PAF acetylhydrolase

PAFアセチルヒドロラーゼ、血小板活性化因子アセチルヒドロラーゼ

関

1-alkyl-2-acetylglycerophosphocholine esterase、lipoprotein-associated phospholipase A2、Lp-PLA2、platelet-activating factor acetylhydrolase

WordNet

1. the 16th letter of the Roman alphabet (同)p

PrepTutorEJDIC

1. personal assistant個人秘書 / public address [system]
2. parking
3. phosphorusの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/12/14 06:28:38」(JST)

wiki en

[Wiki en表示]

PAF acetylhydrolase is an enzyme that catabolizes platelet-activating factor. There are multiple enzymes with this function:

• Lipoprotein-associated phospholipase A2
• Platelet-activating factor acetylhydrolase 2, cytoplasmic
• Platelet-activating factor acetylhydrolase 1b: regulatory subunit 1, catalytic subunit 2, catalytic subunit 3

External links

• PAF acetylhydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
• EC 3.1.1.47

UpToDate Contents

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• 1. 脳卒中のための血液バイオマーカー blood biomarkers for stroke
• 2. 心血管疾患と同等のリスクと確立した危険因子の概要 overview of the risk equivalents and established risk factors for cardiovascular disease
• 3. アテローム性動脈硬化症の病因 pathogenesis of atherosclerosis
• 4. 心血管疾患の二次予防 secondary prevention of cardiovascular disease
• 5. 乳児における母乳の利益 infant benefits of breastfeeding

English Journal

• Bioactive oxidatively truncated phospholipids in inflammation and apoptosis: Formation, targets, and inactivation.

• McIntyre TM.AbstractThis report reviews structurally related phospholipid oxidation products that are biologically active where molecular mechanisms have been defined. Phospholipids containing polyunsaturated fatty acyl residues are chemically or enzymatically oxidized to phospholipid hydroperoxides, which may fragment on either side of the newly introduced peroxy function to form phospholipids with a truncated sn-2 residue. These truncated phospholipids not subject to biologic control of their production and, depending on the sn-2 residue length and structure, can stimulate the plasma membrane receptor for PAF. Alternatively, these chemically formed products can be internalized by a transport system to either stimulate the lipid activated nuclear transcription factor PPARγ or at higher levels interact with mitochondria to initiate the intrinsic apoptotic cascade. Intracellular PAF acetylhydrolases specifically hydrolyze truncated phospholipids, and not undamaged, biosynthetic phospholipids, to protect cells from oxidative death. Truncated phospholipids are also formed within cells where they couple cytokine stimulation to mitochondrial damage and apoptosis. The relevance of intracellular truncated phospholipids is shown by the complete protection from cytokine induced apoptosis by PAF acetylhydrolase expression. This protection shows truncated phospholipids are the actual effectors of cytokine mediated toxicity. This article is part of a Special Issue entitled: Oxidized phospholipids-their properties and interactions with proteins.
• Biochimica et biophysica acta.Biochim Biophys Acta.2012 Oct;1818(10):2456-64. Epub 2012 Mar 16.
• This report reviews structurally related phospholipid oxidation products that are biologically active where molecular mechanisms have been defined. Phospholipids containing polyunsaturated fatty acyl residues are chemically or enzymatically oxidized to phospholipid hydroperoxides, which may fragment
• PMID 22445850

• Modulation of oxidative stress, inflammation, and atherosclerosis by lipoprotein-associated phospholipase A2.

