cytomegalic inclusion disease

巨細胞封入体症

WordNet

1. an impairment of health or a condition of abnormal functioning
2. the relation of comprising something; "he admired the inclusion of so many ideas in such a short work" (同)comprehension
3. the state of being included
4. the act of including
5. caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
6. of or relating to or characterized by greatly enlarged cells

PrepTutorEJDIC

1. Criminal investigation Department [of Scotland Yard]ロンドン警視庁捜査課
2. (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
3. 女性の話術芸人 =diseur
4. 〈U〉(…を)中に含めること,(…の)包含《+『of』+『名』》 / 〈C〉中に含まれた物
5. 病気にかかった / 病的な,不健全な(morbid)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/15 08:23:10」(JST)

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Cytomegalovirus
Classification and external resources
Specialty	Infectious disease
ICD-10	B25
ICD-9-CM	078.5
MedlinePlus	000568
Patient UK	Cytomegalovirus
MeSH	D003586

Cytomegalovirus
Typical "owl eye" inclusion indicating CMV infection of a lung pneumocyte
Virus classification
Group:	Group I (dsDNA)
Order:	Herpesvirales
Family:	Herpesviridae
Subfamily:	Betaherpesvirinae
Genus:	Cytomegalovirus
Type species
Human cytomegalovirus

Main article: Human cytomegalovirus

Cytomegalovirus (from the Greek cyto-, "cell", and megalo-, "large") is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. Human and monkeys serve as natural hosts. There are currently eight species in this genus including the type species human herpesvirus 5. Diseases associated with HHV-5 include mononucleosis, and pneumonias. It is typically abbreviated as CMV.

The species that infects humans is commonly known as human CMV (HCMV) or human herpesvirus-5 (HHV-5), and is the most studied of all cytomegaloviruses. Within Herpesviridae, CMV belongs to the Betaherpesvirinae subfamily, which also includes the genera Muromegalovirus and Roseolovirus (HHV-6 and HHV-7). It is related to other herpesviruses within the subfamilies of Alphaherpesvirinae that includes herpes simplex viruses (HSV)-1 and -2 and varicella-zoster virus (VZV), and the Gammaherpesvirinae subfamily that includes Epstein–Barr virus.

All herpesviruses share a characteristic ability to remain latent within the body over long periods. Although they may be found throughout the body, CMV infections are frequently associated with the salivary glands in humans and other mammals. Other CMV viruses are found in several mammal species, but species isolated from animals differ from HCMV in terms of genomic structure, and have not been reported to cause human disease.

Taxonomy

Group: dsDNA

Order: Herpesvirales

• Family: Herpesviridae

  • Sub-Family: Betaherpesvirinae

    • Genus: Cytomegalovirus 

      • Aotine herpesvirus 1
      • Cebine herpesvirus 1
      • Cercopithecine herpesvirus 5
      • Human herpesvirus 5
      • Macacine herpesvirus 3
      • Panine herpesvirus 2
      • Papiine herpesvirus 3
      • Saimiriine herpesvirus 4

Species

Classified Cytomegaloviruses

Scientific Name	Host	Common Name
Human herpesvirus 5 (HHV-5) Cercopithecine herpesvirus 5 (CeHV-5) Cercopithecine herpesvirus 8 (CeHV-8) Panine herpesvirus 2 (PoHV-2) Pongine herpesvirus 4 (PoHV-4) Aotine herpesvirus 1 (AoHV-1)—tentative classification Aotine herpesvirus 3 (AoHV-3)—tentative classification	Human African green monkey Rhesus monkey Chimpanzee Orangutan Night monkey "	Human CMV (HCMV) Simian CMV (SCCMV) Rhesus CMV (RhCMV) Chimpanzee CMV (CCMV) " Herpesvirus aotus 1 Herpesvirus aotus 3

Several species of Cytomegalovirus have been identified and classified for different mammals. The most studied is Human cytomegalovirus (HCMV), which is also known as Human herpesvirus 5 (HHV-5). Other primate CMV species include Chimpanzee cytomegalovirus (CCMV) that infects chimpanzees and orangutans, and Simian cytomegalovirus (SCCMV) and Rhesus cytomegalovirus (RhCMV) that infect macaques; CCMV is known as both Panine herpesvirus 2 (PaHV-2) and Pongine herpesvirus-4 (PoHV-4). SCCMV is called Cercopithecine herpesvirus-5 (CeHV-5) and RhCMV, Cercopithecine herpesvirus 8 (CeHV-8). A further two viruses found in the night monkey are tentatively placed in the Cytomegalovirus genus, and are called Herpesvirus aotus 1 and Herpesvirus aotus 3. Rodents also have viruses previously called cytomegaloviruses that are now reclassified under the genus Muromegalovirus; this genus contains Mouse cytomegalovirus (MCMV) is also known as Murid herpesvirus 1 (MuHV-1) and the closely related Murid herpesvirus 2 (MuHV-2) that is found in rats. In addition, there many other viral species with the name Cytomegalovirus identified in distinct mammals that are as yet not completely classified; these were predominantly isolated from primates and rodents.

Structure

Viruses in Cytomegalovirus are enveloped, with icosahedral, Spherical to pleomorphic, and Round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 200kb in length.

Genus	Structure	Symmetry	Capsid	Genomic Arrangement	Genomic Segmentation
Cytomegalovirus	Spherical Pleomorphic	T=16	Enveloped	Linear	Monopartite

Life Cycle

Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral glycoproteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA templated transcription, with some alternative splicing mechanism is the method of transcription. Translation takes place by leaky scanning. The virus exits the host cell by nuclear egress, and budding. Human and monkeys serve as the natural host. Transmission routes are contact, urine, and saliva.

