WordNet

place signs, as along a road; "sign an intersection"; "This road has been signed"
(medicine) any objective evidence of the presence of a disorder or disease; "there were no signs of asphyxiation"
a perceptible indication of something not immediately apparent (as a visible clue that something has happened); "he showed signs of strain"; "they welcomed the signs of spring" (同)mark
a character indicating a relation between quantities; "dont forget the minus sign"
a fundamental linguistic unit linking a signifier to that which is signified; "The bond between the signifier and the signified is arbitrary"--de Saussure
a gesture that is part of a sign language
a public display of a message; "he posted signs in all the shop windows"
engage by written agreement; "They signed two new pitchers for the next season" (同)contract, sign on, sign_up
approve and express assent, responsibility, or obligation; "All parties ratified the peace treaty"; "Have you signed your contract yet?" (同)ratify
communicate silently and non-verbally by signals or signs; "He signed his disapproval with a dismissive hand gesture"; "The diner signaled the waiters to bring the menu" (同)signal, signalize, signalise
mark with ones signature; write ones name (on); "She signed the letter and sent it off"; "Please sign here" (同)subscribe
be engaged by a written agreement; "He signed to play the casino on Dec. 18"; "The soprano signed to sing the new opera"
communicate in sign language; "I dont know how to sign, so I could not communicate with my deaf cousin"
notably out of the ordinary; "the year saw one signal triumph for the Labour party"
an electric quantity (voltage or current or field strength) whose modulation represents coded information about the source from which it comes
any nonverbal action or gesture that encodes a message; "signals from the boat suddenly stopped" (同)signaling, sign
any incitement to action; "he awaited the signal to start"; "the victory was a signal for wild celebration"
(psychiatry) a relatively permanent state of worry and nervousness occurring in a variety of mental disorders, usually accompanied by compulsive behavior or attacks of panic (同)anxiousness
a vague unpleasant emotion that is experienced in anticipation of some (usually ill-defined) misfortune

PrepTutorEJDIC

(ある事実・状態・感情などの)『表れ』,印,気配,徴侯(indication);(…の)こん跡,計跡《+『of』+『名』》・『身ぶり』,手まね,合図 / 『標識』,看板 / (数学・音楽などの)記号 / (…の)『象徴』,シンボル(symbol)《+『of』+『名』》・《文》(…の)『前兆』,きざし《+『of』+『名』》・宮(きゅう)(黄道12区分の一つ) ・〈手紙・書類・作品など〉‘に'『署名する』・(…に)〈名前など〉‘を'書く《+『名』+『on』(『to』)+『名』》 / …‘を'雇う契約に署名する・…‘を'合図する,知らせる;…に合図する・署名する・契約書に署名して雇われる
(警告・指示・情報などを伝える)『信号』,合図 / (…の)きっかけ,動機,導火線《+『for』+『名』》 / 〈人・車など〉‘に'『合図する』,信号を送る / …‘を'『合図』(信号)『で知らせる』 / 『合図する』,信号する / 合図の,信号の / めざましい,顕著な
〈U〉(…についての)『心配』,不安,気がかり《+『about(for)』+『名』》 / 〈C〉心配事,心配の種 / 〈U〉《話》『切望』,熱望;〈C〉切望する事(物)

UpToDate Contents

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1. 緩和ケアにおける不安の概要 overview of anxiety in palliative care
2. 統合失調症における不安 anxiety in schizophrenia
3. 成人の社会不安障害への治療アプローチ approach to treating social anxiety disorder in adults
4. 成人における物質使用障害および不安関連障害の併発：疫学、病因、臨床症状、経過、評価および診断 co occurring substance use disorder and anxiety related disorders in adults epidemiology pathogenesis clinical manifestations course assessment and diagnosis
5. 成人のがん生存者における心理社会的問題の概要 overview of psychosocial issues in the adult cancer survivor

English Journal

Absence of system xc- in mice decreases anxiety and depressive-like behavior without affecting sensorimotor function or spatial vision.

Bentea E1, Demuyser T2, Van Liefferinge J2, Albertini G2, Deneyer L1, Nys J3, Merckx E1, Michotte Y2, Sato H4, Arckens L3, Massie A1, Smolders I5.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2015 Jun 3;59:49-58. doi: 10.1016/j.pnpbp.2015.01.010. Epub 2015 Jan 23.
There is considerable preclinical and clinical evidence indicating that abnormal changes in glutamatergic signaling underlie the development of mood disorders. Astrocytic glutamate dysfunction, in particular, has been recently linked with the pathogenesis and treatment of mood disorders, including a
PMID 25619129

In vivo occupancy of the 5-HT1A receptor by a novel pan 5-HT1(A/B/D) receptor antagonist, GSK588045, using positron emission tomography.

Comley RA1, van der Aart J1, Gulyás B2, Garnier M3, Iavarone L3, Halldin C2, Rabiner EA4.
Neuropharmacology.Neuropharmacology.2015 May;92:44-8. doi: 10.1016/j.neuropharm.2014.11.017. Epub 2014 Dec 2.
5-hydroxytryptamine 1 (5-HT1) receptor blockade in combination with serotonin reuptake inhibition may provide a more rapid elevation of synaptic 5-HT compared to serotonin reuptake alone, by blocking the inhibitory effect of 5-HT1 receptor activation on serotonin release. GSK588045 is a novel compou
PMID 25476970

Testing the role of reward and punishment sensitivity in avoidance behavior: A computational modeling approach.

Sheynin J1, Moustafa AA2, Beck KD3, Servatius RJ4, Myers CE5.
Behavioural brain research.Behav Brain Res.2015 Apr 15;283:121-38. doi: 10.1016/j.bbr.2015.01.033. Epub 2015 Jan 29.
Exaggerated avoidance behavior is a predominant symptom in all anxiety disorders and its degree often parallels the development and persistence of these conditions. Both human and non-human animal studies suggest that individual differences as well as various contextual cues may impact avoidance beh
PMID 25639540

Japanese Journal

Yokukansan, a traditional Japanese herbal medicine, promotes neurite outgrowth in PC12 cells through the activation of extracellular signal regulated kinase 1/2 and phosphatidylinositol 3-kinase/Akt