farnesyl diphosphate synthase

ファルネシル二リン酸合成酵素、ファルネシル二リン酸シンターゼ、ファルネシルジホスフェートシンターゼ

関

farnesyl-PP synthase、FPPS、geranyltranstransferase

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/17 07:51:44」(JST)

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Z-farnesyl diphosphate synthase
Identifiers
EC number	2.5.1.68
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a Z-farnesyl diphosphate synthase (EC 2.5.1.68) is an enzyme that catalyzes the chemical reaction

geranyl diphosphate + isopentenyl diphosphate diphosphate + (2Z,6E)-farnesyl diphosphate

Thus, the two substrates of this enzyme are geranyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and (2Z,6E)-farnesyl diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase. This enzyme is also called (Z)-farnesyl diphosphate synthase.

References

• F, Bertini S, Brennan PJ, Crick DC (2001). "Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis". J. Biol. Chem. 276 (15): 11624–30. doi:10.1074/jbc.M007168200. PMID 11152452. 

UpToDate Contents

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English Journal

• Identification and characterization of a kunzeaol synthase from Thapsia garganica: implications for the biosynthesis of the pharmaceutical thapsigargin.

• Pickel B, Drew DP, Manczak T, Weitzel C, Simonsen HT, Ro DK.Source*Department of Biological Sciences, University of Calgary, Calgary, Canada, T2N 1N4.
• The Biochemical journal.Biochem J.2012 Dec 1;448(2):261-71. doi: 10.1042/BJ20120654.
• Thapsigargin is a major terpenoid constituent of Thapsia garganica root. Owing to its potent antagonistic effect on the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, thapsigargin has been widely used to study Ca2+ signalling and is also a potential drug for prostate cancer. Despite its importance,
• PMID 22938155

• Exploration and characterization of genes involved in the synthesis of diterpene defence secretion in nasute termite soldiers.

• Hojo M, Maekawa K, Saitoh S, Shigenobu S, Miura T, Hayashi Y, Tokuda G, Maekawa H.SourceTropical Biosphere Research Center, University of the Ryukyus, Okinawa, Japan.
• Insect molecular biology.Insect Mol Biol.2012 Dec;21(6):545-57. doi: 10.1111/j.1365-2583.2012.01162.x. Epub 2012 Sep 17.
• Nasutitermes takasagoensis soldiers defend their colonies using characteristic diterpenes. Diterpenes are thought to be synthesized in the frontal gland cells surrounding the gland reservoir. To identify the genes involved in diterpene synthesis, a cDNA library was prepared from the frontal gland ce
• PMID 22984844

Japanese Journal

• 1P-055 シミュレーションを用いたファルネシル二リン酸合成酵素の不斉認識機構解析(酵素学,酵素工学,一般講演)

• SAMORI Petrus Y.,吉田 康隆,安達 由依,草苅 美穂,村上 聡,波多野 豊平,大谷 典正,木島 龍朗
• 日本生物工学会大会講演要旨集 65, 31, 2013-08-25
• NAID 110009737435

• Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid

• Idrees Atif S. M.,Sugie Tomoharu,Inoue Chiyomi,Murata-Hirai Kaoru,Okamura Haruki,Morita Craig T.,Minato Nagahiro,Toi Masakazu,Tanaka Yoshimasa
• Cancer Science 104(5), 536-542, 2013-05
• … In this study, we determined the Zol concentrations required to stimulate half maximal tumor necrosis factor-α production by γδ T cells cultured with various tumor cell lines pretreated with Zol and compared these concentrations with those required for half maximal inhibition of farnesyl diphosphate synthase (FPPS) in the same tumor cell lines. …
• NAID 120005295848

• Drastic changes in the substrate specificity of geranylgeranyl diphosphate synthase from Sulfolobus acidocaldarius by a single amino acid substitution

• , ,
• Transactions of the Materials Research Society of Japan 37(2), 325-328, 2012
• … Geranylgeranyl diphosphate (GGPP) synthase catalyzes the condensation of isopentenyl diphosphate with dimethylallyl diphosphate, geranyl diphosphate or farnesyl diphosphate to produce GGPP as the final product. … GGPP synthase in the thermophilic bacterium Sulfolobus acidocaldarius can hardly accept substrate analogs possessing oxygen atoms in their prenyl chains. …
• NAID 130003399112

Related Links

• Z-farnesyl diphosphate synthase - Wikipedia, the free encyclopedia

In enzymology, a Z-farnesyl diphosphate synthase (EC 2.5.1.68) is an enzyme that catalyzes the chemical reaction. geranyl diphosphate + isopentenyl diphosphate \rightleftharpoons diphosphate + (2Z,6E)-farnesyl diphosphate. Thus, the two ...

• Farnesyl pyrophosphate - Wikipedia, the free encyclopedia

Farnesyl pyrophosphate synthase (a prenyl transferase) catalyzes sequential condensation reactions of dimethylallyl pyrophosphate with 2 units of 3- isopentenyl pyrophosphate to form farnesyl pyrophosphate, as is shown in the following two ...

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★リンクテーブル★

リンク元	「ファルネシル二リン酸合成酵素」「ファルネシル二リン酸シンターゼ」「ファルネシルジホスフェートシンターゼ」「FPPS」「farnesyl-PP synthase」
関連記事	「synthase」「diphosphate」

「ファルネシル二リン酸合成酵素」

　　[★]

英

farnesyl diphosphate synthase、farnesyl-PP synthase、FPPS

関

ファルネシル二リン酸シンターゼ、ファルネシルジホスフェートシンターゼ、ゲラニルトランストランスフェラーゼ

「ファルネシル二リン酸シンターゼ」

　　[★]

英

farnesyl diphosphate synthase

関

ファルネシル二リン酸合成酵素、ファルネシルジホスフェートシンターゼ

「ファルネシルジホスフェートシンターゼ」

　　[★]

英

farnesyl diphosphate synthase

関

ファルネシル二リン酸合成酵素、ファルネシル二リン酸シンターゼ

「FPPS」

　　[★]

• ファルネシル二リン酸合成酵素

関

farnesyl diphosphate synthase、farnesyl-PP synthase

「farnesyl-PP synthase」

　　[★]

• ファルネシル二リン酸合成酵素

関

farnesyl diphosphate synthase、FPPS

「synthase」

　　[★]

• n.

• (脱離酵素リアーゼの逆反応である合成方向の反応を指す) シンターゼ, 合成酵素, 付加酵素

関

lyase、synthetase、transferase

「diphosphate」

　　[★] 二リン酸エステル、二リン酸塩、二リン酸

関

bisphosphate、diphosphoric acid、pyrophosphate