• Rosenson RS, Stafforini DM.SourceMount Sinai School of Medicine, New York, NY 10029; and.
• Journal of lipid research.J Lipid Res.2012 Sep;53(9):1767-82. Epub 2012 Jun 4.
• Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), also known as platelet-activating factor acetylhydrolase (PAF-AH), is a unique member of the phospholipase A(2) superfamily. This enzyme is characterized by its ability to specifically hydrolyze PAF as well as glycerophospholipids containing sho
• PMID 22665167

Japanese Journal

• Pitavastatin Increases HDL Particles Functionally Preserved with Cholesterol Efflux Capacity and Antioxidative Actions in Dyslipidemic Patients

• , , , , , , ,
• Journal of Atherosclerosis and Thrombosis 20(9), 708-716, 2013
• … The cholesterol efflux capacity and activities of the antioxidative enzymes paraoxonase-1 (PON-1) and platelet-activating factor acetylhydrolase (PAF-AH) were evaluated using polyethethylene glycol-treated HDL fractions before and after pitavastatin treatment.Results: Pitavastatin treatment decreased the serum LDL-C level by 39% and increased the serum HDL-C level by 9% (p＜0.05). …
• NAID 130004845448

• Lp-PLA2 (PAF acetylhydrolase) (今月の主題 広義のアポリポ蛋白) -- (臨床検査への応用の可能性)

• 今泉 忠淳,吉田 秀見,松宮 朋穂 [他]
• 臨床検査 54(4), 389-393, 2010-04
• NAID 40017066108

• 血漿PAF-AH欠損症 (特集 脳卒中と遺伝子)

• 佐藤 敬
• Brain and nerve 60(11), 1319-1324, 2008-11
• NAID 40016342488

Related Links

• PAF Acetylhydrolase Assay Kit | アッセイキット | 脂質 ...- フナコシ

platelet-activating factor（PAF）は刺激を受けた様々な細胞で合成される生理活性を有したリン脂質です。PAFは，細胞および血漿中に存在し，PAF-AH（PAF acetylhydrolase）によって不活性lyso-PAFになります。血漿PAF-AHは，sn-2 ...

• Platelet-Activating Factor, PAF Acetylhydrolase, and Severe ...

Original Article from The New England Journal of Medicine — Platelet-Activating Factor, PAF Acetylhydrolase, and Severe Anaphylaxis ... Results Mean (±SD) serum PAF levels were significantly higher in patients with ...

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★リンクテーブル★

リンク元	「PAFアセチルヒドロラーゼ」「Lp-PLA2」「1-alkyl-2-acetylglycerophosphocholine esterase」「lipoprotein-associated phospholipase A2」「血小板活性化因子アセチルヒドロラーゼ」
関連記事	「PA」「P」「PAF」「acetylhydrolase」

「PAFアセチルヒドロラーゼ」

　　[★]

英

PAF acetylhydrolase

関

血小板活性化因子アセチルヒドロラーゼ、1-アルキル-2-アセチルグリセロホスホコリンエステラーゼ、リ・タンパク質関連ホスホリパーゼA2

「Lp-PLA2」

　　[★]

• リ・タンパク質関連ホスホリパーゼA2

関

1-alkyl-2-acetylglycerophosphocholine esterase、lipoprotein-associated phospholipase A2、PAF acetylhydrolase

「1-alkyl-2-acetylglycerophosphocholine esterase」

　　[★]

1-アルキル-2-アセチルグリセロホスホコリンエステラーゼ

関

lipoprotein-associated phospholipase A2、Lp-PLA2、PAF acetylhydrolase

「lipoprotein-associated phospholipase A2」

　　[★]

リポタンパク質関連ホスホリパーゼA2

関

1-alkyl-2-acetylglycerophosphocholine esterase、Lp-PLA2、PAF acetylhydrolase

「血小板活性化因子アセチルヒドロラーゼ」

　　[★]

英

platelet-activating factor acetylhydrolase、PAF acetylhydrolase

関

PAFアセチルヒドロラーゼ

「PA」

　　[★]

• 肺動脈弁閉鎖症 pulmonary atresia
• 肺動脈 pulmonary artery、肺動脈幹
• 原発性アルドステロン症 primary aldosteronism

• 微生物学：粒子凝集法(particle agglutination test)
• 薬理学：

　

「P」

　　[★]

• プロリン proline
• P波 P wave
• リン phosphorus

　 　 　

「PAF」

　　[★] 血小板活性化因子, platelet activating factor, platelet-activating factor

「acetylhydrolase」

　　[★]

アセチルヒドロラーゼ