PrepTutorEJDIC

English Journal

Miura K1, Shirasaka T, Yamaue H, Sasaki I.
Expert opinion on drug delivery.Expert Opin Drug Deliv.2012 Mar;9(3):273-86. doi: 10.1517/17425247.2012.652945. Epub 2012 Jan 11.
INTRODUCTION: 5-FU is a core anticancer agent for GI and other malignancies, and infusional 5-FU regimens have been widely utilized. Orally administrable fluoropyrimidine prodrugs have been developed to enhance the anticancer efficacy of 5-FU and to reduce its adverse reactions.AREAS COVERED: S-1 is
PMID 22235991

Decreased fluorouracil cytotoxic effect on EB-virus transformed lymphocytes from hereditary orotic aciduria.

Andou M1, Sumi S, Togari H, Wada Y.
International journal of molecular medicine.Int J Mol Med.2000 Jul;6(1):69-72.
5-Fluorouracil (5-FU), used widely for malignancies, phosphorylate mostly by uracil phosphoribosyl transferase (UPRT). Patients with hereditary orotic aciduria lack the orotate phosphoribosyl transferase (OPRT) activity. In the cancer cells, the OPRT activity is paralleled with the UPRT activity. Th
PMID 10851269

Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families.

Suchi M1, Mizuno H, Kawai Y, Tsuboi T, Sumi S, Okajima K, Hodgson ME, Ogawa H, Wada Y.
American journal of human genetics.Am J Hum Genet.1997 Mar;60(3):525-39.
Uridine monophosphate (UMP) synthase is a bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT) and orotidine-5'-monophosphate decarboxylase (ODC). Loss of either enzymatic activity results in hereditary orotic aciduria, a rare
PMID 9042911

Increase of protein synthesis by uridine supplement in lectin-stimulated peripheral blood lymphocytes and EB virus-transformed B cell line of hereditary orotic aciduria type I.