slow-reacting substance

同

SRS

WordNet

1. not moving quickly; taking a comparatively long time; "a slow walker"; "the slow lane of traffic"; "her steps were slow"; "he was slow in reacting to the news"; "slow but steady growth"
2. cause to proceed more slowly; "The illness slowed him down" (同)slow down, slow up
3. become slow or slower; "Production slowed" (同)slow down, slow up, slack, slacken
4. (used of timepieces) indicating a time earlier than the correct time; "the clock is slow"
5. at a slow tempo; "the band played a slow waltz"
6. material of a particular kind or constitution; "the immune response recognizes invading substances"
7. a particular kind or species of matter with uniform properties; "shigella is one of the most toxic substances known to man"
8. the real physical matter of which a person or thing consists; "DNA is the substance of our genes"

PrepTutorEJDIC

1. (速度・動作などが)『遅い』,のろい / 《補語または名詞の後にのみ用いて》(時計などが)『遅れている』 / 『ゆったりした』,あわてない / (人が)理解の遅い,頭の鈍い / (生活・パーティーなどが)『活気のない』,おもしろくない / 遅く,ゆっくり(slowly) / 『遅くなる』,速度を落とす《+『down』(『up』)》 / …‘を'『遅くする』,‘の'速度を落とす《+『名』+『down』(『up』),+『down』(『up』)+『名』》
2. 〈U〉『物質』,物 / 〈U〉《the~》(…の)『趣旨』,本音《+of+名》 / 〈U〉(スープなどの)濃さ,こく,中身[の詰まっていること] / 〈U〉『実質』,実 / 〈U〉《古》財産,資産

UpToDate Contents

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• 1. 統合失調症と物質使用障害の併発：疫学、病因、臨床症状、および診断 co occurring schizophrenia and substance use disorder epidemiology pathogenesis clinical manifestations and diagnosis
• 2. HIV感染患者における薬物乱用および中毒 substance abuse and addiction in hiv infected patients
• 3. 授乳中の乳幼児：物質使用障害による抗精神病薬、リチウム、刺激薬、および薬剤への曝露の安全性 breastfeeding infants safety of exposure to antipsychotics lithium stimulants and medications for substance use disorders
• 4. 喘息の治療において5-リポキシゲナーゼ経路に影響する薬剤 agents affecting the 5 lipoxygenase pathway in the treatment of asthma
• 5. 統合失調症と物質使用障害の併発に対する治療 treatment of co occurring schizophrenia and substance use disorder

English Journal

• [Leukotrien antagonists in the treatment of allergic rhinitis and comorbidities].

• Sacre Hazouri JA1.
• Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993).Rev Alerg Mex.2008 Jul-Aug;55(4):164-75.
• Leukotrienes comprise a family of products of the 5-lipoxigenase pathway of arachidonic acid metabolism. The cysteinil leukotrienes C4, D4 and E4 account for the biologic activity that was previously termed "slow-reacting substance of anaphylaxis". The proinflammatory effects of cysteinil leukotrien
• PMID 19058495

• The cysteinyl leukotrienes: where do they come from? What are they? Where are they going?

• Austen KF1.
• Nature immunology.Nat Immunol.2008 Feb;9(2):113-5. doi: 10.1038/ni0208-113.
• Cysteinyl leukotrienes are established mediators of bronchial asthma and have agonist roles analogous to those of histamine in allergic rhinitis. We now know that the substance originally termed slow-reacting substance of anaphylaxis was composed of three cysteinyl leukotrienes that act in the infla
• PMID 18204420

• Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis.

