hydroxymethylglutaryl-CoA

ヒドロキシメチルグルタリルCoA

関

3-hydroxy-3-methylglutaryl-coenzyme A、HMG-CoA

WordNet

1. the 3rd letter of the Roman alphabet (同)c
2. (music) the keynote of the scale of C major
3. a general-purpose programing language closely associated with the UNIX operating system

PrepTutorEJDIC

1. carbonの化学記号
2. cobaltの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/10/18 13:51:33」(JST)

wiki en

[Wiki en表示]

HMG-CoA

Names
IUPAC name (9R,21S)-1-[(2R,3S,4R,5R)-5- (6-amino-9H-purin-9-yl)-4-hydroxy- 3-(phosphonooxy)tetrahydrofuran-2-yl]- 3,5,9,21-tetrahydroxy-8,8,21-trimethyl- 10,14,19-trioxo-2,4,6-trioxa-18-thia- 11,15-diaza-3,5-diphosphatricosan-23- oic acid 3,5-dioxide
Identifiers
CAS Number	1553-55-5 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:61659 Y
ChemSpider	392859 Y
ECHA InfoCard	100.014.820
IUPHAR/BPS	3040
MeSH	HMG-CoA
PubChem CID	445127
InChI InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 Y Key: CABVTRNMFUVUDM-VRHQGPGLSA-N Y InChI=1/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 Key: CABVTRNMFUVUDM-VRHQGPGLBX
SMILES O=C(O)C[C@@](O)(C)CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n2cnc1c(ncnc12)N)[C@H](O)[C@@H]3OP(=O)(O)O
Properties
Chemical formula	C27H44N7O20P3S
Molar mass	911.661 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is YN ?)
Infobox references

HMG-CoA (or 3-hydroxy-3-methylglutaryl-coenzyme A) is an intermediate in the mevalonate and ketogenesis pathways. It is formed from acetyl CoA and acetoacetyl CoA by HMG-CoA synthase. The researches of Minor J. Coon and Bimal Kumar Bachhawat in the 1950s at University of Illinois led to its discovery.

It is also an intermediate in the metabolism of leucine. Its immediate precursor is 3-methylglutaconyl CoA.

Mevalonate pathway

Main article: Mevalonate pathway

HMG-CoA reductase converts it into mevalonic acid.

Mevalonate pathway

Ketogenesis pathway

HMG-CoA lyase breaks it into acetyl CoA and acetoacetate.

Ketogenesis

See also

• Steroidogenic enzyme

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. スタチン：作用、副作用、および投与 statins actions side effects and administration
• 2. ペルオキシソーム病 peroxisomal disorders
• 3. 慢性閉塞性肺疾患（COPD）：危険因子およびリスク低減 chronic obstructive pulmonary disease risk factors and risk reduction
• 4. 脳腱黄色腫症 cerebrotendinous xanthomatosis
• 5. HELLP症候群 hellp syndrome

English Journal

• Which nonautoimmune myopathies are most frequently misdiagnosed as myositis?

• Mammen AL1.
• Current opinion in rheumatology.Curr Opin Rheumatol.2017 Nov;29(6):618-622. doi: 10.1097/BOR.0000000000000441.
• PMID 28832350

• Opinions of nephrologists on the efficacy and tolerance of statins in hemodialysis patients.

• Budzisz E1, Nowicki M1.
• Renal failure.Ren Fail.2017 Nov;39(1):277-282. doi: 10.1080/0886022X.2016.1260032. Epub 2016 Nov 25.
• PMID 27885903

• Efficacy comparison of atorvastatin versus rosuvastatin on blood lipid and microinflammatory state in maintenance hemodialysis patients.

