セフチゾキシム
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2019/04/30 20:01:03」(JST)
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Ceftizoxime |
Clinical data |
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Trade names | Cefizox |
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AHFS/Drugs.com | Consumer Drug Information |
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MedlinePlus | a684043 |
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ATC code | |
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Identifiers |
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IUPAC name
- (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
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CAS Number | |
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PubChem CID | |
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ChemSpider | |
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UNII | |
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KEGG | |
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ChEMBL | |
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CompTox Dashboard (EPA) | |
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ECHA InfoCard | 100.210.846 |
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Chemical and physical data |
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Formula | C13H13N5O5S2 |
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Molar mass | 383.405 g/mol g·mol−1 |
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Ceftizoxime is a third-generation cephalosporin available for parenteral administration.
Unlike other third-generation cephalosporins, the whole C-3 side chain in ceftizoxime has been removed to prevent deactivation by hydrolytic enzymes.
It rather resembles cefotaxime in its properties, but is not subject to metabolism. It was removed from the US Market in 2007.
Synthesis
Injectable third generation cephalosporin antibiotic related to cefotaxime, q.v. Exhibits broad spectrum activity and resistance to β-lactamase hydrolysis.
Ceftizoxime synthesis:
[1]
References
- ^ T. Takaya et al., ‹See Tfd›DE 2810922 ; eidem, U.S. Patent 4,427,674 (1978, 1984 both to Fujisawa).
Antibiotics active on the cell wall and envelope (J01C-J01D) |
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Intracellular |
- Inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
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Glycopeptide |
- Inhibit PG chain elongation: Vancomycin# (Oritavancin
- Telavancin)
- Teicoplanin (Dalbavancin)
- Ramoplanin
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β-lactams/ (inhibit PBP cross-links) | |
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Other |
- polymyxins/detergent
- depolarizing
- Hydrolyze NAM-NAG
- Tyrothricin
- Isoniazid#
- Teixobactin
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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UpToDate Contents
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English Journal
- Prophylactic ceftizoxime for elective cesarean delivery at Soba Hospital, Sudan.
- Osman B, Abbas A, Ahmed MA, Abubaker MS, Adam I.AbstractABSTRACT: BACKGROUND: A prophylactic antibiotic is recommended to reduce infection-related complication following cesarean delivery. There is a current debate on the time of prophylactic antibiotic in cesarean delivery.
- BMC research notes.BMC Res Notes.2013 Feb 8;6(1):57. [Epub ahead of print]
- ABSTRACT: BACKGROUND: A prophylactic antibiotic is recommended to reduce infection-related complication following cesarean delivery. There is a current debate on the time of prophylactic antibiotic in cesarean delivery.METHODS: An opened randomized, controlled clinical trial was conducted at Soba ho
- PMID 23394621
- Prevalence of multiple antibiotic-resistant Gram-negative bacteria on bagged, ready-to-eat baby spinach.
- Walia S, Rana SW, Maue D, Rana J, Kumar A, Walia SK.SourceDepartment of Biological Sciences, Oakland University, Rochester, MI, USA. walia@oakland.edu
- International journal of environmental health research.Int J Environ Health Res.2013;23(2):108-18. doi: 10.1080/09603123.2012.708916. Epub 2012 Jul 27.
- In this study, multiple antibiotic-resistant (MAR) Gram-negative bacteria (GNB) were isolated from triple-washed, bagged, ready-to-eat (RTE) baby spinach. Biochemical identification of randomly selected bacterial colonies showed the predominance of cytochrome oxidase-positive Pseudomonas species. Am
- PMID 22838727
- Cough syncope: constrictive pericarditis.
- Zeng W, Deng H.SourceDepartment of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, China.
- Internal medicine (Tokyo, Japan).Intern Med.2013;52(4):463-5. Epub 2013 Feb 15.
- An 87-year-old man with a diagnosis of constrictive pericarditis suffered from cough syncope up to 10 times per day on most days during his three-day stay at our hospital. After undergoing a series of treatments (diuretics, codeine and intravenous ceftizoxime), the patient still had a mild cough, al
- PMID 23411702
Japanese Journal
- Screening for Group B Streptococci with Reduced Penicillin Susceptibility in Clinical Isolates Obtained between 1977 and 2005
- Cough Syncope: Constrictive Pericarditis
- オキサシリン, セフォキシチン, セフチゾキシムを用いたMRSA鑑別能の比較検討
- 医学検査 : 日本臨床衛生検査技師会誌 = The Japanese journal of medical technology 57(2), 159-166, 2008-02-25
- NAID 10026954741
Related Links
- セフチゾキシム, ceftizoxime, CZX, セフチゾキシムナトリウム, エポセリン, 第三世代 セフェム. セフトリアキソン, ceftriaxone, CTRX ... セフチゾキシム アラピボキシル, ceftizoxime alapivoxil, CZX-AP, 第三世代セフェム経口剤. セフテラム ピボキシル, cefteram ...
Related Pictures
★リンクテーブル★
[★]
- 英
- cephalosporin antibiotics, cephalosporin, cephalosporins
- 同
- セフェム系抗菌薬?、セフェム系抗生物質? cephem antibiotic? cephem antibiotics
- 関
- 抗菌薬、βラクタム系抗菌薬 、第三世代抗生物質
特徴
- グラム陽性菌、グラム陰性菌
構造
副作用
- 過敏症(ペニシリン系抗菌薬と同様であるが、頻度はペニシリン系に比べ低い)
- (1)ジスルフィラム様作用、(2)ビタミンK依存性の凝固因子の産生低下(cefotetanとcefoperazoneに特徴的。共通点はN-methylthiotetrazole(NMTT) side chainを持つこと)。(PPC.612)
セフェム系抗菌薬
[★]
- 同
- 第3世代セフェム、第三世代抗生物質 antibiotics of third generation、第三世代セフェム系抗生物質 cephem antibiotics of third generation、第3世代セファロスポリン
- 関
- セファロスポリン系抗菌薬
特徴
- 第3世代セフェム以上は口腔内嫌気性細菌をカバーできる ・・・ わざわざABPC/SBTを選択しなくて良い。
第三世代セフェム
[★]
- 英
- ceftizoxime, CZX
- ラ
- ceftizoximum
- 化
- セフチゾキシムナトリウム ceftizoxime sodium、塩酸セフチゾキシムアラピボキシル ceftizoxime alapivoxil hydrochloride
- 商
- エポセリン
- 関
- セファロスポリン系抗菌薬
[★]
- 関
- ceftizoxime、ceftizoxime alapivoxil hydrochloride
[★]
- 関
- ceftizoxime、ceftizoxime sodium