WordNet
- (physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide"
- instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer"
- a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going" (同)scheme
- a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender" (同)system of rules
- a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion"
- a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation"
- the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system"
- in or near a center or constituting a center; the inner area; "a central position"
- a workplace that serves as a telecommunications facility where lines from telephones can be connected together to permit communication (同)telephone exchange, exchange
- easily agitated; "a nervous addict"; "a nervous thoroughbred"
- of or relating to the nervous system; "nervous disease"; "neural disorder" (同)neural
- a closed sac that develops abnormally in some body structure
PrepTutorEJDIC
- 〈C〉(関連した部分から成る)『体系』,系統,組織[網],装置 / 〈C〉(教育・政治などの)『制度』,機構;《the~》体制 / 〈C〉(思想・学問などの)『体系』,学説 / 〈C〉(…の)『方法』,方式,やり方《+of doing》 / 〈U〉正しい方針(筋道,順序) / 〈U〉《the~》(身体の)組織,系統 / 〈U〉《the~,one's~》身体,全身
- 『中心の』,中央の,中心からの / 『主要な』,中心的な(main) / (音声が)中舌音の / 電話交換局(《英》[telephone]exchange)
- 『神経の』 / 『神経質な』,神経過敏な / 『心配な』,不安な
- 胞嚢(ほうのう)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/05/21 02:28:01」(JST)
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- 1. 二次性中枢神経系リンパ腫の臨床症状および診断 clinical presentation and diagnosis of secondary central nervous system lymphoma
- 2. Primary angiitis of the central nervous system in adults
- 3. ノカルジア症の臨床症状および診断 clinical manifestations and diagnosis of nocardiosis
- 4. 中枢神経系シャントおよび他のデバイスの感染 infections of central nervous system shunts and other devices
- 5. 中枢神経系病変を有するHIV感染患者に対するアプローチ approach to hiv infected patients with central nervous system lesions
English Journal
- Megalencephalic leukoencephalopathy with subcortical cysts protein-1 modulates endosomal pH and protein trafficking in astrocytes: Relevance to MLC disease pathogenesis.
- Brignone MS1, Lanciotti A2, Visentin S3, De Nuccio C4, Molinari P5, Camerini S6, Diociaiuti M7, Petrini S8, Minnone G9, Crescenzi M10, Laudiero LB11, Bertini E12, Petrucci TC13, Ambrosini E14.Author information 1Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: mariastefania.brignone@gmail.com.2Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: angela.lanciotti@iss.it.3Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: sergio.visentin@iss.it.4Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: chiara.denuccio@iss.it.5Department of Pharmacology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: paola.molinari@iss.it.6Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: serena.camerini@iss.it.7Department of Technology and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: marco.diociaiuti@iss.it.8Unit of Neurodegenerative Disorders, Laboratory of Molecular Medicine, Bambino Gesù Pediatric Research Hospital, Piazza S. Onofrio 4, 00165 Rome, Italy. Electronic address: stefania.petrini@opbg.net.9Unit of Neurodegenerative Disorders, Laboratory of Molecular Medicine, Bambino Gesù Pediatric Research Hospital, Piazza S. Onofrio 4, 00165 Rome, Italy. Electronic address: gaetana.minnone@yahoo.it.10Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: marco.crescenzi@iss.it.11Unit of Neurodegenerative Disorders, Laboratory of Molecular Medicine, Bambino Gesù Pediatric Research Hospital, Piazza S. Onofrio 4, 00165 Rome, Italy; Institute of Translational Pharmacology, CNR, Via del Fosso Cavaliere 100, 00133 Rome, Italy. Electronic address: luisa.braccilaudiero@inmm.cnr.it.12Unit of Neurodegenerative Disorders, Laboratory of Molecular Medicine, Bambino Gesù Pediatric Research Hospital, Piazza S. Onofrio 4, 00165 Rome, Italy. Electronic address: ebertini@gmail.com.13Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: tcpetrucci.petrucci61@gmail.com.14Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: elena.ambrosini@iss.it.AbstractMegalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare leukodystrophy caused by mutations in the gene encoding MLC1, a membrane protein mainly expressed in astrocytes in the central nervous system. Although MLC1 function is unknown, evidence is emerging that it may regulate ion fluxes. Using biochemical and proteomic approaches to identify MLC1 interactors and elucidate MLC1 function we found that MLC1 interacts with the vacuolar ATPase (V-ATPase), the proton pump that regulates endosomal acidity. Because we previously showed that in intracellular organelles MLC1 directly binds Na, K-ATPase, which controls endosomal pH, we studied MLC1 endosomal localization and trafficking and MLC1 effects on endosomal acidity and function using human astrocytoma cells overexpressing wild-type (WT) MLC1 or MLC1 carrying pathological mutations. We found that WT MLC1 is abundantly expressed in early (EEA1(+), Rab5(+)) and recycling (Rab11(+)) endosomes and uses the latter compartment to traffic to the plasma membrane during hyposmotic stress. We also showed that WT MLC1 limits early endosomal acidification and influences protein trafficking in astrocytoma cells by stimulating protein recycling, as revealed by FITC-dextran measurement of endosomal pH and transferrin protein recycling assay, respectively. WT MLC1 also favors recycling to the plasma-membrane of the TRPV4 cation channel which cooperates with MLC1 to activate calcium influx in astrocytes during hyposmotic stress. Although MLC disease-causing mutations differentially affect MLC1 localization and trafficking, all the mutated proteins fail to influence endosomal pH and protein recycling. This study demonstrates that MLC1 modulates endosomal pH and protein trafficking suggesting that alteration of these processes contributes to MLC pathogenesis.
