アナフィラキシー遅延反応物質, SRS-A
WordNet
- not moving quickly; taking a comparatively long time; "a slow walker"; "the slow lane of traffic"; "her steps were slow"; "he was slow in reacting to the news"; "slow but steady growth"
- cause to proceed more slowly; "The illness slowed him down" (同)slow down, slow up
- become slow or slower; "Production slowed" (同)slow down, slow up, slack, slacken
- (used of timepieces) indicating a time earlier than the correct time; "the clock is slow"
- at a slow tempo; "the band played a slow waltz"
- material of a particular kind or constitution; "the immune response recognizes invading substances"
- a particular kind or species of matter with uniform properties; "shigella is one of the most toxic substances known to man"
- the real physical matter of which a person or thing consists; "DNA is the substance of our genes"
- hypersensitivity reaction to the ingestion or injection of a substance (a protein or drug) resulting from prior contact with a substance
PrepTutorEJDIC
- (速度・動作などが)『遅い』,のろい / 《補語または名詞の後にのみ用いて》(時計などが)『遅れている』 / 『ゆったりした』,あわてない / (人が)理解の遅い,頭の鈍い / (生活・パーティーなどが)『活気のない』,おもしろくない / 遅く,ゆっくり(slowly) / 『遅くなる』,速度を落とす《+『down』(『up』)》 / …‘を'『遅くする』,‘の'速度を落とす《+『名』+『down』(『up』),+『down』(『up』)+『名』》
- 《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
- 〈U〉『物質』,物 / 〈U〉《the~》(…の)『趣旨』,本音《+of+名》 / 〈U〉(スープなどの)濃さ,こく,中身[の詰まっていること] / 〈U〉『実質』,実 / 〈U〉《古》財産,資産
- OLD French古[代]フランス語
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/02/21 12:23:19」(JST)
[Wiki en表示]
The slow-reacting substance of anaphylaxis or SRS-A is a mixture of the leukotrienes LTC4, LTD4 and LTE4. Mast cells secrete it during the anaphylactic reaction, inducing inflammation.[1] It can be found in basophils.
It induces prolonged, slow contraction of smooth muscle and has a major bronchoconstrictor role in asthma.[2] Compared to histamine, it is approximately 5000 times more potent and has a slower onset but longer duration of action.[citation needed]
References
- ^ "Dorland's Medical Dictionary". Retrieved December 15, 2006.
- ^ Howard R. Morris; Graham W. Taylor; Priscilla J. Piper; John R. Tippins. "Structure of slow-reacting substance of anaphylaxis from guinea-pig lung". Retrieved December 15, 2006.
External links
- Slow Reacting Substance of Anaphylaxis at the US National Library of Medicine Medical Subject Headings (MeSH)
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Eicosanoids
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| Precursor |
|
| Prostanoids |
| Prostaglandins (PG) |
| Precursor |
|
| Active |
| D/J |
|
| E/F |
|
| I |
- I2 (Prostacyclin/Epoprostenol):
|
|
|
| Thromboxanes (TX) |
|
|
| Leukotrienes (LT) |
| Precursor |
- Arachidonic acid 5-hydroperoxide
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| Initial |
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| SRS-A |
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|
| Eoxins (EX) |
| Precursor |
- Arachidonic acid 15-hydroperoxide
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| Eoxins |
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| Nonclassic |
- Lipoxins (LX) (A4, B4)
- Virodhamine
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| By function |
- vasoconstriction
- vasodilation
- platelets: induce
- inhibit
- leukocytes: induce
- inhibit
- labor stimulation:
- PGE2 (Dinoprostone)
- PGF2α (Dinoprost)
|
UpToDate Contents
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English Journal
- M2-like macrophages induce colon cancer cell invasion via matrix metalloproteinases.
- Vinnakota K1, Zhang Y1, Selvanesan BC1, Topi G1, Salim T1, Sand-Dejmek J1, Jönsson G1, Sjölander A1.
- Journal of cellular physiology.J Cell Physiol.2017 Dec;232(12):3468-3480. doi: 10.1002/jcp.25808. Epub 2017 Feb 13.
- PMID 28098359
- Microsomal glutathione transferase 2 modulates LTC4 synthesis and ROS production in Apostichopus japonicus.
- Zhang Z1, Lv Z1, Wei Z1, Li C2, Shao Y1, Zhang W1, Zhao X1, Xiong J1.
- Molecular immunology.Mol Immunol.2017 Nov;91:114-122. doi: 10.1016/j.molimm.2017.09.002. Epub 2017 Sep 8.
- PMID 28892748
- Cysteinyl leukotriene E4 activates human group 2 innate lymphoid cells and enhances the effect of prostaglandin D2 and epithelial cytokines.
- Salimi M1, Stöger L2, Liu W3, Go S3, Pavord I3, Klenerman P4, Ogg G1, Xue L5.
- The Journal of allergy and clinical immunology.J Allergy Clin Immunol.2017 Oct;140(4):1090-1100.e11. doi: 10.1016/j.jaci.2016.12.958. Epub 2017 Jan 20.
- PMID 28115217
Japanese Journal
- 日本薬理学雑誌 : FOLIA PHARMACOLOGICA JAPONICA 124(4), 415-425, 2004-10-01
- NAID 10025739505
- トロンボキサンA2受容体拮抗薬 : セラトロダストの創製研究
- Synthesis and Antiallergy Activity of [1,3,4]Thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one Derivatives. I
★リンクテーブル★
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- 英
- slow reacting substance of anaphylaxis, SRS-A, slow-reacting substance of anaphylaxis
- 同
- アナフィラキシー遅延反応性物質
[show details]
[★]
アナフィラキシー遅延反応物質, slow reacting substance of anaphylaxis, slow-reacting substance of anaphylaxis
[★]
- (比較級slower-最上級slowest)緩徐な、遅い、ゆっくりとした、緩慢な
- 関
- gradual、gradually、late、slowly、sluggish
[★]
- 関
- entity、material、matter
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アナフィラキシー