WordNet
- the 16th letter of the Roman alphabet (同)p
PrepTutorEJDIC
- parking
- phosphorusの化学記号
- parental guidance(映画の観客指定で)親の認可[映画]
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/08 15:07:55」(JST)
wiki en
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 単純ヘルペスウイルス1型感染の病因 pathogenesis of herpes simplex virus type 1 infection
- 2. 肺移植：ドナー肺の保存 lung transplantation donor lung preservation
- 3. マラリアにおける貧血 anemia in malaria
- 4. アスピリンによる呼吸器疾患の増悪 aspirin exacerbated respiratory disease
- 5. 非ステロイド性抗炎症剤（NSAIDs）（アスピリンを含む）：胃十二指腸障害の病因 nsaids including aspirin pathogenesis of gastroduodenal toxicity
English Journal
- Assessment of genotoxicity of catecholics using impedimetric DNA-biosensor.
- Ensafi AA, Amini M, Rezaei B.Author information Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran. Electronic address: Ensafi@cc.iut.ac.ir.AbstractThe potential toxicity of catecholics is a big concern, because the catechol-derived semiquinone radical after the oxidation of catechol (CA) can donate an H-atom to generate quinone, and during this process a superoxide anion radical may be produced. Considering the fact that catecholics are highly consumed in our daily life and some drugs also contain one or more CA moieties, we speculate that CA's toxicity might not be insurmountable. Therefore, finding approaches to investigate catecholics potential toxicity is of great significance. Here in, an electrochemical protocol for direct monitoring of genotoxicity of catecholics is described. CA encapsulated on MWCNTs (CA@MWCNT) through continuous cyclic voltammetric on the surface of pencil graphite electrode (PGE). Subsequently, a DNA functionalized biosensor (DNA/CA@MWCNT/PGE) was prepared and characterized for the detection and the investigation of DNA damage induced by radicals generated from catecholics. The change in the charge transfer resistance (Rct) after the incubation of the DNA biosensor in the damaging solution for a certain time was used as an indicator for DNA damage. Incubation of DNA-modified electrode with CA solution containing Cu(II), Cr(VI) and Fe(III) has been shown to result in oxidative damage to the DNA and change in the electrochemical properties. It was found that the presence of Cu(II), Cr(VI) and Fe(III) in solution caused damage to DNA. The inhibitory effect of glutathione and plumbagin on the CA-mediated DNA damage has also been investigated using the biosensor. The minimum concentration of the metal ions for CA induced DNA damage was investigated. Recognition of suitable matrixes for CA-mediated DNA damage can be assessed using proposed DNA biosensor. Such direct monitoring of the DNA damage holds great promise for designing new biosensors with modification of the biosensor with different damaging agents.
- Biosensors & bioelectronics.Biosens Bioelectron.2014 Mar 15;53:43-50. doi: 10.1016/j.bios.2013.09.030. Epub 2013 Sep 19.
- The potential toxicity of catecholics is a big concern, because the catechol-derived semiquinone radical after the oxidation of catechol (CA) can donate an H-atom to generate quinone, and during this process a superoxide anion radical may be produced. Considering the fact that catecholics are highly
- PMID 24121207
- Two novel mutations in the SLCO2A1 gene in a Chinese patient with primary hypertrophic osteoarthropathy.
- Zhang Z1, He JW2, Fu WZ2, Zhang CQ3, Zhang ZL4.Author information 1Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated the Sixth People's Hospital, Shanghai 200233, 600 Yi-Shan Rd., PR China; Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated the Sixth People's Hospital, Shanghai 200233, 600 Yi-Shan Rd., PR China.2Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated the Sixth People's Hospital, Shanghai 200233, 600 Yi-Shan Rd., PR China.3Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated the Sixth People's Hospital, Shanghai 200233, 600 Yi-Shan Rd., PR China.4Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated the Sixth People's Hospital, Shanghai 200233, 600 Yi-Shan Rd., PR China. Electronic address: zzl2002@medmail.com.cn.AbstractPrimary hypertrophic osteoarthropathy (PHO) is a rare monogenetic disease characterized by digital clubbing, periostosis and pachydermia. Mutations in the 15-hydroxy-prostaglandin dehydrogenase (HPGD) gene and solute carrier organic anion transporter family member 2A1 (SLCO2A1) gene have been shown to be associated with PHO. Here, we described clinical characteristics in a Chinese patient with PHO, and identified two novel mutations in SLCO2A1: a heterozygous guanine-to-thymidine transition at the invariant -1 position of the acceptor site of intron 2 (c.235-1G>T) and a heterozygous missense mutation p.Pro219Leu (c.656C>T) in exon 5.
- Gene.Gene.2014 Jan 25;534(2):421-3. doi: 10.1016/j.gene.2013.10.051. Epub 2013 Nov 1.
