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any of the salts of hydrobromic acid; formerly used as a sedative but now generally replaced by safer drugs

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〈U〉臭化物(鎮静剤・睡眠剤として用いる) / 〈C〉《話》陳腐なことば

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/13 02:10:10」(JST)

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Distigmine (as distigmine bromide) is a parasympathomimetic. Distigmine is similar to pyridostigmine and neostigmine but has a longer duration of action. It is available as tablets on prescription only. Distigmine has a greater risk of causing cholinergic crisis because of accumulation of the drug being more likely than with neostigmine or pyridostigmine and so distigmine is rarely used as a treatment for myasthenia gravis, unlike pyridostigmine and neostigmine.

References

^ ^a ^b ^c The Japanese Pharmacopoeia, Edition 14/I: Official Monographs, Yakuji Nippo. Ltd., Tokyo (2001), ISBN 978-4840806725, Page 599.

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English Journal

Effects of Silodosin, an α1A-Adrenoceptor Antagonist, and Distigmine, an Acetylcholinesterase Inhibitor, and Their Combined Effects on Impaired Voiding Function in Zucker Diabetic Fatty Rats.

Tatemichi S1, Tsuchioka K, Yonekubo S, Maruyama K, Kobayashi M.
Pharmacology.Pharmacology.2015 May 22;95(5-6):285-292. [Epub ahead of print]
BACKGROUND/AIMS: To evaluate the effects of silodosin (α1A-adrenoceptor antagonist) and distigmine (acetylcholinesterase inhibitor), alone or in combination, on voiding dysfunction in Zucker diabetic fatty (ZDF) rats, a type 2 diabetes model, by pressure flow study.METHODS: Male ZDF rats were anest
PMID 26023044

Effects of bethanechol chloride and distigmine bromide on postvoiding residual volume in patients with underactive bladder.

Izumi K1, Maolake A, Maeda Y, Shigehara K, Namiki M.
Minerva urologica e nefrologica = The Italian journal of urology and nephrology.Minerva Urol Nefrol.2014 Dec;66(4):241-7.
AIM: The efficacy of cholinergic drugs for reduction of post-voiding residual volume (PVR) in patients with underactive bladder is still controversial. This study was performed to examine whether cholinergic drugs have such an effect on PVR.METHODS: Patients with underactive bladder treated for more
PMID 25531193

Japanese Journal

ジスチグミン臭化物錠適正使用プロトコール導入効果 : 薬学的介入に対する薬剤師と患者の意識調査

医薬品情報学 = Japanese journal of drug informatics 18(2), 95-105, 2016-08
NAID 40020944393

症例直腸癌術後にdistigmine bromideによるコリン作動性クリーゼと中毒性巨大結腸症を併発した1例

外科 = Surgery : 臨床雑誌 78(2), 190-193, 2016-02
NAID 40020719825

症例報告臭化ジスチグミン内服中に腸閉塞をきたし急速に呼吸不全に至ったコリン作動性クリーゼの1例

The Japanese journal of clinical toxicology = 中毒研究 : 日本中毒学会機関誌 29(1), 26-29, 2016
NAID 40020757360

「ジスチグミン」

Distigmine
	Distigmine bromide
Systematic (IUPAC) name
	(1-methylpyridin-1-ium-3-yl) N-methyl-N-{6-[methyl-; (1-methylpyridin-1-ium-3-yl)oxycarbonylamino]; hexyl}carbamate dibromide
Clinical data
Routes of; administration	oral, i.m.
Pharmacokinetic data
Bioavailability	4.65 %
Biological half-life	65 h
Excretion	renal
Identifiers
CAS Number	15876-67-2
ATC code	N07AA03 (WHO)
PubChem	CID 27522
ChemSpider	25613
UNII	T940307O7B
KEGG	D01228
ChEMBL	CHEMBL1098285
Chemical data
Formula	C22H32Br2N4O4
Molar mass	576.322 g/mol
	SMILES [Br-].[Br-].O=C(Oc1ccc[n+](c1)C)N(CCCCCCN(C(=O)Oc2ccc[n+](c2)C)C)C ;
	InChI InChI=1S/C22H32N4O4.2BrH/c1-23-13-9-11-19(17-23)29-21(27)25(3)15-7-5-6-8-16-26(4)22(28)30-20-12-10-14-24(2)18-20;;/h9-14,17-18H,5-8,15-16H2,1-4H3;2*1H/q+2;;/p-2 ; Key:GJHSNEVFXQVOHR-UHFFFAOYSA-L ;
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