Genus	Host Details	Tissue Tropism	Entry Details	Release Details	Replication Site	Assembly Site	Transmission
Cytomegalovirus	Humans; monkeys	Epithelial mucosa	Glycoprotiens	Budding	Nucleus	Nucleus	Urine; saliva

Genetic engineering

The CMV promoter is commonly included in vectors used in genetic engineering work conducted in mammalian cells, as it is a strong promoter and drives constitutive expression of genes under its control.

References

External links

• Viralzone: Cytomegalovirus
• ICTV

UpToDate Contents

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English Journal

• Identification of a novel HLA-A*24:02-restricted adenovirus serotype 11-specific CD8(+) T-cell epitope for adoptive immunotherapy.

• Imahashi N, Nishida T, Ito Y, Kawada J, Nakazawa Y, Toji S, Suzuki S, Terakura S, Kato T, Murata M, Naoe T.SourceDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Research Fellow of Japan Society for the Promotion of Science, Japan.
• Molecular immunology.Mol Immunol.2013 Dec 31;56(4):399-405. doi: 10.1016/j.molimm.2013.05.232. Epub 2013 Aug 1.
• Subgroup B adenovirus serotype 11 (Ad11) occasionally causes fatal infections in immunocompromised patients. The present study describes a novel Ad11 epitope presented by HLA-A*24:02 that could be used for adoptive immunotherapy. Ten synthetic Ad11 hexon protein-derived nonamer peptides that bound t
• PMID 23911395

• Infections and inflammatory bowel disease: Challenges in Asia.

• Ng SC, Chan FK.SourceDepartment of Medicine and Therapeutics, Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong SAR, China.
• Journal of digestive diseases.J Dig Dis.2013 Nov;14(11):567-573. doi: 10.1111/1751-2980.12091.
• The diagnosis and management of inflammatory bowel disease (IBD) in Asia can be challenging as certain infections can mimic IBD and lead to a misdiagnosis. Colitis can be caused by bacterial infections, ileitis can result from Yersinia and Salmonella infections and ileocolonic ulcers can be seen in
• PMID 23875824

• Selective reactivation of human herpesvirus 6 in patients with autoimmune connective tissue diseases.

• Broccolo F, Drago F, Cassina G, Fava A, Fusetti L, Matteoli B, Ceccherini-Nelli L, Sabbadini MG, Lusso P, Parodi A, Malnati MS.SourceDepartment of Health Sciences, University of Milano-Bicocca, Milano, Italy.
• Journal of medical virology.J Med Virol.2013 Nov;85(11):1925-34. doi: 10.1002/jmv.23670.
• Viral infections have been associated with autoimmune connective tissue diseases. To evaluate whether active infection by Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus (HHV)-6, -7, -8, as well as parvovirus B19 (B19V) occur in patients with autoimmune connective tissue diseases,
• PMID 23983182

Japanese Journal

• サイトメガロウイルス

• 栄鶴 義人,南嶋 洋一
• Virus report 3(1), 117-125, 2006-00-00
• NAID 40007383412

• Brain slice culture for analysis of developmental brain disorders with special reference to congenital cytomegalovirus infection

• Kawasaki Hideya,Tsutsui Yoshihiro
• 2003-06-00
• … Cytomegalovirus (CMV) is the most significant infectious cause of congenital abnormalities of the central nervous system (CNS) with variation from the fatal cytomegalic inclusion disease to functional brain disorder. …
• NAID 120005305046

• Brain slice culture for analysis of developmental brain disorders with special reference to congenital cytomegalovirus infection

• Kawasaki Hideya,Tsutsui Yoshihiro
• Congenital anomalies 43(2), 105-113, 2003-06-00
• NAID 110002785606

Related Links

• cytomegalic inclusion disease - definition of cytomegalic ...

cytomegalic inclusion disease n. A disease caused by infection with cytomegalovirus, characterized by the presence of inclusion bodies in infected cells, enlargement of the liver and spleen, jaundice, purpura, thrombocytopenia, and ...

• cytomegalic inclusion, generalized disease - definition of ...

disease /dis·ease/ (dĭ-zēz´) any deviation from or interruption of the normal structure or function of any body part, organ, or system that is manifested by a characteristic set of symptoms and signs and whose etiology, pathology, and ...

Related Pictures

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★リンクテーブル★

リンク元	「巨細胞封入体症」「CID」「inclusion disease」「巨細胞封入体病」
関連記事	「disease」「inclusion」「inclusion disease」

「巨細胞封入体症」

　　[★]

英

cytomegalic inclusion disease, CID

関

サイトメガロウイルス感染症、封入体病、巨細胞封入体病

サイトメガロウイルス

先天性サイトメガロウイルス感染症

「CID」

　　[★]

• 衝突解離 collision-induced dissociation
• combined immunodeficiency
• 巨細胞封入体症 cytomegalic inclusion disease

　

「inclusion disease」

　　[★]

封入体病

関

cytomegalic inclusion disease、cytomegalovirus infection

「巨細胞封入体病」

　　[★]

英

cytomegalic inclusion disease

関

巨細胞封入体症

「disease」

　　[★]

• n.

疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)

特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)

• something that is very wrong with people's attitudes, way of life or with society.

関

ail、ailment、disease entity、disorder、ill、illness、malady、sick、sickness

• 注意

disease ≠ illness ≠ disorder

　 　 　

「inclusion」

　　[★]

• n.

• 包含、包括。算入
• 中に含まれるもの、含有物

　 　 　 　

「inclusion disease」

　　[★]

封入体病

関

cytomegalic inclusion disease、cytomegalovirus infection