関: titin

WordNet

a rod that transmits motion (especially one that connects a rotating wheel to a reciprocating shaft)
a flight with an intermediate stop and a change of aircraft (possibly a change of airlines)
a hotel room that shares a wall with an adjoining room and is connected by a private door
land on or hit solidly; "The brick connected on her head, knocking her out"
be or become joined or united or linked; "The two streets connect to become a highway"; "Our paths joined"; "The travelers linked up again at the airport" (同)link, link up, join, unite
connect, fasten, or put together two or more pieces; "Can you connect the two loudspeakers?"; "Tie the ropes together"; "Link arms" (同)link, tie, link up
be scheduled so as to provide continuing service, as in transportation; "The local train does not connect with the Amtrak train"; "The planes dont connect and you will have to wait for four hours"
establish a rapport or relationship; "The President of this university really connects with the faculty"
hit or play a ball successfully; "The batter connected for a home run"
join by means of communication equipment; "The telephone company finally put in lines to connect the towns in this area"
join for the purpose of communication; "Operator, could you connect me to the Raffles in Singapore?"

PrepTutorEJDIC

〈2個の物〉'を'『連結する』,結びつける;(…と)…'を'結合する電話でつなぐ《+『名』+『with』(『to』)+『名』》 / 《受動態で》(…と)…'を'『関係させる』,親類関係にする《+『名』+『with』+『名』》 / (…で)…'を'連想する,結びつけて考える《+『名』+『with』+『名』》 / 〈物・事柄などが〉(…と)関連している,つながる《+『with』+『名』(『wh-節』)》 / 〈交通機関が〉(…と)連絡(接続)している《+『with』+『名』》

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/22 09:37:43」(JST)

wiki en

Titin /ˈtaɪtɪn/, also known as connectin, is a protein that, in humans, is encoded by the TTN gene.^[1]^[2] Titin is a giant protein, greater than 1 µm in length,^[3] that functions as a molecular spring which is responsible for the passive elasticity of muscle. It is composed of 244 individually folded protein domains connected by unstructured peptide sequences.^[4] These domains unfold when the protein is stretched and refold when the tension is removed.^[5]

Titin is important in the contraction of striated muscle tissues. It connects the Z line to the M line in the sarcomere. The protein contributes to force transmission at the Z line and resting tension in the I band region.^[6] It limits the range of motion of the sarcomere in tension, thus contributing to the passive stiffness of muscle. Variations in the sequence of titin between different types of muscle (e.g., cardiac or skeletal) have been correlated with differences in the mechanical properties of these muscles.^[1]^[7]

After myosin and actin, titin is the third most abundant protein in muscle and an adult human contains approximately 0.5 kg of titin.^[8] With its length of ~27,000 to ~33,000 amino acids (depending on the splice isoform), titin is the largest known protein.^[9] Furthermore, the gene for titin contains the largest number of exons (363) discovered in any single gene,^[10] as well as the longest single exon (17,106 bp).

Discovery

Reiji Natori in 1954 was the first to propose an elastic structure in muscle fiber to account for the return to the resting state when muscles are stretched and then released.^[11] In 1977, Koscak Maruyama and coworkers isolated an elastic protein from muscle fiber which they called connectin.^[12] Two years later, Kuan Wang and coworkers identified a doublet band on electrophoresis gel corresponding to a high molecular weight elastic protein which they named titin.^[13]^[14]

Labeit in 1990 isolated a partial cDNA clone of titin.^[2] In 1995, Labeit and Kolmerer determined the cDNA sequence of human cardiac titin.^[4] Bang and coworkers in 2001 determined the complete sequence of the human titin gene.^[10]^[15]

Genomics

The human gene that encodes titin is found on chromosome 2 and contains 363 exons.

Isoforms

A number of titin isoforms are produced in different striated muscle tissues as a result of alternative splicing.^[16] All but one of these isoforms are in the range of ~27,000 to ~33,000 amino acid residues in length. The exception is the small cardiac novex-3 isoform which is only 5,604 amino acid residues in length. The following table lists the known titin isoforms:

Isoform	alias/description	length	MW
Q8WZ42-1	the "canonical" full length sequence	34,350	3,816,030
Q8WZ42-2		34,258	3,805,708
Q8WZ42-3	small cardiac N2-B	26,926	2,992,939
Q8WZ42-4	soleus	33,445	3,716,027
Q8WZ42-5		32,900	3,653,085
Q8WZ42-6	small cardiac novex-3, phosphorylated on Thr-5304 and Ser-5306.	5,604	631,567
Q8WZ42-7	cardiac novex-2	27,118	3,734,648
Q8WZ42-8	cardiac novex-1	27,051	3,829,846
Q8WZ42-9		27,118	3,013,957
Q8WZ42-10		27,051	3,006,755
Q8WZ42-11		33,423	3,713,600

