- 同
- PGE,
WordNet
- a potent substance that acts like a hormone and is found in many bodily tissues (and especially in semen); produced in response to trauma and may affect blood pressure and metabolism and smooth muscle activity
- the 5th letter of the Roman alphabet (同)e
- the base of the natural system of logarithms; approximately equal to 2.718282...
PrepTutorEJDIC
- einsteiniumの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/06/08 07:13:06」(JST)
[Wiki en表示]
Prostaglandin E is a family of naturally occurring prostaglandins and may be used pharmaceutically in medicine.
Types include:
- Prostaglandin E1 also termed Alprostadil
- Prostaglandin E2 also termed Dinoprostone
It is created from prostaglandin E synthase.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[1]
Prostaglandin E2
Prostaglandin E2 is secreted in microvessels by the endothelium. It is a direct vasodilator and it inhibits the release of noradrenaline from sympathetic nerve terminals. It doesn't have the effect on platelets PGI2 does.
References
- ^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
Pharmacology 2007. Rang, Dale, Ritter, Flower. Churchill Livingstone Elsevier.
External links
- Prostaglandins E at the US National Library of Medicine Medical Subject Headings (MeSH)
Eicosanoids
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Precursor |
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Prostanoids |
Prostaglandins (PG) |
Precursor |
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Active |
D/J |
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E/F |
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I |
- I2 (Prostacyclin/Epoprostenol):
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Thromboxanes (TX) |
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Leukotrienes (LT) |
Precursor |
- Arachidonic acid 5-hydroperoxide
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Initial |
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SRS-A |
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Eoxins (EX) |
Precursor |
- Arachidonic acid 15-hydroperoxide
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Eoxins |
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Nonclassic |
- Lipoxins (LX) (A4, B4)
- Virodhamine
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By function |
- vasoconstriction
- vasodilation
- platelets: induce
- inhibit
- leukocytes: induce
- inhibit
- labor stimulation:
- PGE2 (Dinoprostone)
- PGF2α (Dinoprost)
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Cyclooxygenase-2-related signaling in the hypothalamus plays differential roles in response to various acute stresses.
- Ma Y, Matsuwaki T, Yamanouchi K, Nishihara M.SourceDepartment of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
- Brain research.Brain Res.2013 May 1;1508:23-33. doi: 10.1016/j.brainres.2013.02.042. Epub 2013 Feb 28.
- We previously suggested that cyclooxygenase (COX)-2 plays a role as a common mediator of stresses in the brain. In the present study, we evaluated the possible involvement of COX-2-related signaling in the activation of the hypothalamic-pituitary-adrenal (HPA) axis under three different stress condi
- PMID 23458502
- NADPH Oxidase NOX5-S and Nuclear Factor κB1 Mediate Acid-Induced Microsomal Prostaglandin E Synthase-1 Expression in Barrett's Esophageal Adenocarcinoma Cells.
- Zhou X, Li D, Resnick MB, Wands J, Cao W.SourceDepartment of Pathology and Medicine, The Warren Alpert Medical School of Brown University & Rhode Island Hospital, 55 Claverick St, Room 337, Providence, RI 02903. wcao@hotmail.com.
- Molecular pharmacology.Mol Pharmacol.2013 May;83(5):978-90. doi: 10.1124/mol.112.083287. Epub 2013 Feb 25.
- The mechanisms of progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EA) are not known. Cycloxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) has been shown to be important in esophageal tumorigenesis. We have shown that COX-2 mediates acid-induced PGE2 production. The prostag
- PMID 23439561
- The effect of prostaglandin E1 on brainstem blood flow disturbance in an animal model of vertebrobasilar insufficiency.
- Yamanaka T, Murai T, Sawai Y, Okamoto H, Hosoi H.SourceDepartment of Otolaryngology-Head and Neck Surgery, Nara Medical University School of Medicine, 840 Shijo, Kashihara, Nara, 634-8522, Japan, toshya@naramed-u.ac.jp.
- European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.Eur Arch Otorhinolaryngol.2013 Apr 17. [Epub ahead of print]
- Using an animal model of vertebrobasilar insufficiency (VBI), in which brainstem circulatory disturbance was induced in rats, we examined how prostaglandin E1 (PG-E1) affects brainstem blood flow (BBF) to clarify whether it is effective against VBI. Fifteen healthy male Wister rats that displayed po
- PMID 23591797
Japanese Journal
- Antiinflammatory Activities of Crebanine by Inhibition of NF-κB and AP-1 Activation through Suppressing MAPKs and Akt Signaling in LPS-Induced RAW264.7 Macrophages
- Protective effects of manassantin A against ethanol-induced gastric injury in rats
- Antiinflammatory Activities of Crebanine by Inhibition of NF-κB and AP-1 Activation through Suppressing MAPKs and Akt Signaling in LPS-Induced RAW 264.7 Macrophages
Related Links
- 掲載カタログ Index 2nd Ed. p.689 ニュース 2012年9月1日号 p.25 ニュース 2011年8月15日号(No.496) p.20 製品記事 Luteinizing Hormone EIA Kit Prostaglandin E 2 EIA Kit 関連記事 CAY ケイマン ケミカル Cayman Chemical Company
- prostaglandin-E synthase human microsomal prostaglandin E synthase 1 with bound glutathione. PDB entry 3DWW [1] Identifiers EC number 5.3.99.3 CAS number 52227-79-9 Databases IntEnz IntEnz view BRENDA BRENDA entry
★リンクテーブル★
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- 英
- prostaglandin E PGE
- 関
- プロスタグランジン
-PGE
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- 関
- PGE2 receptor
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16
- 関
- 16,16-dimethyl-PGE2
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プロスタグランジンE2
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プロスタグランジン prostaglandins PG
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アインスタイニウム
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- einsteinium
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