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1. 小児の頸椎の可動性抑制pediatric cervical spinal motion restriction [show details]
…patients is as follows: Manual in-line stabilization of the cervical spine which may be augmented by a rigid cervical collar; Log-rolling of the patient while cervical spine motion is being restricted …
2. 子宮頸部上皮内腫瘍：治療およびフォローアップcervical intraepithelial neoplasia treatment and follow up [show details]
… tests for cervical cancer include cervical cytology and testing for oncogenic subtypes of human papillomavirus Follow-up of abnormalities in screening tests with colposcopy and cervical biopsy may… Hysterectomy is not a first-line treatment for CIN because the risk of significant…
3. 小児や青年の頸椎損傷の評価と急性期のマネージメントevaluation and acute management of cervical spine injuries in children and adolescents [show details]
…evaluating the posterior cervical (Swischuk) line between the anterior aspects of the C1 and C3 spinous processes . True subluxation should be suspected if the posterior cervical line misses the anterior aspect …
4. 自然早産予測のための、妊娠中期の子宮頸部長測定second trimester evaluation of cervical length for prediction of spontaneous preterm birth [show details]
… separate, straight lines joined at an angle along the curved length of cervix is determined: This sum is used for the cervical length if the distance between the angle and a straight line from the internal …
5. 小児期や思春期のアスリートにおける頸髄および頸部末梢神経損傷の概要overview of cervical spinal cord and cervical peripheral nerve injuries in the child or adolescent athlete [show details]
… relieve the pressure on the nerve. These include maintenance of proper posture and the use of in-line cervical traction devices. Antiinflammatory and analgesic measures such as nonsteroidal antiinflammatory …

English Journal

Photosynthesized gold nanoparticles from Catharanthus roseus induces caspase-mediated apoptosis in cervical cancer cells (HeLa).

Ke Y, Al Aboody MS, Alturaiki W, Alsagaby SA, Alfaiz FA, Veeraraghavan VP, Mickymaray S.
Artificial cells, nanomedicine, and biotechnology. 2019 Dec;47(1)1938-1946.
Bionanotechnology has pivotal role in the development of a novel therapy, applications of gold nanoparticles (AuNPs) in the treatment of cancer. In this study, we found that therapeutics, pharmaceutics and diagnostic effectiveness of photosynthesized Catharanthus roseus (CR) AuNPs induces mitochondr
PMID 31099261

Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview.

Farooq MA, Aquib M, Farooq A, Haleem Khan D, Joelle Maviah MB, Sied Filli M, Kesse S, Boakye-Yiadom KO, Mavlyanova R, Parveen A, Wang B.
Artificial cells, nanomedicine, and biotechnology. 2019 Dec;47(1)1674-1692.
Cisplatin cis-(diammine)dichloridoplatinum(II) (CDDP) is the first platinum-based complex approved by the food and drug administration (FDA) of the United States (US). Cisplatin is the first line chemotherapeutic agent used alone or combined with radiations or other anti-cancer agents for a broad ra
PMID 31066300

miR-429 suppresses cell growth and induces apoptosis of human thyroid cancer cell by targeting ZEB1.

Wu G, Zheng H, Xu J, Guo Y, Zheng G, Ma C, Hao S, Liu X, Chen H, Wei S, Song X, Wang X.
Artificial cells, nanomedicine, and biotechnology. 2019 Dec;47(1)548-554.
Thyroid cancer is now the most common endocrine malignancy and the effect of miR-429 in the development of thyroid cancer still need to be further investigated. The expression level of miR-429 was quantified by qPCR in both clinical samples and cultured cell lines. MTT, flow cytometry, migration ana
PMID 30849921

Japanese Journal

Anterior and Posterior Segmental Decompression and Fusion for Severely Localized Ossification of the Posterior Longitudinal Ligament of the Cervical Spine: Technical Note

ARIMA Hironori,NAITO Kentaro,YAMAGATA Toru,KAWAHARA Shinichi,OHATA Kenji,TAKAMI Toshihiro
Neurologia medico-chirurgica, 2019
… <p>The surgical strategy for severely localized ossification of the posterior longitudinal ligament (OPLL) of the cervical spine is still not straightforward. … We describe the surgical technique of extended anterior cervical discectomy and fusion (ACDF) with partial resection of OPLL followed by posterior cervical segmental decompression and fusion (PCDF). …
NAID 130007638104

造影超音波検査の後血管相で不整形高エコー像を認めたPD-1抗体薬に起因する肝機能障害の1例

小坂正成,岩堂昭太,詫間義隆,植松周二,岡本良一,皆木正人,山崎理恵,市村浩一,荒木康之
超音波医学, 2019
<p>症例は60代，男性．左舌癌・頸部リンパ節転移に対し，切除術とリンパ節郭清が施行され，2ヵ月後に局所再発，骨転移のため化学療法施行されるもProgressive Diseaseと効果判定された．免疫チェックポイント阻害剤のニボルマブを使用し，3クール投与後，ASTとALT高値のGrade4の肝機能障害（CTCAEv4.0）が出現した．発症日の造影MRIにて肝S2に腫瘤を認めたが，そ …
NAID 130007635923

Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation

Wakaea Kousho,Nishiyama Tomoaki,Kondo Satoru,Izuka Takashi,Que Lusheng,Chen Cong,Kase Kina,Kitamura Kouichi,Md Monjurul,Wang Zhe,Ahasan Md Monjurul,Nakamura Mitsuhiro,Fujiwara Hiroshi,Yoshizaki Tomokazu,Hosomochi Kazuyoshi,Tajima Atsushi,Nakahara Tomomi,Kiyono Tohru,Muramatsu Masamichi
Scientific Reports = 8 (1), 9745, 2018-12-01
… In this study, we report that consecutive C-to-T mutations (hypermutations), a unique feature of mutations induced by APOBECs, are found in mtDNA from cervical dysplasia and oropharyngeal cancers. … In vitro, we found that APOBEC3A (A3A) and 3B (A3B) expression, as well as mtDNA hypermutation, were induced in a cervical dysplastic cell line W12 when cultured in a differentiating condition. …
NAID 120006602143

「LINE」

　　[★]

日: 長い散在反復配列、長散在型反復配列、長い散在性反復配列、ライン、広範囲散在反復配列
英: long interspersed nuclear element, long interspersed nucleotide element, long interspersed element, long interspersed repetitive elements, LINEs, long interspersed repeat sequences
関: レトロトランスポゾン

quoted from http://en.wikipedia.org/wiki/Long_interspersed_nucleotide_elements#LINEs

Long interspersed nuclear elements[8] are a group of genetic elements that are found in large numbers in eukaryotic genomes. They are transcribed (or are the evolutionary remains of what was once transcribed) to an RNA using an RNA polymerase II promoter that resides inside the LINE. LINEs code for the enzyme reverse transcriptase, and many LINEs also code for an endonuclease (e.g. RNase H). The reverse transcriptase has a higher specificity for the LINE RNA than other RNA, and makes a DNA copy of the RNA that can be integrated into the genome at a new site.

The 5' UTR contains the promoter sequence, while the 3' UTR contains a polyadenylation signal (AATAAA) and a poly-A tail.[10] Because LINEs move by copying themselves (instead of moving, like transposons do), they enlarge the genome. The human genome, for example, contains about 20,000-40,000 LINEs, which is roughly 21% of the genome.