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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/15 16:12:26」(JST)

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Leukotriene D4 (LTD4) is one of the leukotrienes. Its function main in the body is to induce the contraction of smooth muscle, resulting in bronchoconstriction and vasoconstriction. It also increases vascular permeability. LTD-4 is released by basophils. Other leukotrienes that function in a similar manner are leukotrienes C4 and E4. Pharmacological agents that inhibit the function of these leukotrienes are leukotriene receptor antagonists (e.g. Zafirlukast, montelukast) and are useful for asthmatic individuals.

Eicosanoid synthesis. (Leukotrienes at right.)

References

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3. 好酸球の生物学および好酸球増多症の原因 eosinophil biology and causes of eosinophilia
4. 12歳未満の小児における慢性喘息：持続性喘息の治療およびコントロール薬 asthma in children younger than 12 years treatment of persistent asthma with controller medications
5. 喘息のマネージメントの概要 an overview of asthma management

English Journal

Simultaneous quantification of leukotrienes and hydroxyeicosatetraenoic acids in cell culture medium using liquid chromatography/tandem mass spectrometry.

Furugen A1, Yamaguchi H2, Mano N2.
Biomedical chromatography : BMC.Biomed Chromatogr.2015 Jul;29(7):1084-93. doi: 10.1002/bmc.3395. Epub 2014 Dec 2.
Leukotrienes (LTs) and hydroxyeicosatetraenoic acids (HETEs) are important bioactive lipid mediators that participate in various pathophysiological processes. To advance understanding of the mechanisms that regulate these mediators in physiological and pathological processes, an analytical method us
PMID 25451304

α-Galactosylceramide suppresses murine eosinophil production through interferon-γ-dependent induction of NO synthase and CD95.

Gaspar-Elsas MI1, Queto T1, Masid-de-Brito D2, Vieira BM1,2, de Luca B1, Cunha FQ3, Xavier-Elsas P3.
British journal of pharmacology.Br J Pharmacol.2015 Jul;172(13):3313-25. doi: 10.1111/bph.13126. Epub 2015 Apr 24.
BACKGROUND AND PURPOSE: α-Galactosylceramide (α-GalCer), a pleiotropic immunomodulator with therapeutic potential in neoplastic, autoimmune and allergic diseases, activates invariant natural killer T-cells throughCD1-restricted receptors for α-GalCer on antigen-presenting cells, inducing cytokine
PMID 25752588

Arachidonic acid-derived signaling lipids and functions in impaired healing.

Dhall S1,2, Wijesinghe DS3,4,5,6, Karim ZA7, Castro A1, Vemana HP8, Khasawneh FT7, Chalfant CE4,5,6,7, Martins-Green M1,2.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.Wound Repair Regen.2015 Jun 30. doi: 10.1111/wrr.12337. [Epub ahead of print]
Very little is known about lipid function during wound healing, and much less during impaired healing. Such understanding will help identify what roles lipid signaling plays in the development of impaired/chronic wounds. We took a lipidomics approach to study the alterations in lipid profile in the
PMID 26135854

Japanese Journal

Improvement of Film Quality in CuInSe2 Thin Films Fabricated by a Non-Vacuum, Nanoparticle-Based Approach

Zhang Yiwen,Ito Manabu,Tamura Tomoaki [他],Yamada Akira,Konagai Makoto
Jpn J Appl Phys 50(4), 04DP12-04DP12-4, 2011-04-25
To improve the quality of CuInSe2 (CIS) thin films fabricated by a non-vacuum, nanoparticle-based approach, in this study, two categories of nanoparticles, Cu (InGa) Se2 (CIGS) nanoparticles and coppe …
NAID 150000055693

Enhanced Durability of Antisticking Layers by Recoating a Silica Surface with Fluorinated Alkylsilane Derivatives by Chemical Vapor Surface Modification

Kohno Akihiro,Sakai Nobuji,Matsui Shinji [他],Masaru Nakagawa
Jpn J Appl Phys 49(6), 06GL12-06GL12-6, 2010-06-25
Adsorbed monolayers from (3,3,3-trifluoropropyl)trimethoxysilane (FAS3), (tridecafluoro-1,1,2,2-tetrahydrooctyl)trimethoxysilane (FAS13), (heptadecafluoro-1,1,2,2-tetrahydrodecyl)trimethoxysilane (FAS …
NAID 150000054184

Related Pictures

★リンクテーブル★

リンク元	「ロイコトリエン」「leukotriene D4」「leukotriene D」「ロイコトリエンD4」
関連記事	「LT」「LTD」

「ロイコトリエン」

Leukotriene D4
Identifiers
CAS Registry Number	73836-78-9
ChEBI	CHEBI:28666
ChEMBL	ChEMBL288943
Jmol-3D images	Image
MeSH	Leukotriene+D4
PubChem	5280878
	SMILES CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O ;
Properties
Chemical formula	C25H40N2O6S
Molar mass	496.661 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is: /?)
	Infobox references

　　[★]

英: leukotriene, LT
関: アラキドン酸、5-リポキシゲナーゼ

合成

ホスホリパーゼA₂の作用によりホスファチジルコリンから遊離したアラキドン酸から合成される。

アラキドン酸→LTA4→LTB4

白血球遊走

アラキドン酸→LTA4→LTC4→LTD4→LTE4

気管支平滑筋収縮、細動脈収縮、血管透過性亢進

構造

二重結合を複数持つ不飽和脂肪酸。トリエン構造

種類

ロイコトリエンA₄	ロイコトリエンB₄とロイコトリエンC₄の前駆物質
ロイコトリエンB₄	chemotaxis
ロイコトリエンC₄	気管支収縮、血管拡張、血管透過性亢進、ロイコトリエンD₄の前駆物質
ロイコトリエンD₄	気管支収縮、血管拡張、血管透過性亢進、ロイコトリエンE₄の前駆物質
ロイコトリエンE₄	気管支収縮、血管拡張、血管透過性亢進

「leukotriene D4」

　　[★]

ロイコトリエンD4

関: leukotriene D、LTD4
同: LTD4

「leukotriene D」

　　[★]

ロイコトリエンD

関: leukotriene D4、LTD4

「ロイコトリエンD4」

　　[★]

英: LTD4
関: ロイコトリエン

「LT」

　　[★]

「LTD」

　　[★]

長期抑制

関: long-term depression

匿名

検索

案内

案内

LTD4