- Neurobiology of disease.Neurobiol Dis.2014 Jun;66:1-18. doi: 10.1016/j.nbd.2014.02.003. Epub 2014 Feb 19.
- Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare leukodystrophy caused by mutations in the gene encoding MLC1, a membrane protein mainly expressed in astrocytes in the central nervous system. Although MLC1 function is unknown, evidence is emerging that it may regulate ion f
- PMID 24561067
- Routine drug and food interactions during antihelminthic treatment of neurocysticercosis: a reason for the variable efficacy of albendazole and praziquantel?
- Romo ML1, Carpio A, Kelvin EA.Author information 1CUNY School of Public Health, New York, NY, USA.AbstractNeurocysticercosis (NC) or infection of the central nervous system with Taenia solium larvae is a leading cause of preventable seizures and epilepsy in endemic regions across the globe. Albendazole and praziquantel are commonly used antihelminthic agents to treat NC; however, viable cysts persist in the majority of patients, putting them at risk for future seizures and other neurological complications. Because of their pharmacokinetic profiles, albendazole and praziquantel have the potential to interact with many different drugs. During antihelminthic treatment, antiepileptic drugs and corticosteroids are commonly co-administered to manage seizures and cerebral edema; however, the most commonly used agents from these drug classes are known to significantly alter plasma concentrations of albendazole and praziquantel. The overarching issue with drug interactions during the treatment of NC is whether or not they have clinical relevance, as the plasma concentrations of albendazole and praziquantel have not been directly linked with eradication of viable cysts. Future studies should attempt to evaluate the validity of a causal relationship between antihelminthic plasma concentrations and outcomes so that drug interactions can be better understood and managed and so that treatment can be optimized.
- Journal of clinical pharmacology.J Clin Pharmacol.2014 Apr;54(4):361-7. doi: 10.1002/jcph.269. Epub 2014 Jan 25.
- Neurocysticercosis (NC) or infection of the central nervous system with Taenia solium larvae is a leading cause of preventable seizures and epilepsy in endemic regions across the globe. Albendazole and praziquantel are commonly used antihelminthic agents to treat NC; however, viable cysts persist in
- PMID 24443292
- Mucoepidermoid carcinoma: A yet unreported cancer associated with familial adenomatous polyposis.
- Cazorla A1, Viennet G2, Uro-Coste E3, Valmary-Degano S4.Author information 1Department of Pathology, CHU Besançon, F-25000, France.2Department of Pathology, CHU Besançon, F-25000, France; Univ Franche-Comte, F-25000 Besançon, France.3Service d'Anatomie Pathologique et Histologie-Cytologie, CHU Rangueil, 1 Avenue Jean Poulhès, TSA 50032, 31059 Toulouse Cedex 9, France; INSERM UMR 1037, F-31000 Toulouse, France.4Department of Pathology, CHU Besançon, F-25000, France; Univ Franche-Comte, F-25000 Besançon, France. Electronic address: svalmary@univ-fcomte.fr.AbstractTurcot's syndrome is a rare clinical syndrome, characterized by the association between familial adenomatous polyposis (FAP) and a primary central nervous system tumour. Gardner's syndrome is characterized by the association between FAP and several tumour types such as multiple osteomas, fibromas, epidermoid cysts and desmoid tumours. We report here the case of a twenty-six year-old woman with a history of both Turcot's and Gardner syndromes. She had a family history of adenomatous polyposis with a mutation in the APC (Adenomatous Polyposis Coli) gene. At the age of 26, she presented a mucoepidermoid carcinoma of the right parotid gland in which the MECT1-MAML2 fusion was showed. We discuss the possible addition of this latter cancer type in the definition of Gardner's syndrome.
- Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.J Craniomaxillofac Surg.2014 Apr;42(3):262-4. doi: 10.1016/j.jcms.2013.05.012. Epub 2013 Jul 5.
- Turcot's syndrome is a rare clinical syndrome, characterized by the association between familial adenomatous polyposis (FAP) and a primary central nervous system tumour. Gardner's syndrome is characterized by the association between FAP and several tumour types such as multiple osteomas, fibromas, e
- PMID 23830771
Japanese Journal
- A Case of Rapid Growing Frontal Sinus Cysts after Endoscopic Sinus Surgery for Eosinophilic Chronic Sinusitis
- , , , , , , ,
- 耳鼻咽喉科臨床 補冊 140(0), 56-57, 2014
- … Interestingly, the patient did not complain of any symptoms, central nervous system deficits, headaches or head heaviness though the cysts developed in the rather short period of seven months. …
- NAID 130004707441
- 好酸球性副鼻腔炎術後1年で骨欠損をきたした両側前頭洞嚢胞例
- 原田 博之,篠原 尚吾,金沢 佑治,藤原 敬三,菊地 正弘,十名 理紗,岸本 逸平,内藤 泰
- 耳鼻咽喉科臨床 107(2), 121-126, 2014
- … Interestingly, the patient did not complain of any symptoms, central nervous system deficits, headaches or head heaviness though the cysts developed in the rather short period of seven months. …
- NAID 130003395611
- 精巣腫瘍との鑑別が困難であった精巣上体乳頭状嚢胞腺腫の1例
- 加納 英人,足立 康久,長浜 克志 [他]
- 泌尿器科紀要 58(1), 39-43, 2012-01
- … Although CT imaging showed a simple cyst in the right kidney, no other lesions in the kidneys, adrenal glands, pancreas or the central nervous system were detected. … Grossly the specimen consisted of a multilocular cystic tumor, 12.5×8.5×8.5 cm in size, with a 2.7 cm tan-colored solid component within the wall of the cyst. …
- NAID 40019146810
Related Links
- Central Nervous System Cyst: Symptoms Incidence, Prevalence & Riskfactors Laboratory, Imaging & ECG Complications and Differential diagnoses on Symptoma®, the medical search engine for physicians. ... Central nervous ...
- Cysts of the central nervous system : a clinicopathologic study of 145 cases. Sundaram C, Paul TR, Raju BV, Ramakrishna Murthy T, Sinha AK, Prasad VS, Purohit AK Department of Pathology, Nizam's Institute of Medical ...
Related Pictures
★リンクテーブル★
| リンク元 | 「ラトケ嚢胞」「中枢神経系嚢胞」 |
| 関連記事 | 「nervous」「central」「system」 |
「ラトケ嚢胞」
- 英
- Rathke's cleft cyst、Rathke cleft cyst
- 同
- Rathke嚢胞、Rathke pouch cyst、下垂体エナメル上皮腫 pituitary adamantinoma
- 関
- 中枢神経系嚢胞 central nervous system cyst
- 胎生期に下垂体付近に形成される非腫瘍性嚢胞
- 検査：
- MRI
- Gd造影：嚢胞壁が濃染されない。
- 鑑別疾患：頭蓋咽頭腫(ラトケ嚢に遺残した口腔粘膜上皮(扁平上皮細胞巣)より発生する良性腫瘍)
「中枢神経系嚢胞」
「nervous」
- adj.
- 神経の、心配な、神経質な
- 関
- anxiety、anxious、anxiously、care、concern、fear、nerve、nervi、nervousness、nervus、neural、neuro、neuron、neuroticism、trouble、uneasy、worrisome、worry
「central」
- adj.
- 中心の、中心的な、中心性の、中枢的な、中枢性の、中枢の、中枢神経性の
「system」
- n.