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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/29 11:46:08」(JST)
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- 1. ポリオ後症候群 post polio syndrome
- 2. 筋萎縮性側索硬化症およびその他の運動ニューロン疾患の診断 diagnosis of amyotrophic lateral sclerosis and other forms of motor neuron disease
- 3. 新生児、乳児、および小児における肺動脈狭窄（PS） pulmonic stenosis ps in neonates infants and children
- 4. ポリオおよび前角細胞への感染性疾患 polio and infectious diseases of the anterior horn
- 5. 両側性横隔膜麻痺の原因および診断 causes and diagnosis of bilateral diaphragmatic paralysis
English Journal
- A 6-week randomized, double-blind, placebo-controlled, comparator referenced trial of vabicaserin in acute schizophrenia.
- Shen JH1, Zhao Y2, Rosenzweig-Lipson S3, Popp D4, Williams JB5, Giller E4, Detke MJ6, Kane JM7.Author information 1Hengrui Medicine Co., Ltd, Shanghai, China.2Skyview Research, Pennsylvania, USA.3IVS Pharma Consulting, USA.4MedAvante Inc, Hamilton, NJ, USA.5MedAvante Inc, Hamilton, NJ, USA; College of Physicians and Surgeons, Columbia University, USA. Electronic address: jwilliams@medavante.com.6Detke Biopharma Consulting LLC, Carmel, IN, USA; Indiana University School of Medicine, USA.7The Zucker Hillside Hospital, Glen Oaks, NY, USA; The Albert Einstein College of Medicine, Bronx, NY, USA.AbstractVabicaserin, a potent 5-HT2C receptor agonist, decreases nucleus accumbens extracellular dopamine levels in rats, without affecting striatal dopamine, indicating mesolimbic selectivity. This is the first study of efficacy, safety and tolerability of vabicaserin in adults with acute schizophrenia. Three hundred fourteen hospitalized subjects were randomized to: Vabicaserin 200 or 400 mg/day, olanzapine 15 mg/day or placebo. Central raters assessed the PANSS and CGI-S. Site raters performed the BPRS and CGI-I. Central rated PANSS Positive (PANSS-PPS) was the primary endpoint. Two hundred eighty-nine subjects were included in the mITT efficacy analysis. Vabicaserin was well tolerated with no major safety concerns. Olanzapine, but not vabicaserin, caused weight gain. Vabicaserin 200 mg/day and olanzapine demonstrated significant improvement at week 6 vs. placebo on PANSS-PSS. A non-significant decrease vs. placebo was observed for 400 mg/day. Both vabicaserin groups demonstrated significant improvement over baseline on PANSS Negative while placebo worsened. Vabicaserin 200 mg/day and olanzapine demonstrated significantly greater improvement over placebo on PANSS Total whereas 400 mg/day showed a trend toward improvement. There was no significant improvement vs. placebo for either vabicaserin group on site-rated BPRS. Vabicaserin 200 mg/day and olanzapine demonstrated significant improvement vs. placebo on CGI-I and CGI-S but not 400 mg/day vabicaserin. Vabicaserin demonstrated efficacy on primary and secondary endpoints at 200 mg/day, but not at 400 mg/day which showed a trend for efficacy. The 200 mg/day vabicaserin group achieved proof of concept using central ratings. Both vabicaserin doses were well tolerated with no significant safety signals and no weight gain. Trial Registration: clinicaltrials.gov. Identifier: NCT00265551.
- Journal of psychiatric research.J Psychiatr Res.2014 Jun;53:14-22. doi: 10.1016/j.jpsychires.2014.02.012. Epub 2014 Feb 24.
- Vabicaserin, a potent 5-HT2C receptor agonist, decreases nucleus accumbens extracellular dopamine levels in rats, without affecting striatal dopamine, indicating mesolimbic selectivity. This is the first study of efficacy, safety and tolerability of vabicaserin in adults with acute schizophrenia. Th
- PMID 24613032
- Impact of road safety interventions on traffic-related occupational injuries in Spain, 2004-2010.
- López-Ruiz M1, Martínez JM2, Pérez K3, Novoa AM4, Tobías A5, Benavides FG6.Author information 1CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Center for Research in Occupational Health, Universitat Pompeu Fabra, Spain. Electronic address: maria.lopez@upf.edu.2CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Center for Research in Occupational Health, Universitat Pompeu Fabra, Spain.3CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Agència de Salut Pública de Barcelona, Spain; Institut d'Investigació Biomédica (IIB Sant Pau), Spain.4Agència de Salut Pública de Barcelona, Spain; Institut d'Investigació Biomédica (IIB Sant Pau), Spain.5Institute of Environmental Assessment and Water Research (IDAEA), Spanish Council for Scientific Research (CSIC), Spain.6CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Center for Research in Occupational Health, Universitat Pompeu Fabra, Spain; IIS IMIM - Parc Salut Mar, Spain.AbstractOBJECTIVES: To evaluate the impact of road safety interventions, including the penalty point system (PPS) and the reformed Spanish penal code (RPC), on traffic-related occupational injuries in Spain.