• Tian J1, Hou X1,2, Hu L1, Chen T1, Wu K3, Cai C3, Bai X1.
• Renal failure.Ren Fail.2017 Nov;39(1):153-158. doi: 10.1080/0886022X.2016.1256309. Epub 2016 Nov 15.
• PMID 27846790

Japanese Journal

• Rationale and Design of the Standard Versus Intensive Statin Therapy for Hypercholesterolemic Patients with Diabetic Retinopathy (EMPATHY) Study: a Randomized Controlled Trial

• Journal of Atherosclerosis and Thrombosis advpub(0), 2016
• NAID 130005131899

• Biochemical effects, hypolipidemic and anti-inflammatory activities of <i>Artemisia vulgaris</i> extract in hypercholesterolemic rats

• Journal of Clinical Biochemistry and Nutrition 57(1), 33-38, 2015
• NAID 130005085267

• Biochemical effects, hypolipidemic and anti-inflammatory activities of <i>Artemisia vulgaris</i> extract in hypercholesterolemic rats

• Journal of Clinical Biochemistry and Nutrition advpub(0), 2015
• NAID 130005065118

Related Links

• Hydroxymethylglutaryl-CoA | definition of ...

hydroxymethylglutaryl-CoA a regulatory enzyme involved in the maintenance of the level of cholesterol in cells; key intermediate in synthesis of cholesterol in cytosol; also produced in mitochondria during ketogenesis.

• HMGCS2 - Hydroxymethylglutaryl-CoA synthase ...

Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1), Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2) 3-hydroxy-3-methylglutaryl coenzyme A reductase, ...

---

★リンクテーブル★

リンク元	「ヒドロキシメチルグルタリルCoA」「3-hydroxy-3-methylglutaryl-coenzyme A」
拡張検索	「NADP-dependent hydroxymethylglutaryl-CoA-reductase」「NAD-dependent hydroxymethylglutaryl-CoA reductase」「hydroxymethylglutaryl-CoA reductase」「hydroxymethylglutaryl-CoA reductase inhibitor」
関連記事	「C」「CoA」「hydroxymethylglutaryl」「COA」「Co」

「ヒドロキシメチルグルタリルCoA」

　　[★]

英

hydroxymethylglutaryl-CoA, HMG-CoA

同

3-ヒドロキシ-3-メチルグルタリルCoA　3-hydroxy-3-methylglutaryl-CoA

関

HMG-CoA還元酵素阻害薬、コレステロールの生合成

==参考

• 1.

http://ja.wikipedia.org/wiki/%E3%83%92%E3%83%89%E3%83%AD%E3%82%AD%E3%82%B7%E3%83%A1%E3%83%81%E3%83%AB%E3%82%B0%E3%83%AB%E3%82%BF%E3%83%AA%E3%83%ABCoA

「3-hydroxy-3-methylglutaryl-coenzyme A」

　　[★]

3-ヒドロキシ-3-メチルグルタリル補酵素A、3-ヒドロキシ-3-メチルグルタリルCoA

関

HMG-CoA、hydroxymethylglutaryl-CoA

「NADP-dependent hydroxymethylglutaryl-CoA-reductase」

　　[★]

• NADP依存性ヒドロキシメチルグルタリルCoA還元酵素

「NAD-dependent hydroxymethylglutaryl-CoA reductase」

　　[★]

• NAD依存性ヒドロキシメチルグルタリルCoA還元酵素

「hydroxymethylglutaryl-CoA reductase」

　　[★] ヒドロキシメチルグルタリルCoA還元酵素

「hydroxymethylglutaryl-CoA reductase inhibitor」

　　[★] HMG-CoA還元酵素阻害薬

「C」

　　[★]

• 炭素 carbon
• シトシン cytosine
• システイン cysteine
• シチジン
• セルシウス度 摂氏 degrees Celsius degree C
• 産婦人科領域で「子宮外頚 子宮外頚部 exocervix」を表現するための略語

　 　 　 　

「CoA」

　　[★]

• 大動脈縮窄症 coactation of the aorta
• 補酵素A coenzyme A

「hydroxymethylglutaryl」

　　[★]

ヒドロキシメチルグルタリル

「COA」

　　[★] 補酵素A coenzyme A CoA

「Co」

　　[★] コバルト cobalt