Structure

Titin is the largest known protein; its human variant consists of 34,350 amino acids, with the molecular weight of the mature "canonical" isoform of the protein being approximately 3,816,188.13 Da.^[17] Its mouse homologue is even larger, comprising 35,213 amino acids with a MW of 3,906,487.6 Da.^[18] It has a theoretical isoelectric point of 6.01.^[17] The protein's empirical chemical formula is C_{169 723}H_{270 464}N_{45 688}O_{52 243}S₉₁₂.^[17] It has a theoretical instability index (II) of 42.41, classifying the protein as unstable.^[17] The protein's in vivo half-life, the time it takes for half of the amount of protein in a cell to break down after its synthesis in the cell, is predicted to be approximately 30 hours (in mammalian reticulocytes).^[16]

The titin protein is located between the myosin thick filament and the Z disk.^[19] Titin consists primarily of a linear array of two types of modules (also referred to as protein domains; 244 copies in total): type I (fibronectin type III domain; 132 copies) and type II (immunoglobulin domain; 112 copies).^[4] This linear array is further organized into two regions:

N-terminal I-band: acts as the elastic part of the molecule and is composed mainly of type II modules. More specifically the I-band contains two regions of tandem type II immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine.^[19]
C-terminal A-band: is thought to act as a protein-ruler and possesses kinase activity. The A-band is composed of alternating type I and II modules with super-repeat segments. These have been shown to align to the 43 nm axial repeats of myosin thick filaments with immunoglobulin domains correlating to myosin crowns.^[20]

Function

Sliding filament model of muscle contraction. (Titin labeled at upper right.)

Titin is a large abundant protein of striated muscle. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle-associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes.^[21]^[22] Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Of the many titin variants identified, five are described with complete transcript information available.^[1]^[2]

Titin interacts with many sarcomeric proteins including:^[10]

Z line region: telethonin and alpha-actinin
I band region: calpain-3 and obscurin
M line region: myosin-binding protein C, calmodulin 1, CAPN3, and MURF1

Clinical relevance

Mutations anywhere within the unusually long sequence of this gene can cause premature stop codons or other defects. Titin mutations are associated with hereditary myopathy with early respiratory failure, early-onset myopathy with fatal cardiomyopathy, core myopathy with heart disease, centronuclear myopathy, Limb-girdle muscular dystrophy type 2J, familial dilated cardiomyopathy 9,^[6]^[23] hypertrophic cardiomyopathy and tibial muscular dystrophy.^[24] Further research also suggests that no genetically linked form of any dystrophy or myopathy can be safely excluded from being caused by a mutation on the TTN gene.^[25] Truncating mutations in dilated cardiomyopathy patients are most commonly found in the A region; although truncations in the upstream I region might be expected to prevent translation of the A region entirely, alternative splicing creates some transcripts that do not encounter the premature stop codon, ameliorating its effect.^[26]

Autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.^[21]

Interactions

Titin has been shown to interact with:

ANK1,^[27]
ANKRD1,^[28]
ANKRD23^[28]
CAPN3,^[29]^[30]
FHL2,^[31]
OBSCN,^[32]
TCAP,^[33]^[34]^[35]^[36] and
TRIM63.^[37]

Linguistic significance

The name titin is derived from the Greek Titan (a giant deity, anything of great size).^[13]

As the largest known protein, titin also has the longest IUPAC name of a protein. The full chemical name of the human canonical form of titin, which starts methionyl... and ends ...isoleucine, contains 189,819 letters and is sometimes stated to be the longest word in the English language, or any language.^[38]^[39] However, lexicographers regard generic names of chemical compounds as verbal formulae rather than English words.^[40]

