- 関
- ceftizoxime、ceftizoxime alapivoxil hydrochloride
WordNet
- a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
PrepTutorEJDIC
- ソジウム,ナトリウム(金属元素;化学記号はNa)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/12/08 07:41:36」(JST)
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Ceftizoxime
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Clinical data |
Trade names |
Cefizox |
AHFS/Drugs.com |
Consumer Drug Information |
MedlinePlus |
a684043 |
ATC code |
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Identifiers |
IUPAC name
- (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
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CAS Number |
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PubChem CID |
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ChemSpider |
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UNII |
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KEGG |
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ChEMBL |
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ECHA InfoCard |
100.210.846 |
Chemical and physical data |
Formula |
C13H13N5O5S2 |
Molar mass |
383.405 g/mol |
Ceftizoxime is a third-generation cephalosporin available for parenteral administration. Unlike other third-generation cephalosporins, the whole C-3 side chain in ceftizoxime has been removed to prevent deactivation by hydrolytic enzymes. It rather resembles cefotaxime in its properties, but is not subject to metabolism. It was removed from the US Market in 2007.
Synthesis
Injectable third generation cephalosporin antibiotic related to cefotaxime, q.v. Exhibits broad spectrum activity and resistance to β-lactamase hydrolysis.
Ceftizoxime synthesis:
[1]
References
- ^ T. Takaya et al., DE 2810922 ; eidem, U.S. Patent 4,427,674 (1978, 1984 both to Fujisawa).
Antibiotics active on the cell wall and envelope (J01C-J01D)
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Intracellular |
- Inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
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Glycopeptide |
- Inhibit PG chain elongation: Vancomycin# (Oritavancin
- Telavancin)
- Teicoplanin (Dalbavancin)
- Ramoplanin
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β-lactams/
(inhibit PBP
cross-links) |
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Other |
- polymyxins/detergent
- depolarizing
- Hydrolyze NAM-NAG
- Tyrothricin
- Isoniazid#
- Teixobactin
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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UpToDate Contents
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English Journal
- Penicillin-susceptible group B streptococcal clinical isolates with reduced cephalosporin susceptibility.
- Nagano N1, Nagano Y2, Toyama M1, Kimura K3, Shibayama K2, Arakawa Y4.
- Journal of clinical microbiology.J Clin Microbiol.2014 Sep;52(9):3406-10. doi: 10.1128/JCM.01291-14. Epub 2014 Jun 11.
- We characterized penicillin-susceptible group B streptococcal (PSGBS) clinical isolates exhibiting no growth inhibition zone around a ceftibuten disk (CTB(r) PSGBS). The CTB(r) PSGBS isolates, for which augmented MICs of cefaclor and ceftizoxime were found, shared a T394A substitution in penicillin-
- PMID 24920773
- Temporal trends in in vitro antimicrobial susceptibility patterns of bacteria isolated from foals with sepsis: 1979-2010.
- Theelen MJ1, Wilson WD, Edman JM, Magdesian KG, Kass PH.
- Equine veterinary journal.Equine Vet J.2014 Mar;46(2):161-8. doi: 10.1111/evj.12130. Epub 2013 Sep 11.
- REASONS FOR PERFORMING THE STUDY: Monitoring the development of antimicrobial resistance is important for the rational selection of appropriate antimicrobial drugs to initiate treatment of foals with sepsis.OBJECTIVES: To identify temporal trends in antimicrobial susceptibility patterns of bacteria
- PMID 23808791
- Correlation of cefpodoxime susceptibility with cephalothin and cefuroxime for urinary tract isolates.
- Bookstaver DA1, Bland CM, Woodberry MW, Mansell KB.
- Journal of medical microbiology.J Med Microbiol.2014 Feb;63(Pt 2):218-21. doi: 10.1099/jmm.0.063040-0. Epub 2013 Nov 8.
- This study attempted to determine whether cefuroxime was superior to cephalothin as a surrogate marker for cefpodoxime among urinary tract isolates. The MicroScan system (Siemens) was used to determine susceptibility for cephalothin and cefuroxime on consecutive cultures with a colony count of ≥50
- PMID 24214230
Japanese Journal
- 抗生物質の副作用の特徴 : 厚生省「医薬品副作用情報」の副作用集計結果に基づいた検討
- 港谷 明則,粟津 荘司
- 病院薬学 20(1), 24-32, 1994-02-20
- … The first principal component score of ceftizoxime sodium constituted the largest extreme. …
- NAID 110001798997
- フィブリン糊の抗生剤, Ceftizoxime Sodium (Epocelin), Cephazolin sodium (Cephamezin) に対する徐放効果
Related Pictures
★リンクテーブル★
[★]
- 英
- ceftizoxime, CZX
- ラ
- ceftizoximum
- 化
- セフチゾキシムナトリウム ceftizoxime sodium、塩酸セフチゾキシムアラピボキシル ceftizoxime alapivoxil hydrochloride
- 商
- エポセリン
- 関
- セファロスポリン系抗菌薬
[★]
- 関
- ceftizoxime、ceftizoxime sodium
[★]
- 英
- ceftizoxime sodium
- 関
- セフチゾキシム