1-アルキル-2-アセチルグリセロホスホコリンエステラーゼ
- 関
- lipoprotein-associated phospholipase A2、Lp-PLA2、PAF acetylhydrolase
WordNet
- any of a series of univalent groups of the general formula CnH2n+1 derived from aliphatic hydrocarbons (同)alkyl_group, alkyl radical
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/25 00:41:19」(JST)
[Wiki en表示]
| 1-alkyl-2-acetylglycerophosphocholine esterase |
| Identifiers |
| EC number |
3.1.1.47 |
| CAS number |
76901-00-3 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, a 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) is an enzyme that catalyzes the chemical reaction
- 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O 1-alkyl-sn-glycero-3-phosphocholine + acetate
Thus, the two substrates of this enzyme are 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine and H2O, whereas its two products are 1-alkyl-sn-glycero-3-phosphocholine and acetate.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase. Other names in common use include 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, and alkylacetyl-GPC:acetylhydrolase. This enzyme participates in ether lipid metabolism.
Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1BWP, 1BWQ, 1BWR, 1ES9, 1FXW, 1VYH, and 1WAB.
References
- Blank ML, Lee T, Fitzgerald V, Snyder F (1981). "A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid)". J. Biol. Chem. 256 (1): 175–8. PMID 7451433.
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Hydrolase: esterases (EC 3.1)
|
|
3.1.1: Carboxylic
ester hydrolases |
- Cholinesterase
- Acetylcholinesterase
- Butyrylcholinesterase
- Pectinesterase
- 6-phosphogluconolactonase
- PAF acetylhydrolase
- Lipase
- Bile salt-dependent
- Gastric/Lingual
- Pancreatic
- Lysosomal
- Hormone-sensitive
- Endothelial
- Hepatic
- Lipoprotein
- Monoacylglycerol
- Diacylglycerol
|
|
| 3.1.2: Thioesterase |
- Palmitoyl protein thioesterase
- Ubiquitin carboxy-terminal hydrolase L1
- 4-hydroxybenzoyl-CoA thioesterase
|
|
| 3.1.3: Phosphatase |
- Alkaline phosphatase
- Acid phosphatase (Prostatic)/Tartrate-resistant acid phosphatase/Purple acid phosphatases
- Nucleotidase
- Glucose 6-phosphatase
- Fructose 1,6-bisphosphatase
- Protein phosphatase
- OCRL
- Pyruvate dehydrogenase phosphatase
- Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
- PTEN
- Phytase
- Inositol-phosphate phosphatase
- Protein phosphatase: Protein tyrosine phosphatase
- Protein serine/threonine phosphatase
- Dual-specificity phosphatase
|
|
3.1.4:
Phosphodiesterase |
- Autotaxin
- Phospholipase
- Sphingomyelin phosphodiesterase
- PDE1
- PDE2
- PDE3
- PDE4A/PDE4B
- PDE5
- Lecithinase (Clostridium perfringens alpha toxin)
- Cyclic nucleotide phosphodiesterase
|
|
| 3.1.6: Sulfatase |
- arylsulfatase
- Arylsulfatase A
- Arylsulfatase B
- Arylsulfatase E
- Steroid sulfatase
- Galactosamine-6 sulfatase
- Iduronate-2-sulfatase
- N-acetylglucosamine-6-sulfatase
|
|
Nuclease (includes
deoxyribonuclease
and ribonuclease) |
3.1.11-16:
Exonuclease |
| Exodeoxyribonuclease |
|
|
| Exoribonuclease |
|
|
|
3.1.21-31:
Endonuclease |
| Endodeoxyribonuclease |
- Deoxyribonuclease I
- Deoxyribonuclease II
- Deoxyribonuclease IV
- Restriction enzyme
- UvrABC endonuclease
|
|
| Endoribonuclease |
- RNase III
- RNase H
- RNase P
- RNase A
- RNase T1
- RNA-induced silencing complex
|
|
| either deoxy- or ribo- |
- Aspergillus nuclease S1
- Micrococcal nuclease
|
|
|
|
Enzymes
|
|
| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
|
|
| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
|
| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
|
| Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
|
| Types |
- EC1 Oxidoreductases (list)
- EC2 Transferases (list)
- EC3 Hydrolases (list)
- EC4 Lyases (list)
- EC5 Isomerases (list)
- EC6 Ligases (list)
|
UpToDate Contents
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English Journal
- [Association study of LIS1 and TSNAX genes with bipolar disorder in Chinese Han population].
