3-hydroxy-3-methylglutaryl-CoA

同

HMGCoA

WordNet

1. the 3rd letter of the Roman alphabet (同)c
2. (music) the keynote of the scale of C major
3. a general-purpose programing language closely associated with the UNIX operating system
4. being or containing a hydroxyl group

PrepTutorEJDIC

1. carbonの化学記号
2. cobaltの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/08/17 16:56:31」(JST)

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[Wiki en表示]

HMG-CoA
IUPAC name (9R,21S)-1-[(2R,3S,4R,5R)-5- (6-amino-9H-purin-9-yl)-4-hydroxy- 3-(phosphonooxy)tetrahydrofuran-2-yl]- 3,5,9,21-tetrahydroxy-8,8,21-trimethyl- 10,14,19-trioxo-2,4,6-trioxa-18-thia- 11,15-diaza-3,5-diphosphatricosan-23- oic acid 3,5-dioxide
Identifiers
CAS number	1553-55-5 Y
PubChem	445127
ChemSpider	392859 Y
MeSH	HMG-CoA
ChEBI	CHEBI:61659 Y
Jmol-3D images	Image 1
SMILES O=C(O)C[C@@](O)(C)CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n2cnc1c(ncnc12)N)[C@H](O)[C@@H]3OP(=O)(O)O
InChI InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 Y Key: CABVTRNMFUVUDM-VRHQGPGLSA-N Y InChI=1/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 Key: CABVTRNMFUVUDM-VRHQGPGLBX
Properties
Molecular formula	C27H44N7O20P3S
Molar mass	911.661 g/mol
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

HMG-CoA (or 3-hydroxy-3-methylglutaryl-coenzyme A) is an intermediate in the mevalonate and ketogenesis pathways. It is formed from acetyl CoA and acetoacetyl CoA by HMG-CoA synthase.

It is also an intermediate in the metabolism of leucine. Its immediate precursor is 3-methylglutaconyl CoA.

Mevalonate pathway

Main article: Mevalonate pathway

HMG-CoA reductase converts it into mevalonic acid.

Mevalonate pathway

Ketogenesis pathway

HMG-CoA lyase breaks it into acetyl CoA and acetoacetate.

Ketogenesis

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• 3-hydroxy-3-methylglutaryl-CoA lyase deficiency

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HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction ...

Related Pictures

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★リンクテーブル★

リンク元	「ヒドロキシメチルグルタリルCoA」
拡張検索	「3-hydroxy-3-methylglutaryl-CoA reductase」
関連記事	「C」「hydroxy」「CoA」「COA」「hydro」

「ヒドロキシメチルグルタリルCoA」

　　[★]

英

hydroxymethylglutaryl-CoA, HMG-CoA

同

3-ヒドロキシ-3-メチルグルタリルCoA　3-hydroxy-3-methylglutaryl-CoA

関

HMG-CoA還元酵素阻害薬、コレステロールの生合成

==参考

• 1.

http://ja.wikipedia.org/wiki/%E3%83%92%E3%83%89%E3%83%AD%E3%82%AD%E3%82%B7%E3%83%A1%E3%83%81%E3%83%AB%E3%82%B0%E3%83%AB%E3%82%BF%E3%83%AA%E3%83%ABCoA

「3-hydroxy-3-methylglutaryl-CoA reductase」

　　[★] ヒドロキシメチルグルタリルCoA還元酵素

同

HMGCoA

「C」

　　[★]

• 炭素 carbon
• シトシン cytosine
• システイン cysteine
• シチジン
• セルシウス度 摂氏 degrees Celsius degree C
• 産婦人科領域で「子宮外頚 子宮外頚部 exocervix」を表現するための略語

　 　 　 　

「hydroxy」

　　[★]

ヒドロキシ、ハイドロキシ、水酸化

関

hydroxylation

　

「CoA」

　　[★]

• 大動脈縮窄症 coactation of the aorta
• 補酵素A coenzyme A

「COA」

　　[★] 補酵素A coenzyme A CoA

「hydro」

　　[★] ヒドロ、ハイドロ