セリン型D-Ala-D-Alaカルボキシペプチダーゼ
WordNet
- write by means of a keyboard with types; "type the acceptance letter, please" (同)typewrite
- a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"
- (biology) the taxonomic group whose characteristics are used to define the next higher taxon
- a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"
- all of the tokens of the same symbol; "the word `element contains five different types of character"
- printed characters; "small type is hard to read"
- identify as belonging to a certain type; "Such people can practically be typed" (同)typecast
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
- the 4th letter of the Roman alphabet (同)d
- a wing of an insect
- a flat wing-shaped process or winglike part of an organism; "the alae of the nose"; "the alae of a maple seed"; "the flat petals of a pea blossom are alae"
PrepTutorEJDIC
- 〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ
- answer / ampere
- deuteriumの化学記号
- (おもに人称代名詞・固有名詞(人名),thereの後で)had, wouldの短縮形 / (疑問文でwhere,what,whenの後で)didの短縮形;Where'd he go?=Where did he go?
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/22 23:11:51」(JST)
[Wiki en表示]
| Serine-type D-Ala-D-Ala carboxypeptidase |
| Identifiers |
| EC number |
3.4.16.4 |
| CAS number |
9077-67-2 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
A transpeptidase (EC 3.4.16.4, DD-peptidase, DD-transpeptidase, DD-carboxypeptidase, D-alanyl-D-alanine carboxypeptidase, D-alanyl-D-alanine-cleaving-peptidase, D-alanine carboxypeptidase, D-alanyl carboxypeptidase, and serine-type D-Ala-D-Ala carboxypeptidase.[1]) is a bacterial enzyme that cross-links peptidoglycan chains to form rigid cell walls. In Gram-positive bacteria, the peptidoglycan molecules are cross-linked by a pentapeptide bridge, whereas, in Gram-negative bacteria, the peptidoglycan molecules are directly covalently bound to each other.
The antibiotic penicillin irreversibly binds to and inhibits the activity of the transpeptidase enzyme by forming a highly stable penicilloyl-enzyme intermediate. Because of the interaction between penicillin and transpeptidase, this enzyme is also known as penicillin-binding protein (PBP).
See also
- Vancomycin, an antibiotic that binds the D-ala-D-ala residues, inhibiting elongation via glycosyltransferase
References
- ^ "E.C.3.4.16.4 Serine-type D-Ala-D-Ala carboxypeptidase". Enzyme Structures Database. Retrieved February 26, 2006.
External links
- The MEROPS online database for peptidases and their inhibitors: S11.001
- EC 3.4.16.4
- Serine-Type D-Ala-D-Ala Carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Hydrolase: proteases (EC 3.4)
|
|
| 3.4.11-19: Exopeptidase |
| 3.4.11 |
- Aminopeptidase
- Alanine
- Arginyl
- Aspartyl
- Cystinyl
- Leucyl
- Glutamyl
- Methionyl
- O
|
|
| 3.4.13 |
|
|
| 3.4.14 |
- Dipeptidyl peptidase
- Cathepsin C
- Dipeptidyl peptidase-4
- Tripeptidyl peptidase
- Tripeptidyl peptidase I
- Tripeptidyl peptidase II
|
|
| 3.4.15 |
- Angiotensin-converting enzyme
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|
| 3.4.16 |
- Serine type carboxypeptidases: Cathepsin A
- DD-transpeptidase
|
|
| 3.4.17 |
- Metalloexopeptidases
- Carboxypeptidase
- A
- A2
- B
- C
- E
- Glutamate II
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|
| Other/ungrouped |
|
|
|
| 3.4.21-24: Endopeptidase |
- Serine proteases
- Cysteine protease
- Aspartic acid protease
- Metalloendopeptidases
- Other/ungrouped: Amyloid precursor protein secretase
- Alpha secretase
- Beta-secretase 1
- Beta-secretase 2
- Gamma secretase
|
|
| 3.4.99: Unknown |
|
|
- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
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|
UpToDate Contents
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English Journal
- Comparison of the enzymatic and functional properties of three cytosolic carboxypeptidase family members.
- Wu HY1, Rong Y1, Correia K1, Min J2, Morgan JI3.
- The Journal of biological chemistry.J Biol Chem.2015 Jan 9;290(2):1222-32. doi: 10.1074/jbc.M114.604850. Epub 2014 Nov 21.
- Nna1 (CCP1) defines a subfamily of M14 metallocarboxypeptidases (CCP1-6) and is mutated in pcd (Purkinje cell degeneration) mice. Nna1, CCP4, and CCP6 are involved in the post-translational process of polyglutamylation, where they catalyze the removal of polyglutamate side chains. However, it is unk
- PMID 25416787
- Biochemical and biophysical characterization of an unexpected bacteriolytic activity of VanX, a member of the vancomycin-resistance vanA gene cluster.
- Sohya S1, Kamioka T1, Fujita C1, Maki T2, Ohta Y1, Kuroda Y3.
- The Journal of biological chemistry.J Biol Chem.2014 Dec 26;289(52):35686-94. doi: 10.1074/jbc.M114.590265. Epub 2014 Oct 7.
- VanX is a d-alanyl-d-alanine (d-Ala-d-Ala) dipeptidase encoded in the vancomycin-resistance vanA gene cluster. Here we report that strong bacteriolysis occurred when isolated VanX was expressed in Escherichia coli at temperatures lower than 30 °C, which was unexpected because the vanA operon confer
- PMID 25294880
- Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation.
- Ye B1, Li C1, Yang Z2, Wang Y1, Hao J1, Wang L1, Li Y3, Du Y1, Hao L1, Liu B1, Wang S1, Xia P1, Huang G1, Sun L1, Tian Y4, Fan Z4.
- The Journal of experimental medicine.J Exp Med.2014 Nov 17;211(12):2439-54. doi: 10.1084/jem.20141123. Epub 2014 Oct 20.
- Bone marrow progenitor cells develop into mature megakaryocytes (MKs) to produce platelets for hemostasis and other physiological functions. However, the molecular mechanisms underlying megakaryopoiesis are not completely defined. We show that cytosolic carboxypeptidase (CCP) 6 deficiency in mice ca
- PMID 25332286
Related Links
- Serine-Type D-Ala-D-Ala Carboxypeptidase; D-D Carboxypeptidase. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between ...
- Species, Research Topics, Genomes and Genes, Scientific Experts, Research Grants, Publications about serine type d ala d ala carboxypeptidase ... ..On the basis of amino acid alignments we propose, that PBP4 and class A beta ...
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