- Li X1, Guan L, Lin Y, Zhang X, Deng W, Yang Z, Ma X, Lao G, Ye B, Huang W, Jiang Z, Miao G, Xu G, Liu W, Wang Y, Li T, Cao L.
- Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics.Zhonghua Yi Xue Yi Chuan Xue Za Zhi.2014 Jun;31(3):357-61. doi: 10.3760/cma.j.issn.1003-9406.2014.03.022.
- OBJECTIVE: To assess the association of neural development-related genes LIS1and TSNAX with bipolar disorder in a Chinese Han population.METHODS: Three hundred and eight five patients (including 188 males and 197 females) from Guangzhou Brain Hospital with bipolar disorder meeting the Diagnostic and
- PMID 24928020
- A genomic copy number variant analysis implicates the MBD5 and HNRNPU genes in Chinese children with infantile spasms and expands the clinical spectrum of 2q23.1 deletion.
- Du X, An Y, Yu L, Liu R, Qin Y, Guo X, Sun D, Zhou S, Wu B, Jiang YH1, Wang Y.
- BMC medical genetics.BMC Med Genet.2014 May 29;15:62. doi: 10.1186/1471-2350-15-62.
- BACKGROUND: Infantile spasms (IS) is a specific type of epileptic encephalopathy associated with severe developmental disabilities. Genetic factors are strongly implicated in IS, however, the exact genetic defects remain unknown in the majority of cases. Rare mutations in a single gene or in copy nu
- PMID 24885232
- [Lp-PLA2 and sPLA2: cardiovascular biomarkers].
- Ait-Oufella H1, Mallat Z2, Tedgui A3.
- Médecine sciences : M/S.Med Sci (Paris).2014 May;30(5):526-31. doi: 10.1051/medsci/20143005015. Epub 2014 Jun 13.
- Phospholipases A2 (PLA2) belong to a superfamily of enzymes that catalyze the hydrolysis of glycerophospholipids at the sn-2 position, producing nonesterified fatty acids and lysophospholipids. Many experimental studies have shown that PLA2 are involved in lipid metabolism and immuno-inflammatory re
- PMID 24939539
Japanese Journal
- Association of Lipoprotein-associated Phospholipase A2 with Coronary Calcification among American and Japanese Men
- EL-SAED Aiman,SEKIKAWA Akira,ZAKY Riad Wahid,KADOWAKI Takashi,TAKAMIYA Tomoko,OKAMURA Tomonori,EDMUNDOWICZ Daniel,KITA Yoshikuni,KULLER Lewis H.,UESHIMA Hirotsugu
- Journal of epidemiology 17(6), 179-185, 2007-11-01
- … To determine whether lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are related to the difference in the prevalence of CAC between the two populations.METHODS: A total of 200 men aged 40-49 years were examined: 100 residents in Allegheny County, Pennsylvania, United States, and 100 residents in Kusatsu City, Shiga, Japan. …
- NAID 10025811498
Related Links
- In enzymology, a 1-alkyl-2-acetylglycerophosphocholine esterase is an enzyme that catalyzes the chemical reaction 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H₂O 1-alkyl-sn-glycero-3-phosphocholine + acetate Thus, the two ...
- "1-Alkyl-2-acetylglycerophosphocholine Esterase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject ... A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the ...
★リンクテーブル★
[★]
PAFアセチルヒドロラーゼ、血小板活性化因子アセチルヒドロラーゼ
- 関
- 1-alkyl-2-acetylglycerophosphocholine esterase、lipoprotein-associated phospholipase A2、Lp-PLA2、platelet-activating factor acetylhydrolase
[★]
- 関
- 1-alkyl-2-acetylglycerophosphocholine esterase、lipoprotein-associated phospholipase A2、PAF acetylhydrolase
[★]
- 英
- 1-alkyl-2-acetylglycerophosphocholine esterase
- 関
- PAFアセチルヒドロラーゼ、リ・タンパク質関連ホスホリパーゼA2
[★]
リポタンパク質関連ホスホリパーゼA2
- 関
- 1-alkyl-2-acetylglycerophosphocholine esterase、Lp-PLA2、PAF acetylhydrolase
[★]
エステラーゼ、エステル加水分解酵素、エステル分解酵素