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- distigmine bromide
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/10/02 09:59:29」(JST)
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Distigmine
Distigmine bromide
|
Clinical data |
Routes of
administration |
oral, i.m. |
ATC code |
|
Pharmacokinetic data |
Bioavailability |
4.65% [1] |
Biological half-life |
65 h [1] |
Excretion |
renal [1] |
Identifiers |
IUPAC name
- (1-methylpyridin-1-ium-3-yl) N-methyl-N-{6-[methyl-
(1-methylpyridin-1-ium-3-yl)oxycarbonylamino]
hexyl}carbamate dibromide
|
CAS Number |
|
PubChem CID |
|
ChemSpider |
|
UNII |
|
KEGG |
|
ChEMBL |
|
ECHA InfoCard |
100.036.360 |
Chemical and physical data |
Formula |
C22H32Br2N4O4 |
Molar mass |
576.322 g/mol |
3D model (JSmol) |
|
SMILES
-
[Br-].[Br-].O=C(Oc1ccc[n+](c1)C)N(CCCCCCN(C(=O)Oc2ccc[n+](c2)C)C)C
|
InChI
-
InChI=1S/C22H32N4O4.2BrH/c1-23-13-9-11-19(17-23)29-21(27)25(3)15-7-5-6-8-16-26(4)22(28)30-20-12-10-14-24(2)18-20;;/h9-14,17-18H,5-8,15-16H2,1-4H3;2*1H/q+2;;/p-2 Y
-
Key:GJHSNEVFXQVOHR-UHFFFAOYSA-L Y
|
NY (what is this?) (verify) |
Distigmine (as distigmine bromide) is a parasympathomimetic. Distigmine is similar to pyridostigmine and neostigmine but has a longer duration of action. It is available as tablets on prescription only. Distigmine has a greater risk of causing cholinergic crisis because of accumulation of the drug being more likely than with neostigmine or pyridostigmine and so distigmine is rarely used as a treatment for myasthenia gravis, unlike pyridostigmine and neostigmine.
References
- ^ a b c The Japanese Pharmacopoeia, Edition 14/I: Official Monographs, Yakuji Nippo. Ltd., Tokyo (2001), ISBN 978-4840806725, Page 599.
Acetylcholine metabolism and transport modulators
|
Enzyme
(modulators) |
ChAT |
- Inhibitors: 1-(-Benzoylethyl)pyridinium
- 2-(α-Naphthoyl)ethyltrimethylammonium
- 3-Chloro-4-stillbazole
- 4-(1-Naphthylvinyl)pyridine
- Acetylseco hemicholinium-3
- Acryloylcholine
- AF64A
- B115
- BETA
- CM-54,903
- N,N-Dimethylaminoethylacrylate
- N,N-Dimethylaminoethylchloroacetate
|
AChE |
|
BChE |
- Inhibitors: Affinine
- Affinisine
- Conodurine
- Cymserine
- Ladostigil
- Profenamine (ethopropazine)
- Rivastigmine
- Tacrine
- ZINC-12613047
- Many of the other AChE inhibitors listed above
|
|
Transporter
(modulators) |
CHT |
- Inhibitors: Hemicholinium-3 (hemicholine)
- Triethylcholine
|
VAChT |
|
|
Release
(modulators) |
Inhibitors |
- SNAP-25 inactivators: Botulinum toxin (A, C, E)
- VAMP inactivators: Botulinum toxin (B, D, F, G)
- Others: Bungarotoxins (β-bungarotoxin, γ-bungarotoxin)
|
Enhancers |
- LPHN agonists: α-Latrotoxin
- Others: Atracotoxin (e.g., robustoxin, versutoxin)
- Crotoxin
|
|
See also: Receptor/signaling modulators • Muscarinic acetylcholine receptor modulators • Nicotinic acetylcholine receptor modulators
|
English Journal
- Promising Effects of a Novel EP2 and EP3 Receptor Dual Agonist, ONO-8055, on Neurogenic Underactive Bladder in a Rat Lumbar Canal Stenosis Model.
- Sekido N1, Kida J2, Mashimo H2, Wakamatsu D2, Okada H2, Matsuya H2.
- The Journal of urology.J Urol.2016 Aug;196(2):609-16. doi: 10.1016/j.juro.2016.02.064. Epub 2016 Feb 13.
- PURPOSE: We investigated whether the novel EP (prostaglandin E2) receptor agonist ONO-8055 would improve the lower urinary tract dysfunction of neurogenic underactive bladder in a rat lumbar spinal canal stenosis model.MATERIALS AND METHODS: First, we studied the agonistic effect of ONO-8055 on EP r
- PMID 26880410
- [Bowel obstruction-induced cholinergic crisis with progressive respiratory failure following distigmine bromide treatment].
- Kobayashi K, Sekiguchi H, Sato N, Hirose Y.
- Chūdoku kenkyū : Chūdoku Kenkyūkai jun kikanshi = The Japanese journal of toxicology.Chudoku Kenkyu.2016 Mar;29(1):26-9.
- A 54-year-old female experienced rapid respiratory failure while being transported in an ambulance to our emergency department for evaluation and management of constipation and abdominal pain. The patient was on treatment with distigmine bromide for postoperative urination disorder and magnesium oxi
- PMID 27255021
- Spectrophotometric Determination of Distigmine Bromide, Cyclopentolate HCl, Diaveridine HCl and Tetrahydrozoline HCl via Charge Transfer Complex Formation with TCNQ and TCNE Reagents.
- Mohamed GG1, Rizk MS1, Zaky Frag EY1.
- Iranian journal of pharmaceutical research : IJPR.Iran J Pharm Res.2015 Summer;14(3):701-14.
- The purpose of this investigation was directed to propose sensitive, accurate and reproducible methods of analysis that can be applied to determine distigmine bromide (DTB), cyclopentolate hydrochloride (CPHC), diaveridine hydrochloride (DVHC) and tetrahydrozoline hydrochloride (THHC) drugs in pure
- PMID 26330858
Japanese Journal
- The Long-Lasting Enhancing Effect of Distigmine on Acetylcholine-Induced Contraction of Guinea Pig Detrusor Smooth Muscle Correlates with Its Anticholinesterase Activity
- Distigmine Bromide Produces Sustained Potentiation of Guinea-Pig Urinary Bladder Motility by Inhibiting Cholinesterase Activity
- 症例 直腸癌術後にdistigmine bromideによるコリン作動性クリーゼと中毒性巨大結腸症を併発した1例
Related Links
- Look at other dictionaries: Distigmine — bromide Systematic (IUPAC) name (1 methylpyridin 1 ium 3 yl) N methyl N {6 [methyl (1 methylpyridin 1 ium 3 yl)oxycarbonylamino] hexyl}carbamate dibromide … Wikipedia distigmine — n ...
- Distigmine information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Search Specialists by State and City
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- 英
- distigmine
- 化
- 臭化ジスチグミン distigmine bromide
- ラ
- distigmini bromidum
- 商
- ウブレチド、ウブテック
- 関
- 抗コリンエステラーゼ薬、ネオスチグミン
適応
- 経口:重症筋無力症、手術後および神経因性膀胱などの低緊張性膀胱による排尿困難
- 点眼剤:緑内障、や調節性内斜視
禁忌
- 消化管・尿路の器質的閉塞、迷走神経緊張症、脱分極性筋弛緩薬(スキサメトニウム)を投与中の患者
副作用
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