References

^ ^a ^b ^c "Entrez Gene: TTN titin".
^ ^a ^b ^c Labeit S, Barlow DP, Gautel M, Gibson T, Holt J, Hsieh CL, Francke U, Leonard K, Wardale J, Whiting A (1990). "A regular pattern of two types of 100-residue motif in the sequence of titin". Nature 345 (6272): 273–6. doi:10.1038/345273a0. PMID 2129545.
^ Eric H. Lee. "The Chain-like Elasticity of Titin". Theoretical and Computational Biophysics Group, University of Illinois. Retrieved September 2014.
^ ^a ^b ^c Labeit S, Kolmerer B (1995). "Titins: giant proteins in charge of muscle ultrastructure and elasticity". Science 270 (5234): 293–6. doi:10.1126/science.270.5234.293. PMID 7569978.
^ Minajeva A, Kulke M, Fernandez JM, Linke WA (2001). "Unfolding of titin domains explains the viscoelastic behavior of skeletal myofibrils". Biophys. J. 80 (3): 1442–51. doi:10.1016/S0006-3495(01)76116-4. PMC 1301335. PMID 11222304.
^ ^a ^b Itoh-Satoh M, Hayashi T, Nishi H, Koga Y, Arimura T, Koyanagi T, Takahashi M, Hohda S, Ueda K, Nouchi T, Hiroe M, Marumo F, Imaizumi T, Yasunami M, Kimura A (2002). "Titin mutations as the molecular basis for dilated cardiomyopathy". Biochem. Biophys. Res. Commun. 291 (2): 385–93. doi:10.1006/bbrc.2002.6448. PMID 11846417.
^ Online 'Mendelian Inheritance in Man' (OMIM) 188840
^ Labeit S, Kolmerer B, Linke WA (1997). "The giant protein titin. Emerging roles in physiology and pathophysiology". Circ. Res. 80 (2): 290–4. doi:10.1161/01.RES.80.2.290. PMID 9012751.
^ Opitz CA, Kulke M, Leake MC, Neagoe C, Hinssen H, Hajjar RJ, Linke WA (2003). "Damped elastic recoil of the titin spring in myofibrils of human myocardium". Proc. Natl. Acad. Sci. U.S.A. 100 (22): 12688–93. doi:10.1073/pnas.2133733100. PMC 240679. PMID 14563922.
^ ^a ^b ^c Bang ML, Centner T, Fornoff F, Geach AJ, Gotthardt M, McNabb M, Witt CC, Labeit D, Gregorio CC, Granzier H, Labeit S (2001). "The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system". Circ. Res. 89 (11): 1065–72. doi:10.1161/hh2301.100981. PMID 11717165.
^ Natori R (1954). "Skinned Fibres of Skeletal Muscle and the Mechanism of Muscle Contraction－A Chronological Account of the Author's Investigations into Muscle Physiology" (PDF). Jikeikai Medical Journal 54 (1).
^ Maruyama K, Matsubara S, Natori R, Nonomura Y, Kimura S (1977). "Connectin, an elastic protein of muscle. Characterization and Function". J. Biochem. 82 (2): 317–37. PMID 914784.
^ ^a ^b Wang K, McClure J, Tu A (1979). "Titin: major myofibrillar components of striated muscle". Proc. Natl. Acad. Sci. U.S.A. 76 (8): 3698–702. doi:10.1073/pnas.76.8.3698. PMC 383900. PMID 291034.
^ Maruyama K (1994). "Connectin, an elastic protein of striated muscle". Biophys. Chem. 50 (1-2): 73–85. doi:10.1016/0301-4622(94)85021-6. PMID 8011942.
^ Online 'Mendelian Inheritance in Man' (OMIM) Titin -188840
^ ^a ^b "Titin - Homo sapiens (Human)". Universal Protein Resource. UniProt Consortium. 2010-10-05. Retrieved 2010-10-15.
^ ^a ^b ^c ^d "ProtParam for human titin". ExPASy Proteomics Server. Swiss Institute of Bioinformatics. Retrieved 2011-07-25.
^ "ProtParam for mouse titin". ExPASy Proteomics Server. Swiss Institute of Bioinformatics. Retrieved 2010-05-06.
^ ^a ^b Wang K, McCarter R, Wright J, Beverly J, Ramirez-Mitchell R (1991). "Regulation of skeletal muscle stiffness and elasticity by titin isoforms: a test of the segmental extension model of resting tension". Proc. Natl. Acad. Sci. U.S.A. 88 (16): 7101–5. doi:10.1073/pnas.88.16.7101. PMC 52241. PMID 1714586.
^ Bennett PM, Gautel M (1996). "Titin domain patterns correlate with the axial disposition of myosin at the end of the thick filament". J. Mol. Biol. 259 (5): 896–903. doi:10.1006/jmbi.1996.0367. PMID 8683592.
^ ^a ^b Machado C, Sunkel CE, Andrew DJ (1998). "Human autoantibodies reveal titin as a chromosomal protein". J. Cell Biol. 141 (2): 321–33. doi:10.1083/jcb.141.2.321. PMC 2148454. PMID 9548712.
^ Machado C, Andrew DJ (2000). "Titin as a chromosomal protein". Adv. Exp. Med. Biol. 481: 221–32; discussion 232–6. doi:10.1007/978-1-4615-4267-4_13. PMID 10987075.
