α: FP-(PGF2α) (PTGFR) - PTGFR
- PGI2 (prostacyclin): IP-(PGI2) (PTGIR) - PTGIR
- TXA2 (thromboxane): TP-(TXA2) (TBXA2R) - TBXA2R
References[edit]
- ^ DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA (1998). "The nuclear eicosanoid receptor, PPAR-γ, is aberrantly expressed in colonic cancers". Carcinogenesis 19 (1): 49–53. doi:10.1093/carcin/19.1.49. PMID 9472692.
- ^ Coleman RA, Smith WL, Narumiya S (1994). "International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes". Pharmacol. Rev. 46 (2): 205–29. PMID 7938166.
- ^ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T (2003). "International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors". Pharmacol. Rev. 55 (1): 195–227. doi:10.1124/pr.55.1.8. PMID 12615958.
- ^ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T (2004). "International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor". Pharmacol. Rev. 56 (1): 149–57. doi:10.1124/pr.56.1.4. PMID 15001665.
External links[edit]
- "Leukotriene Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- "Prostanoid Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Eicosanoid receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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Cell surface receptor: G protein-coupled receptors
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|
Class A:
Rhodopsin like |
|
|
| Class B: Secretin like |
|
Orphan
|
- GPR (56
- 64
- 97
- 98
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 123
- 124
- 125
- 126
- 128
- 133
- 143
- 144
- 155
- 157)
|
|
|
Other
|
- Brain-specific angiogenesis inhibitor (1
- 2
- 3)
- Cadherin (1
- 2
- 3)
- Calcitonin
- CALCRL
- CD97
- Corticotropin-releasing hormone (1
- 2)
- EMR (1
- 2
- 3)
- Glucagon (GR
- GIPR
- GLP1R
- GLP2R)
- Growth hormone releasing hormone
- PACAPR1
- GPR
- Latrophilin (1
- 2
- 3
- ELTD1)
- Methuselah-like proteins
- Parathyroid hormone (1
- 2)
- Secretin
- Vasoactive intestinal peptide (1
- 2)
|
|
|
Class C: Metabotropic
glutamate / pheromone |
|
Taste
|
- TAS1R (1
- 2
- 3)
- TAS2R (1
- 3
- 4
- 5
- 7
- 8
- 9
- 10
- 13
- 14
- 16
- 19
- 20
- 30
- 31
- 38
- 39
- 40
- 41
- 42
- 43
- 45
- 46
- 50
- 60)
|
|
|
Other
|
- Calcium-sensing receptor
- GABA B (1
- 2)
- Glutamate receptor (Metabotropic glutamate (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8))
- GPRC6A
- GPR (156
- 158
- 179)
- RAIG (1
- 2
- 3
- 4)
|
|
|
Class F:
Frizzled / Smoothened |
|
Frizzled
|
- Frizzled (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10)
|
|
|
Smoothened
|
|
|
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
|
|
|
Membrane proteins, receptors: cell surface receptors
|
|
| G protein-coupled receptor |
| Class A |
- Eicosanoid receptor (Prostaglandin receptor)
- Protease-activated receptor
- Neurotransmitter receptor
- Purinergic receptor
- Biogenic amine receptor
- Olfactory receptor
|
|
| Class B |
|
|
| Class C |
- Metabotropic glutamate receptor
|
|
| Class D |
|
|
| Class E |
|
|
| Class F |
|
|
|
| Ligand-gated ion channel |
|
|
| Enzyme-linked receptor |
- Serine/threonine-specific protein kinase
- Receptor tyrosine kinase
- Guanylate cyclase
|
|
| Other/ungrouped |
- Asialoglycoprotein receptor
- Tumor necrosis factor receptor
- Immunoglobulin superfamily
- N-Acetylglucosamine receptor
- Neuropilins
- Transferrin receptor
- EDAR
- Lipoprotein receptor-related protein
|
|
- See also
- cell surface receptor deficiencies
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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|
UpToDate Contents
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English Journal
- The Epoxyeicosatrienoic Acid Pathway Enhances Hepatic Insulin Signaling and Is Repressed in Insulin-Resistant Mouse Liver.
- Schaefer A1, Neschen S2, Kahle M2, Sarioglu H1, Gaisbauer T2, Imhof A3, Adamski J2, Hauck SM4, Ueffing M5.
- Molecular & cellular proteomics : MCP.Mol Cell Proteomics.2015 Jun 12. pii: mcp.M115.049064. [Epub ahead of print]
- While it is widely accepted that ectopic lipid accumulation in the liver is associated with hepatic insulin resistance, the underlying molecular mechanisms have not been well characterized. Here we employed time resolved quantitative proteomic profiling of mice fed a high fat diet to determine which
- PMID 26070664
- Cannabinoid-dopamine interactions in the physiology and physiopathology of the basal ganglia.
- García C1,2,3, Palomo-Garo C1,2,3, Gómez-Gálvez Y1,2,3, Fernández-Ruiz J1,2,3.
- British journal of pharmacology.Br J Pharmacol.2015 Jun 8. doi: 10.1111/bph.13215. [Epub ahead of print]
- Endocannabinoids and their receptors play a modulatory role in the control of dopamine transmission at the basal ganglia. However, this influence is generally indirect and exerted through the modulation of GABA and glutamate inputs received by nigrostriatal dopaminergic neurons, which lack of CB1 re
- PMID 26059564
- Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites.
- Turcotte C1, Chouinard F1, Lefebvre JS1, Flamand N2.
- Journal of leukocyte biology.J Leukoc Biol.2015 Jun;97(6):1049-1070. Epub 2015 Apr 15.
- 2-Arachidonoyl-glycerol (2-AG) and arachidonyl-ethanolamide (AEA) are endocannabinoids that have been implicated in many physiologic disorders, including obesity, metabolic syndromes, hepatic diseases, pain, neurologic disorders, and inflammation. Their immunomodulatory effects are numerous and are
- PMID 25877930
Japanese Journal
- Santosh Nigam Memorial "Outstanding Young Scientist" Award
- リン脂質によるシグナル伝達の研究の進歩 －細胞間と細胞内におけるシグナル伝達分子としてのリン脂質分解産物、その代謝物および特定ホスファチジルコリン分子種－
- Roles of eicosanoids in pulmonary fibrosis
Related Links
- From Wikipedia, the free encyclopedia. Jump to: navigation, search. An eicosanoid receptor is an integral membrane protein which detects the presence of eicosanoid signaling molecules. Most, though not all, are G protein-coupled receptors ...
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- 英
- eicosanoid receptor
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- エイコサノイド受容体