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1. 神経筋疾患の評価における筋酵素muscle enzymes in the evaluation of neuromuscular diseases [show details]
… myopathies. Thus, serum creatine kinase (CK) activity >1000 units/L helps to distinguish muscle disease from neurogenic causes of weakness and muscle atrophy. More modest elevation of CK may occur in some primary …
2. 腎不全患者における血清心臓バイオマーカーserum cardiac biomarkers in patients with renal failure [show details]
…isoenzyme of creatine kinase (CK-MB) is not the preferred biomarker but can still be used in the absence of cardiac troponin assays. This topic reviews the clinical use of cardiac troponins and CK-MB in patients …
3. デュシェンヌ型およびベッカー型筋ジストロフィー：臨床的特徴および診断duchenne and becker muscular dystrophy clinical features and diagnosis [show details]
…Serum creatine kinase (CK) concentrations are elevated in children with DMD prior to the appearance of any clinical signs of disease; increased levels are even observed among newborns . Serum CK peaks… dystrophin analysis is indicated, including transcriptome analysis if available . A Western blot assay of dystrophin derived from a muscle biopsy specimen can also be used to predict the severity of the …
4. 横紋筋融解症の臨床症状および診断clinical manifestations and diagnosis of rhabdomyolysis [show details]
… electrocardiogram (ECG) signs of myocardial infarction. Additionally, the CK-MM fraction is elevated, while little or no CK-MB is present. Assays for cardiac troponins (both the I and T isoforms) are highly sensitive …
5. トロポニンを除く心臓外傷のバイオマーカーbiomarkers of cardiac injury other than troponin [show details]
… adjunct to either troponin or creatine kinase MB (CK-MB) for the early diagnosis of myocardial infarction (MI) . With contemporary, highly sensitive cardiac troponin (cTn) assays and the use of the 99th percentile …

English Journal

Relation of Chronic Total Occlusion to In-Hospital Mortality in the Patients With Sudden Cardiac Arrest Due to Acute Coronary Syndrome.

Shinouchi K, Ueda Y, Kato T, Nishida H, Ozaki T, Kosugi S, Iida Y, Toriyama C, Ohashi T, Nakamura M, Fukushima T, Horiuchi K, Mishima T, Abe H, Awata M, Date M, Uematsu M, Koretsune Y.
The American journal of cardiology. 2019 Jun;123(12)1915-1920.
Although the presence of chronic total occlusion (CTO) has been associated with long-term mortality in the patients with ST-segment elevation myocardial infarction, the influence of having CTO on in-hospital mortality in sudden cardiac arrest (SCA)-acute coronary syndrome (ACS) patients has not been
PMID 30967290

Expression of miRNA-214 in the sera of elderly patients with acute myocardial infarction and its effect on cardiomyocyte apoptosis.

Yin Y, Lv L, Wang W.
Experimental and therapeutic medicine. 2019 Jun;17(6)4657-4662.
The aim of the present study was to investigate the expression of microRNA (miRNA/miR)-214 in the sera of elderly patients with acute myocardial infarction (AMI) and the mechanism of how its expression affects cardiomyocyte apoptosis in these patients. The expression levels of miRNA-214 in elderly p
PMID 31086597

Pre-treatment with a combination of Shenmai and Danshen injection protects cardiomyocytes against hypoxia/reoxygenation- and HO-induced injury by inhibiting mitochondrial permeability transition pore opening.

Li L, Sha Z, Wang Y, Yang D, Li J, Duan Z, Wang H, Li Y.
Experimental and therapeutic medicine. 2019 Jun;17(6)4643-4652.
Increasing evidence has indicated that opening of the mitochondrial permeability transition pore (mPTP) has a vital role in myocardial ischemia/reperfusion (I/R) injury. Shenmai injection (SMI) plus Danshen injection (DSI) combination, termed Yiqi Yangyin Huoxue (YYH) therapy is used in the clinic t
PMID 31086595

Japanese Journal

診断未確定慢性ミオパチーにおける壊死性ミオパチー関連抗体スクリーニング

久留聡,鈴木重明,尾方克久,小林道雄,石田千穂,渡辺千種,松村剛
臨床神経学 57(10), 562-566, 2017
<p>診断未確定慢性ミオパチーを対象に抗signal recognition particle（SRP）抗体および抗HMG-CoA還元酵素（3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMGCR）抗体のスクリーニングを行った．対象42例のうち抗SRP抗体陽性2例，抗HMGCR抗体陽性2例であった．抗SRP抗体陽性例は，嚥下障害を示し …
NAID 130006183836

Simultaneous Measurement of Adenosine 3',5'-Cyclic Monophosphate and Guanosine 3',5'-Cyclic Monophosphate in Biological Samples

Seya Kazuhiko,Motomura Shigeru,Imaizumi Tadaatsu,Furukawa Ken-Ichi
弘前医学 68(1), 52-61, 2017
… The remaining GDP was converted to GTP by creatine kinase.Cyclic GMP and cAMP, absorbed into a Sep-Pak amino propyl cartridge, were eluted to separate from GTP, andthen were simultaneously quantified using improved enzymatic fluorometric assay. …
NAID 120006353796

Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders

Yatsuga Shuichi,Fujita Yasunori,Ishii Akiko,Fukumoto Yoshihiro,Arahata Hajime,Kakuma Tatsuyuki,Kojima Toshio,Ito Masafumi,Tanaka Masashi,Saiki Reo,Koga Yasutoshi
Annals of neurology 78(5), 814-823, 2015-11
… GDF-15 and FGF-21 concentrations were measured by enzyme-linked immunosorbant assay and compared with lactate, pyruvate, creatine kinase, and the lactate-to-pyruvate ratio. …
NAID 120005678336