• Ago H1, Kanaoka Y, Irikura D, Lam BK, Shimamura T, Austen KF, Miyano M.
• Nature.Nature.2007 Aug 2;448(7153):609-12. Epub 2007 Jul 15.
• The cysteinyl leukotrienes, namely leukotriene (LT)C4 and its metabolites LTD4 and LTE4, the components of slow-reacting substance of anaphylaxis, are lipid mediators of smooth muscle constriction and inflammation, particularly implicated in bronchial asthma. LTC4 synthase (LTC4S), the pivotal enzym
• PMID 17632548

Japanese Journal

• ロイコトリエン・リポキシゲナーゼ代謝系と創薬

• 阿部 正義,吉本 谷博
• 日本薬理学雑誌 : FOLIA PHARMACOLOGICA JAPONICA 124(4), 415-425, 2004-10-01
• … ロイコトリエン・リポキシゲナーゼ系に関連した薬の中で最初に臨床的に確かな評価を得たのは，構造式の決定に長年の研究を要したslow reacting substance of anaphylaxis（SRS-A）を抑制するものであった．最初に抗喘息薬として登場したのは5-リポキシゲナーゼ阻害薬であったが，次に開発されたcysteinyl-leukotriene type 1 receptor（cysLT1R）拮抗薬が5-リポキシゲナーゼ阻害薬と同等以上の効果 …
• NAID 10025739505

• トロンボキサンA2受容体拮抗薬 : セラトロダストの創製研究

• 寺尾 秦次,白石 充,松本 辰美 [他],蘆田 康子
• 藥學雜誌 119(5), 377-390, 1999-05-01
• … We were interested in RCS (rabbit aorta contracting substance) and SRS-A(slow reacting substance of anaphylaxis) and their involvement in human bronchial asthma. …
• NAID 110003648745

• Synthesis and Structure-Activity Relationships of Antiallergic N-[4-[4-(1H-Indol-3-yl)piperidinoalkyl]-2-thiazolyl]alkanamides Possessing Both Antihistaminic and Anti Slow-Reacting Substance (SRS) Activites

• 重永 信次,真鍋 孝司,松田 博,藤井 隆,松尾 昌昭
• Chemical & pharmaceutical bulletin 42(9), 1822-1827, 1994-09-15
• … A series of N-[4-[4-(1H-indol-3-yl)piperidinoalkyl]-2-thiazolyl]alkanamide derivatives were synthesized and tested for in vivo antianaphylactic activity and in vitro anti slow-reacting substance (SRS) activity. …
• NAID 110003631242

Related Links

• slow-reacting substance of anaphylaxis - definition of slow ...

substance /sub·stance/ (sub´stans) 1. matter with a particular set of characteristics. 2. material constituting an organ or body. 3. psychoactive s. black substance substantia nigra. controlled substance any drug regulated under the ...

• Slow-reacting substance of anaphylaxis. - National Center for ...

Feldberg W, Kellaway CH. Liberation of histamine and formation of lysocithin-like substances by cobra venom. J Physiol. 1938 Nov 14; 94 (2):187–226. [PMC free article] [PubMed] Feldberg W, Kellaway CH. Liberation of histamine ...

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★リンクテーブル★

リンク元	「SRS」「遅発性反応性物質」
拡張検索	「slow-reacting substance of anaphylaxis」
関連記事	「slow」「substance」「slowing」

「SRS」

　　[★]

• 性別適合手術 sex reassignment surgery
• slow-reacting substance
• ソマトスタチン受容体シンチグラフィ somatostatin receptor scintigraphy
• 定位手術的照射 stereotactic radiosurgery

「遅発性反応性物質」

　　[★]

関

遅発反応性物質 slow-reacting substance slow-reacting substance of anaphylaxis

「slow-reacting substance of anaphylaxis」

　　[★] アナフィラキシー遅延反応物質, SRS-A

「slow」

　　[★]

• adj.

• (比較級slower-最上級slowest)緩徐な、遅い、ゆっくりとした、緩慢な

• v.

• 遅くする

関

gradual、gradually、late、slowly、sluggish

　 　 　 　 　 　

「substance」

　　[★]

• n.

• 物質、サブスタンス、実体

関

entity、material、matter

　 　 　 　

「slowing」

　　[★]

• n.

• 緩徐化、徐脈化