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1. 免疫グロブリン軽鎖（AL）アミロイドーシスの臨床症状、検査所見、診断clinical presentation laboratory manifestations and diagnosis of immunoglobulin light chain al amyloidosis [show details]
…neoplasm. There are four major groups of MIDD: AL amyloidosis; Light chain deposition disease; Light and heavy chain deposition disease; Heavy chain deposition disease; All of these entities will have evidence …
2. 多発性骨髄腫における病期分類および予後研究staging and prognostic studies in multiple myeloma [show details]
… The serum kappa/lambda free light chain (FLC) assay is a sensitive method for the detection of excess FLCs and an abnormal kappa/lambda FLC ratio is used as a surrogate marker for clonal expansion. The …
3. 免疫グロブリン軽鎖（AL）アミロイドーシスおよび軽鎖重鎖沈着症の病因pathogenesis of immunoglobulin light chain al amyloidosis and light and heavy chain deposition diseases [show details]
… the filtration of intact light chains, not the light chain fragments responsible for tissue deposition in amyloidosis or LCDD. The availability of amyloidogenic lambda light chain-secreting human cell lines …
4. 免疫遺伝学immunoglobulin genetics [show details]
…chromosome is successful, a complete IgM (mu) heavy chain mRNA is made, IgM heavy chain protein is synthesized and complexed with surrogate light chains, then expressed on the cell surface as the pre-B cell …
5. BおよびTリンパ球の正常な発生normal b and t lymphocyte development [show details]
… heavy chain genes complete V-D-J recombination, allowing the surface expression of a complex consisting of an Ig heavy chain and molecules called surrogate light chains that show homology to Ig light chain …

English Journal

Reaching an evidence-based prognosis for personalized treatment of multiple sclerosis.

Rotstein D, Montalban X.
Nature reviews. Neurology. 2019 May;15(5)287-300.
Personalized treatment is ideal for multiple sclerosis (MS) owing to the heterogeneity of clinical features, but current knowledge gaps, including validation of biomarkers and treatment algorithms, limit practical implementation. The contemporary approach to personalized MS therapy depends on eviden
PMID 30940920

Salicylic acid amplifies Carbachol-induced bronchoconstriction in human precision-cut lung slices.

Jude J, Botelho D, Karmacharya N, Cao GY, Jester W, Panettieri RA.
Respiratory research. 2019 Apr;20(1)72.
Asthma exacerbations evoke emergency room visits, progressive loss of lung function and increased mortality. Environmental and industrial toxicants exacerbate asthma, although the underlying mechanisms are unknown. We assessed whether 3 distinct toxicants, salicylic acid (SA), toluene diisocyanate (
PMID 30971247

Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation.

Hayakawa K, Li YS, Shinton SA, Bandi SR, Formica AM, Brill-Dashoff J, Hardy RR.
Frontiers in immunology. 2019 ;10()457.
The Lin28bLet7 axis in fetal/neonatal development plays a role in promoting CD5 B1a cell generation as a B-1 B cell developmental outcome. Here we identify the Let7 target, Arid3a, as a crucial molecular effector of the B-1 cell developmental program. Arid3a expression is increased at pro-B cell sta
PMID 30930899

Japanese Journal

Distorted antibody repertoire developed in the absence of pre-B cell receptor formation

Sun Lin,Kono Naoko,Shimizu Takeyuki,Toh Hiroyuki,Xue Hanbing,Numata Osamu,Ato Manabu,Itamura Shigeyuki,Ohnishi Kazuo
Biochemical and biophysical research communications 495(1), 1411-1417, 2018-01
… The pre-B cell receptor (pre-BCR), consisting of the μ heavy chain (μHC) and the surrogate light chain (SLC, Vpre-B and λ5), plays important roles during B cell development. … Analysis of the CDR-H3 amino acid sequences of μ-chain repertoires revealed that certain bone marrow B cells with particular CDR-H3 profiles undergo clonal expansion in λ5−/− mice. …
NAID 120006454816

The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver