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1. リウマチ性疾患におけるサイトカインの役割role of cytokines in rheumatic diseases [show details]
…elaboration of growth factors like fibroblast growth factor. Similar cells derived from the synovium of patients with RA also produce macrophage migration inhibitory factor (MIF), a cytokine which stimulates …
2. 全身性硬化症（強皮症）の病因pathogenesis of systemic sclerosis scleroderma [show details]
… of growth factors and cytokines able to mediate the proliferation and activation of vascular and connective tissue cells, particularly fibroblasts. The importance of cytokines in the pathogenesis… the TGF-beta superfamily of cytokines. Some (eg, Smad3) activate intracellular signaling, whereas others (eg, Smad7) are inhibitory.… down-regulators of collagen synthesis by normal dermal fibroblasts and also modulate cell morphology, proliferative capacity, and cytokine responsiveness.…
3. 心不全における一酸化窒素、その他のホルモン、サイトカイン、およびケモカインnitric oxide other hormones cytokines and chemokines in heart failure [show details]
… tight control by regulatory factors. In contrast, iNOS is normally not expressed, but when induced by inflammatory cytokines can generate large amounts of… reduction in NO synthesis via eNOS as well as a decrease in endothelial release of and response to NO. HF is often characterized by increases in circulating proinflammatory cytokines (TNFa,…
4. 細胞性免疫応答the adaptive cellular immune response t cells and cytokines [show details]
…proliferation and cytokine production. Programmed cell death 1 (PD-1) is an inhibitory homologue of CD28 that is expressed late after T cell activation . PD-1 interacts with the inhibitory B7 homologues… including membrane-bound cytokines such as tumor necrosis factor (TNF) alpha.…
5. 関節リウマチの病因pathogenesis of rheumatoid arthritis [show details]
… into citrulline and NO. NO synthesis is induced by cytokines in macrophages, synovial cells, and chondrocytes. Although well-recognized as endothelial-derived relaxing factor, NO has a less well-defined …

English Journal

Cell division cycle protein 42 regulates the inflammatory response in mice bearing inflammatory bowel disease.

Dong LM, Chen XW, He XX, Jiang XP, Wu F.
Artificial cells, nanomedicine, and biotechnology. 2019 Dec;47(1)1833-1838.
This study aimed to explore the effect of cell division cycle protein 42 (CDC42) on inflammatory response and immune response in mice bearing inflammatory bowel disease (IBD). Trinitrobenzene sulfonic acid was injected into the colon of mice to establish IBD model. The mice were divided into four gr
PMID 31062617

β-Sitosterol modulates macrophage polarization and attenuates rheumatoid inflammation in mice.

Liu R, Hao D, Xu W, Li J, Li X, Shen D, Sheng K, Zhao L, Xu W, Gao Z, Zhao X, Liu Q, Zhang Y.
Pharmaceutical biology. 2019 Dec;57(1)161-168.
β-Sitosterol (BS), the primary constituent of plants and vegetables, exhibits multiple biological effects. This study explores its effect of immune-regulation on macrophages and its potential for rheumatoid arthritis (RA) therapy. In vitro, bone marrow-derived macrophages (BMDMs) were treated with
PMID 30905278

Decreased number and impaired function of type 1 regulatory T cells in autoimmune diseases.

Jia X, Zhai T, Wang B, Yao Q, Li Q, Mu K, Zhang JA.
Journal of cellular physiology. 2019 Aug;234(8)12442-12450.
Type 1 regulatory T (Tr1) cell is a special type of T regulatory cells with surface molecular markers such as lymphocyte-activation gene 3 and CD49b. A key property of Tr1 cells is the capability to produce high-level interleukin 10 (IL-10) upon activation, in a FOXP3-independent manner. The immunos
PMID 30666652

Japanese Journal

Pro-inflammatory cytokine TNF-alpha is a key inhibitory factor for lactose synthesis pathway in lactating mammary epithelial cells

Kobayashi Ken,Kuki Chinatsu,Oyama Shoko,Kumura Haruto
Experimental cell research 340(2), 295-304, 2016-01-16
… Lactose synthesis is downregulated under conditions causing inflammation such as mastitis, in which MECs are exposed to high concentrations of inflammatory cytokines. … In this study, we investigated whether inflammatory cytokines (TNF-alpha, IL-1 beta, and IL-6) directly influence the lactose synthesis pathway by using two types of murine MEC culture models: the monolayer culture of MECs to induce lactogenesis; …
NAID 120005853071

Anti-inflammatory and Anti-melanogenic Proanthocyanidin Oligomers from Peanut Skin

Tatsuno Takanori,Jinno Megumi,Arima Yukiko [他],Kawabata Tetsuro,Hasegawa Tatsuya,Yahagi Nobuo,Takano Fumihide,Ohta Tomihisa
Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 35(6), 909-916, 2012
… To determine whether proanthocyanidin has beneficial effects on skin, we tested for inhibitory activity of proanthocyanidins isolated from peanut skin on inflammatory cytokine production and melanin synthesis in cultured cell lines. … It also decreased production of inflammatory cytokines (PSE at 100 µg/mL), tumor necrosis factor-α …
NAID 130001872173

3-Deoxysappanchalcone Inhibits Tumor Necrosis Factor-.ALPHA.-Induced Matrix Metalloproteinase-9 Expression in Human Keratinocytes through Activated Protein-1 Inhibition and Nuclear Factor-Kappa B DNA Binding Activity

Youn Ui Joung,Nam Kung-Woo,Kim Hui-Seong [他],Choi Goya,Jeong Woo Seok,Lee Mi Young,Chae Sungwook
Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 34(6), 890-893, 2011
… Tumor necrosis factor α … (TNF-α), which is a primary cytokine responsible for inflammatory responses in skin, induces the synthesis of matrix metalloproteinase-9 (MMP-9), which causes skin aging. … The results showed that 3-deoxysappanchalcone inhibited MMP-9 expression at the protein and mRNA level, by blocking the activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF-κB). …
NAID 130000738066