関: adjuvant arthritis、collagen arthritis、collagen-induced arthritis、experimental arthritis

WordNet

reason or establish by induction
cause to arise; "induce a crisis" (同)bring_on
produce electric current by electrostatic or magnetic processes (同)induct
cause to do; cause to act in a specified manner; "The ads induced me to buy a VCR"; "My children finally got me to buy a computer"; "My wife made me buy a new sofa" (同)stimulate, cause, have, get, make
cause to occur rapidly; "the infection precipitated a high fever and allergic reactions" (同)stimulate, rush, hasten
an additive that enhances the effectiveness of medical treatment
enhancing the action of a medical treatment; "the adjuvant action of certain bacteria"
brought about or caused; not spontaneous; "a case of steroid-induced weakness"
inflammation of a joint or joints

PrepTutorEJDIC

〈人〉‘に'『勧めて』(…)『させる』 / …‘を'『引き起こす』,もたらす(cause) / 〈電気〉‘を'誘導する / …‘を'帰納する
関節炎

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 乾癬性若年性特発性関節炎：病因、臨床症状、および診断 psoriatic juvenile idiopathic arthritis pathogenesis clinical manifestations and diagnosis
2. 乾癬性若年性特発性関節炎：管理および予後 psoriatic juvenile idiopathic arthritis management and prognosis
3. 成人における敗血症性関節炎 septic arthritis in adults
4. 関節リウマチの全身および非関節症状の概要 overview of the systemic and nonarticular manifestations of rheumatoid arthritis
5. 乾癬性関節炎の臨床症状および診断 clinical manifestations and diagnosis of psoriatic arthritis

English Journal

[Letter to the Editor regarding the article "Evaluation of complete Freund's adjuvant-induced arthritis in a Wistar rat model"]

-.
Zeitschrift fur Rheumatologie.Z Rheumatol.2014 Mar 2. [Epub ahead of print]
PMID 24577489

A4.10 Early bone microarchitecture changes in adjuvant-induced arthritis rats.

Courbon G1, Cleret D, Vico L, Marotte H.Author information 1INSERM U1059/LBTO, Jean Monnet University, Lyon University, Saint-Étienne.AbstractBACKGROUND AND OBJECTIVES: Hallmarks of rheumatoid arthritis (RA) are joint synovitis and subchondral bone erosions, resulting in loss of joint function. However, occurrence and kinetics of periarticular bone loss remain unclear in RA. So, we used the rat adjuvant-induced arthritis (AIA) model to characterise finely bone loss kinetics for 4 different bones from inflamed ankle; then, we investigated early bone microarchitecture changes, at the time of arthritis onset.
Annals of the rheumatic diseases.Ann Rheum Dis.2014 Mar 1;73 Suppl 1:A60-1. doi: 10.1136/annrheumdis-2013-205124.137.
BACKGROUND AND OBJECTIVES: Hallmarks of rheumatoid arthritis (RA) are joint synovitis and subchondral bone erosions, resulting in loss of joint function. However, occurrence and kinetics of periarticular bone loss remain unclear in RA. So, we used the rat adjuvant-induced arthritis (AIA) model to ch
PMID 24489264

Therapeutic effect of farnesylthiosalicylic acid on adjuvant-induced arthritis through suppressed release of inflammatory cytokines.

Aizman E1, Blacher E, Ben-Moshe O, Kogan T, Kloog Y, Mor A.Author information 1Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel.AbstractRheumatoid arthritis (RA) is an autoimmune disease characterized by pronounced inflammation and leucocyte infiltration in affected joints. Despite significant therapeutic advances, a new targeted approach is needed. Our objective in this work was to investigate the anti-inflammatory effects of the Ras inhibitor farnesylthiosalicylic acid (FTS) on adjuvant-induced arthritis (AIA) in rats, an experimental model for RA. Following AIA induction in Lewis rats by intradermal injection of heat-killed Mycobacterium tuberculosis, rats were treated with either FTS or dexamethasone and assessed daily for paw swelling. Joints were imaged by magnetic resonance imaging and computerized tomography and analysed histologically. The anti-inflammatory effect of FTS was assessed by serum assay of multiple cytokines. After adjuvant injection rats demonstrated paw swelling, leucocyte infiltration, cytokine secretion and activation of Ras-effector pathways. Upon FTS treatment these changes reverted almost to normal. Histopathological analysis revealed that the synovial hyperplasia and leucocyte infiltration observed in the arthritic rats were alleviated by FTS. Periarticular bony erosions were averted. Efficacy of FTS treatment was also demonstrated by inhibition of CD4(+) and CD8(+) T cell proliferation and of interferon (IFN)-γ, tumour necrosis factor (TNF)-α, interleukin (IL)-6 and IL-17 release. The Ras effectors PI3K, protein kinase B (AKT), p38, and extracellular-regulated kinase (ERK) were significantly attenuated and forkhead box protein 3 (FoxP3) transcription factor, a marker of regulatory T cells, was significantly increased. Thus, FTS possesses significant anti-inflammatory and anti-arthritic properties and accordingly shows promise as a potential therapeutic agent for RA. Its effects are apparently mediated, at least in part, by a decrease in proinflammatory cytokines.
Clinical and experimental immunology.Clin Exp Immunol.2014 Mar;175(3):458-67. doi: 10.1111/cei.12235.
Rheumatoid arthritis (RA) is an autoimmune disease characterized by pronounced inflammation and leucocyte infiltration in affected joints. Despite significant therapeutic advances, a new targeted approach is needed. Our objective in this work was to investigate the anti-inflammatory effects of the R
PMID 24215151

Japanese Journal

ラットアジュバント関節炎モデルで生じる膝関節拘縮の責任病巣

医療工学雑誌 (9), 1-12, 2015
NAID 40020751228

Pharmacokinetics and Antiinflammatory Effect of a Novel Gel System Containing Ketoprofen Solid Nanoparticles

Biological and Pharmaceutical Bulletin 38(12), 1918-1924, 2015
NAID 130005112631

Excessive Interleukin 18 Relate the Aggravation of Indomethacin-Induced Intestinal Ulcerogenic Lesions in Adjuvant-Induced Arthritis Rat

Biological and Pharmaceutical Bulletin 38(10), 1580-1590, 2015
NAID 130005101573

★リンクテーブル★

リンク元	「collagen-induced arthritis」「adjuvant arthritis」「collagen arthritis」「experimental arthritis」「アジュバント誘発関節炎」
関連記事	「induce」「adjuvant」「induced」