- 同
- 異型性髄膜腫
WordNet
- not representative of a group, class, or type; "a group that is atypical of the target audience"; "a class of atypical mosses"; "atypical behavior is not the accepted type of response that we expect from children" (同)untypical
- deviating from normal expectations; somewhat odd, strange, or abnormal; "these days large families are atypical"; "atypical clinical findings"; "atypical pneumonia"; "highly irregular behavior" (同)irregular
- a tumor arising in the meninges which surround the brain and spinal cord; usually slow growing and sometimes malignant
PrepTutorEJDIC
- 型にはまらない,異常な
UpToDate Contents
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English Journal
- Solitary Fibrous Tumor of the Central Nervous System: A 15-year Literature Survey of 220 Cases (August 1996-July 2011).
- Bisceglia M, Galliani C, Giannatempo G, Lauriola W, Bianco M, D?angelo V, Pizzolitto S, Vita G, Pasquinelli G, Magro G, Dor DB.Source*Departments of Pathology ‡Radiology §Neurosciences, IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo (FG), Italy †Department of Pathology, Cook Children's Medical Center, Fort Worth, TX ∥Department of Pathology and Laboratory Medicine, "S. Maria della Misericordia" General Hospital, Udine, Italy ¶Unit of Anatomic Pathology, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture (PZ), Italy #Department of Hematology, Oncology and Clinical Pathology, Policlinico S. Orsola, University of Bologna, Bologna, Italy **Department of Pathology, University of Catania, Catania, Italy ††Department of Pathology, Barzilai Medical Center, Ashkelon, Israel.
- Advances in anatomic pathology.Adv Anat Pathol.2011 Sep;18(5):356-392.
- We reviewed the world literature on solitary fibrous tumors of the central nervous system from August 1996 to July 2011, focusing on both clinicopathological features and diagnostic findings. The anatomical distribution of the 220 cases reported so far reveals that most are intracranial and just ove
- PMID 21841406
- Management of meningeal neoplasms: meningiomas and hemangiopericytomas.
- Lamar Z, Lesser GJ.SourceSection of Hematology and Oncology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. zlamar@wfubmc.edu
- Current treatment options in oncology.Curr Treat Options Oncol.2011 Sep;12(3):230-9. doi: 10.1007/s11864-011-0156-2.
- OPINION STATEMENT: Meningiomas are the most frequently diagnosed primary brain tumor accounting for nearly one third of all primary brain and central nervous system tumors reported in the United States. According to the 2007 World Health Organization classification scheme, Grade I meningiomas are be
- PMID 21537847
Japanese Journal
- Two Meningiomas With Different Histological Grades in the Same Patient : Case Report
- EMMEZ Hakan,KALE Aydemir,TONGE Mehmet,CAKIR Asli,CEVIKER Necdet
- Neurologia medico-chirurgica = 神経外科 50(8), 686-688, 2010-08-15
- … Histological examination found both meningothelial and atypical meningiomas. … The present case emphasizes the need for follow up of all patients with meningioma even if the neuroimaging features indicate benign character. …
- NAID 10026651559
- Fluorescent In Situ Hybridization 1p/19q Deletion/Imbalance Analysis of Low-Grade and Atypical Meningiomas
- NAGASAKA Toru,GUNJI Masaharu,HOSOKAI Noboru,HAYASHI Kumiko,FUJINO Masahiko,IKEDA Hiroshi,ITO Masafumi,INAO Suguru
- Neurologia medico-chirurgica = 神経外科 50(1), 27-32, 2010-01-15
- … The chromosomal 1p/19q state was analyzed in 16 low-grade meningiomas and 7 atypical meningiomas using fluorescent in situ hybridization (FISH) analysis. … Chromosome 1p aberrations were observed in all atypical meningiomas, but in only one low-grade meningioma. … Atypical meningiomas showed 19q deletion or imbalance, suggesting chromosomal instability of 19q. … A small group of low-grade meningioma showed 19q aberrations. …
- NAID 10025949809
Related Links
- 1)異型性髄膜腫Atypical meningioma、グレードII 高い細胞分裂能を示す髄膜腫、 あるいは、腫瘍細胞の密度の上昇、核/細胞質比の高い小型細胞の巣状の出現、明瞭 な核小体、配列の特徴的がない一様なシート状の増殖、自然発生的あるいは地図状 壊死 ...
★リンクテーブル★
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- 英
- meningioma
- 同
- メニンジオーマ
- 関
- 脳腫瘍
概念
疫学
分類
部位
悪性度
病理
- 腫瘍細胞のシート状、渦巻き状に配列。壊死巣や核分裂像はほとんど見られない。(SCN.230)
- 22番染色体長腕の腫瘍抑制遺伝子の欠損・変異によって生じる。
- 血管に富んでおり、造影CT,MRIで均一、強く造影される。
検査
- 頭部単純X線写真:頭蓋骨内板の骨肥厚・骨破壊、頭蓋骨の硬膜血管溝拡大、腫瘍の一部石灰化が少なからず見られる(SCN.179)
- CT:境界明瞭な高度吸収域。(造影CT)均一かつ著明に増強
- MRI:(T1)やや低信号、(T2)高信号、(造影)均一にに増強。腫瘍付着部硬膜に線状の増強効果(dural tail sign)。
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治療
- 外科手術:腫瘍は骨・硬膜に浸潤していることが多いが全摘を目指すが、重要な組織に付着した腫瘍は残す。
- 術中の出血量を減らすために外頚動脈系の栄養動脈 feeding arteryを塞栓することがある。
- 放射線・ガンマナイフ:残存例、悪性度の高い髄膜腫
- × 化学療法、放射線療法は感受性が低くほぼ無効。
参考
- http://www.ebm.jp/disease/brain/07noshuyo2/guide.html
- http://www.gsic.jp/cancer/cc_19/hc/cc_19_021.html
国試
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- 関
- atypia、atypically、atypism、meta、nonclassic、off-type、variant