WordNet

exhibiting variation and change; "letters variant in size"
differing from a norm or standard; "a variant spelling"
any disease of the throat or fauces marked by spasmodic attacks of intense suffocative pain

PrepTutorEJDIC

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

Genetic Variants of the NLRP3 Inflammasome Are Associated with Stroke in Patients with Rheumatoid Arthritis.

Kastbom A1, Ärlestig L1, Rantapää-Dahlqvist S1.
The Journal of rheumatology.J Rheumatol.2015 Jul 15. pii: jrheum.141529. [Epub ahead of print]
OBJECTIVE: Inflammasomes are intracellular protein complexes important for the production of proinflammatory cytokines. Studies have suggested that the NLRP3 inflammasome influences both the severity of rheumatoid arthritis (RA) and development of atherosclerosis. Therefore, we investigated whether
PMID 26178285

Double hazards of ischemia and reperfusion arrhythmias in a patient with variant angina pectoris.

Xu M1, Yang X2.
Journal of electrocardiology.J Electrocardiol.2015 Jul-Aug;48(4):739-43. doi: 10.1016/j.jelectrocard.2015.05.006. Epub 2015 May 8.
Variant angina pectoris, also called Prinzmetal's angina, is a syndrome caused by vasospasms of the coronary arteries. It can lead to myocardial infarction, ventricular arrhythmias, atrioventricular block and even sudden cardiac death. We report the case of a 53 year-old male patient with recurrent
PMID 26025204

Diurnal and twenty-four hour patterning of human diseases: cardiac, vascular, and respiratory diseases, conditions, and syndromes.

Smolensky MH1, Portaluppi F2, Manfredini R2, Hermida RC3, Tiseo R2, Sackett-Lundeen LL4, Haus EL4.
Sleep medicine reviews.Sleep Med Rev.2015 Jun;21:3-11. doi: 10.1016/j.smrv.2014.07.001. Epub 2014 Jul 18.
Various medical conditions, disorders, and syndromes exhibit predictable-in-time diurnal and 24 h patterning in the signs, symptoms, and grave nonfatal and fatal events, e.g., respiratory ones of viral and allergic rhinorrhea, reversible (asthma) and non-reversible (bronchitis and emphysema) chron
PMID 25129838

Severity of Myocardial Fatty Acid Dysmetabolism Induced by Coronary Spasm Does not Differ With Thrombolysis in Myocardial Infarction (TIMI) Grade During Intracoronary Acetylcholine Provocation Tests

, , , , , , , , , , ,
International Heart Journal 55(5), 416-421, 2014
Whether additional intracoronary acetylcholine (ACH) injections are required for severe coronary spasm without limited coronary flow in the ACH provocation test remains unclear. We used 123I-β-methyl- …
NAID 130004678100

Metabolic Planar Imaging Using 123I-β-Methyl-Iodophenyl Pentadecanoic Acid Identifies Myocardial Ischemic Memory After Intracoronary Acetylcholine Provocation Tests in Patients With Vasospastic Angina

, , , , , , ,
International Heart Journal 55(2), 113-118, 2014
… The aim of this study was to determine the diagnostic accuracy of early/delayed 123I-β-methyl-iodophenyl pentadecanoic acid (123I-BMIPP) planar images to detect disrupted fatty acid metabolism in patients with vasospastic angina (VSA). …
NAID 130003392068

渡邊岳博
日本保険医学会誌 110(1), 12-21, 2012-03-17
冠攣縮(れんしゅく)性狭心症の告知および診断書を目にする機会は少なくないが,生命保険の査定者にとって冠攣縮という現象および冠攣縮性狭心症は理解が難しいものと考える。冠攣縮は日本人に多く,異型狭心症のみならず他の狭心症や急性心筋梗塞等虚血性心疾患全般にも重要な役割を果たしている。本稿では近年発行された日本循環器学会の「冠攣縮性狭心症の診断と治療に関するガイドライン」を概説するとともに,最近の知見およ …
NAID 110009426020

英: variant form of angina, variant form of angina pectoris, variant angina pectoris, VAP
同: プリンツメタル型狭心症 Prinzmetal angina Prinzmetal's variant angina Prinzmetal's angina
関: 狭心症

HIM.1531

may involve increased sympathetic activity in combination with endothelial dysfunction.

心外膜の冠動脈における巣状攣縮 focal spasm of an epicardial coronary artery (HIM.1531)

冠攣縮：粥状班は冠動脈の完全閉塞をきたさないが、多くの患者で冠動脈の近位部に少なくとも一ヵ所見いだされる。この粥状班から1cmのところで攣縮が起こる。大抵、右冠動脈でfocal spasmがおこるのが一般的である。1本の動脈に単発or多発することもあるし、多枝同時におこるこももある。(HIM.1531)

HIM.1531

臨床診断はST上昇、安静時狭心痛で行う(HUM.1531)
エルゴノビン、アセチルコリン、あるいはその他の血管収縮薬の服用、または過呼吸は冠攣縮を誘発するの使われ、またこれらで診断をつけることができるfocal coronary stenosisがはっきりと示される。(HUM.1531)

nitrates, calcium blocker がメインである。舌下錠は発作に対して、長期作用薬 long-acting nitrate は発作の再発予防に有用。calcium channel blockerは冠攣縮の予防に非常に有用でできるだけ多く処方すべき。
β blockerは禁忌である　→　冠攣縮を誘発するおそれ。β2Rをblockするから？？？