補体D因子、補体因子D
- 関
- factor D
WordNet
- make complete or perfect; supply what is wanting or form the complement to; "I need some pepper to complement the sweet touch in the soup"
- a complete number or quantity; "a full complement"
- one of a series of enzymes in the blood serum that are part of the immune response
- something added to complete or embellish or make perfect; "a fine wine is a perfect complement to the dinner"; "wild rice was served as an accompaniment to the main dish" (同)accompaniment
- number needed to make up a whole force; "a full complement of workers" (同)full complement
- a word or phrase used to complete a grammatical construction
- either of two parts that mutually complete each other
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- the 4th letter of the Roman alphabet (同)d
PrepTutorEJDIC
- (あるものを完全にするため)(…を)補う物(事)《+『of』+『名』》 / 補語(文法で文の成分の一つ) / (必要な)全数,全量;(船の)定員 / …を補足する,補う
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
- deuteriumの化学記号
- (おもに人称代名詞・固有名詞(人名),thereの後で)had, wouldの短縮形 / (疑問文でwhere,what,whenの後で)didの短縮形;Where'd he go?=Where did he go?
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/27 17:57:28」(JST)
[Wiki en表示]
| complement factor D (adipsin) |
|
Factor D in Homo sapiens [1]
|
| Identifiers |
| Symbol |
CFD |
| Alt. symbols |
DF, PFD |
| Entrez |
1675 |
| HUGO |
2771 |
| OMIM |
134350 |
| RefSeq |
NM_001928 |
| UniProt |
P00746 |
| Other data |
| Locus |
Chr. 19 p13.3 |
Factor D (EC 3.4.21.46, C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, CFD, adipsin) a protein which in humans is encoded by the CFD gene.[2] Factor D is involved in the alternative complement pathway of the complement system where it cleaves factor B.
Contents
- 1 Function
- 2 Clinical significance
- 3 Structure
- 4 References
- 5 External links
Function
The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.[2]
Alternative pathway. ( 4. Is factor D cleaving B to Bb and Ba)
Factor D is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis.[3]
Clinical significance
The level of Factor D is elevated in the obese, this elevation may be due to high activity or resistance but exact cause is not totally known.
Structure
All members of the chymotrypsin family of serine proteases have very similar structures. In all cases, including factor D, there are two antiparallel β-barrel domains with each barrel containing six β-strands with the same typology in all enzymes. The major difference in backbone structure between Factor D and the other serine proteases of the chymotrpsin family is in the surface loops connecting the secondary structural elements. Factor D displays different conformations of major catalytic and substrate-binding residues typically found in the chrotrypsin family. These features suggest the catalytic activity of factor D is prohibited unless conformational changes are induced by a realignment.[4]
References
- ^ PDB 1HFD; Narayana SV, Carson M, el-Kabbani O et al. (January 1994). "Structure of human factor D. A complement system protein at 2.0 A resolution". J. Mol. Biol. 235 (2): 695–708. doi:10.1006/jmbi.1994.1021. PMID 8289289.
- ^ a b "Entrez Gene: CFD".
- ^ Ronti T, Lupattelli G, Mannarino E (April 2006). "The endocrine function of adipose tissue: an update". Clin. Endocrinol. (Oxf) 64 (4): 355–65. doi:10.1111/j.1365-2265.2006.02474.x. PMID 16584505. Lay summary – medscape.com.
- ^ Volanakis JE, Narayana SV (April 1996). "Complement factor D, a novel serine protease". Protein Sci. 5 (4): 553–64. doi:10.1002/pro.5560050401. PMC 2143395. PMID 8845746.
