AICA riboside deficiency

同

5-amino-4-imidazolecarboxamide

PrepTutorEJDIC

1. 〈U〉〈C〉(…の)(量・額などの)不足,欠乏《+『of』(『in』)+『名』》 / 〈C〉不足分,不足量,不足額 / 〈C〉(精神・肉体などの)欠陥

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• 1. 選択的IgE欠損症 selective ige deficiency
• 2. 選択的IgA欠損症：管理および予後 selective iga deficiency management and prognosis
• 3. 稀な（劣性遺伝性）凝固異常 rare recessively inherited coagulation disorders
• 4. ビタミンB12および葉酸欠乏症の病因および臨床症状 etiology and clinical manifestations of vitamin b12 and folate deficiency
• 5. Antithrombin (AT III) deficiency: Clinical manifestations and diagnosis

English Journal

• AMPK-dependent and independent effects of AICAR and compound C on T-cell responses.

• Rao E, Zhang Y, Li Q, Hao J, Egilmez NK, Suttles J, Li B.
• Oncotarget. 2016 Jun;7(23)33783-95.
• As a master metabolic sensor, AMP-activated protein kinase (AMPK) is involved in different fundamental cellular processes. Regulation of AMPK activity either by agonists (e.g., AICAR) or by antagonists (e.g., Compound C) has been widely employed to study the physiological functions of AMPK. However,
• PMID 27177226

• Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner.

• Li Y, Yang J, Chen MH, Wang Q, Qin MJ, Zhang T, Chen XQ, Liu BL, Wen XD.
• Pharmacological research. 2015 Sep;99()101-15.
• Ilexgenin A is a natural triterpenoid with beneficial effects on lipid disorders. This study aimed to investigate the effects of ilexgenin A on endothelial homeostasis and its mechanisms. Palmitate (PA) stimulation induced endoplasmic reticulum stress (ER stress) and subsequent thioredoxin-interacti
• PMID 26054569

• ERK1/2 antagonize AMPK-dependent regulation of FcεRI-mediated mast cell activation and anaphylaxis.

• Hwang SL, Lu Y, Li X, Kim YD, Cho YS, Jahng Y, Son JK, Lee YJ, Kang W, Taketomi Y, Murakami M, Moon TC, Chang HW.
• The Journal of allergy and clinical immunology. 2014 Sep;134(3)714-721.e7.
• Extracellular signal-regulated kinases 1/2 (ERK1/2) make important contributions to allergic responses via their regulation of degranulation, eicosanoid production, and cytokine expression by mast cells, yet the mechanisms underlying their positive effects on FcεRI-dependent signaling are not fully
• PMID 24948367

Related Links

• AICA-Ribosiduria: A Novel, Neurologically Devastating Inborn ...

As in ADSL deficiency, the succinylpurines S-Ado and SAICA-riboside accumulate in ATIC deficiency, although to a lesser extent. This accumulation is probably the result of inhibition of ADSL by accumulating AICAR (Sabina et al ...

• AICA-riboside induces apoptosis of pancreatic beta cells ...

1. Diabetologia. 2003 Feb;46(2):250-4. Epub 2003 Feb 8. AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase. Kefas BA, Heimberg H, Vaulont S, Meisse D, Hue L, Pipeleers D ...

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★リンクテーブル★

関連記事	「deficiency」「AI」「AIC」「AICA」

「deficiency」

　　[★]

• n.

• 不足、欠乏、欠失、欠如、欠損、不十分。栄養不足、栄養素欠乏、欠乏症。(遺伝子)(染色体内の)遺伝子欠失
• 欠けているもの、不足している物。不足分。不完全なもの、欠点のあるもの

関

absence, agenesis, dearth, defect, defective, deficient, deficit, delete, deletion, deletional, depletion, deprivation, deprive, lack, miss, missing, morphological defect, paucity, scarce, scarcity, starve

　

「AI」

　　[★]

• 大動脈弁閉鎖不全症 aortic valve insufficiency
• adequate intake
• 無呼吸発作児

「AIC」

　　[★]

赤池の情報量基準

関

Akaike information criterion

「AICA」

　　[★] 前下小脳動脈 anterior inferior cerebellar artery