WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

PrepTutorEJDIC

ソジウム,ナトリウム(金属元素;化学記号はNa)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/12/08 07:41:36」(JST)

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Ceftizoxime is a third-generation cephalosporin available for parenteral administration. Unlike other third-generation cephalosporins, the whole C-3 side chain in ceftizoxime has been removed to prevent deactivation by hydrolytic enzymes. It rather resembles cefotaxime in its properties, but is not subject to metabolism. It was removed from the US Market in 2007.

Synthesis

Injectable third generation cephalosporin antibiotic related to cefotaxime, q.v. Exhibits broad spectrum activity and resistance to β-lactamase hydrolysis.

Ceftizoxime synthesis:^[1]

References

^ T. Takaya et al., DE 2810922 ; eidem, U.S. Patent 4,427,674 (1978, 1984 both to Fujisawa).

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UpToDate Contents

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1. セフェム系 cephalosporins
2. 合併症のない淋菌感染の治療 treatment of uncomplicated gonococcal infections
3. 成人における化膿性耳下腺炎 suppurative parotitis in adults
4. 骨盤内炎症性疾患：治療 pelvic inflammatory disease treatment
5. 分娩後子宮内膜炎 postpartum endometritis

English Journal

Penicillin-susceptible group B streptococcal clinical isolates with reduced cephalosporin susceptibility.

Nagano N1, Nagano Y2, Toyama M1, Kimura K3, Shibayama K2, Arakawa Y4.
Journal of clinical microbiology.J Clin Microbiol.2014 Sep;52(9):3406-10. doi: 10.1128/JCM.01291-14. Epub 2014 Jun 11.
We characterized penicillin-susceptible group B streptococcal (PSGBS) clinical isolates exhibiting no growth inhibition zone around a ceftibuten disk (CTB(r) PSGBS). The CTB(r) PSGBS isolates, for which augmented MICs of cefaclor and ceftizoxime were found, shared a T394A substitution in penicillin-
PMID 24920773

Temporal trends in in vitro antimicrobial susceptibility patterns of bacteria isolated from foals with sepsis: 1979-2010.

Theelen MJ1, Wilson WD, Edman JM, Magdesian KG, Kass PH.
Equine veterinary journal.Equine Vet J.2014 Mar;46(2):161-8. doi: 10.1111/evj.12130. Epub 2013 Sep 11.
REASONS FOR PERFORMING THE STUDY: Monitoring the development of antimicrobial resistance is important for the rational selection of appropriate antimicrobial drugs to initiate treatment of foals with sepsis.OBJECTIVES: To identify temporal trends in antimicrobial susceptibility patterns of bacteria
PMID 23808791

Correlation of cefpodoxime susceptibility with cephalothin and cefuroxime for urinary tract isolates.

Bookstaver DA1, Bland CM, Woodberry MW, Mansell KB.
Journal of medical microbiology.J Med Microbiol.2014 Feb;63(Pt 2):218-21. doi: 10.1099/jmm.0.063040-0. Epub 2013 Nov 8.
This study attempted to determine whether cefuroxime was superior to cephalothin as a surrogate marker for cefpodoxime among urinary tract isolates. The MicroScan system (Siemens) was used to determine susceptibility for cephalothin and cefuroxime on consecutive cultures with a colony count of ≥50
PMID 24214230

Japanese Journal

抗生物質の副作用の特徴 : 厚生省「医薬品副作用情報」の副作用集計結果に基づいた検討

港谷明則,粟津荘司
病院薬学 20(1), 24-32, 1994-02-20
… The first principal component score of ceftizoxime sodium constituted the largest extreme. …
NAID 110001798997

フィブリン糊の抗生剤, Ceftizoxime Sodium (Epocelin), Cephazolin sodium (Cephamezin) に対する徐放効果

新城清
日本骨・関節感染症研究会記録誌 5, 75-76, 1991
NAID 50003703761

★リンクテーブル★

リンク元	「セフチゾキシム」「ceftizoxime alapivoxil hydrochloride」「セフチゾキシムナトリウム」

「セフチゾキシム」

Ceftizoxime
Clinical data
Trade names	Cefizox
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a684043
ATC code	J01DD07 (WHO);
Identifiers
	IUPAC name (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;
CAS Number	68401-81-0 68401-82-1;
PubChem CID	6533629;
ChemSpider	5018818;
UNII	C43C467DPE;
KEGG	D07658;
ChEMBL	CHEMBL528;
ECHA InfoCard	100.210.846
Chemical and physical data
Formula	C13H13N5O5S2
Molar mass	383.405 g/mol