The slow-reacting substance of anaphylaxis or SRS-A is a mixture of the leukotrienes LTC4, LTD4 and LTE4. Mast cells secrete it during the anaphylactic reaction, inducing inflammation.[1] It can be found in basophils.
It induces prolonged, slow contraction of smooth muscle and has a major bronchoconstrictor role in asthma.[2] Compared to histamine, it is approximately 5000 times more potent and has a slower onset but longer duration of action.[citation needed]
References
^"Dorland's Medical Dictionary". Archived from the original on January 9, 2007. Retrieved December 15, 2006.
^Howard R. Morris; Graham W. Taylor; Priscilla J. Piper; John R. Tippins. "Structure of slow-reacting substance of anaphylaxis from guinea-pig lung". Retrieved December 15, 2006.
External links
Slow+Reacting+Substance+of+Anaphylaxis at the US National Library of Medicine Medical Subject Headings (MeSH)
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t
e
Eicosanoids
Precursor
Arachidonic acid
Prostanoids
Prostaglandins (PG)
Precursor
H2
Active
D/J
D2
E/F
E2 (Dinoprostone)
E1 (Alprostadil)
F2α (Dinoprost):
I
I2 (Prostacyclin/Epoprostenol):
Thromboxanes (TX)
A2
B2
Leukotrienes (LT)
Precursor
Arachidonic acid 5-hydroperoxide
Initial
A4
B4
SRS-A
C4
D4
E4
Eoxins (EX)
Precursor
Arachidonic acid 15-hydroperoxide
Eoxins
A4
C4
D4
E4
Nonclassic
Lipoxins (LX) (A4, B4)
Virodhamine
By function
bronchoconstriction
PGD2
TXA2
LTC4
LTD4
LTE4
vasoconstriction
PGF2α
TXA2
TXB2)
vasodilation
PGE2
PGI2
LTC4
LTD4
LTE4
platelets: induce
TXA2
inhibit
PGD2
PGI2
leukocytes: induce
TXA2
LTB4
inhibit
PGD2
PGE2
fever stimulation:
PGE2
labor stimulation:
PGE2 (Dinoprostone)
PGF2α (Dinoprost)
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SRS-A slow-reacting substance of anaphylaxis; see under substance. SRS-A abbr. slow-reacting substance of anaphylaxis SRS-A, abbreviation for slow-reacting substance of anaphylaxis. substance [sub´stans] 1. physical material ...