WordNet
- limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
- control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
- limit the range or extent of; "Contact between the young was inhibited by strict social customs"
- a substance that retards or stops an activity
- the 8th letter of the Roman alphabet (同)h
- infection by the human immunodeficiency virus
PrepTutorEJDIC
- 〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》
- 抑制する人(物) / 化学反応抑制剤
- hydrogenの化学記号
- 鉛筆の硬度 / 《俗》heroin
- Hawaii
UpToDate Contents
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- 1. インテグラーゼ阻害剤の薬理学 pharmacology of integrase inhibitors
- 2. HIV抗レトロウイルス療法に関する臨床試験：インテグラーゼ阻害剤 clinical trials of hiv antiretroviral therapy integrase inhibitors
- 3. 妊娠時の抗レトロウイルス剤：侵入阻害剤およびインテグラーゼ阻害剤 antiretroviral medications in pregnancy entry and integrase inhibitors
- 4. HIV薬剤耐性検査の解釈についての手引 primer on interpretation of hiv drug resistance testing
- 5. 未治療HIV感染患者のための抗レトロウイルス療法の選択 selecting antiretroviral regimens for the treatment naive hiv infected patient
English Journal
- Integrase-independent HIV-1 infection is augmented under conditions of DNA damage and produces a viral reservoir.
- Ebina H, Kanemura Y, Suzuki Y, Urata K, Misawa N, Koyanagi Y.AbstractHIV-1 possesses a viral protein, integrase (IN), which is necessary for its efficient integration in target cells. However, it has been reported that an IN-defective HIV strain is still capable of integration. Here, we assessed the ability of wild type (WT) HIV-1 to establish infection in the presence of IN inhibitors. We observed a low, yet clear infection of inhibitor-incubated cells infected with WT HIV which was identical to cells infected with IN-deficient HIV, D64A. Furthermore, the IN-independent integration could be enhanced by the pretreatment of cells with DNA-damaging agents suggesting that integration is mediated by a DNA repair system. Moreover, significantly faster viral replication kinetics with augmented viral DNA integration was observed after infection in irradiated cells treated with IN inhibitor compared to nonirradiated cells. Altogether, our results suggest that HIV DNA has integration potential in the presence of an IN inhibitor and may serve as a virus reservoir.
- Virology.Virology.2012 May 25;427(1):44-50. Epub 2012 Feb 27.
- HIV-1 possesses a viral protein, integrase (IN), which is necessary for its efficient integration in target cells. However, it has been reported that an IN-defective HIV strain is still capable of integration. Here, we assessed the ability of wild type (WT) HIV-1 to establish infection in the presen
- PMID 22374236
- Simple and General Criterion for "In Silico" Screening of Candidate HIV Drugs.
- Veljkovic N, Glisic S, Prljic J, Perovic V, Veljkovic V.SourceCenter for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, P.O. Box 522, 11001 Belgrade, Serbia. vv@vinca.rs.
- Current pharmaceutical biotechnology.Curr Pharm Biotechnol.2012 Mar 20. [Epub ahead of print]
- Highly active antiretroviral therapy (HAART) dramatically has changed the course of HIV infection. Currently, this therapy involves the use of agents from at least two distinct classes of antivirals: a protease inhibitor in combination with two nucleoside/nucleotide reverse transcriptase inhibitors
- PMID 22429138
Japanese Journal
- 最新のHIV感染症治療戦略 (特集 HIV感染症と呼吸器疾患)
- 立川 夏夫
- 日本胸部臨床 70(5), 434-448, 2011-05
- NAID 40018827429
- Quantifying the HIV-1 integrase inhibitor raltegravir in female genital tract secretions using high-performance liquid chromatography with ultraviolet detection
- TALAMEH Jasmine A.,REZK Naser L.,KASHUBA Angela D. M.
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 878(1), 92-96, 2010-01-01
- NAID 10028030715
- インテグラーゼ阻害薬,ケモカインレセプター阻害薬、融合阻害薬 (特集 HIV/AIDS--最新の治療研究の進歩) -- (抗HIV薬・ワクチン研究の進歩)
- 潟永 博之
- 日本臨床 68(3), 520-524, 2010-03
- NAID 40016975407
Related Links
- S2001 Elvitegravir (GS-9137, JTK-303) Elvitegravir (GS-9137, JTK-303) is an HIV integrase inhibitor for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM in cell-free assays ...
- Murray JM, Emery S, Kelleher AD, et al. Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase. AIDS 2007; 21:2315. Wong JK, Lampiris H. Covering all the ...
Related Pictures
★リンクテーブル★
| リンク元 | 「HIVインテグラーゼ阻害剤」「HIVインテグラーゼ阻害薬」 |
| 関連記事 | 「inhibit」「inhibitor」「HIV」「H」「integrase」 |
「HIVインテグラーゼ阻害剤」
「HIVインテグラーゼ阻害薬」
「inhibit」
- v.
- 抑制する、阻害する、阻止する
- 関
- abrogate、block、depress、depression、deter、inhibition、interdict、prevent、prevention、repress、repression、restrain、restraint、suppress、suppression
「inhibitor」
- n.
「HIV」
[★] human immunodeficiency virus HIVウイルス ヒト免疫不全ウイルス
「H」