WordNet

(physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide"
instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer"
a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going" (同)scheme
a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender" (同)system of rules
a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion"
a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation"
the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system"
in or near a center or constituting a center; the inner area; "a central position"
a workplace that serves as a telecommunications facility where lines from telephones can be connected together to permit communication (同)telephone exchange, exchange
easily agitated; "a nervous addict"; "a nervous thoroughbred"
of or relating to the nervous system; "nervous disease"; "neural disorder" (同)neural
a fungal infection characterized by nodular lesions--first in the lungs and spreading to the nervous system

PrepTutorEJDIC

〈C〉(関連した部分から成る)『体系』,系統,組織[網],装置 / 〈C〉(教育・政治などの)『制度』,機構;《the~》体制 / 〈C〉(思想・学問などの)『体系』,学説 / 〈C〉(…の)『方法』,方式,やり方《+of doing》 / 〈U〉正しい方針(筋道,順序) / 〈U〉《the~》(身体の)組織,系統 / 〈U〉《the~,one's~》身体,全身
『中心の』,中央の,中心からの / 『主要な』,中心的な(main) / (音声が)中舌音の / 電話交換局(《英》[telephone]exchange)
『神経の』 / 『神経質な』,神経過敏な / 『心配な』,不安な

UpToDate Contents

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1. クリプトコッカス髄膜脳炎を伴うHIV感染患者の抗真菌治療中の臨床的マネージメントおよびモニタリング clinical management and monitoring during antifungal therapy of the hiv infected patient with cryptococcal meningoencephalitis
2. HIV感染患者におけるクリプトコッカス-ネオフォルマン髄膜脳炎の疫学、臨床症状、および診断 epidemiology clinical manifestations and diagnosis of cryptococcus neoformans meningoencephalitis in hiv infected patients
3. HIV血清陰性患者におけるクリプトコッカス-ネオフォルマン髄膜脳炎および播種性感染症の治療 treatment of cryptococcus neoformans meningoencephalitis and disseminated infection in hiv seronegative patients
4. HIV血清陰性患者におけるクリプトコッカス・ネオフォルマンス髄膜脳炎の臨床症状および診断 clinical manifestations and diagnosis of cryptococcus neoformans meningoencephalitis in hiv seronegative patients
5. 最新の診療アップデート practice changing updates

English Journal

Cryptococcal osteomyelitis: a report of 5 cases and a review of the recent literature.

Medaris LA1, Ponce B2, Hyde Z2, Delgado D1, Ennis D3, Lapidus W4, Larrison M5, Pappas PG1.
Mycoses.Mycoses.2016 Jun;59(6):334-42. doi: 10.1111/myc.12476. Epub 2016 Mar 10.
Cryptococcus neoformans is a fungal pathogen associated with advanced HIV disease and other disorders associated with immune dysfunction. The pulmonary and the central nervous system are the most common manifestations of the disease. Localised osteomyelitis as the sole manifestation of extrapulmonar
PMID 26968335

New clinical phenotypes of fungal infections in special hosts.

Pilmis B1, Puel A2, Lortholary O3, Lanternier F3.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.Clin Microbiol Infect.2016 May 26. pii: S1198-743X(16)30143-4. doi: 10.1016/j.cmi.2016.05.016. [Epub ahead of print]
Invasive fungal infections incidence increases over time with the raise of at risk populations, in particular patients with acquired immunodeficiencies due to immunosuppressive therapies such as anti-tumor necrosis factor alpha (TNF-α) treatment, cirrhosis or burns. Some primary immunodeficiencies
PMID 27237547

Pharmacokinetics/pharmacodynamic correlations of fluconazole in murine model of cryptococcosis.

Santos JR1, César IC2, Costa MC3, Ribeiro NQ3, Holanda RA3, Ramos LH3, Freitas GJ3, Paixão TA4, Pianetti GA2, Santos DA5.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2016 May 25. pii: S0928-0987(16)30203-2. doi: 10.1016/j.ejps.2016.05.022. [Epub ahead of print]
The emergence of fluconazole-resistant Cryptococcus gattii is a global concern, since this azole is the main antifungal used worldwide to treat patients with cryptococcosis. Although pharmacokinetic (PK) and pharmacodynamic (PD) indices are useful predictive factors for therapeutic outcomes, there i
PMID 27235581