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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/30 04:47:23」(JST)
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- 1. 喘息の治療において5-リポキシゲナーゼ経路に影響する薬剤 agents affecting the 5 lipoxygenase pathway in the treatment of asthma
- 2. 肥満細胞由来のメディエーター mast cell derived mediators
- 3. Approach to the patient with hyperpigmentation disorders
- 4. 12歳未満の小児における慢性喘息：持続性喘息の治療およびコントロール薬 asthma in children younger than 12 years treatment of persistent asthma with controller medications
- 5. アスピリンによる呼吸器疾患の増悪 aspirin exacerbated respiratory disease
English Journal
- Downregulation of the expression of Orai1 in the airway alleviates murine allergic rhinitis.
- Wang Y, Lin L, Zheng C.AbstractOrai1 is the key subunit of the Ca2+-release-activated Ca2+ channel. Our previous report has demonstrated that Orai1 expression in the airway was upregulated in the ovalbumin (OVA)-induced allergic rhinitis (AR) mouse models. To observe whether inhibition of Orai1 expression in the airway could suppress symptoms in a murine model of AR and to assess the impacts of this inhibition on the responses of local and systemic immunocytes, we administered recombinant lentivirus vectors that encoded shRNA against ORAI1 (lenti-ORAI1) into the nostrils of OVA-sensitized mice before the challenges, and analyzed its effect on allergic responses, as compared with the unsensitized mice and untreated AR mice. Administration of lenti-ORAI1 into the nasal cavity successfully infected cells in the epithelial layer of the nasal mucosa, and significantly decreased the frequencies of sneezing and nasal rubbing of the mice. Protein levels of leukotriene C4, OVA-specific IgE, and IL-4 in the nasal lavage fluid and serum and eosinophil cation protein in the serum were also significantly reduced by lenti-ORAI1, as were the mRNA levels of these factors in the nasal mucosa and spleen. These data suggested that administration of lenti-ORAI1 into the nasal cavity effectively decreased Orai1 expression in the nasal mucosa, alleviated AR symptoms, and partially inhibited the hyperresponsiveness of the local and systemic immune cells including T cells, B cells, mast cells and eosinophils that are involved in the pathogenesis of AR.
- Experimental & molecular medicine.Exp Mol Med.2011 Dec 14. [Epub ahead of print]
- Orai1 is the key subunit of the Ca2+-release-activated Ca2+ channel. Our previous report has demonstrated that Orai1 expression in the airway was upregulated in the ovalbumin (OVA)-induced allergic rhinitis (AR) mouse models. To observe whether inhibition of Orai1 expression in the airway could supp
- PMID 22170034
- Premenstrual asthma and leukotriene variations in the menstrual cycle.
- Pereira-Vega A, Sánchez Ramos JL, Maldonado Pérez JA, Vázquez Oliva R, Bravo Nieto JM, Vázquez Rico I, Ignacio García JM, Romero Palacios P, Alwakil Olbah M, Medina Gallardo JF.SourcePneumology Section, Hospital Juan Ramón Jiménez, Ronda Norte, s/n, 21005 Huelva, Spain.
- Allergologia et immunopathologia.Allergol Immunopathol (Madr).2011 Nov 22. [Epub ahead of print]
- BACKGROUND: Several authors have reported an increase in leukotriene C4 in the premenstrual phase in women with severe premenstrual asthma, indicating that antileukotrienes could be used in treatment.OBJECTIVE: To analyse the role of leukotrienes in premenstrual asthma.METHODS: A questionnaire on re
- PMID 22115570
Japanese Journal
- Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma
- Kang Mi-Jin,Kwon Ji-Won,Kim Byoung-Ju [他]
- Journal of human genetics 56(4), 284-289, 2011-04
- NAID 40018765627
- Leukotrienes in Nociceptive Pathway and Neuropathic/Inflammatory Pain
- Noguchi Koichi,Okubo Masamichi
- Biological & Pharmaceutical Bulletin 34(8), 1163-1169, 2011
- … We found the expression of 5-lipoxygenase (5-LO), FLAP and the cysteinyl leukotrienes (CysLT1) mRNAs in spinal microglia, LTA4h and LTC4s mRNAs in both spinal neurons and microglia, and BLT1 mRNA in spinal neurons. …
- NAID 130000936581
Related Links
- 初めてロイコトリエンについて言及したのは、フェルトベルクとケラウェイであった。彼らは 1938年から1940年にかけて、後にロイコトリエンC (LTC4) と命名される物質である " slow reaction smooth muscle-stimulating substance" (SRS) を、長期間に渡り蛇毒 と ...
- The parent cysteinyl leukotriene produced by LTC4 synthase catalyzed conjugation of glutathione to LTA4. 25 µg · 50 µg · 100 µg.
Related Pictures
★リンクテーブル★
| リンク元 | 「ロイコトリエン」「ロイコトリエンC4」「leukotriene C」「leukotriene C4」 |
| 関連記事 | 「LT」 |
「ロイコトリエン」
- 英
- leukotriene, LT
- 関
- アラキドン酸、5-リポキシゲナーゼ
合成
- ホスホリパーゼA2の作用によりホスファチジルコリンから遊離したアラキドン酸から合成される。
- 白血球遊走
- 気管支平滑筋収縮、細動脈収縮、血管透過性亢進
構造
- 二重結合を複数持つ不飽和脂肪酸。トリエン構造
種類
| ロイコトリエンA4 | ロイコトリエンB4とロイコトリエンC4の前駆物質 |
| ロイコトリエンB4 | chemotaxis |
| ロイコトリエンC4 | 気管支収縮、血管拡張、血管透過性亢進、ロイコトリエンD4の前駆物質 |
| ロイコトリエンD4 | 気管支収縮、血管拡張、血管透過性亢進、ロイコトリエンE4の前駆物質 |
| ロイコトリエンE4 | 気管支収縮、血管拡張、血管透過性亢進 |
「ロイコトリエンC4」
- 英
- leukotriene C4, LTC4
- 関
- ロイコトリエン