- Accident; analysis and prevention.Accid Anal Prev.2014 May;66:114-9. doi: 10.1016/j.aap.2014.01.012. Epub 2014 Jan 30.
- OBJECTIVES: To evaluate the impact of road safety interventions, including the penalty point system (PPS) and the reformed Spanish penal code (RPC), on traffic-related occupational injuries in Spain.METHODS: The study design was an interrupted time-series with a comparison group. The study group had
- PMID 24531113
- Change in position dependency in non-responders after multilevel surgery for obstructive sleep apnea: analysis of polysomnographic parameters.
- Lee YC1, Eun YG, Shin SY, Kim SW.Author information 1Department of Otolaryngology-Head and Neck Surgery, Kyung Hee University School of Medicine, #1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-702, Korea.AbstractThis study was aimed to evaluate the change in positional dependency by analyzing polysomnographic data in non-responders who previously underwent multilevel surgery for obstructive sleep apnea. A total of 48 consecutive patients who had a <50 % reduction of apnea/hypopnea index (AHI) and a postoperative AHI of ≤20 after multilevel surgery were enrolled in this study. Postoperative polysomnography (PSG) was carried out at least 6 months after surgical treatment, and both pre- and postoperative PSG data were analyzed. No significant differences were found in any of the measured polysomnographic parameters before and after multilevel surgery in non-responders. In position-dependent patients, supine AHI, non-supine AHI, supine oxygen desaturation index (ODI) and non -supine ODI did not significantly improve after surgery. However, non-supine AHI and non-supine ODI in non-position-dependent patients (NPPs) improved significantly. Ten of 15 initially NPPs had position dependency after surgery, increasing the proportion of PPs from 68.8 % (33/48) to 83.3 % (40/48). These results suggest that positional therapy may be a useful adjuvant therapy in non-responders with position dependency.
- European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.Eur Arch Otorhinolaryngol.2014 May;271(5):1081-5. doi: 10.1007/s00405-013-2663-1. Epub 2013 Aug 30.
- This study was aimed to evaluate the change in positional dependency by analyzing polysomnographic data in non-responders who previously underwent multilevel surgery for obstructive sleep apnea. A total of 48 consecutive patients who had a <50 % reduction of apnea/hypopnea index (AHI) and a post
- PMID 23990059
Japanese Journal
- Airborne ultrasonic transducer using polymer-based elastomer with high output-to-weight ratio
- Wu Jiang,Mizuno Yosuke,Tabaru Marie,Nakamura Kentaro
- Jpn. J. Appl. Phys. 54(8), 087201, 2015-07-02
- … With the properties of low density, low elastic modulus, and low mechanical loss, poly(phenylene sulfide) (PPS) is a suitable material as the elastomer in an airborne ultrasonic transducer for generating large vibration velocity. … In this study, we design and fabricate a transducer composed of a PPS-based longitudinal vibrator and a PPS-based disk of 0.3 mm thickness to obtain high-intensity ultrasound. …
- NAID 150000111190
- 金属との密着性を向上させたPPSの開発
- 大西 克平,依藤 大輔
- プラスチックスエージ = Plastics age 61(6), 90-93, 2015-06
- NAID 40020488793
- Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse
- Nagatake Takahiro,Fukuyama Satoshi,Sato Shintaro,Okura Hideaki,Tachibana Masashi,Taniuchi Ichiro,Ito Kosei,Shimojou Michiko,Matsumoto Naomi,Suzuki Hidehiko,Kunisawa Jun,Kiyono Hiroshi
- PLOS ONE 10(5), e0127460, 2015-05-22
- … Peyer's patches (PPs), nasopharynx-associated lymphoid tissue (NALT), and tear duct-associated lymphoid tissue (TALT) are representative MALT in the small intestine, nasal cavity, and lacrimal sac, respectively. …
- NAID 120005621897
Related Pictures
★リンクテーブル★
| リンク元 | 「発痛物質」「ポリオ後遺症」「pneumococcal polysaccharide」「包括支払方式」「肺炎球菌ポリサッカライド」 |
| 拡張検索 | 「FPPS」「DPPS」「SPPS」「CP/CPPS」 |
| 関連記事 | 「PP」「P」 |
「発痛物質」
- 英
- algogenic substance, algesic substance, pain-producing substance, PPS
- 関
発痛物質
内因性発痛物質
「ポリオ後遺症」
- 英
- post-Polio syndrome, PPS
- 関
- ポリオ
「pneumococcal polysaccharide」
- 関
- PPS
「包括支払方式」
- 英
- prospective payment system, PPS
- 関
- [[]]
「肺炎球菌ポリサッカライド」
「FPPS」
「DPPS」
「SPPS」
「CP/CPPS」
「PP」
「P」