- Primary hypertrophic osteoarthropathy (PHO) is a rare monogenetic disease characterized by digital clubbing, periostosis and pachydermia. Mutations in the 15-hydroxy-prostaglandin dehydrogenase (HPGD) gene and solute carrier organic anion transporter family member 2A1 (SLCO2A1) gene have been shown
- PMID 24185079
- Label-free voltammetric detection of MicroRNAs at multi-channel screen printed array of electrodes comparison to graphite sensors.
- Erdem A, Congur G.Author information Ege University, Faculty of Pharmacy, Analytical Chemistry Department, Bornova, 35100 Izmir, Turkey. Electronic address: arzum.erdem@ege.edu.tr.AbstractThe multi-channel screen-printed array of electrodes (MUX-SPE16) was used in our study for the first time for electrochemical monitoring of nucleic acid hybridization related to different miRNA sequences (miRNA-16, miRNA-15a and miRNA-660, i.e, the biomarkers for Alzheimer disease). The MUX-SPE16 was also used for the first time herein for the label-free electrochemical detection of nucleic acid hybridization combined magnetic beads (MB) assay in comparison to the disposable pencil graphite electrode (PGE). Under the principle of the magnetic beads assay, the biotinylated inosine substituted DNA probe was firstly immobilized onto streptavidin coated MB, and then, the hybridization process between probe and its complementary miRNA sequence was performed at MB surface. The voltammetric transduction was performed using differential pulse voltammetry (DPV) technique in combination with the single-use graphite sensor technologies; PGE and MUX-SPE16 for miRNA detection by measuring the guanine oxidation signal without using any external indicator. The features of single-use sensor technologies, PGE and MUX-SPE16, were discussed concerning to their reproducibility, detection limit, and selectivity compared to the results in the earlier studies presenting the electrochemical miRNA detection related to different miRNA sequences.
- Talanta.Talanta.2014 Jan 15;118:7-13. doi: 10.1016/j.talanta.2013.09.041. Epub 2013 Oct 7.
- The multi-channel screen-printed array of electrodes (MUX-SPE16) was used in our study for the first time for electrochemical monitoring of nucleic acid hybridization related to different miRNA sequences (miRNA-16, miRNA-15a and miRNA-660, i.e, the biomarkers for Alzheimer disease). The MUX-SPE16 wa
- PMID 24274264
Japanese Journal
- ストレスによる情動制御におけるPGE₂-EP1系の役割 (AYUMI プロスタグランジンと炎症)
- 医学のあゆみ 254(12), 1115-1120, 2015-09-19
- NAID 40020591964
- ストレス関連行動におけるCOX-1-PGE₂-EP1系の役割 (特集 プロスタグランジンによる病態制御の最前線)
- 細胞 47(6), 270-273, 2015-06
- NAID 40020534678
- 腸内真菌の増殖とアレルギー性気道炎症 (第1土曜特集 粘膜免疫Update) -- (粘膜免疫と疾患)
- 医学のあゆみ 253(5), 457-463, 2015-05-02
- NAID 40020442363
Related Links
- Combined natural gas and electric utility provider for northern and central California. Open, close or transfer service, Chapter 11 information, system status, and financial assistance.
- 様々なトラブル対策など調査会社と警備会社を融合し幅広く対応。愛知県小牧市のPGE警備は、愛知県警元刑事の経験を活かした全く新しい警備会社です。名古屋市を中心に警備会社や調査会社（探偵）を網羅し個人から企業防衛まで ...
Related Pictures
★リンクテーブル★
| リンク元 | 「動脈管」「プロスタグランジンE」 |
| 拡張検索 | 「16,16-dimethyl-PGE2」「PGE2 receptor」「PGE2レセプター」「PGE2受容体」「PGE2」 |
| 関連記事 | 「PG」「P」 |
「動脈管」
- 英
- arterial duct
- ラ
- ductus arteriosus
- 同
- Botallo's duct Botallo duct Botallo管 ボタロ管 ボタロー管 ボタロー動脈管
- 関
- 卵円孔、胎児循環
血行動態
- 右室(上半身由来の血液)から駆出された血液は10%程度が肺動脈へ、残りは大動脈に流入する。
閉鎖時期
- 生後1-2日/2-3日(QB.P-192)
- 生後半日で閉鎖し、器質的閉鎖は数日後である。(G10M.29)
動脈管閉鎖の原因
臨床関連
Henry Gray (1825-1861). Anatomy of the Human Body. 1918.
「プロスタグランジンE」
-PGE
「16,16-dimethyl-PGE2」
16
「PGE2 receptor」
「PGE2レセプター」
「PGE2受容体」
「PGE2」
「PG」
- プロスタグランジン prostaglandin
- 大動脈弁最大圧較差
「P」