External links
- Complement Factor D at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Proteins: complement system (C, L, A)
|
|
| Activators/enzymes |
| Early |
- A: Factor B
- Factor D
- Factor P/Properdin
|
|
| Middle |
- C3-convertase
- C5-convertase
|
|
| Late |
|
|
|
| Inhibitors |
- CLA: C1-inhibitor
- Decay-accelerating factor/CD59
- Factor I
|
|
| Complement receptors |
- CR1
- CR2
- CR3
- CR4
- CD11b/CD11c/CD18
- Anaphylatoxin
|
|
|
Index of the immune system
|
|
| Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
|
|
| Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
|
|
| Treatment |
- Procedures
- Drugs
- antihistamines
- immunostimulants
- immunosuppressants
- monoclonal antibodies
|
|
|
|
Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
|
|
| Digestive enzymes |
- Enteropeptidase
- Trypsin
- Chymotrypsin
- Elastase
|
|
| Coagulation |
- factors: Thrombin
- Factor VIIa
- Factor IXa
- Factor Xa
- Factor XIa
- Factor XIIa
- Kallikrein
- PSA
- KLK1
- KLK2
- KLK3
- KLK4
- KLK5
- KLK6
- KLK7
- KLK8
- KLK9
- KLK10
- KLK11
- KLK12
- KLK13
- KLK14
- KLK15
- fibrinolysis: Plasmin
- Plasminogen activator
- Tissue plasminogen activator
- Urinary plasminogen activator
|
|
| Complement system |
- Factor B
- Factor D
- Factor I
- MASP
- C3-convertase
|
|
| Other immune system |
- Chymase
- Granzyme
- Tryptase
- Proteinase 3/Myeloblastin
|
|
| Venombin |
|
|
| Other |
- Acrosin
- Prolyl endopeptidase
- Pronase
- Proprotein convertases
- Reelin
- Subtilisin/Furin
- Streptokinase
- S1P
- Cathepsin
|
|
- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
UpToDate Contents
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- 1. 補体系の後天性疾患 acquired disorders of the complement system
- 2. 尿毒症毒素 uremic toxins
- 3. 血液-血液透析膜の相互作用に関与する生化学的機序 biochemical mechanisms involved in blood hemodialysis membrane interactions
- 4. 補体経路 complement pathways
- 5. 補体系の遺伝性疾患 inherited disorders of the complement system
English Journal
- Mid-trimester amniotic fluid pro-inflammatory biomarkers predict the risk of spontaneous preterm delivery in twins: a retrospective cohort study.
- Lee SM1, Park JS2, Norwitz ER3, Oh S4, Kim EJ2, Kim SM2, Lee J2, Kim BJ1, Park CW2, Jun JK2.
- Journal of perinatology : official journal of the California Perinatal Association.J Perinatol.2015 Apr 9. doi: 10.1038/jp.2015.29. [Epub ahead of print]
- OBJECTIVE: To evaluate the association between the concentrations of immune-related proteins in mid-trimester amniotic fluid (AF) and the subsequent risk of spontaneous preterm delivery in twins.STUDY DESIGN: The study population consisted of consecutive women with a twin pregnancy who underwent cli
- PMID 25856763
- Plasma adipokine levels in Thais.
- Leelahagul P1, Bovornkitti S.
- Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand.Asian Pac J Allergy Immunol.2015 Mar;33(1):59-64. doi: 10.12932/AP0501.33.1.2015.
- OBJECTIVE: To assess three plasma adipokines that might act as biomarkers useful in determining persons exposed to asbestos.METHOD: Sixty subjects were included in the study, 30 male workers from factories manufacturing cement products using chrysotile asbestos, and 30 volunteer controls comprising
- PMID 25840635
- PMID 25467802
Japanese Journal
- Atypical hemolytic uremic syndrome and genetic aberrations in the complement factor H-related 5 gene
- Westra Dineke,Vernon Katherine A,Volokhina Elena B [他]
- Journal of human genetics 57(7), 459-464, 2012-07
- NAID 40019350936
- 吉田 瑶子,松本 雅則,早川 正樹,藤村 吉博
- 日本アフェレシス学会雑誌 31(1), 27-32, 2012-02-29
- … Recent studies have revealed that aHUS is a disease of complement dysregulation with 50-60% of cases involving the complement regulatory genes, factor H (CFH), membrane cofactor protein (MCP;CD46) and factor I (FI) and so on. … Therefore, it is necessary to establish an appropriate diagnostic pathway focusing on the complement system for choosing the most favorable therapeutic approach in Japan. …
- NAID 110009327450
Related Links
- Information about Complement factor d in Free online English dictionary. What is Complement factor d? Meaning of Complement factor d medical term. What does Complement factor d mean? Complement factor d - definition of ...
- 1. Biesma, D. H., Hannema, A. J., van Velzen-Blad, H., Mulder, L., van Zwieten, R., Kluijt, I., Roos, D. A family with complement factor D deficiency. J. Clin. Invest. 108: 233-240, 2001. [PubMed: 11457876, related citations ...
★リンクテーブル★
[★]
- 英
- complement factor D、factor D
- 関
- D因子、補体因子D
[★]
- 英
- complement factor D
- 関
- 補体D因子
[★]
[★]
- 補って完全にする物、補完物。(免疫)補体
- (必要な)全数、善良
[★]
- 関
- actual、actually、in fact、in practice、indeed、practically
[★]
- 関
- element、elementary、factorial、parameter