WordNet

direct the flow of; "channel information towards a broad audience" (同)canalize, canalise
a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels" (同)television channel, TV channel
a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"
(often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms" (同)communication channel, line
a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company" (同)transmission channel
a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"
find a place for and put away for storage; "where should we stow the vegetables?"; "I couldnt store all the books in the attic so I sold some"
a supply of something available for future use; "he brought back a large store of Cuban cigars" (同)stock, fund
keep or lay aside for future use; "store grain for the winter"; "The bear stores fat for the period of hibernation when he doesnt eat" (同)hive away, lay in, put_in, salt away, stack away, stash away
direct or control; projects, businesses, etc.; "She is running a relief operation in the Sudan" (同)run
happen; "What is going on in the minds of the people?"
handle and cause to function; "do not operate machinery after imbibing alcohol"; "control the lever" (同)control
official routes of communication; "you have to go through channels"

PrepTutorEJDIC

〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す
〈C〉《おもに米》[小売]『店』,商店(《英》shop) / 〈C〉(…の)『蓄え』,貯蔵《+『of』+『名』》 / 〈C〉多量,多数,たくさん(の…)《+『of』+『名』》 / 《複数形で》必需品,備品,用品 / 〈C〉倉庫,貯蔵所 / (将来のために)…‘を'蓄える』《+『up』+『名』》 / …‘を'『倉庫に保管する』 / (…を)〈ある場所など〉‘に'供給する,用意する《+『名』〈場所〉+『with』+『名』》
〈機械・身体器官などが〉『動く』,作動する / 〈薬などが〉(…に)『利く』,効果を表す,作用する,影響する《+『on』(『upon』)+『名』》 / (人に…の)『手術をする』《+『on』(『upon』)+『名』〈人〉+『for』+『名』》 / (…に対して)軍事行動をする《+『against』+『名』》 / 〈機械・装置など〉‘を'『動かす』 / …‘を'経営する,運営する;〈株など〉‘を'売買する

UpToDate Contents

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1. T細胞受容体シグナル伝達 t cell receptor signaling
2. 腎集合管ナトリウムチャンネルの遺伝的障害：リドル症候群および偽性低アルドステロン症1型 genetic disorders of the collecting tubule sodium channel liddles syndrome and pseudohypoaldosteronism type 1
3. 赤血球水分量の制御 control of red blood cell hydration
4. 幼児の持続性高インスリン血症性低血糖症の病因、臨床的特徴、および診断 pathogenesis clinical features and diagnosis of persistent hyperinsulinemic hypoglycemia of infancy
5. カルシウム拮抗剤の主な副作用および安全性 major side effects and safety of calcium channel blockers

English Journal

Characterization of novel store-operated calcium entry effectors.

Djillani A1, Nüße O1, Dellis O2.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Oct;1843(10):2341-7. doi: 10.1016/j.bbamcr.2014.03.012. Epub 2014 Mar 20.
2-Aminoethyl diphenylborinate (2-APB) is a well-known effector of the store-operated Ca(2+) entry of several cell types such as immune cells, platelets and smooth muscle cells. 2-APB has a dual effect: potentiation at 1-5μM and inhibition at >30μM. Unfortunately, it is also able to modify the a
PMID 24657813

How ORAI and TRP channels interfere with each other: interaction models and examples from the immune system and the skin.

Saul S1, Stanisz H2, Backes CS1, Schwarz EC1, Hoth M3.
European journal of pharmacology.Eur J Pharmacol.2014 Sep 15;739:49-59. doi: 10.1016/j.ejphar.2013.10.071. Epub 2013 Nov 28.
Four types of Ca(2+) selective ion channels are known, ten voltage gated Ca(2+) (CaV) channels, four CatSper channels, three store operated CRAC channels (ORAI channels) and at least two members of the TRPV subfamily (TRPV5, TRPV6). Some of the other TRP channels also show some Ca(2+) selectivity li
PMID 24291108

Calcium channels, external calcium concentration and cell proliferation.

Borowiec AS1, Bidaux G1, Pigat N2, Goffin V2, Bernichtein S2, Capiod T3.
European journal of pharmacology.Eur J Pharmacol.2014 Sep 15;739:19-25. doi: 10.1016/j.ejphar.2013.10.072. Epub 2013 Nov 28.
Evidence for a role for calcium channel proteins in cell proliferation is numerous suggesting that calcium influx is essential in this physiological process. Several studies in the past thirty years have demonstrated that calcium channel expression levels are determinant in cell proliferation. Volta
PMID 24291106

Japanese Journal

Current Perspective : Key Components of Store-Operated Ca²⁺ Entry in Non-Excitable Cells

Tojyo Yosuke,Morita Takao,Nezu Akihiro [他],Tanimura Akihiko
Journal of Pharmacological Sciences 125(4), 340-346, 2014
… Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ entry pathway in non-excitable cells. … STIM1 is a single-pass transmembrane protein located predominantly in the ER that serves as a Ca2+ sensor within the ER, while Orai1 is a tetraspanning plasma membrane (PM) protein that functions as the pore-forming subunit of store-operated Ca2+ channels. …
NAID 130004677800

Membrane Hyperpolarization Induced by Endoplasmic Reticulum Stress Facilitates Ca2+ Influx to Regulate Cell Cycle Progression in Brain Capillary Endothelial Cells

Kito Hiroaki,Yamamura Hisao,Suzuki Yoshiaki,Ohya Susumu,Asai Kiyofumi,Imaizumi Yuji
Journal of Pharmacological Sciences 125(2), 227-232, 2014
… Upregulation of the Kir2.1 channel during endoplasmic reticulum (ER) stress in t-BBEC117, an immortalized bovine brain endothelial cell line, caused a sustained increase in intracellular Ca2+ concentration ([Ca2+]i) and a facilitation of cell death. …
NAID 130004438630

悪性高熱症 : 最近の話題について

向田圭子,河本昌志
日本臨床麻酔学会誌 = The Journal of Japan Society for Clinical Anesthesia 32(5), 682-690, 2012-09-15
悪性高熱症（MH）は揮発性吸入麻酔薬により骨格筋細胞内のカルシウム（Ca<SUP>2＋</SUP>）濃度が持続的に上昇して発症する．骨格筋小胞体（SR）にあるリアノジン受容体（RYR1）のCa<SUP>2＋</SUP>調節機能の異常が主な原因で，RYR1遺伝子の変異は200以上発見された．変異RYR1遺伝子を有する細胞や遺伝子変異マウスの研究から …
NAID 10031074019