^ Siu BL, Niimura H, Osborne JA, Fatkin D, MacRae C, Solomon S, Benson DW, Seidman JG, Seidman CE (1999). "Familial dilated cardiomyopathy locus maps to chromosome 2q31". Circulation 99 (8): 1022–6. doi:10.1161/01.cir.99.8.1022. PMID 10051295.
^ Hackman P, Vihola A, Haravuori H, Marchand S, Sarparanta J, De Seze J, Labeit S, Witt C, Peltonen L, Richard I, Udd B (2002). "Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin". Am. J. Hum. Genet. 71 (3): 492–500. doi:10.1086/342380. PMC 379188. PMID 12145747.
^ Udd B, Vihola A, Sarparanta J, Richard I, Hackman P (2005). "Titinopathies and extension of the M-line mutation phenotype beyond distal myopathy and LGMD2J". Neurology 64 (4): 636–42. doi:10.1212/01.WNL.0000151853.50144.82. PMID 15728284.
^ Hinson JT, Chopra A, Nafissi N, Polacheck WJ, Benson CC, Swist S, et al. (2015). "Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy". Science 349 (6251): 982–6. doi:10.1126/science.aaa5458. PMID 26315439.
^ Kontrogianni-Konstantopoulos A, Bloch RJ (2003). "The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin". J. Biol. Chem. 278 (6): 3985–91. doi:10.1074/jbc.M209012200. PMID 12444090.
^ ^a ^b Miller MK, Bang ML, Witt CC, Labeit D, Trombitas C, Watanabe K, Granzier H, McElhinny AS, Gregorio CC, Labeit S (2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". J. Mol. Biol. 333 (5): 951–64. doi:10.1016/j.jmb.2003.09.012. PMID 14583192.
^ Ono Y, Shimada H, Sorimachi H, Richard I, Saido TC, Beckmann JS, Ishiura S, Suzuki K (1998). "Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A". J. Biol. Chem. 273 (27): 17073–8. doi:10.1074/jbc.273.27.17073. PMID 9642272.
^ Sorimachi H, Kinbara K, Kimura S, Takahashi M, Ishiura S, Sasagawa N, Sorimachi N, Shimada H, Tagawa K, Maruyama K (1995). "Muscle-specific calpain, p94, responsible for limb girdle muscular dystrophy type 2A, associates with connectin through IS2, a p94-specific sequence". J. Biol. Chem. 270 (52): 31158–62. doi:10.1074/jbc.270.52.31158. PMID 8537379.
^ Lange S, Auerbach D, McLoughlin P, Perriard E, Schäfer BW, Perriard JC, Ehler E (2002). "Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2". J. Cell. Sci. 115 (Pt 24): 4925–36. doi:10.1242/jcs.00181. PMID 12432079.
^ Young P, Ehler E, Gautel M (2001). "Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly". J. Cell Biol. 154 (1): 123–36. doi:10.1083/jcb.200102110. PMC 2196875. PMID 11448995.
^ Gregorio CC, Trombitás K, Centner T, Kolmerer B, Stier G, Kunke K, Suzuki K, Obermayr F, Herrmann B, Granzier H, Sorimachi H, Labeit S (1998). "The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity". J. Cell Biol. 143 (4): 1013–27. doi:10.1083/jcb.143.4.1013. PMC 2132961. PMID 9817758.
^ Mayans O, van der Ven PF, Wilm M, Mues A, Young P, Fürst DO, Wilmanns M, Gautel M (1998). "Structural basis for activation of the titin kinase domain during myofibrillogenesis". Nature 395 (6705): 863–9. doi:10.1038/27603. PMID 9804419.
^ Zou P, Gautel M, Geerlof A, Wilmanns M, Koch MH, Svergun DI (2003). "Solution scattering suggests cross-linking function of telethonin in the complex with titin". J. Biol. Chem. 278 (4): 2636–44. doi:10.1074/jbc.M210217200. PMID 12446666.
^ Mues A, van der Ven PF, Young P, Fürst DO, Gautel M (1998). "Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin". FEBS Lett. 428 (1-2): 111–4. doi:10.1016/S0014-5793(98)00501-8. PMID 9645487.
^ Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S (2001). "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain". J. Mol. Biol. 306 (4): 717–26. doi:10.1006/jmbi.2001.4448. PMID 11243782.
^ McCulloch S. "Longest word in English". Sarah McCulloch.com. Retrieved 2010-05-24.
^ "What is the longest word in the English language?". CliffsNotes.com. Retrieved 2014-08-12.
^ Oxford Word and Language Service team. "Ask the experts - What is the longest English word?". AskOxford.com / Oxford University Press. Archived from the original on 2008-09-13. Retrieved 2008-01-13.

External links

GeneReviews/NIH/NCBI/UW entry on Familial Hypertrophic Cardiomyopathy Overview
GeneReviews/NCBI/NIH/UW entry on Udd Distal Myopathy, Tibial Muscular Dystrophy, Udd Myopathy
GeneReviews/NIH/NCBI/UW entry on Salih Myopathy or Early-Onset Myopathy with Fatal Cardiomyopathy
Full chemical name of Titin
Part of the chemical name of Titin pronounced
World's Longest Word Has 189,819 Letters, Takes 3.5 Hours To Pronounce (Now With Video Pronunciation!) | Geekologie

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

English Journal

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Lindstedt SL1, Nishikawa KC2.
American journal of physiology. Regulatory, integrative and comparative physiology.Am J Physiol Regul Integr Comp Physiol.2015 Jun 15;308(12):R983-R989. doi: 10.1152/ajpregu.00405.2014. Epub 2015 Apr 8.
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Necklace cytoplasmic bodies in hereditary myopathy with early respiratory failure.

Uruha A1, Hayashi YK2, Oya Y3, Mori-Yoshimura M3, Kanai M3, Murata M3, Kawamura M4, Ogata K5, Matsumura T6, Suzuki S7, Takahashi Y8, Kondo T9, Kawarabayashi T10, Ishii Y11, Kokubun N11, Yokoi S12, Yasuda R13, Kira J14, Mitsuhashi S15, Noguchi S15, Nonaka I16, Nishino I15.
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BACKGROUND: In hereditary myopathy with early respiratory failure (HMERF), cytoplasmic bodies (CBs) are often localised in subsarcolemmal regions, with necklace-like alignment (necklace CBs), in muscle fibres although their sensitivity and specificity are unknown.OBJECTIVE: To elucidate the diagnost
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Japanese Journal

コネクチンnovex-3は低酸素下の胎児期心筋細胞の分裂を促進する

生体医工学 Annual56(Abstract), S344-S344, 2018
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Extension restriction of coronary circulation hearts by shortening of the elastic protein connectin

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拡張検索	「connecting fiber」「connecting strand」「connecting filament」
関連記事	「connect」

「connecting fiber」

Titin
	The three-dimensional structure of a type I module from titin. PDB rendering based on 1bpv.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1BPV, 1G1C, 1NCT, 1NCU, 1TIT, 1TIU, 1TKI, 1TNM, 1TNN, 1WAA, 1YA5, 2A38, 2BK8, 2F8V, 2ILL, 2J8H, 2J8O, 2NZI, 2RQ8, 2WP3, 2WWK, 2WWM, 2Y9R, 3B43, 3KNB, 3LCY, 3LPW, 3PUC, 3Q5O, 3QP3, 4C4K, 4JNW, 4O00, 4UOW
Identifiers
Symbols	TTN ; CMD1G; CMH9; CMPD4; EOMFC; HMERF; LGMD2J; MYLK5; TMD
External IDs	OMIM: 188840 MGI: 98864 HomoloGene: 130650 GeneCards: TTN Gene
EC number	2.7.11.1
Gene ontology
Molecular function	• protease binding; • protein serine/threonine kinase activity; • protein tyrosine kinase activity; • calcium ion binding; • protein binding; • calmodulin binding; • ATP binding; • structural constituent of muscle; • enzyme binding; • protein kinase binding; • telethonin binding; • identical protein binding; • actinin binding; • protein self-association; • actin filament binding; • muscle alpha-actinin binding; • structural molecule activity conferring elasticity;
Cellular component	• condensed nuclear chromosome; • extracellular region; • cytosol; • striated muscle thin filament; • Z disc; • M band; • I band; • extracellular exosome;
Biological process	• platelet degranulation; • cardiac muscle hypertrophy; • muscle contraction; • striated muscle contraction; • mitotic chromosome condensation; • blood coagulation; • peptidyl-tyrosine phosphorylation; • muscle filament sliding; • platelet activation; • skeletal muscle thin filament assembly; • skeletal muscle myosin thick filament assembly; • detection of muscle stretch; • sarcomere organization; • regulation of protein kinase activity; • cardiac muscle fiber development; • sarcomerogenesis; • regulation of catalytic activity; • response to calcium ion; • cardiac myofibril assembly; • cardiac muscle tissue morphogenesis; • cardiac muscle contraction;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;